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Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system
Authors: Richter, M and Fairhall, EA and Hoffmann, SA and Tröbs, S and Knöspel, F and Probert, PME and Oakley, F and Stroux, A and Wright, MC and Zeilinger, K
Journal: Toxicology Research (2016): 278--290

Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin
Authors: Huwyler J, Wright MB, Gutmann H, Drewe J.
Journal: Curr Drug Metab (2006): 119

Luminogenic cytochrome P450 assays
Authors: Cali JJ, Ma D, Sobol M, Simpson DJ, Frackman S, Good TD, Daily WJ, Liu D.
Journal: Expert Opin Drug Metab Toxicol (2006): 629

Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4
Authors: Isin EM, Guengerich FP.
Journal: J Biol Chem (2006): 9127

Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration
Authors: Fern, undefined and o H, Halpert JR, Davydov DR.
Journal: Biochemistry (2006): 4199

Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy
Authors: Stortelder A, Keizers PH, Oostenbrink C, De Graaf C, De Kruijf P, Vermeulen NP, Gooijer C, Comm and eur JN, Van der Zwan G.
Journal: Biochem J (2006): 635

Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4
Authors: Lampe JN, Atkins WM.
Journal: Biochemistry (2006): 12204

Methoxy-resorufin ether as an electrochemically active biological probe for cytochrome P450 O-demethylation
Authors: Jenkins AT, Dash HA, Boundy S, Halliwell CM, ffrench-Constant RH.
Journal: Bioelectrochemistry (2006): 67

Cytochrome P450 (CYP) inhibition screening: comparison of three tests
Authors: Turpeinen M, Korhonen LE, Tolonen A, Uusitalo J, Juvonen R, Raunio H, Pelkonen O.
Journal: Eur J Pharm Sci (2006): 130

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction
Authors: Zhao Y, White MA, Muralidhara BK, Sun L, Halpert JR, Stout CD.
Journal: J Biol Chem (2006): 5973

Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate
Authors: Greenblatt DJ, von Moltke LL, Luo Y, Perloff ES, Horan KA, Bruce A, Reynolds RC, Harmatz JS, Avula B, Khan IA, Goldman P.
Journal: J Clin Pharmacol (2006): 214

Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS
Authors: Di L, Kerns EH, Li SQ, Carter GT.
Journal: Int J Pharm. (2006)

Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography
Authors: Kool J, van Liempd SM, Ramautar R, Schenk T, Meerman JH, Irth H, Comm and eur JN, Vermeulen NP.
Journal: J Biomol Screen (2005): 427

Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity
Authors: Kang KD, Jones PD, Huang H, Zhang R, Mostovich LA, Wheelock CE, Watanabe T, Gulyaeva LF, Hammock BD.
Journal: Anal Biochem (2005): 183

Bimolecular fluorescence complementation analysis of cytochrome p450 2c2, 2e1, and NADPH-cytochrome p450 reductase molecular interactions in living cells
Authors: Ozalp C, Szczesna-Skorupa E, Kemper B.
Journal: Drug Metab Dispos (2005): 1382

Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis
Authors: Kim D, Wu ZL, Guengerich FP.
Journal: J Biol Chem (2005): 40319

Kinetic study of cytochrome P450 3A4 activity on warfarin by capillary electrophoresis with fluorescence detection
Authors: Zhang J, Ha PT, Lou Y, Hoogmartens J, Van Schepdael A.
Journal: J Chromatogr A (2005): 235

Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants
Authors: Lussenburg BM, Babel LC, Vermeulen NP, Comm and eur JN., undefined
Journal: Anal Biochem (2005): 148

Cytochrome P450 expression and catalytic activity in coronary arteries and liver of cattle
Authors: Grasso E, Longo V, Coceani F, Giovanni Gervasi P.
Journal: Biochim Biophys Acta (2005): 116

Fluorescent photoaffinity labeling of cytochrome P450 3A4 by lapachenole: identification of modification sites by mass spectrometry
Authors: Wen B, Doneanu CE, Gartner CA, Roberts AG, Atkins WM, Nelson SD.
Journal: Biochemistry (2005): 1833

Highly miniaturized formats for in vitro drug metabolism assays using vivid fluorescent substrates and recombinant human cytochrome P450 enzymes
Authors: Trubetskoy OV, Gibson JR, Marks BD.
Journal: J Biomol Screen (2005): 56

Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI
Authors: Lawson RJ, von Wachenfeldt C, Haq I, Perkins J, Munro AW.
Journal: Biochemistry (2004): 12390

Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors
Authors: Naritomi Y, Teramura Y, Terashita S, Kagayama A.
Journal: Drug Metab Pharmacokinet (2004): 55

Allosterism in the elementary steps of the cytochrome P450 reaction cycle
Authors: Yoon MY, Campbell AP, Atkins WM.
Journal: Drug Metab Rev (2004): 219

Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis
Authors: Lawson RJ, Leys D, Sutcliffe MJ, Kemp CA, Cheesman MR, Smith SJ, Clarkson J, Smith WE, Haq I, Perkins JB, Munro AW.
Journal: Biochemistry (2004): 12410

EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme
Authors: Ogura H, Nishida CR, Hoch UR, Perera R, Dawson JH, Ortiz de Montellano PR.
Journal: Biochemistry (2004): 14712

Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity
Authors: Kullman SW, Kashiwada S, Hinton DE.
Journal: Mar Environ Res (2004): 469

Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes
Authors: Donato MT, Jimenez N, Castell JV, Gomez-Lechon MJ.
Journal: Drug Metab Dispos (2004): 699

Regiospecific hydroxylation of isoflavones by cytochrome p450 81E enzymes from Medicago truncatula
Authors: Liu CJ, Huhman D, Sumner LW, Dixon RA.
Journal: Plant J (2003): 471

In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products
Authors: Foster BC, V and enhoek S, Hana J, Krantis A, Akhtar MH, Bryan M, Budzinski JW, Ramputh A, Arnason JT.
Journal: Phytomedicine (2003): 334

Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation
Authors: Weaver R, Graham KS, Beattie IG, Riley RJ.
Journal: Drug Metab Dispos (2003): 955

Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4
Authors: Stresser DM, Turner SD, Blanchard AP, Miller VP, Crespi CL.
Journal: Drug Metab Dispos (2002): 845

Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site
Authors: Dabrowski MJ, Schrag ML, Wienkers LC, Atkins WM.
Journal: J Am Chem Soc (2002): 11866

Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism
Authors: Arora V, Cate ML, Ghosh C, Iversen PL.
Journal: Drug Metab Dispos (2002): 757

Coumarin substrates for cytochrome P450 2D6 fluorescence assays
Authors: Nakamura K, Hanna IH, Cai H, Nishimura Y, Williams KM, Guengerich FP.
Journal: Anal Biochem (2001): 280

Development of a miniaturized 384-well high throughput screen for the detection of substrates of cytochrome P450 2D6 and 3A4 metabolism
Authors: Kariv I, Fereshteh MP, Oldenburg KR.
Journal: J Biomol Screen (2001): 91

Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4
Authors: Lu P, Lin Y, Rodrigues AD, Rushmore TH, Baillie TA, Shou M.
Journal: Drug Metab Dispos (2001): 1473

Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes
Authors: Renwick AB, Lavignette G, Worboy PD, Williams B, Surry D, Lewis DF, Price RJ, Lake BG, Evans DC.
Journal: Xenobiotica (2001): 861

Binding of camphor to Pseudomonas putida cytochrome p450(cam): steady-state and picosecond time-resolved fluorescence studies
Authors: Prasad S, Mazumdar S, Mitra S.
Journal: FEBS Lett (2000): 157

Fluorometric high-throughput screening for inhibitors of cytochrome P450
Authors: Miller VP, Stresser DM, Blanchard AP, Turner S, Crespi CL.
Journal: Ann N Y Acad Sci (2000): 26

Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin
Authors: Venhorst J, Onderwater RC, Meerman JH, Vermeulen NP, Comm and eur JN., undefined
Journal: Eur J Pharm Sci (2000): 151

A direct, highly sensitive fluorometric assay for a microsomal cytochrome P450-mediated O-demethylation using a novel coumarin analog as substrate
Authors: Roser R, Thomas H.
Journal: Z Naturforsch [C] (2000): 915

Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes
Authors: Khan KK, Halpert JR.
Journal: Arch Biochem Biophys (2000): 335

Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity
Authors: Venhorst J, Onderwater RC, Meerman JH, Comm and eur JN, Vermeulen NP.
Journal: Drug Metab Dispos (2000): 1524

Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes
Authors: Yamazaki H, Tanaka M, Shimada T.
Journal: J Chromatogr B Biomed Sci Appl (1999): 13

Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes
Authors: Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R, Bocker RH, Beckurts KT, Lang W, Fuhr U.
Journal: Pharmacol Toxicol (1999): 299

Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening
Authors: Onderwater RC, Venhorst J, Comm and eur JN, Vermeulen NP.
Journal: Chem Res Toxicol (1999): 555

Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential
Authors: Moody GC, Griffin SJ, Mather AN, McGinnity DF, Riley RJ.
Journal: Xenobiotica (1999): 53

High-performance liquid chromatographic method for measurement of cytochrome P450-mediated metabolism of 7-ethoxy-4-trifluoromethylcoumarin
Authors: Morse MA, Lu J.
Journal: J Chromatogr B Biomed Sci Appl (1998): 290

Influence of mutation of the amino-terminal signal anchor sequence of cytochrome P450 2B4 on the enzyme structure and electron transfer processes
Authors: Lehnerer M, Schulze J, Pernecky SJ, Lewis DF, Eulitz M, Hlavica P.
Journal: J Biochem (Tokyo) (1998): 396

Activation of microsomal cytochrome P450 mono-oxygenase by Ca2+ store depletion and its contribution to Ca2+ entry in porcine aortic endothelial cells
Authors: Hoebel BG, Kostner GM, Graier WF.
Journal: Br J Pharmacol (1997): 1579

Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation
Authors: Munns AJ, De Voss JJ, Hooper WD, Dickinson RG, Gillam EM.
Journal: Chem Res Toxicol (1997): 1049

Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase
Authors: Shen S, Strobel HW.
Journal: Arch Biochem Biophys (1993): 257

A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation of 7-ethoxy-4-trifluoromethylcoumarin
Authors: Buters JT, Schiller CD, Chou RC.
Journal: Biochem Pharmacol (1993): 1577

Cytochrome P450-benzphetamine interactions in the endoplasmic reticulum: studies using a monoclonal antibody to P450b
Authors: Omata Y, Friedman FK.
Journal: Biochemistry (1992): 8862

Location of functional centers in the microsomal cytochrome P450 system
Authors: Centeno F, Gutierrez-Merino C.
Journal: Biochemistry (1992): 8473

A fluorescence study of the interactions of benzo[a]pyrene, cytochrome P450c and NADPH-cytochrome P450 reductase
Authors: Omata Y, Friedman FK.
Journal: Biochem Pharmacol (1991): 97

7-Alkoxyquinolines: new fluorescent substrates for cytochrome P450 monooxygenases
Authors: Mayer RT, Netter KJ, Heubel F, Hahnemann B, Buchheister A, Mayer GK, Burke MD.
Journal: Biochem Pharmacol (1990): 1645