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Chrysamine G *CAS 6472-91-9*

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Physical properties
Molecular weight482.44
SolventDMSO
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12352200

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CAS
6472-91-9
Molecular weight
482.44
Chrysamine G is a lipophilic, bis-salicylic acid analog of Congo Red that displays both high (Kd = 200 nM; Bmax = 1.13 moles per mole of Ab40) and low (Kd = 38.77 µM; Bmax = 23.10 moles per mole of Ab40) affinity binding sites for beta-amyloid (Ab) fibrils. It can cross the blood-brain barrier and serve as a useful probe for detecting senile plaques (Ab aggregate).

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Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Chrysamine G *CAS 6472-91-9* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM207.28 µL1.036 mL2.073 mL10.364 mL20.728 mL
5 mM41.456 µL207.28 µL414.559 µL2.073 mL4.146 mL
10 mM20.728 µL103.64 µL207.28 µL1.036 mL2.073 mL

Molarity calculator

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Product Family


NameExcitation (nm)Emission (nm)
Sulforhodamine G *CAS 5873-16-5*531552

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References


View all 13 references: Citation Explorer
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
Authors: Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.
Journal: J Biol Chem (2005): 5892
Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain
Authors: Mathis CA, Wang Y, Klunk WE.
Journal: Curr Pharm Des (2004): 1469
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
Authors: Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT.
Journal: J Neuropathol Exp Neurol (2002): 797
Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice
Authors: Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H.
Journal: Neurosci Lett (2002): 5
Amyloid binding ligands as Alzheimer's disease therapies
Authors: Lee VM., undefined
Journal: Neurobiol Aging (2002): 1039
In vitro affinity of 99Tcm-labelled N2S2 conjugates of chrysamine G for amyloid deposits of systemic amyloidosis
Authors: Dezutter NA, Sciot RM, de Groot TJ, Bormans GM, Verbruggen AM.
Journal: Nucl Med Commun (2001): 553
Evaluation of 99mTc-MAMA-chrysamine G as an in vivo probe for amyloidosis
Authors: Dezutter NA, L and man WJ, Jager PL, de Groot TJ, Dupont PJ, Tooten PC, Zekarias B, Gruys E, Verbruggen AM.
Journal: Amyloid (2001): 202
In search of the ideal radiotracer for soft-tissue amyloid scanning
Authors: Lee VW, Shah NP.
Journal: Amyloid (2001): 220
Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles
Authors: Smith DL, Portier R, Woodman B, Hockly E, Mahal A, Klunk WE, Li XJ, Wanker E, Murray KD, Bates GP.
Journal: Neurobiol Dis (2001): 1017
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
Authors: Heiser V, Scherzinger E, Boeddrich A, Nordhoff E, Lurz R, Schugardt N, Lehrach H, Wanker EE.
Journal: Proc Natl Acad Sci U S A (2000): 6739