11-beta-hydroxysteroid dehydrogenase 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	N-[4-(2-Cyanoethyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	1.4 [1]
	(6S)-3-[(1S)-1-[4-(2,4-Difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one	IC50	2.5 [1]
	N-Cyclopropyl-N-(4-pyridin-3-ylcyclohexyl)-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	3.0 [1]
	Enoxolone	IC50	13.0 [1]
	2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide	IC50	52.0 [1]
	N-Cyclopropyl-N-(4-phenylcyclohexyl)-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	9.8 [1]
	(6R)-3-[(1S)-1-[4-(2,4-Difluorophenyl)phenyl]ethyl]-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one	IC50	0.72 [1]
	(R)-3-((S)-1-(4'-Fluorobiphenyl-4-yl)ethyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one	IC50	0.6 [1]
	(S)-3-((S)-1-(4'-Fluorobiphenyl-4-yl)ethyl)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one	IC50	1.5 [1]
	3-[(6R)-3-[(1S)-1-[4-(2,4-Difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propanamide	IC50	5.0 [1]
	N-[3-[(6R)-3-[(1S)-1-[4-(2,4-Difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propyl]methanesulfonamide	IC50	3.7 [1]
	{(3s)-1-[5-(Cyclohexylcarbamoyl)-6-(Propylsulfanyl)pyridin-2-Yl]piperidin-3-Yl}acetic Acid	IC50	2.0 [1]
	1-[[(3R)-3-Methyl-4-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]sulfonylpiperazin-1-yl]methyl]cyclopropane-1-carboxamide	IC50	0.7 [1], 0.83 [2], 1.2 [3], 7.3 [4], 14.0 [5]
	1-[[(3R)-3-Methyl-4-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]sulfonylpiperazin-1-yl]methyl]cyclopropane-1-carboxamide	Ki	1.1 [1], 2.7 [2]
	N-Cyclopropyl-N-(4-cyclopropyl-4-hydroxycyclohexyl)-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	52.0 [1]
	(6S)-3-[(1S)-1-(4-Bromophenyl)ethyl]-6-(4-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-1,3-oxazinan-2-one	IC50	1.9 [1]
	Amg-221	IC50	7.0 [1], 10.1 [2], 10000.0 [3]
	Amg-221	Ki	12.8 [1]
	N-[4-(4-Cyanophenyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	3.4 [1]
	9-[[2-Methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]bicyclo[3.3.1]nonane-3-carboxamide	IC50	88.0 [1]
	N-[4-(2-Cyano-2-methylpropyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	2.0 [1]
	N-Cyclopropyl-N-(4-hydroxy-4-phenylcyclohexyl)-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	150.0 [1]
	N-(4-Cyano-4-pyridin-2-ylcyclohexyl)-N-cyclopropyl-4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	39.0 [1]
	N-[4-(3-Amino-3-oxopropyl)cyclohexyl]-N-cyclopropyl-4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	17.0 [1]
	N-[4-Cyano-4-(4-fluorophenyl)cyclohexyl]-N-cyclopropyl-4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	48.0 [1]
	N-[4-(Cyanomethyl)cyclohexyl]-N-cyclopropyl-4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	16.0 [1]
	Carbenoxolone	IC50	83.0 [1], 330.0 [2], 500.0 [3]
	3-(1-Adamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine	IC50	7.5 [1], 7.8 [2], 8.0 [3]
	N-Adamantan-2-Yl-1-Ethyl-D-Prolinamide	IC50	4.0 [1], 4.1 [2], 4.15 [3], 90.0 [4]
	N-Adamantan-2-Yl-1-Ethyl-D-Prolinamide	Ki	1.4 [1]
	N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide	IC50	130.0 [1], 15000.0 [2]
	N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide	Ki	8.0 [1], 67.0 [2]
	(6S)-3-[3-(2,4-Difluorophenyl)phenyl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one	IC50	0.77 [1], 11.97 [2]
	(6S)-3-[(1S)-1-[4-(4-Fluorophenyl)phenyl]ethyl]-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one	IC50	1.08 [1], 19.54 [2]
	(S)-3-((S)-1-(4-Bromophenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one	IC50	0.79 [1], 8.94 [2]
	(6S)-3-[6-(4-Fluorophenyl)pyridin-2-yl]-6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-2-one	IC50	1.44 [1], 15.24 [2]
	(6S)-3-[(1S)-1-[4-(Difluoromethoxy)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one	IC50	1.3 [1], 8.94 [2]
	3-[6-(2,4-Difluorophenyl)pyridin-2-yl]-6-(2-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one	IC50	1.8 [1], 14.16 [2]
	(6S)-3-[(1S)-1-[4-(2,4-Difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-1,3-oxazinan-2-one	IC50	1.48 [1], 37.58 [2]
	3-((R)-3-((S)-1-(4'-Fluorobiphenyl-4-yl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide	IC50	0.55 [1], 13.4 [2]
	Acetoxolone	IC50	800.0 [1], 3450.0 [2], 7100.0 [3], 7138.0 [4]
	3-(4-Fluorophenyl)-5-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazole	IC50	2.0 [1], 2.2 [2], 2200.0 [3]
	N-(2-Adamantyl)piperidine-1-carboxamide	IC50	16.0 [1], 16.1 [2], 32.0 [3], 873.0 [4]
	(5s)-2-{[(1s)-1-(2-Fluorophenyl)ethyl]amino}-5-Methyl-5-(Trifluoromethyl)-1,3-Thiazol-4(5h)-One	IC50	33.0 [1], 10000.0 [2]
	(5s)-2-{[(1s)-1-(2-Fluorophenyl)ethyl]amino}-5-Methyl-5-(Trifluoromethyl)-1,3-Thiazol-4(5h)-One	Ki	22.0 [1]
	[4-[Cyclopropyl-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzoyl]amino]-1-(4-fluorophenyl)cyclohexyl]methyl carbamate	IC50	0.5 [1], 12.0 [2], 15.0 [3], 34.0 [4]
	(2R)-1-[(4-Tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine	IC50	3.0 [1], 57.0 [2]
	9-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]bicyclo[3.3.1]nonane-3-carboxamide	IC50	5.0 [1], 5.01 [2], 8.0 [3], 21.88 [4]
	(6R)-6-(2-Aminoethyl)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one	IC50	2.7 [1], 66.0 [2], 66.5 [3]
	6-[4-(4-Cyanophenyl)piperazin-1-yl]-N-(5-hydroxy-2-adamantyl)pyridine-2-carboxamide	IC50	2.8 [1], 6.7 [2]
	4-[[1-[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]cyclopropanecarbonyl]amino]adamantane-1-carboxylic acid	IC50	45.0 [1], 1900.0 [2]
	4-[[1-[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]cyclopropanecarbonyl]amino]adamantane-1-carboxylic acid	Ki	7.0 [1], 250.0 [2]
	N-[(E)-5-Fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide	IC50	450.0 [1], 550.0 [2]
	N-[(E)-5-Fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide	Ki	26.0 [1], 32.0 [2]
	N-(5-Hydroxy-2-adamantyl)-1-piperidin-1-ylcyclopropane-1-carboxamide	IC50	7.0 [1], 390.0 [2]
	N-(5-Hydroxy-2-adamantyl)-1-piperidin-1-ylcyclopropane-1-carboxamide	Ki	2.0 [1], 6.0 [2]
	4-[[1-[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]cyclopropanecarbonyl]amino]adamantane-1-carboxamide	IC50	22.0 [1], 490.0 [2]
	4-[[1-[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]cyclopropanecarbonyl]amino]adamantane-1-carboxamide	Ki	8.0 [1], 13.0 [2]
	(S)-N-(trans-4-Fluorocyclohexyl)-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide	IC50	4.1 [1], 6.6 [2], 36.0 [3], 140.0 [4]
	9-[4-[(5-Cyanopyridin-2-yl)oxymethyl]-3,3-dimethyl-2-oxopyrrolidin-1-yl]bicyclo[3.3.1]nonane-3-carboxamide	IC50	5.0 [1], 39.0 [2], 510.0 [3]
	9-[4-[(5-Cyanopyridin-2-yl)oxymethyl]-3,3-dimethyl-2-oxopyrrolidin-1-yl]bicyclo[3.3.1]nonane-3-carboxamide	Ki	29.0 [1]
	N-[4-(3-Amino-3-oxopropyl)-4-phenylcyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	0.8 [1], 3.9 [2], 17.0 [3], 37.0 [4]
	N-(5-Fluoro-7-hydroxy-2-adamantyl)-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanamide	IC50	120.0 [1], 3400.0 [2]
	N-(5-Fluoro-7-hydroxy-2-adamantyl)-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanamide	Ki	12.0 [1], 46.0 [2]
	(6S)-6-(2-Hydroxy-2-methylpropyl)-3-[(1S)-1-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one	IC50	1.6 [1], 1.67 [2], 3.3 [3], 6.44 [4]
	(6S)-6-(2-Hydroxy-2-methylpropyl)-3-[(1S)-1-[4-(1-methyl-2-oxopyridin-4-yl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one	IC50	1.62 [1], 1.7 [2], 4.3 [3], 5.54 [4]
	[4-[Cyclopropyl-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzoyl]amino]-1-(5-fluoropyridin-2-yl)cyclohexyl]methyl carbamate	IC50	2.4 [1], 30.0 [2], 31.0 [3], 93.0 [4]
	N-[4-(3-Amino-3-oxopropyl)-4-(4-fluorophenyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	1.8 [1], 12.0 [2], 24.0 [3], 55.0 [4]
	[4-[Cyclopropyl-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzoyl]amino]-1-phenylcyclohexyl]methyl carbamate	IC50	1.0 [1], 4.6 [2], 8.8 [3], 20.0 [4]
	N-Cyclopropyl-N-[4-(2-hydroxyethyl)-4-phenylcyclohexyl]-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	1.9 [1], 12.0 [2], 15.0 [3], 35.0 [4]
	N-[4-(Acetamidomethyl)-4-phenylcyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	2.2 [1], 6.7 [2], 17.0 [3], 129.0 [4]
	[4-[Cyclopropyl-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzoyl]amino]-1-(1,3-thiazol-4-yl)cyclohexyl]methyl carbamate	IC50	1.8 [1], 16.0 [2], 18.0 [3], 63.0 [4]
	[4-[Cyclopropyl-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzoyl]amino]-1-(2-fluorophenyl)cyclohexyl]methyl carbamate	IC50	0.6 [1], 5.7 [2], 14.0 [3], 135.0 [4]
	[4-[Cyclopropyl-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzoyl]amino]-1-pyridin-2-ylcyclohexyl]methyl carbamate	IC50	3.5 [1], 19.0 [2], 25.0 [3], 74.0 [4]
	N-Cyclopropyl-N-[4-(methanesulfonamidomethyl)-4-phenylcyclohexyl]-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	1.7 [1], 20.0 [2], 86.0 [3], 259.0 [4]
	N-[4-(3-Amino-3-oxopropyl)-4-(2-fluorophenyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide	IC50	1.3 [1], 7.0 [2], 36.0 [3], 109.0 [4]
	(6R)-6-(3-Hydroxypropyl)-3-[(1S)-1-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one	IC50	1.4 [1], 1.44 [2], 3.42 [3], 5.7 [4]
	Glycyrrhizic acid	IC50	6.0 [1], 10.0 [2], 18.6 [3]
	3-Chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide	IC50	3341.0 [1], 10000.0 [2]
	3-(1-Adamantyl)-4-methyl-5-phenyl-1,2,4-triazole	IC50	37.0 [1], 109.0 [2]
	4-Methyl-3-(4-pentyl-1-bicyclo[2.2.2]octanyl)-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazole	IC50	1.8 [1], 2.0 [2]
	3-(1-(4-Chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine	IC50	1.0 [1], 1.3 [2]
	2-(Phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethanone	IC50	187.0 [1], 190.0 [2]
	N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propionamide	IC50	5.0 [1], 29.0 [2]
	N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propionamide	Ki	5.0 [1]
	1-(3-Hydroxyazetidin-1-yl)-2-(6-hydroxy-2-phenyl-2-adamantyl)ethanone	IC50	10.0 [1], 37.3 [2]
	1-(3-Hydroxyazetidin-1-yl)-2-(6-hydroxy-2-phenyl-2-adamantyl)ethanone	Ki	3.8 [1]
	3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole	IC50	11.0 [1]
	2-(2-Chloro-4-fluorophenoxy)-2-methyl-N-[5-(2H-tetrazol-5-yl)-2-adamantyl]propanamide	IC50	10.96 [1], 11.0 [2], 54.0 [3]
	4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxylic acid	IC50	21.88 [1], 22.0 [2], 220.0 [3]
	E-4-[(2-Methyl-2-phenoxypropanoyl)amino]adamantane-1-carboxamide	IC50	5.0 [1], 5.01 [2], 24.0 [3]
	4-[[2-(4-Methoxyphenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxamide	IC50	6.0 [1], 6.03 [2], 21.0 [3]
	4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxamide	IC50	6.0 [1], 6.03 [2], 22.0 [3]
	4-[[2-(2-Chlorophenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxylic acid	IC50	7.94 [1], 8.0 [2], 59.0 [3]
	4-(2-(4-Chlorophenoxy)-2-methylpropanamido)bicyclo[2.2.2]octane-1-carboxamide	IC50	12.88 [1], 13.0 [2], 450.0 [3]
	1-Naphthalen-2-ylsulfonyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine	IC50	11.0 [1], 13.0 [2], 547.0 [3]
	1-(Phenylsulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine	IC50	45.0 [1], 724.0 [2]
	1-Naphthalen-1-ylsulfonyl-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine	IC50	13.0 [1], 329.0 [2]
	9-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-3-oxabicyclo[3.3.1]nonane-7-carboxamide	IC50	25.0 [1], 25.12 [2], 2400.0 [3]
	2-(4-Chlorophenoxy)-N-(1-hydroxy-2-oxatricyclo[3.3.1.13,7]decan-6-yl)-2-methylpropanamide	IC50	15.0 [1], 15.14 [2], 199.0 [3]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ 11-beta-hydroxysteroid dehydrogenase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/11-beta-hydroxysteroid-dehydrogenase-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ 11-beta-hydroxysteroid dehydrogenase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/11-beta-hydroxysteroid-dehydrogenase-1-inhibitors-ic50-ki.
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