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ICG amine

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Physical properties
Molecular weight1001.08
SolventDMSO
Spectral properties
Correction Factor (280 nm)0.076
Extinction coefficient (cm -1 M -1)230000
Excitation (nm)789
Emission (nm)813
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12171501
Direct upgrades
iFluor® 790 amine

OverviewpdfSDSpdfProtocol


Molecular weight
1001.08
Correction Factor (280 nm)
0.076
Extinction coefficient (cm -1 M -1)
230000
Excitation (nm)
789
Emission (nm)
813
Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption close to 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. This ICG amine can be used to modify the molecules that contain a carbonyl group (such as an aldehyde or a carboxy group).

Calculators


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of ICG amine to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM99.892 µL499.461 µL998.921 µL4.995 mL9.989 mL
5 mM19.978 µL99.892 µL199.784 µL998.921 µL1.998 mL
10 mM9.989 µL49.946 µL99.892 µL499.461 µL998.921 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)Molecular weightVolume (Calculate)Concentration (Calculate)Moles
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Spectrum


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spectrum

Spectral properties

Correction Factor (280 nm)0.076
Extinction coefficient (cm -1 M -1)230000
Excitation (nm)789
Emission (nm)813

Product Family


NameExcitation (nm)Emission (nm)Extinction coefficient (cm -1 M -1)Quantum yieldCorrection Factor (280 nm)
ICG-ATT [3-ICG-acyl-1,3-thiazolidine-2-thione]789813230000-0.076
ICG-OSu789813230000-0.076
XFD488 amine *Same Structure to Alexa Fluor™ 488 amine*499520710000.9210.11
XFD594 amine *Same Structure to Alexa Fluor™ 594 amine*590618900000.6610.56
XFD532 amine534553810000.6110.09
XFD555 amine5535681550000.110.08
XFD568 amine579603880000.6910.46
XFD647 amine6506712700000.3310.03
XFD750 amine7527762900000.1210.04
ICG-Osu *UltraPure Grade*789813230000-0.076
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Citations


View all 7 citations: Citation Explorer
Comparison of Near-Infrared Imaging Agents Targeting the PTPmu Tumor Biomarker
Authors: Johansen, Mette L and Vincent, Jason and Rose, Marissa and Sloan, Andrew E and Brady-Kalnay, Susann M
Journal: Molecular Imaging and Biology (2023): 1--14
Intravenous anti-VEGF agents with RGD peptide-targeted core cross-linked star (CCS) polymers modified with indocyanine green for imaging and treatment of laser-induced choroidal neovascularization
Authors: Cai, Wenting and Chen, Qijing and Shen, Tianyi and Yang, Qian and Hu, Weinan and Zhao, Peng and Yu, Jing
Journal: Biomaterials Science (2020): 4481--4491
Assessment of Lexiscan for Blood Brain Barrier disruption to facilitate Fluorescence brain imaging
Authors: Pak, Rebecca W and Le, Hanh and Valentine, Heather and Thorek, Daniel and Rahmim, Arman and Wong, Dean and Kang, Jin U
Journal: (2017): ATu3B--2
Assessment of Lexiscan for Blood Brain Barrier disruption to facilitate Fluorescence brain imaging
Authors: Pak, Rebecca W and Le, Hanh ND and Valentine, Heather and Thorek, Daniel and Rahmim, Arman and Wong, Dean and Kang, Jin U
Journal: (2017): ATu3B--2
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
Authors: Zhao, Shuting and Xu, Zhaobin and Wang, Hai and Reese, Benjamin E and Gushchina, Liubov V and Jiang, Meng and Agarwal, Pranay and Xu, Jiangsheng and Zhang, Mingjun and Shen, Rulong and others, undefined
Journal: Nature Communications (2016): 13306
Single-Layer MoS2 Nanosheets with Amplified Photoacoustic Effect for Highly Sensitive Photoacoustic Imaging of Orthotopic Brain Tumors
Authors: Chen, Jingqin and Liu, Chengbo and Hu, Dehong and Wang, Feng and Wu, Haiwei and Gong, Xiaojing and Liu, Xin and Song, Liang and Sheng, Zonghai and Zheng, Hairong
Journal: Advanced Functional Materials (2016)
Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites
Authors: Liu, Yu and Kang, Ning and Lv, Jing and Zhou, Zijian and Zhao, Qingliang and Ma, Lingceng and Chen, Zhong and Ren, Lei and Nie, Liming
Journal: Advanced Materials (2016)

References


View all 193 references: Citation Explorer
Ultrastaging of colon cancer by sentinel node biopsy using fluorescence navigation with indocyanine green
Authors: Hirche C, Mohr Z, Kneif S, Doniga S, Murawa D, Strik M, Hunerbein M.
Journal: Int J Colorectal Dis (2012): 319
Sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in cutaneous head and neck/lip mucosa melanomas
Authors: Hayashi T, Furukawa H, Oyama A, Funayama E, Saito A, Yamao T, Yamamoto Y.
Journal: Head Neck (2012): 758
Efficacy of indocyanine green videography and real-time evaluation by FLOW 800 in the resection of a spinal cord hemangioblastoma in a child
Authors: Ueba T, Abe H, Matsumoto J, Higashi T, Inoue T.
Journal: J Neurosurg Pediatr (2012): 428
Concentration of indocyanine green does not significantly influence lymphatic function as assessed by near-infrared imaging
Authors: Aldrich MB, Davies-Venn C, Angermiller B, Robinson H, Chan W, Kwon S, Sevick-Muraca EM.
Journal: Lymphat Res Biol (2012): 20
Comparative Study of the Optical and Heat Generation Properties of IR820 and Indocyanine Green
Authors: Fern, undefined and ez-Fern, undefined and ez A, Manch and a R, Lei T, Carvajal DA, Tang Y, Zahid Raza Kazmi S, McGoron AJ.
Journal: Mol Imaging (2012): 99
Sentinel lymph node biopsy using a new indocyanine green fluorescence imaging system with a colour charged couple device camera for oral cancer
Authors: Iwai T, Maegawa J, Hirota M, Tohnai I.
Journal: Br J Oral Maxillofac Surg. (2012)
Usefulness of indocyanine green angiography to depict the distant retinal vascular anomalies associated with branch retinal vein occlusion causing serous macular detachment
Authors: Ueda T, Gomi F, Suzuki M, Sakaguchi H, Sawa M, Kamei M, Nishida K.
Journal: Retina (2012): 308
Application of indocyanine green videoangiography in surgery for spinal vascular malformations
Authors: Misra BK, Pur and are HR., undefined
Journal: J Clin Neurosci. (2012)
Indocyanine-Green Angiography Findings in Susac's Syndrome
Authors: Balaskas K, Guex-Crosier Y, Borruat FX.
Journal: Klin Monbl Augenheilkd (2012): 426
Gold nanomaterials conjugated with indocyanine green for dual-modality photodynamic and photothermal therapy
Authors: Kuo WS, Chang YT, Cho KC, Chiu KC, Lien CH, Yeh CS, Chen SJ.
Journal: Biomaterials (2012): 3270