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Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells
Authors: Rath, Matthias and Schwefel, Konrad and Malinverno, Matteo and Skowronek, Dariush and Leopoldi, Alexandra and Pilz, Robin A and Biedenweg, Doreen and Bekeschus, Sander and Penninger, Josef M and Dejana, Elisabetta and others,
Journal: Cellular and Molecular Life Sciences (2022): 1--20

Combination of Goniothalamin and Sol-Gel-Derived Bioactive Glass 45S5 Enhances Growth Inhibitory Activity via Apoptosis Induction and Cell Cycle Arrest in Breast Cancer Cells MCF-7
Authors: Bakar, Siti Aishah Abu and Ali, Abdul Manaf and Noor, Siti Noor Fazliah Mohd and Hamid, Shahrul Bariyah Sahul and Azhar, Nur Asna and Mohamad, Noor Muzamil and Ahmad, Nor Hazwani
Journal: BioMed Research International (2022)

RPL21 siRNA blocks proliferation in pancreatic cancer cells by inhibiting DNA replication and inducing G1 arrest and apoptosis
Authors: Li, Chaodong and Ge, Mei and Chen, Daijie and Sun, Tao and Jiang, Hua and Xie, Yueqing and Lu, Huili and Zhang, Baohong and Han, Lei and Chen, Junsheng and others,
Journal: Frontiers in oncology (2020): 1730

CD5L-induced activation of autophagy is associated with hepatoprotection in ischemic reperfusion injury via the CD36/ATG7 axis
Authors: Li, Junjian and Lin, Wei and Zhuang, Lei
Journal: Experimental and Therapeutic Medicine (2020): 2588--2596

LncRNA-NEAT1 from the competing endogenous RNA network promotes cardioprotective efficacy of mesenchymal stem cell-derived exosomes induced by macrophage migration inhibitory factor via the miR-142-3p/FOXO1 signaling pathway
Authors: Chen, Hanbin and Xia, Wenzheng and Hou, Meng
Journal: Stem cell research \& therapy (2020): 31

Promotion of osteointegration under diabetic conditions by tantalum coating-based surface modification on 3-dimensional printed porous titanium implants
Authors: Wang, Lin and Hu, Xiaofan and Ma, Xiangyu and Ma, Zhensheng and Zhang, Yang and Lu, Yizhao and Li, Xiang and Lei, Wei and Feng, Yafei
Journal: Colloids and Surfaces B: Biointerfaces (2016): 440--452

microRNA-186 inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma by targeting SKP2
Authors: He, Wei and Feng, Jianfang and Zhang, Yan and Wang, Yuanyuan and Zang, Wenqiao and Zhao, Guoqiang
Journal: Laboratory Investigation (2016): 317--324

Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy.
Authors: Knoll, Gertrud and Bittner, Sebastian and Kurz, Maria and Jantsch, Jonathan and Ehrenschwender, Martin
Journal: Oncotarget (2016)

Role of delta-like ligand-4 in chemoresistance against docetaxel in MCF-7 cells
Authors: Wang, Q and Shi, Y and Butler, HJ and Xue, J and Wang, G and Duan, P and Zheng, H
Journal: Human & Experimental Toxicology (2016): 0960327116650006

Angiopoietins Modulate Survival, Migration, and the Components of the Ang-Tie2 Pathway of Chronic Lymphocytic Leukaemia (CLL) Cells In Vitro
Authors: Palma, Luis Mario Aguirre and Flamme, Hanna and Gerke, Iris and Kreuzer, Karl-Anton
Journal: Cancer Microenvironment (2016): 13--26

t-BHQ Provides Protection against Lead Neurotoxicity via Nrf2/HO-1 Pathway
Authors: Ye, Fang and Li, Xiaoyi and Li, Lili and Yuan, Jing and Chen, Jun
Journal: Oxidative medicine and cellular longevity (2015)

Insulin improves osteogenesis of titanium implants under diabetic conditions by inhibiting reactive oxygen species overproduction via the PI3K-Akt pathway
Authors: Wang, Lin and Zhao, Xiong and Wei, Bo-yuan and Liu, Yi and Ma, Xiang-yu and Wang, Jian and Cao, Peng-chong and Zhang, Yang and Yan, Ya-bo and Lei, Wei and others, undefined
Journal: Biochimie (2015): 85--93

Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signaling
Authors: Han, Jianjun and Zhang, Lu and Guo, Hui and Wysham, Weiya Z and Roque, Dario R and Willson, Adam K and Sheng, Xiugui and Zhou, Chunxiao and Bae-Jump, Victoria L
Journal: Gynecologic oncology (2015): 668--675

IL-7 abrogates the immunosuppressive function of human double-negative T cells by activating Akt/mTOR signaling
Authors: Allgäuer, Andrea and Schreiner, Elisabeth and Ferrazzi, Fulvia and Ekici, Arif B and Gerbitz, Armin and Mackensen, Andreas and Völkl, Simon
Journal: The Journal of Immunology (2015): 3139--3148

LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts
Authors: Zhang, Hui and Sweezey, Neil B and Kaplan, Feige
Journal: American Journal of Physiology-Lung Cellular and Molecular Physiology (2015): L391--L402

Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo
Authors: Chen, Daijie and Luo, Minyu and Ge, Mei and Zhu, Jianwei and others, undefined
Journal: Biotechnology journal (2014): 652--663

Lipoplex mediated silencing of membrane regulators (CD46, CD55 and CD59) enhances complement-dependent anti-tumor activity of trastuzumab and pertuzumab
Authors: Mamidi, Srinivas and Cinci, Marc and Hasmann, Max and Fehring, Volker and Kirschfink, Michael
Journal: Molecular oncology (2013): 580--594

Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility anddelivery of curcumin
Authors: Ucisik, Mehmet H and Küpcü, Seta and Schuster, Bernhard and Sleytr, Uwe B
Journal: Journal of nanobiotechnology (2013): 1

Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death
Authors: Okamura, Kayo and Dummer, Patrick and Kopp, Jeffrey and Qiu, Liru and Levi, Moshe and Faubel, Sarah and Blaine, Judith
Journal: PloS one (2013): e54817

Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay
Authors: Sirisoma N, Pervin A, Drewe J, Tseng B, Cai SX.
Journal: Bioorg Med Chem Lett (2009): 2710

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure-activity relationships of the 4-, 5-, 6-, 7- and 8-positions
Authors: Kemnitzer W, Kuemmerle J, Jiang S, Sirisoma N, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.
Journal: Bioorg Med Chem Lett (2009): 3481

Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor
Authors: Schmidt MF, El-Dahshan A, Keller S, Rademann J.
Journal: Angew Chem Int Ed Engl (2009): 6346

Modified caspase-3 assay indicates correlation of caspase-3 activity with immunity of nonhuman primates to Yersinia pestis infection
Authors: Welkos S, Norris S, Adamovicz J.
Journal: Clin Vaccine Immunol (2008): 1134

Liver apoptosis following normothermic ischemia-reperfusion: in vivo evaluation of caspase activity by FLIVO assay in rats
Authors: Cursio R, Colosetti P, Auberger P, Gugenheim J.
Journal: Transplant Proc (2008): 2038

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions
Authors: Kemnitzer W, Drewe J, Jiang S, Zhang H, Crogan-Grundy C, Labreque D, Bubenick M, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.
Journal: J Med Chem (2008): 417

Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay
Authors: Jiang S, Crogan-Grundy C, Drewe J, Tseng B, Cai SX.
Journal: Bioorg Med Chem Lett (2008): 5725

A dual-step fluorescence resonance energy transfer-based quenching assay for screening of caspase-3 inhibitors
Authors: Valanne A, Malmi P, Appelblom H, Niemela P, Soukka T.
Journal: Anal Biochem (2008): 71

Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro -1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay
Authors: Drewe J, Kasibhatla S, Tseng B, Shelton E, Sper and io D, Yee RM, Litvak J, Sendzik M, Spencer JR, Cai SX.
Journal: Bioorg Med Chem Lett (2007): 4987

Split GFP complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of GSK3beta activation and caspase 3 cleavage
Authors: Chun W, Waldo GS, Johnson GV.
Journal: J Neurochem (2007): 2529

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7,8-positions
Authors: Kemnitzer W, Drewe J, Jiang S, Zhang H, Zhao J, Crogan-Grundy C, Xu L, Lamothe S, Gourdeau H, Denis R, Tseng B, Kasibhatla S, Cai SX.
Journal: J Med Chem (2007): 2858

Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay
Authors: Tawa P, Giroux A, Grimm E, Han Y, Nicholson DW, Xanthoudakis S.
Journal: Anal Biochem (2006): 32

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group
Authors: Sirisoma N, Kasibhatla S, Nguyen B, Pervin A, Wang Y, Claassen G, Tseng B, Drewe J, Cai SX.
Journal: Bioorg Med Chem (2006): 7761

A sensitive flow cytometry-based cytotoxic T-lymphocyte assay through detection of cleaved caspase 3 in target cells
Authors: He L, Hakimi J, Salha D, Miron I, Dunn P, Radvanyi L.
Journal: J Immunol Methods (2005): 43

N-DEVD-N'-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay
Authors: Wang ZQ, Liao J, Diwu Z.
Journal: Bioorg Med Chem Lett (2005): 2335

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions
Authors: Kemnitzer W, Kasibhatla S, Jiang S, Zhang H, Zhao J, Jia S, Xu L, Crogan-Grundy C, Denis R, Barriault N, Vaillancourt L, Charron S, Dodd J, Attardo G, Labrecque D, Lamothe S, Gourdeau H, Tseng B, Drewe J, Cai SX.
Journal: Bioorg Med Chem Lett (2005): 4745

Detection of programmed cell death in cells exposed to genotoxic agents using a caspase activation assay
Authors: Gehring ME, Koty PP.
Journal: Methods Mol Biol (2005): 465

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group
Authors: Kemnitzer W, Drewe J, Jiang S, Zhang H, Wang Y, Zhao J, Jia S, Herich J, Labreque D, Storer R, Meerovitch K, Bouffard D, Rej R, Denis R, Blais C, Lamothe S, Attardo G, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.
Journal: J Med Chem (2004): 6299

Caspase multiplexing: simultaneous homogeneous time-resolved quenching assay (TruPoint) for caspases 1, 3, and 6
Authors: Karvinen J, Elomaa A, Makinen ML, Hakala H, Mukkala VM, Peuralahti J, Hurskainen P, Hovinen J, Hemmila I.
Journal: Anal Biochem (2004): 317

Measurement of CTL-induced cytotoxicity: the caspase 3 assay
Authors: Jerome KR, Sloan DD, Aubert M.
Journal: Apoptosis (2003): 563

Discovery of substituted N-phenyl nicotinamides as potent inducers of apoptosis using a cell- and caspase-based high throughput screening assay
Authors: Cai SX, Nguyen B, Jia S, Herich J, Guastella J, Reddy S, Tseng B, Drewe J, Kasibhatla S.
Journal: J Med Chem (2003): 2474

One-step cellular caspase-3/7 assay
Authors: Carrasco RA, Stamm NB, Patel BK.
Journal: Biotechniques (2003): 1064

Caspase-3 colorimetric assay
Authors: Zeng L, Smith LD.
Journal: Biotechniques (2002): 1196

Homogeneous time-resolved fluorescence quenching assay (LANCE) for caspase-3
Authors: Karvinen J, Hurskainen P, Gopalakrishnan S, Burns D, Warrior U, Hemmila I.
Journal: J Biomol Screen (2002): 223

A homogeneous caspase-3 activity assay using HTRF technology
Authors: Preaudat M, Ouled-Diaf J, Alpha-Bazin B, Mathis G, Mitsugi T, Aono Y, Takahashi K, Takemoto H.
Journal: J Biomol Screen (2002): 267

Assay of caspase activation in situ combined with probing plasma membrane integrity to detect three distinct stages of apoptosis
Authors: Smolewski P, Grabarek J, Halicka HD, Darzynkiewicz Z.
Journal: J Immunol Methods (2002): 111

Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay
Authors: Cai SX, Zhang HZ, Guastella J, Drewe J, Yang W, Weber E.
Journal: Bioorg Med Chem Lett (2001): 39

Development and application of a GFP-FRET intracellular caspase assay for drug screening
Authors: Jones J, Heim R, Hare E, Stack J, Pollok BA.
Journal: J Biomol Screen (2000): 307

A yeast genetic assay for caspase cleavage of the amyloid-beta precursor protein
Authors: Gunyuzlu PL, White WH, Davis GL, Hollis GF, Toyn JH.
Journal: Mol Biotechnol (2000): 29

Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo
Authors: Gorman AM, Hirt UA, Zhivotovsky B, Orrenius S, Ceccatelli S.
Journal: J Immunol Methods (1999): 43

Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay
Authors: Chu W, Rothfuss J, Zhou D, Mach RH
Journal: Bioorg Med Chem Lett : 2192