15-hydroxyprostaglandin dehydrogenase [NAD+] Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(5Z)-5-[[4-(2-Cyclohexylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	50.9 [1], 51.0 [2]
	2-(Butane-1-sulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	2.2 [1]
	2-(Butane-1-sulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine	Ki	0.1 [1]
	5-[(Z)-4-(Cyclopentylmethoxy)benzylidene]thiazolidine-2,4-dione	IC50	42.5 [1], 45.0 [2]
	CID 46836953	IC50	7.2 [1], 8.0 [2]
	(5Z)-5-[4-[2-(2-Pyridinyl)ethoxy]benzylidene]thiazolidine-2,4-dione	IC50	592.2 [1], 660.0 [2]
	(5Z)-5-[[4-[(4-Methylphenyl)methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	232.0 [1], 727.9 [2]
	(5Z)-5-[[4-[2-(1,1-Dioxo-1,4-thiazinan-4-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	274.0 [1], 1373.4 [2]
	(5Z)-5-[[4-(2-Thiophen-2-ylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	31.0 [1], 95.9 [2]
	(5Z)-5-[[4-(2-Morpholin-4-ylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	514.8 [1], 713.0 [2]
	(5Z)-5-[[4-(2-Thiophen-3-ylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	60.0 [1], 148.5 [2]
	(5Z)-5-[[4-(2-Propan-2-yloxyethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	961.4 [1], 1248.0 [2]
	(5Z)-5-[[4-[2-(Cyclohexylamino)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	2614.9 [1], 3719.0 [2]
	(5Z)-5-[[4-(2-Piperidin-1-ylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	1425.1 [1], 1442.0 [2]
	(5Z)-5-[[4-[2-(4-Methyl-1,3-thiazol-5-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	636.0 [1], 1170.2 [2]
	(5Z)-5-[[4-[3-(1,1-Dioxo-1,4-thiazinan-4-yl)propoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	1960.0 [1], 3041.5 [2]
	(5Z)-5-[[4-(Thiophen-2-ylmethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	250.8 [1], 287.0 [2]
	(5Z)-5-[[4-(Thiophen-3-ylmethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	391.7 [1], 429.0 [2]
	(5Z)-5-[[4-(2-Cyclopentylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	114.6 [1], 116.0 [2]
	(5Z)-5-[[4-(Furan-2-ylmethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	893.0 [1], 1876.2 [2]
	(5Z)-5-[[4-(Pyridin-2-ylmethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	2585.0 [1], 3640.2 [2]
	(5Z)-5-[[4-(1,3-Benzodioxol-5-ylmethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	252.0 [1], 310.1 [2]
	(5Z)-5-[[4-[[4-(Chloromethyl)phenyl]methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	124.0 [1], 124.5 [2]
	(5Z)-5-[[4-[(4-Methylcyclohexyl)methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	52.0 [1], 66.4 [2]
	(5Z)-5-[[4-(2-Cyclohexyloxyethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	218.7 [1], 219.0 [2]
	(5Z)-5-[[4-(2-Cyclohexylethoxy)phenyl]methylidene]-3-(2-hydroxyethyl)-1,3-thiazolidine-2,4-dione	IC50	526.0 [1]
	5-[(Z)-3-Chloro-4-(cyclohexyloxy)benzylidene]thiazolidine-2,4-dione	IC50	47.0 [1], 48.9 [2]
	(5Z)-5-[[3-Chloro-4-(cyclohexylmethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	26.9 [1], 28.0 [2]
	(5Z)-5-[[3-Chloro-4-(3-cyclohexylpropoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	10.0 [1], 10.3 [2]
	(5Z)-5-[[3-Chloro-4-(4-cyclohexylbutoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	24.0 [1], 26.3 [2]
	(5Z)-5-[(3-Chloro-4-phenylmethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione	IC50	47.5 [1], 48.0 [2]
	(5Z)-5-[[3-Chloro-4-(2-phenylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	19.8 [1], 20.0 [2]
	(5Z)-5-[[3-Chloro-4-(3-phenylpropoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	38.0 [1], 38.1 [2]
	(5Z)-5-[[3-Bromo-4-(2-cyclohexylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	6.6 [1], 19.0 [2]
	(5Z)-5-[[2-Chloro-4-(2-cyclohexylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	13.0 [1], 19.6 [2]
	(5Z)-5-[[3-Chloro-4-[2-(1,1-dioxo-1,4-thiazinan-4-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	223.0 [1], 307.9 [2]
	(5Z)-5-[(2-Chloro-4-phenylmethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione	IC50	487.0 [1]
	(5Z)-5-[[2-Chloro-4-(2-phenylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	178.0 [1]
	(5Z)-5-[[2-Chloro-4-(3-phenylpropoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	52.0 [1]
	(5Z)-5-[[2-Chloro-4-(4-phenylbutoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	81.0 [1]
	(5Z)-5-[[3-Chloro-4-(2-propan-2-yloxyethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	2737.5 [1], 2738.0 [2]
	(5Z)-5-[[3-Chloro-4-(2-thiophen-2-ylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	84.0 [1], 84.1 [2]
	(5Z)-5-[[2-Chloro-4-(2-pyridin-2-ylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	8914.7 [1], 8915.0 [2]
	(5Z)-5-[[3-Chloro-4-(4-phenylbutoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	47.5 [1], 48.0 [2]
	(5Z)-5-[[3-Chloro-4-(2-cyclopentylethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	99.0 [1], 99.3 [2]
	Ciglitazone	IC50	2700.0 [1]
	5-(4-Hydroxybenzylidene)thiazolidine-2,4-dione	IC50	10058.1 [1]
	3-(2,5-Dimethyl-1-phenyl-3-pyrrolyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine	IC50	54.0 [1]
	5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4-dione	IC50	1739.1 [1]
	[1-(3-Methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone	IC50	19.0 [1]
	N-Phenyl-2-({[1-(2-thienyl)ethylidene]amino}oxy)acetamide	IC50	6000.0 [1]
	(5Z)-5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	546.6 [1]
	N-Cyclopentyl-1-(3-methylphenyl)-1H-benzimidazole-5-carboxamide	IC50	961.0 [1]
	(Z)-5-(4-Benzyloxybenzylidene)thiazolidine-2,4-dione	IC50	1043.9 [1]
	(5Z)-5-[(4-Phenoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione	IC50	20000.0 [1]
	[1-(4-Methoxyphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone	IC50	19.0 [1]
	5-[2-Chloro-3-(3-phenylpropoxy)benzylidene]thiazolidine-2,4-dione	IC50	44.9 [1]
	3-[1-(4-Fluorophenyl)-2,5-dimethylpyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine	IC50	121.0 [1]
	5-(4-Methylbenzylidene)thiazolidine-2,4-dione	IC50	5820.4 [1]
	3-[2,5-Dimethyl-1-(4-methylphenyl)pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine	IC50	34.0 [1]
	Ethyl 3-amino-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate	IC50	7500.0 [1]
	(5Z)-5-[[4-(2,3-Dihydro-1,4-benzodioxin-3-ylmethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione	IC50	172.4 [1]
	6-Butylsulfinyl-2,4-diphenylthieno[2,3-d]pyrimidine	IC50	93.0 [1]
	4-(3-Amino-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-2-yl)sulfinylbutanenitrile	IC50	8.7 [1]
	2-(3-Fluoropropylsulfinyl)-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine	IC50	6.1 [1]
	[4-[3-Amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]phenyl]methyl 2-(dimethylamino)acetate	IC50	3.5 [1]
	6-Butylsulfinyl-2-phenyl-4-piperidin-1-ylthieno[2,3-d]pyrimidine	IC50	1320.0 [1]
	3-(3-Amino-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-2-yl)sulfinylpropan-1-ol	IC50	37.0 [1]
	2-(3-Methoxypropylsulfinyl)-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine	IC50	2.1 [1]
	2-Butylsulfinyl-4-(3-methyl-2-propan-2-ylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	20.5 [1]
	2-Butylsulfinyl-4-(2-methyl-1H-imidazol-5-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	2.3 [1]
	2-Butylsulfinyl-4-(1-methylimidazol-2-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	1.8 [1]
	2-Butylsulfinyl-4-(2-cyclopropyl-3-methylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	2.0 [1]
	2-Butylsulfinyl-4,6-bis(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	1.8 [1]
	Methyl 3-[3-amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]benzoate	IC50	9.0 [1]
	2-Butylsulfinyl-5-thiophen-2-yl-1H-imidazo[4,5-b]pyridine	IC50	7500.0 [1]
	6-Butylsulfinyl-2-(1,3-oxazol-4-yl)-4-phenylthieno[2,3-d]pyrimidin-5-amine	IC50	2.6 [1]
	2-Butylsulfinyl-4-pyridin-3-yl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	2.6 [1]
	3-Amino-2-propylsulfinyl-6-thiophen-2-ylthieno[2,3-b]pyridine-4-carboxylic acid	IC50	71.0 [1]
	2-[4-[3-Amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]phenoxy]ethanol	IC50	158.0 [1]
	4-Methyl-2-propylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	5.3 [1]
	Ethyl 3-amino-2-propylsulfinyl-6-thiophen-2-ylthieno[2,3-b]pyridine-4-carboxylate	IC50	2.0 [1]
	2-Butylsulfinyl-6-(1-methylimidazol-2-yl)-4-phenylthieno[2,3-b]pyridin-3-amine	IC50	6.7 [1]
	4-Methyl-6-morpholin-4-yl-2-propylsulfinylthieno[2,3-b]pyridin-3-amine	IC50	136.0 [1]
	Methyl 4-[3-amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]benzoate	IC50	15.1 [1]
	2-Butylsulfanyl-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine	IC50	80.0 [1]
	6-Butylsulfinyl-2-(1-methylimidazol-2-yl)-4-phenylthieno[2,3-d]pyrimidin-5-amine	IC50	3.7 [1]
	4-(2,3-Dimethylimidazol-4-yl)-2-(2-methoxyethylsulfinyl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	IC50	1.8 [1]
	2-(3-Chloropropylsulfinyl)-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine	IC50	4.0 [1]
	3-[3-Amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]-N,N-dimethylbenzamide	IC50	18.5 [1]
	3-[3-Amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]-N-(2-hydroxyethyl)benzamide	IC50	3.4 [1]
	[3-[3-Amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]phenyl]methanol	IC50	4.3 [1]
	[4-[3-Amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]phenyl]methanol	IC50	2.5 [1]
	4-Phenyl-2-propan-2-ylsulfinyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine	IC50	3.2 [1]
	4-Phenyl-2-propylsulfinyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine	IC50	2.1 [1]
	6-Butylsulfinyl-4-phenyl-2-(1,3-thiazol-2-yl)thieno[2,3-d]pyrimidin-5-amine	IC50	1.0 [1]
	4-[3-Amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]-N,N-dimethylbenzamide	IC50	5.9 [1]
	4-[3-Amino-2-butylsulfinyl-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-4-yl]benzoic acid	IC50	3.4 [1]
	2-Butylsulfinyl-6-(1,3-oxazol-2-yl)-4-phenylthieno[2,3-b]pyridin-3-amine	IC50	1.4 [1]
	2-Butylsulfinyl-5-thiophen-2-yl-[1,3]thiazolo[5,4-b]pyridine	IC50	1230.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ 15-hydroxyprostaglandin dehydrogenase [NAD+] Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/15-hydroxyprostaglandin-dehydrogenase-nad-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 8). Quest Database™ 15-hydroxyprostaglandin dehydrogenase [NAD+] Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/15-hydroxyprostaglandin-dehydrogenase-nad-inhibitors-ic50-ki.
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