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AssayWise Letters 2017, Vol. 6(1)
Latest News & Events

Buccutite™ Crosslinking Technology

NAADP-AM, A New Player in Calcium Signaling Pathways

Nucleic Acid Detection, Quantification and Imaging

Quantitative Analysis of Thiols and Maleimides

AssayWise Letters Vol. 6(1)


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Featured Article
NAADP-AM, A New Player in Calcium Signaling Pathways
Nicotinic acid adenine dinucleotide phosphate (NAADP, Cat# 20999) is a secondary messenger that plays a key role in calcium signaling pathways. First discovered in the early 1980s, this dinucleotide has become the focus of intense research in recent years. It has been proposed as a pharmacological target for a variety of diseases affecting the pancreas, heart and nervous system. Experiments with NAADP have shown it to be an extremely potent calcium mobilizer as well as a modulating agent for other cellular pathways, such as those involving inositol trisphosphate (IP3). The strong interest in NAADP has also led to the discovery and development of several key research tools, namely, NED-19 (a NAADP antagonist) and NAADP-AM (a cell-permeable form of NAADP). Read More...



Buccutite™ Crosslinking Technology
A novel approach to protein-protein conjugation that requires minimal purification and leads to optimized yields. Buccutite™ crosslinking technology offers significant improvements over traditional NHS and SMCC methods.

Nucleic Acid Detection, Quantification and Imaging
A review of common and novel reagents for quantification of nucleic acids as well as spatiotemporal imaging and localization techniques.

Quantitative Analysis of Thiols and Maleimides
Quantification of thiols and maleimides presents significant challenges to analytical chemistry. Recent developments in assay technology serve to address some of the limitations.