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Indocyanine Green *CAS 3599-32-4*

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Physical properties
Molecular weight774.96
SolventDMSO
Spectral properties
Correction Factor (280 nm)0.076
Extinction coefficient (cm -1 M -1)230000
Excitation (nm)789
Emission (nm)813
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12171501

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CAS
3599-32-4
Molecular weight
774.96
Correction Factor (280 nm)
0.076
Extinction coefficient (cm -1 M -1)
230000
Excitation (nm)
789
Emission (nm)
813
Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. ICG is used for determining cardiac output, hepatic function, liver blood flow, and for ophthalmic angiography. ICG has a peak spectral absorption close to 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. ICG binds tightly to plasma proteins and becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice. A recent study indicated ICG targets atheromas within 20 min of injection and provides sufficient signal enhancement for in vivo detection of lipid-rich, inflamed, coronary-sized plaques in atherosclerotic rabbits. Ex vivo fluorescence reflectance imaging showed high plaque target-to-background ratios in atheroma-bearing rabbits injected with ICG compared to atheroma-bearing rabbits injected with saline.

Calculators


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Indocyanine Green *CAS 3599-32-4* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM129.039 µL645.195 µL1.29 mL6.452 mL12.904 mL
5 mM25.808 µL129.039 µL258.078 µL1.29 mL2.581 mL
10 mM12.904 µL64.519 µL129.039 µL645.195 µL1.29 mL

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Spectrum


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spectrum

Spectral properties

Correction Factor (280 nm)0.076
Extinction coefficient (cm -1 M -1)230000
Excitation (nm)789
Emission (nm)813

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Citations


View all 1 citations: Citation Explorer
Nanodiamonds for bioapplications, recent developments
Authors: Bondon, Nicolas and Raehm, Laurence and Charnay, Clarence and Boukherroub, Rabah and Durand, Jean-Olivier
Journal: Journal of Materials Chemistry B (2020): 10878--10896

References


View all 37 references: Citation Explorer
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Single-molecule fluorescence spectroelectrochemistry of cresyl violet
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Journal: J Histochem Cytochem (2003): 959
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Journal: Biotechniques (2003): 1080
Ala-Pro-cresyl violet, a synthetic fluorogenic substrate for the analysis of kinetic parameters of dipeptidyl peptidase IV (CD26) in individual living rat hepatocytes
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Journal: Anal Biochem (1997): 71
Cresyl violet: a red fluorescent Nissl stain
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Journal: J Neurosci Methods (1990): 129