Name: ICG Xtra-OSu
Brand: AAT Bioquest
SKU: 186
Price: 232 USD
Availability: InStock

ICG Xtra-OSu

Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption at about 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. ICG binds tightly to plasma proteins and becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice. AAT Bioquest offers a variety of ICG derivatives for preparing ICG bioconjugates. Among them the two most popular ones are ICG-Sulfo-OSu and ICG-OSu, which generate the identical bioconjugates upon reacting with biomolecules containing amino groups. However, some of our customers and our scientists found that the antibody conjugates from the reactions of ICG-Sulfo-OSu and ICG-OSu are extremely difficult to be separated from the ICG acid resulted from the spontaneous hydrolysis of ICG-Sulfo-OSu and ICG-OSu. ICG Xtra-OSu has been developed to address this problem. It has comparable binding properties to plasma proteins. The antibody conjugates from the reactions of ICG Xtra-OSu can be readily separated from the ICG Xtra acid by a simple desalting column or SEC columns, making the ICG Xtra-OSu conjugations much more robust and easier to perform. In addition, ICG Xtra conjugates have much better water solubility than the corresponding ICG conjugate, making ICG Xtra a superior replacement for ICG for preparing the conjugates with hydrophobic antibodies.

<p>Excitation emission spetrum of Cat#186</p>

Protocol

SDS

COA

Catalog	Size	Price	Quantity
186	1 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of ICG Xtra-OSu to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	81.128 µL	405.64 µL	811.28 µL	4.056 mL	8.113 mL
5 mM	16.226 µL	81.128 µL	162.256 µL	811.28 µL	1.623 mL
10 mM	8.113 µL	40.564 µL	81.128 µL	405.64 µL	811.28 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	1232.62 g/mol	=	mL	x	mM	=	mmol

Citations

View all 5 citations: Citation Explorer

Comparison of Near-Infrared Imaging Agents Targeting the PTPmu Tumor Biomarker

Authors:

Johansen, Mette L and Vincent, Jason and Rose, Marissa and Sloan, Andrew E and Brady-Kalnay, Susann M

Journal:

Molecular Imaging and Biology (2023): 1--14

Assessment of Lexiscan for Blood Brain Barrier disruption to facilitate Fluorescence brain imaging

Authors:

Pak, Rebecca W and Le, Hanh and Valentine, Heather and Thorek, Daniel and Rahmim, Arman and Wong, Dean and Kang, Jin U

Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

Authors:

Zhao, Shuting and Xu, Zhaobin and Wang, Hai and Reese, Benjamin E and Gushchina, Liubov V and Jiang, Meng and Agarwal, Pranay and Xu, Jiangsheng and Zhang, Mingjun and Shen, Rulong and others, undefined

Journal:

Nature Communications (2016): 13306

Single-Layer MoS2 Nanosheets with Amplified Photoacoustic Effect for Highly Sensitive Photoacoustic Imaging of Orthotopic Brain Tumors

Authors:

Chen, Jingqin and Liu, Chengbo and Hu, Dehong and Wang, Feng and Wu, Haiwei and Gong, Xiaojing and Liu, Xin and Song, Liang and Sheng, Zonghai and Zheng, Hairong

Journal:

Advanced Functional Materials (2016)

Deep Photoacoustic/Luminescence/Magnetic Resonance Multimodal Imaging in Living Subjects Using High-Efficiency Upconversion Nanocomposites

Authors:

Liu, Yu and Kang, Ning and Lv, Jing and Zhou, Zijian and Zhao, Qingliang and Ma, Lingceng and Chen, Zhong and Ren, Lei and Nie, Liming

Journal:

Advanced Materials (2016)

References

View all 193 references: Citation Explorer

Sentinel lymph node biopsy using intraoperative indocyanine green fluorescence imaging navigated with preoperative CT lymphography for superficial esophageal cancer

Authors:

Yuasa Y, Seike J, Yoshida T, Takechi H, Yamai H, Yamamoto Y, Furukita Y, Goto M, Minato T, Nishino T, Inoue S, Fujiwara S, Tangoku A.

Journal:

Ann Surg Oncol (2012): 486

Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy: a pilot study

Authors:

Yannuzzi LA, Slakter JS, Gross NE, Spaide RF, Costa DL, Huang SJ, Klancnik JM, Jr., Aizman A.

Journal:

Retina (2012): 288

Using indocyanine green fluorescent lymphography and lymphatic-venous anastomosis for cancer-related lymphedema

Authors:

Mihara M, Murai N, Hayashi Y, Hara H, Iida T, Narushima M, Todokoro T, Uchida G, Yamamoto T, Koshima I.

Journal:

Ann Vasc Surg (2012): 278 e1

Management of peripheral polypoidal choroidal vasculopathy with intravitreal bevacizumab and indocyanine green angiography-guided laser photocoagulation

Authors:

Rishi P, Das A, Sarate P, Rishi E.

Journal:

Indian J Ophthalmol (2012): 60

Synthesis and characterization of bovine serum albumin-coated nanocapsules loaded with indocyanine green as potential multifunctional nanoconstructs

Authors:

Jung B, Anvari B.

Journal:

Biotechnol Prog (2012): 533

Physical properties

Molecular weight	1232.62
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.09
Correction factor (280 nm)	0.055
Extinction coefficient (cm ^-1 M ^-1)	230000
Excitation (nm)	790
Emission (nm)	814

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

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Page updated on October 11, 2025