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11-beta-hydroxysteroid dehydrogenase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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EnoxoloneIC501.2 [1], 1.22 [2], 1.3 [3], 257.0 [4]
AcetoxoloneIC50201.0 [1], 750.0 [2], 6430.0 [3]
Glycyrrhizic acidIC500.4 [1], 0.7 [2], 1.0 [3]
2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamideIC5010000.0 [1], 200000.0 [2]
3-(1-Adamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepineIC503000.0 [1]
3-(1-(4-Chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC504000.0 [1]
4H-1,2,4-Triazole, 3-(trans-1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl-IC504000.0 [1]
3-(1-Adamantyl)-4-methyl-5-phenyl-1,2,4-triazoleIC504000.0 [1]
2-(Phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethanoneIC50200000.0 [1]
N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamideIC5010000.0 [1], 100000.0 [2]
3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazoleIC504000.0 [1]
3-(4-Pentyl-1-bicyclo[2.2.2]octanyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC50180.0 [1], 183.0 [2]
3-(1-(4-Chlorophenyl)cyclobutyl)-4-methyl-5-phenyl-4H-1,2,4-triazoleIC504000.0 [1]
3-[4-(2-Ethylsulfonylethyl)-1-bicyclo[2.2.2]octanyl]-4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazoleIC507.5 [1], 4000.0 [2]
N-Cyclopropyl-N-(4-phenylcyclohexyl)-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamideIC5010000.0 [1]
3-[4-(Ethylsulfonylmethyl)-1-bicyclo[2.2.2]octanyl]-4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazoleIC5031.2 [1], 4000.0 [2]
9-[[2-Methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]bicyclo[3.3.1]nonane-3-carboxamideIC5030000.0 [1], 100000.0 [2]
[(3S,4Ar,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-[hydroxy(methyl)carbamoyl]-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl] acetateIC502.9 [1]
[4-[5-(4-Methoxyphenyl)pyrimidin-2-yl]-2,3-dihydroquinoxalin-1-yl]-[3-(1H-pyrazol-4-yl)pyrrolidin-1-yl]methanoneIC5010000.0 [1]
2-[[(3S,4Ar,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-methoxycarbonyl-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]benzoic acidIC50280.0 [1], 48000.0 [2]
N-[(E)-5-Fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamideIC5020000.0 [1], 100000.0 [2]
N-(5-Hydroxy-2-adamantyl)-1-piperidin-1-ylcyclopropane-1-carboxamideIC508300.0 [1], 100000.0 [2]
4-[[1-[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]cyclopropanecarbonyl]amino]adamantane-1-carboxamideIC5010000.0 [1], 100000.0 [2]
(2S,4As,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-amino-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acidIC5060.0 [1], 6040.0 [2]
9-[4-[(5-Cyanopyridin-2-yl)oxymethyl]-3,3-dimethyl-2-oxopyrrolidin-1-yl]bicyclo[3.3.1]nonane-3-carboxamideIC5022000.0 [1], 100000.0 [2]
11beta-HydroxyprogesteroneIC50490.0 [1]
11alpha-HydroxyprogesteroneIC50400.0 [1]
3-Chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamideIC5010000.0 [1]
Amg-221IC5010000.0 [1]
Abt-384IC5010000.0 [1]
3-Oxoglycyrrhetinic acidIC50329.0 [1]
Ent-KaurenolIC5010000.0 [1]
{(3s)-1-[5-(Cyclohexylcarbamoyl)-6-(Propylsulfanyl)pyridin-2-Yl]piperidin-3-Yl}acetic AcidIC5030000.0 [1]
(1S,4S,5R,9S,10R,13S,14R)-14-Hydroxy-14-(hydroxymethyl)-5,9-dimethyltetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acidIC501000000.0 [1]
3-(4-Fluorophenyl)-5-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]-1-bicyclo[2.2.2]octanyl]-1,2,4-oxadiazoleIC503.0 [1]
1-(2,3-Dihydroindol-1-yl)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]ethanoneIC508900.0 [1]
2-(Phenylsulfonyl)-1-p-tolylethanoneIC50200000.0 [1]
Unii-9RT16rbu2YIC504000.0 [1]
1-[[(3R)-3-Methyl-4-[4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl]sulfonylpiperazin-1-yl]methyl]cyclopropane-1-carboxamideIC50100000.0 [1]
4-[4-(2-Adamantylcarbamoyl)-5-Tert-Butyl-Pyrazol-1-Yl]benzoic AcidIC5030000.0 [1]
4-Methyl-3-(4-pentyl-1-bicyclo[2.2.2]octanyl)-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazoleIC501300.0 [1]
N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propionamideIC50100000.0 [1]
N-Cyclopropyl-N-(4-pyridin-3-ylcyclohexyl)-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamideIC5010000.0 [1]
(3S,5R,8R,9R,10R,12R,13R,14R,17R)-3,12-Dihydroxy-17-methoxy-4,4,8,10,14-pentamethyl-1,2,3,5,6,7,9,11,12,13,16,17-dodecahydrocyclopenta[a]phenanthren-15-oneIC5025500.0 [1]
(3S,5R,8R,9R,10R,12R,13R,14R)-3,12-Dihydroxy-4,4,8,10,14-pentamethyl-1,2,3,5,6,7,9,11,12,13-decahydrocyclopenta[a]phenanthren-15-oneIC50283600.0 [1]
3-(1-Adamantyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC504000.0 [1]
N-(4-(4-(Trifluoromethyl)phenyl)oxazol-2-yl)benzenesulfonamideIC50200000.0 [1]
2-(2-Chloro-4-fluorophenoxy)-2-methyl-N-[5-(2H-tetrazol-5-yl)-2-adamantyl]propanamideIC50550.0 [1]
4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxylic acidIC5030000.0 [1]
E-4-[(2-Methyl-2-phenoxypropanoyl)amino]adamantane-1-carboxamideIC5023000.0 [1]
4-[[2-(4-Methoxyphenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxamideIC5018000.0 [1]
4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxamideIC5012000.0 [1]
4-[[2-(2-Chlorophenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxylic acidIC501800.0 [1]
2-(Hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-oneIC5010000.0 [1]
1-(4-Fluorophenyl)-2-(phenylsulfonyl)ethanoneIC50200000.0 [1]
N-[4-(2-Cyanoethyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamideIC5010000.0 [1]
4-(2-(4-Chlorophenoxy)-2-methylpropanamido)bicyclo[2.2.2]octane-1-carboxamideIC50100000.0 [1]
1-(3-Methoxyphenyl)-2-(phenylsulfonyl)ethanoneIC50200000.0 [1]
N-[4-(4-Cyanophenyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamideIC5010000.0 [1]
N-(4-Phenyloxazol-2-yl)benzenesulfonamideIC50200000.0 [1]
3-Chloro-N-(4-(4-cyanophenyl)oxazol-2-yl)-2-methylbenzenesulfonamideIC50200000.0 [1]
9-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]bicyclo[3.3.1]nonane-3-carboxamideIC50100000.0 [1]
9-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-3-oxabicyclo[3.3.1]nonane-7-carboxamideIC50100000.0 [1]
2-(4-Chlorophenoxy)-N-(1-hydroxy-2-oxatricyclo[3.3.1.13,7]decan-6-yl)-2-methylpropanamideIC5070000.0 [1]
8-[[2-Methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]bicyclo[3.2.1]octane-3-carboxylic acidIC5030000.0 [1]
9-[[2-Methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]bicyclo[3.3.1]nonane-3-carboxylic acidIC50100000.0 [1]
4-[[2-Methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]bicyclo[2.2.2]octane-1-carboxamideIC5090000.0 [1]
4-[(2-Methyl-2-phenoxypropanoyl)amino]adamantane-1-carboxylic acidIC5017000.0 [1]
4-[[2-(3-Chlorophenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxylic acidIC503500.0 [1]
4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-N-[[4-(2H-tetrazol-5-yl)phenyl]methyl]adamantane-1-carboxamideIC5026000.0 [1]
N-(2-Amino-2-oxoethyl)-4-[[2-(4-chlorophenoxy)-2-methylpropanoyl]amino]adamantane-1-carboxamideIC5020000.0 [1]
2-(4-Chlorophenoxy)-N-[5-(hydroxymethyl)-2-adamantyl]-2-methylpropanamideIC5025000.0 [1]
2-[[4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-1-adamantyl]methoxy]acetic acidIC50100000.0 [1]
3-[3-Chloro-4-[5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-1,2,4-triazol-3-yl]phenyl]pyridineIC504000.0 [1]
2-[(1R)-1'-(2-Adamantylcarbamoyl)-4-bromospiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetic acidIC5010000.0 [1]
4-Cyclopentyl-N-(5-hydroxy-2-adamantyl)-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamideIC5030000.0 [1]
(2S,4As,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-acetamido-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acidIC50458.0 [1]
(6S)-3-[(1S)-1-[4-(2,4-Difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-oneIC5010000.0 [1]
11beta-AminoprogesteroneIC502200.0 [1]
3-[1-(2-Fluorophenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC501270.0 [1]
3-[1-(2-Methylphenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC503318.0 [1]
3-[1-(4-Methylphenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC502006.0 [1]
3-[1-[2-(Trifluoromethyl)phenyl]cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC504000.0 [1]
3-[1-(4-Fluorophenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC504000.0 [1]
3-(1-Phenylcyclopentyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC501035.0 [1]
[(3S,5R,8R,9R,10R,12R,13S,14R,17R)-3-Hydroxy-17-methoxy-4,4,8,10,14-pentamethyl-15-oxo-1,2,3,5,6,7,9,11,12,13,16,17-dodecahydrocyclopenta[a]phenanthren-12-yl] acetateIC5040700.0 [1]
[(3S,5R,8R,9R,10R,12R,13S,14R,17R)-3,17-Dihydroxy-4,4,8,10,14-pentamethyl-15-oxo-1,2,3,5,6,7,9,11,12,13,16,17-dodecahydrocyclopenta[a]phenanthren-12-yl] acetateIC50299600.0 [1]
[(3S,5R,8R,9R,10R,12R,13R,14R)-3-Hydroxy-4,4,8,10,14-pentamethyl-15-oxo-1,2,3,5,6,7,9,11,12,13-decahydrocyclopenta[a]phenanthren-12-yl] acetateIC5011300.0 [1]
3-(1-(4-Chlorophenyl)cyclobutyl)-4-methyl-5-(2-(trifluoromethoxy)phenyl)-4H-1,2,4-triazoleIC504000.0 [1]
3-(1-(4-Chlorophenyl)cyclobutyl)-4-methyl-5-o-tolyl-4H-1,2,4-triazoleIC504000.0 [1]
3-[1-(5,6,7,8,9,10-Hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)cyclopentyl]phenolIC504000.0 [1]
3-(1-Phenylcyclopropyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC504000.0 [1]
3-[1-(4-Chlorophenyl)cyclopropyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC504000.0 [1]
3-[1-(4-Methylphenyl)cyclopentyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC50503.0 [1]
3-(1-(4-Chlorophenyl)cyclobutyl)-5-(2-fluorophenyl)-4-methyl-4H-1,2,4-triazoleIC504000.0 [1]
3-[1-(4-Chlorophenyl)cyclohexyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC50613.0 [1]
3-[1-(2-Fluorophenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC504000.0 [1]
3-[1-(4-Methylphenyl)cyclohexyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC50216.0 [1]
3-[1-(3-Methylphenyl)cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocineIC504000.0 [1]
3-(1-Phenylcyclohexyl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocineIC501037.0 [1]
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References

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MLA

"Quest Database™ 11-beta-hydroxysteroid dehydrogenase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/11-beta-hydroxysteroid-dehydrogenase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ 11-beta-hydroxysteroid dehydrogenase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/11-beta-hydroxysteroid-dehydrogenase-2-inhibitors-ic50-ki.
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