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ICG-ATT [3-ICG-acyl-1,3-thiazolidine-2-thione]
Ordering information
| Price | |
| Catalog Number | |
| Unit Size | |
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Additional ordering information
| Telephone | 1-800-990-8053 |
| Fax | 1-800-609-2943 |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | 760.49 |
| Solvent | DMSO |
Spectral properties
| Correction Factor (280 nm) | 0.076 |
| Extinction coefficient (cm -1 M -1) | 230000 |
| Excitation (nm) | 789 |
| Emission (nm) | 813 |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C); Minimize light exposure |
| UNSPSC | 12171501 |
| Overview |  SDSProtocol |
See also: Indocyanine Green
Molecular weight 760.49 | Correction Factor (280 nm) 0.076 | Extinction coefficient (cm -1 M -1) 230000 | Excitation (nm) 789 | Emission (nm) 813 |
Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption close to 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. ICG binds tightly to plasma proteins and becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice. A recent study indicated ICG targets atheromas within 20 min of injection and provides sufficient signal enhancement for in vivo detection of lipid-rich, inflamed, coronary-sized plaques in atherosclerotic rabbits. Ex vivo fluorescence reflectance imaging showed high plaque target-to-background ratios in atheroma-bearing rabbits injected with ICG compared to atheroma-bearing rabbits injected with saline. This amino-reactive ICG derivative is used to make ICG bioconjugates with antibodies and other biological molecules. It need be dissolved in DMSO for labeling uses. ICG-Sulfo-OSu has better water solubility.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of ICG-ATT [3-ICG-acyl-1,3-thiazolidine-2-thione] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 131.494 µL | 657.471 µL | 1.315 mL | 6.575 mL | 13.149 mL |
| 5 mM | 26.299 µL | 131.494 µL | 262.988 µL | 1.315 mL | 2.63 mL |
| 10 mM | 13.149 µL | 65.747 µL | 131.494 µL | 657.471 µL | 1.315 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Spectrum
Open in Advanced Spectrum Viewer
Spectral properties
| Correction Factor (280 nm) | 0.076 |
| Extinction coefficient (cm -1 M -1) | 230000 |
| Excitation (nm) | 789 |
| Emission (nm) | 813 |
Product Family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) | Correction Factor (280 nm) |
| ICG-OSu | 789 | 813 | 230000 | 0.076 |
| ICG amine | 789 | 813 | 230000 | 0.076 |
| ICG acid | 789 | 813 | 230000 | 0.076 |
| ICG Maleimide | 789 | 813 | 230000 | 0.076 |
| ICG azide | 789 | 813 | 230000 | 0.076 |
| ICG alkyne | 789 | 813 | 230000 | 0.076 |
| ICG hydrazide | 789 | 813 | 230000 | 0.076 |
| ICG-Osu *UltraPure Grade* | 789 | 813 | 230000 | 0.076 |
Images
Figure 1. Chemical structure for ICG-ATT [3-ICG-acyl-1,3-thiazolidine-2-thione]
Citations
View all 4 citations: Citation Explorer
Assessment of Lexiscan for Blood Brain Barrier disruption to facilitate Fluorescence brain imaging
Authors: Pak, Rebecca W and Le, Hanh and Valentine, Heather and Thorek, Daniel and Rahmim, Arman and Wong, Dean and Kang, Jin U
Journal: (2017): ATu3B--2
Authors: Pak, Rebecca W and Le, Hanh and Valentine, Heather and Thorek, Daniel and Rahmim, Arman and Wong, Dean and Kang, Jin U
Journal: (2017): ATu3B--2
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
Authors: Zhao, Shuting and Xu, Zhaobin and Wang, Hai and Reese, Benjamin E and Gushchina, Liubov V and Jiang, Meng and Agarwal, Pranay and Xu, Jiangsheng and Zhang, Mingjun and Shen, Rulong and others, undefined
Journal: Nature Communications (2016): 13306
Authors: Zhao, Shuting and Xu, Zhaobin and Wang, Hai and Reese, Benjamin E and Gushchina, Liubov V and Jiang, Meng and Agarwal, Pranay and Xu, Jiangsheng and Zhang, Mingjun and Shen, Rulong and others, undefined
Journal: Nature Communications (2016): 13306
Single-Layer MoS2 Nanosheets with Amplified Photoacoustic Effect for Highly Sensitive Photoacoustic Imaging of Orthotopic Brain Tumors
Authors: Chen, Jingqin and Liu, Chengbo and Hu, Dehong and Wang, Feng and Wu, Haiwei and Gong, Xiaojing and Liu, Xin and Song, Liang and Sheng, Zonghai and Zheng, Hairong
Journal: Advanced Functional Materials (2016)
Authors: Chen, Jingqin and Liu, Chengbo and Hu, Dehong and Wang, Feng and Wu, Haiwei and Gong, Xiaojing and Liu, Xin and Song, Liang and Sheng, Zonghai and Zheng, Hairong
Journal: Advanced Functional Materials (2016)
Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites
Authors: Liu, Yu and Kang, Ning and Lv, Jing and Zhou, Zijian and Zhao, Qingliang and Ma, Lingceng and Chen, Zhong and Ren, Lei and Nie, Liming
Journal: Advanced Materials (2016)
Authors: Liu, Yu and Kang, Ning and Lv, Jing and Zhou, Zijian and Zhao, Qingliang and Ma, Lingceng and Chen, Zhong and Ren, Lei and Nie, Liming
Journal: Advanced Materials (2016)
References
View all 193 references: Citation Explorer
Ultrastaging of colon cancer by sentinel node biopsy using fluorescence navigation with indocyanine green
Authors: Hirche C, Mohr Z, Kneif S, Doniga S, Murawa D, Strik M, Hunerbein M.
Journal: Int J Colorectal Dis (2012): 319
Authors: Hirche C, Mohr Z, Kneif S, Doniga S, Murawa D, Strik M, Hunerbein M.
Journal: Int J Colorectal Dis (2012): 319
Sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in cutaneous head and neck/lip mucosa melanomas
Authors: Hayashi T, Furukawa H, Oyama A, Funayama E, Saito A, Yamao T, Yamamoto Y.
Journal: Head Neck (2012): 758
Authors: Hayashi T, Furukawa H, Oyama A, Funayama E, Saito A, Yamao T, Yamamoto Y.
Journal: Head Neck (2012): 758
Efficacy of indocyanine green videography and real-time evaluation by FLOW 800 in the resection of a spinal cord hemangioblastoma in a child
Authors: Ueba T, Abe H, Matsumoto J, Higashi T, Inoue T.
Journal: J Neurosurg Pediatr (2012): 428
Authors: Ueba T, Abe H, Matsumoto J, Higashi T, Inoue T.
Journal: J Neurosurg Pediatr (2012): 428
Concentration of indocyanine green does not significantly influence lymphatic function as assessed by near-infrared imaging
Authors: Aldrich MB, Davies-Venn C, Angermiller B, Robinson H, Chan W, Kwon S, Sevick-Muraca EM.
Journal: Lymphat Res Biol (2012): 20
Authors: Aldrich MB, Davies-Venn C, Angermiller B, Robinson H, Chan W, Kwon S, Sevick-Muraca EM.
Journal: Lymphat Res Biol (2012): 20
Comparative Study of the Optical and Heat Generation Properties of IR820 and Indocyanine Green
Authors: Fern, undefined and ez-Fern, undefined and ez A, Manch and a R, Lei T, Carvajal DA, Tang Y, Zahid Raza Kazmi S, McGoron AJ.
Journal: Mol Imaging (2012): 99
Authors: Fern, undefined and ez-Fern, undefined and ez A, Manch and a R, Lei T, Carvajal DA, Tang Y, Zahid Raza Kazmi S, McGoron AJ.
Journal: Mol Imaging (2012): 99
Sentinel lymph node biopsy using a new indocyanine green fluorescence imaging system with a colour charged couple device camera for oral cancer
Authors: Iwai T, Maegawa J, Hirota M, Tohnai I.
Journal: Br J Oral Maxillofac Surg. (2012)
Authors: Iwai T, Maegawa J, Hirota M, Tohnai I.
Journal: Br J Oral Maxillofac Surg. (2012)
Usefulness of indocyanine green angiography to depict the distant retinal vascular anomalies associated with branch retinal vein occlusion causing serous macular detachment
Authors: Ueda T, Gomi F, Suzuki M, Sakaguchi H, Sawa M, Kamei M, Nishida K.
Journal: Retina (2012): 308
Authors: Ueda T, Gomi F, Suzuki M, Sakaguchi H, Sawa M, Kamei M, Nishida K.
Journal: Retina (2012): 308
Application of indocyanine green videoangiography in surgery for spinal vascular malformations
Authors: Misra BK, Pur and are HR., undefined
Journal: J Clin Neurosci. (2012)
Authors: Misra BK, Pur and are HR., undefined
Journal: J Clin Neurosci. (2012)
Indocyanine-Green Angiography Findings in Susac's Syndrome
Authors: Balaskas K, Guex-Crosier Y, Borruat FX.
Journal: Klin Monbl Augenheilkd (2012): 426
Authors: Balaskas K, Guex-Crosier Y, Borruat FX.
Journal: Klin Monbl Augenheilkd (2012): 426
Gold nanomaterials conjugated with indocyanine green for dual-modality photodynamic and photothermal therapy
Authors: Kuo WS, Chang YT, Cho KC, Chiu KC, Lien CH, Yeh CS, Chen SJ.
Journal: Biomaterials (2012): 3270
Authors: Kuo WS, Chang YT, Cho KC, Chiu KC, Lien CH, Yeh CS, Chen SJ.
Journal: Biomaterials (2012): 3270
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