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MM 1-43 [N-(3-Triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide] *CAS#: 149838-22-2*

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Physical properties
Molecular weight611.54
SolventWater
Spectral properties
Excitation (nm)473
Emission (nm)579
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12352200

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CAS
149838-22-2
Molecular weight
611.54
Excitation (nm)
473
Emission (nm)
579
MM 1-43 is the abbreviation of our Membrane Marker 1-43, chemically called N-(3-triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide. MM 1-43 is chemically the same molecule of FM 1-43. In literature this membrane marker is also called "FM 1-43" (FM® is the trademark of Molecular Probes). It is a water-soluble membrane probe that belongs to the styryl dye family. It is widely used in cell biology and neurobiology since it has minimal toxicity to cells. MM 1-43 is virtually non-fluorescent in aqueous medium and strongly fluorescent upon binding to membrane. It is efficiently excited with standard fluorescein optical filters, and exhibits an intense fluorescent signal when associated with the plasma membrane. MM 1-43 has frequently been used to quantify exocytosis in neurons. Fluorescence imaging using MM 1-43 and related styryl dyes has provided invaluable insights into presynaptic function of synapses in culture preparations.

Calculators


Common stock solution preparation

Table 1. Volume of Water needed to reconstitute specific mass of MM 1-43 [N-(3-Triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide] *CAS#: 149838-22-2* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM163.522 µL817.608 µL1.635 mL8.176 mL16.352 mL
5 mM32.704 µL163.522 µL327.043 µL1.635 mL3.27 mL
10 mM16.352 µL81.761 µL163.522 µL817.608 µL1.635 mL

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Spectrum


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Spectral properties

Excitation (nm)473
Emission (nm)579

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References


View all 27 references: Citation Explorer
Palytoxin-induced effects on partial reactions of the Na,K-ATPase
Authors: Harmel N, Apell HJ.
Journal: J Gen Physiol (2006): 103
Electrogenic partial reactions of the gastric H,K-ATPase
Authors: Diller A, Vagin O, Sachs G, Apell HJ.
Journal: Biophys J (2005): 3348
Effective gating charge of ion channels induced by toxin syringomycin E in lipid bilayers
Authors: Schagina LV, Gurnev PA, Takemoto JY, Malev VV.
Journal: Bioelectrochemistry (2003): 21
Effect of dipole modifiers on the kinetics of sensitized photoinactivation of gramicidin channels in bilayer lipid membranes
Authors: Antonenko YN, Rokitskaya TI, Kotova EA.
Journal: Membr Cell Biol (1999): 111
Hofmeister effects of anions on the kinetics of partial reactions of the Na+,K+-ATPase
Authors: Ganea C, Babes A, Lupfert C, Grell E, Fendler K, Clarke RJ.
Journal: Biophys J (1999): 267
Influence of anions and cations on the dipole potential of phosphatidylcholine vesicles: a basis for the Hofmeister effect
Authors: Clarke RJ, Lupfert C.
Journal: Biophys J (1999): 2614
Electrogenic partial reactions of the SR-Ca-ATPase investigated by a fluorescence method
Authors: Butscher C, Roudna M, Apell H.
Journal: J Membr Biol (1999): 169
Effect of gramicidin A on the dipole potential of phospholipid membranes
Authors: Shapovalov VL, Kotova EA, Rokitskaya TI, Antonenko YN.
Journal: Biophys J (1999): 299
Cable properties of dendrites in hippocampal neurons of the rat mapped by a voltage-sensitive dye
Authors: Meyer E, Muller CO, Fromherz P.
Journal: Eur J Neurosci (1997): 778
Effect of the dipole potential of a bilayer lipid membrane on gramicidin channel dissociation kinetics
Authors: Rokitskaya TI, Antonenko YN, Kotova EA.
Journal: Biophys J (1997): 850