Name: MitoDNA™ Red 710
Brand: AAT Bioquest
SKU: 22689
Price: 301 USD
Availability: InStock

MitoDNA™ Red 710

MitoDNA™ Red 710 is a near-infrared mitochondrial nucleoid stain that specifically labels mtDNA with exceptional tissue penetration, ideal for in vivo imaging of mitochondrial DNA dynamics.

mtDNA-Specific: Selectively binds to mtDNA without nuclear interference
Live-Cell Compatibility: Easily permeates cells for real-time mtDNA tracking
High Signal Clarity: Large Stokes shift ensures a strong signal-to-noise ratio for multiplex imaging
Broad Research Applicability: Ideal for investigating mtDNA-linked diseases and mitochondrial function

The fluorescence response of MitoDNA™ Red 710 (5 µM) was assessed in HeLa cells before and after DNase treatment (2 units/reaction) at 37°C for 1 hour. Fluorescence intensities were measured using a fluorescence microscope equipped with a Violet long-pass filter (450 nm emission long-pass filter).

Protocol

SDS

COA

Catalog	Size	Price	Quantity
22689	1 mg	Price

Overview

There are limited probes available that effectively detect mitochondrial DNA (mtDNA). Conventional fluorescent DNA probes, such as DAPI, Hoechst, or SYBR® Green, lack the specificity required for mitochondrial targeting and primarily stain nuclear DNA. MitoDNA™ Red 710 is a cell-permeable dye that selectively stains mtDNA in live cells, providing a method for dynamic imaging of mtDNA. This dye exhibits a large Stokes shift (Ex/Em = 510/710 nm), offering a high signal-to-noise ratio and enabling multiplex staining with other fluorescent probes. mtDNA is a small, circular DNA molecule located within the mitochondria in the cytoplasm. It supplements nuclear DNA and encodes 37 genes essential for mitochondrial and cellular functions. Mitochondria are responsible for ATP synthesis through oxidative phosphorylation and house the genetic information necessary for synthesizing key enzymes, transfer RNA (tRNA), and ribosomal RNA (rRNA). Mutations and disorders in mtDNA are implicated in a range of pathologies, including age-related hearing loss, diabetes, and organ dysfunctions in the brain, heart, and liver. Additionally, mtDNA mutations are associated with an elevated risk of various cancers, including lymphomas, leukemias, and tumors in the breast, intestines, liver, and kidneys.

References

View all 49 references: Citation Explorer

Release of damaged mitochondrial DNA: A novel factor in stimulating inflammatory response.

Authors:

Li, Wenting and Li, Yuting and Zhao, Jie and Liao, Jiabao and Wen, Weibo and Chen, Yao and Cui, Huantian

Journal:

Pathology, research and practice (2024): 155330

Mitochondrial DNA drives neuroinflammation through the cGAS-IFN signaling pathway in the spinal cord of neuropathic pain mice.

Authors:

Huang, Penghui and Li, Li and Chen, Yaohua and Li, Yuping and Zhu, Dan and Cui, Jian

Journal:

Open life sciences (2024): 20220872

High number of mitochondrial DNA alterations in postmortem brain tissue of patients with schizophrenia compared to healthy controls.

Authors:

Bulduk, Bengisu K and Tortajada, Juan and Valiente-Pallejà, Alba and Callado, Luís F and Torrell, Helena and Vilella, Elisabet and Meana, J Javier and Muntané, Gerard and Martorell, Lourdes

Journal:

Psychiatry research (2024): 115928

mtDNA-Server 2: advancing mitochondrial DNA analysis through highly parallelized data processing and interactive analytics.

Authors:

Weissensteiner, Hansi and Forer, Lukas and Kronenberg, Florian and Schönherr, Sebastian

Journal:

Nucleic acids research (2024)

Mitochondrial DNA copy number mediated the associations between perfluoroalkyl substances and breast cancer incidence: A prospective case-cohort study.

Authors:

Feng, Yue and You, Yingqian and Li, Mengying and Guan, Xin and Fu, Ming and Wang, Chenming and Xiao, Yang and He, Meian and Guo, Huan

Journal:

The Science of the total environment (2024): 173767

Physical properties

Molecular weight	342.91
Solvent	DMSO

Spectral properties

Excitation (nm)	511
Emission (nm)	707

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

Instrument settings

Fluorescence microscope
Excitation	510 nm
Emission	710 nm
Recommended plate	Black wall/clear bottom

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Page updated on October 12, 2025