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High-dose ascorbate exerts anti-tumor activities and improves inhibitory effect of carboplatin through the pro-oxidant function pathway in uterine serous carcinoma cell lines
Authors: Shen, Xiaochang and Wang, Jiandong and Deng, Boer and Chen, Shuning and John, Catherine and Zhao, Ziyi and Sinha, Nikita and Haag, Jennifer and Sun, Wenchuan and Kong, Weimin and others,
Journal: Gynecologic Oncology (2024): 93--102

Helicobacter pylori secreted protein HP1286 triggers apoptosis in macrophages via TNF-independent and ERK MAPK-dependent pathways
Authors: Tavares, Raquel and Pathak, Sushil Kumar
Journal: Frontiers in Cellular and Infection Microbiology (2017): 58

Helicobacter pylori Secreted Protein HP1286 Triggers Apoptosis in Macrophages via TNF-Independent and ERK MAPK-Dependent Pathways
Authors: Tavares, Raquel and Pathak, Sushil Kumar
Journal: Frontiers in Cellular and Infection Microbiology (2017): 58

Death receptor 3 mediates necroptotic cell death
Authors: Bittner, Sebastian and Knoll, Gertrud and Ehrenschwender, Martin
Journal: Cellular and Molecular Life Sciences (2016): 1--12

Helicobacter pylori protein JHP0290 exhibits proliferative and anti-apoptotic effects in gastric epithelial cells
Authors: Tavares, Raquel and Pathak, Sushil Kumar
Journal: PloS one (2015): e0124407

Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation
Authors: Muller I, Lamers MB, Ritchie AJ, Dominguez C, Munoz-Sanjuan I, Kiselyov A.
Journal: Bioorg Med Chem Lett (2011): 5244

Intracochlear perfusion of leupeptin and z-VAD-FMK: influence of antiapoptotic agents on gunshot-induced hearing loss
Authors: Abaamrane L, Raffin F, Schmerber S, Sendowski I.
Journal: Eur Arch Otorhinolaryngol (2011): 987

In vitro effect of different mediators of apoptosis on canine cranial and caudal cruciate ligament fibroblasts and its reversibility by pancaspase inhibitor zVAD.fmk
Authors: Forterre S, Zurbriggen A, Spreng D.
Journal: Vet Immunol Immunopathol (2011): 264

Experimental study on treatment of rabbits optic nerve injury with Caspase-3 inhibitor z-DEVD-fmk
Authors: Zhang W, Yu JG, Wang X, Shen ZS, Zhang JK, Yan H.
Journal: Zhonghua Yan Ke Za Zhi (2010): 1084

Caspase inhibitor ZVAD-fmk facilitates engraftment of donor hematopoietic stem cells in intra-bone marrow-bone marrow transplantation
Authors: Imai Y, Adachi Y, Shi M, Shima C, Yanai S, Okigaki M, Yamashima T, Kaneko K, Ikehara S.
Journal: Stem Cells Dev (2010): 461

Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk
Authors: Lafont E, Milhas D, Teissie J, Therville N, Andrieu-Abadie N, Levade T, Benoist H, Segui B.
Journal: PLoS One (2010): e13638

Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model
Authors: Equils O, Moffatt-Blue C, Ishikawa TO, Simmons CF, Ilievski V, Hirsch E.
Journal: Infect Dis Obstet Gynecol (2009): 749432

Attenuation of allergic contact dermatitis by Z-VAD-FMK, a broad caspase inhibitor: experiment with mice
Authors: Li YY, Yan CL, Xu W.
Journal: Zhonghua Yi Xue Za Zhi (2008): 3153

Effects of Z-FA.FMK on D-galactosamine/tumor necrosis factor-alpha-induced kidney injury and oxidative stress in mice : effects of Z-FA.FMK on TNF-alpha-mediated kidney injury
Authors: Gezginci-Oktayoglu S, Tunali S, Yanardag R, Bolkent S.
Journal: Mol Cell Biochem (2008): 9

Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge
Authors: Sheen-Chen SM, Hung KS, Eng HL.
Journal: J Gastroenterol Hepatol (2008): 1276

The effect of intracerebroventricular application of the caspase-3 inhibitor zDEVD-FMK on neurological outcome and neuronal cell death after global cerebral ischaemia due to cardiac arrest in rats
Authors: Teschendorf P, Vogel P, Wippel A, Krumnikl JJ, Spohr F, Bottiger BW, Popp E.
Journal: Resuscitation (2008): 85

Caspase inhibitor zVAD.fmk reduces infarct size after myocardial ischaemia and reperfusion in rats but not in mice
Authors: Mersmann J, Zacharowski PA, Schmitz I, Zacharowski K.
Journal: Resuscitation (2008): 468

Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: investigation by flow cytometry and spectral imaging microscopy
Authors: Vejux A, Lizard G, Tourneur Y, Riedinger JM, Frouin F, Kahn E.
Journal: Cytometry A (2007): 550

The effect of Z-FA.FMK on D-galactosamine/TNF-alpha-induced liver injury in mice
Authors: Gezginci S, Bolkent S.
Journal: Cell Biochem Funct (2007): 277

Caspase inhibitor Z-VAD-FMK enhances the freeze-thaw survival rate of human embryonic stem cells
Authors: Heng BC, Clement MV, Cao T.
Journal: Biosci Rep (2007): 257

Labeling of apoptotic JURL-MK1 cells by fluorescent caspase-3 inhibitor FAM-DEVD-fmk occurs mainly at site(s) different from caspase-3 active site
Authors: Kuzelova K, Grebenova D, Hrkal Z.
Journal: Cytometry A (2007): 605

z-VAD-fmk-induced non-apoptotic cell death of macrophages: possibilities and limitations for atherosclerotic plaque stabilization
Authors: Martinet W, Schrijvers DM, Herman AG, De Meyer GR.
Journal: Autophagy (2006): 312

The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo
Authors: Lawrence CP, Kadioglu A, Yang AL, Coward WR, Chow SC.
Journal: J Immunol (2006): 3827

Effects of intracerebroventricular administration of a caspase-3 inhibitor Z-DEVD-FMK on behavior of rats
Authors: Stapanichev M, Kudriashova IV, Iakovlev AA, Vorontsova ON, Lazareva NA, Guliaeva NV.
Journal: Zh Vyssh Nerv Deiat Im I P Pavlova (2006): 247

zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells
Authors: Yee SB, Baek SJ, Park HT, Jeong SH, Jeong JH, Kim TH, Kim JM, Jeong BK, Park BS, Kwon TK, Yoon I, Yoo YH.
Journal: Exp Mol Med (2006): 634

Effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in rat
Authors: Sheen-Chen SM, Ho HT, Chen WJ, Eng HL.
Journal: World J Gastroenterol (2005): 2330

z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species
Authors: Cowburn AS, White JF, Deighton J, Walmsley SR, Chilvers ER.
Journal: Blood (2005): 2970

The augmentation of TNFalpha-induced cell death in murine L929 fibrosarcoma by the pan-caspase inhibitor Z-VAD-fmk through pre-mitochondrial and MAPK-dependent pathways
Authors: Huang J, Wu L, Tashiro S, Onodera S, Ikejima T.
Journal: Acta Med Okayama (2005): 253

Short-term culture with the caspase inhibitor z-VAD.fmk reduces beta cell apoptosis in transplanted islets and improves the metabolic outcome of the graft
Authors: Montolio M, Tellez N, Biarnes M, Soler J, Montanya E.
Journal: Cell Transplant (2005): 59

The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats
Authors: Barut S, Unlu YA, Karaoglan A, Tuncdemir M, Dagistanli FK, Ozturk M, Colak A.
Journal: Surg Neurol (2005): 213

Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury
Authors: Colak A, Karaoglan A, Barut S, Kokturk S, Akyildiz AI, Tasyurekli M.
Journal: J Neurosurg Spine (2005): 327

Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury
Authors: Knoblach SM, Alroy DA, Nikolaeva M, Cernak I, Stoica BA, Faden AI.
Journal: J Cereb Blood Flow Metab (2004): 1119

Rescue of defective branching nephrogenesis in renal-coloboma syndrome by the caspase inhibitor, Z-VAD-fmk
Authors: Clark P, Dziarmaga A, Eccles M, Goodyer P.
Journal: J Am Soc Nephrol (2004): 299

5-fluorouracil-induced oligodendrocyte death and inhibitory effect of cycloheximide, Trolox, and Z-VAD-FMK in murine cortical culture
Authors: Cho KH, Choi SM, Kim BC, Lee SH, Park MS, Kim MK, Kim JK.
Journal: Cancer (2004): 1484

Caspase inhibitor Z-VAD-FMK potentiates heat shock-induced apoptosis and HSP70 synthesis in macrophages
Authors: Malyshev IY, Pshennikova MG, Shimkovich MV, Malysheva EV.
Journal: Bull Exp Biol Med (2004): 230

Alterations in protein expression in HL-60 cells during etoposide-induced apoptosis modulated by the caspase inhibitor ZVAD.fmk
Authors: Navakauskiene R, Treigyte G, Savickiene J, Gineitis A, Magnusson KE.
Journal: Ann N Y Acad Sci (2004): 393

Efficacy of the anticaspase agent zVAD-fmk on post-thaw viability of canine spermatozoa
Authors: Peter AT, Linde-Forsberg C.
Journal: Theriogenology (2003): 1525

Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway
Authors: Lopez-Hern, undefined and ez FJ, Ortiz MA, Bayon Y, Piedrafita FJ.
Journal: Mol Cancer Ther (2003): 255

Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells
Authors: Ilangovan R, Marshall WL, Hua Y, Zhou J.
Journal: J Biol Chem (2003): 30993

Differential modulation of interleukin-2-and interleukin-4-mediated early activation of normal human B lymphocytes by the caspase inhibitor zVAD-fmk
Authors: Mouhamad S, Arnoult D, Auffredou MT, Estaquier J, Vazquez A.
Journal: Eur Cytokine Netw (2002): 439

Effects of BAPTA-AM, Forskolin, DSF and Z.VAD.fmk on PDT-induced apoptosis and m-THPC phototoxicity on B16 cells
Authors: Thibaut S, Bourre L, Hernot D, Rousset N, Lajat Y, Patrice T.
Journal: Apoptosis (2002): 99

Sensitivity of photoreceptor-derived cell line (661W) to baculoviral p35, Z-VAD.FMK, and Fas-associated death domain
Authors: Tuohy G, Millington-Ward S, Kenna PF, Humphries P, Farrar GJ.
Journal: Invest Ophthalmol Vis Sci (2002): 3583

The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide
Authors: Schotte P, Schauvliege R, Janssens S, Beyaert R.
Journal: J Biol Chem (2001): 21153

The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition
Authors: Van Noorden CJ., undefined
Journal: Acta Histochem (2001): 241

The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand
Authors: Ozoren N, Kim K, Burns TF, Dicker DT, Moscioni AD, El-Deiry WS.
Journal: Cancer Res (2000): 6259

zVAD-fmk and DEVD-cho induced late mitosis arrest and apoptotic expressions
Authors: Swe M, Sit KH.
Journal: Apoptosis (2000): 29

Caspase inhibitor z-VAD-FMK inhibits keratocyte apoptosis, but promotes keratocyte necrosis, after corneal epithelial scrape
Authors: Kim WJ, Mohan RR, Wilson SE.
Journal: Exp Eye Res (2000): 225

TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk
Authors: Piguet PF, Vesin C, Donati Y, Barazzone C.
Journal: Lab Invest (1999): 495

Human oligodendroglial cell line, MO3.13, can be protected from apoptosis using the general caspase inhibitor zVAD-FMK
Authors: Craighead MW, Tiwari P, Keynes RG, Waters CM.
Journal: J Neurosci Res (1999): 236

Comparative effects of Bcl-2 over-expression and ZVAD.FMK treatment on dexamethasone and VP16-induced apoptosis in CEM cells
Authors: Benson RS, Dive C, Watson AJ.
Journal: Cell Death Differ (1998): 432

E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
Authors: Lavoie JN, Nguyen M, Marcellus RC, Branton PE, Shore GC.
Journal: J Cell Biol (1998): 637

Caspase inhibitor BD-fmk distinguishes transforming growth factor beta-induced apoptosis from growth inhibition
Authors: Brown TL, Patil S, Basnett RK, Howe PH.
Journal: Cell Growth Differ (1998): 869

Baculovirus p35 and Z-VAD-fmk inhibit thapsigargin-induced apoptosis of breast cancer cells
Authors: Qi XM, He H, Zhong H, Distelhorst CW.
Journal: Oncogene (1997): 1207

Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases
Authors: Shimizu T, Pommier Y.
Journal: Leukemia (1997): 1238

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
Authors: Slee EA, Zhu H, Chow SC, MacFarlane M, Nicholson DW, Cohen GM.
Journal: Biochem J (1996): 21