3-phosphoinositide dependent protein kinase-1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	CID 46215815	IC50	10.0 [1]
	Urea, (2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl)-	IC50	5.0 [1], 6.0 [2], 9.0 [3], 100.0 [4]
	N-[3-[[5-Bromo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide	IC50	2.3 [1], 9.5 [2], 11.0 [3], 26.0 [4]
	1-[(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-phenylpyrrolidin-1-yl]ethanone	IC50	200.0 [1], 300.0 [2], 320.0 [3]
	1-[(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-phenylpyrrolidin-1-yl]ethanone	Ki	1.4 [1]
	2,2-Difluoro-N-[3-[6-(2-methylmorpholin-4-yl)-1H-benzimidazol-2-yl]-1H-indazol-5-yl]cyclopropane-1-carboxamide	IC50	90.0 [1], 94.0 [2], 159.0 [3]
	2,2-Difluoro-N-[3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]cyclopropane-1-carboxamide	IC50	80.0 [1], 143.0 [2]
	(2S,5R)-4-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-5-methyl-N-phenylmorpholine-2-carboxamide	IC50	5.01 [1], 264.0 [2], 594.0 [3], 29300.0 [4]
	(3S,6R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamide	IC50	3.16 [1], 327.0 [2], 333.0 [3], 29300.0 [4]
	(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidine-1-carbaldehyde	IC50	50.0 [1], 70.0 [2], 120.0 [3]
	(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidine-1-carbaldehyde	Ki	0.7 [1]
	1-[(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidin-1-yl]ethanone	IC50	70.0 [1], 80.0 [2], 160.0 [3]
	1-[(2R,3R)-3-[[6-(4-Amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidin-1-yl]ethanone	Ki	1.4 [1]
	Celecoxib	IC50	48000.0 [1]
	N'-[3-[[5-Bromo-2-[3-(pyrrolidine-1-carbonylamino)anilino]pyrimidin-4-yl]amino]propyl]-2,2-dimethylpropanediamide	IC50	30.0 [1], 39.0 [2]
	4-(1H-Pyrrolo[2,3-B]pyridin-3-YL)pyrimidin-2-amine	IC50	5900.0 [1], 10000.0 [2]
	10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine	IC50	60.0 [1]
	N-[3-(6-Morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]cyclopropanecarboxamide	IC50	200.0 [1], 229.0 [2], 283.0 [3]
	4,4-Difluoro-N-[3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-5-yl]cyclohexane-1-carboxamide	IC50	200.0 [1], 265.0 [2], 304.0 [3]
	N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4,4-difluorocyclohexane-1-carboxamide	IC50	400.0 [1], 410.0 [2], 1500.0 [3]
	N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]cyclopropanecarboxamide	IC50	1200.0 [1], 1230.0 [2], 1740.0 [3]
	N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-2,2-difluorocyclopropane-1-carboxamide	IC50	280.0 [1], 300.0 [2], 1940.0 [3]
	2,2-Difluoro-N-[3-[6-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-indazol-5-yl]cyclopropane-1-carboxamide	IC50	1200.0 [1], 1220.0 [2], 3750.0 [3]
	2,2-Difluoro-N-[3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-4-yl]cyclopropane-1-carboxamide	IC50	385.0 [1], 400.0 [2], 4400.0 [3]
	1-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-3-cyclopropylurea	IC50	900.0 [1], 920.0 [2], 11600.0 [3]
	N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-3-fluorobenzamide	IC50	8790.0 [1], 8800.0 [2], 21100.0 [3]
	3-(1H-Benzo[d]imidazol-2-yl)-5-(3-(methylsulfonyl)phenyl)-1H-indazole	IC50	15300.0 [1], 23700.0 [2]
	3-(1H-Benzo[d]imidazol-2-yl)-5-(3-(trifluoromethyl)phenyl)-1H-indazole	IC50	30300.0 [1], 55700.0 [2]
	N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-1,4-dimethylpiperidine-4-carboxamide	IC50	12400.0 [1], 100000.0 [2]
	1-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-3-cyclopentylurea	IC50	53900.0 [1], 100000.0 [2]
	(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamide	IC50	1.58 [1], 165.0 [2], 655.0 [3]
	Tert-butyl N-[(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-5-methylpiperidin-3-yl]carbamate	IC50	6.31 [1], 74.0 [2], 151.0 [3]
	(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-5-ethyl-N-phenylmorpholine-2-carboxamide	IC50	3.16 [1], 57.0 [2], 88.0 [3]
	(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-5-methylmorpholine-2-carboxamide	IC50	3.16 [1], 24.0 [2], 30.0 [3]
	(2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-5-ethylmorpholine-2-carboxamide	IC50	6.31 [1], 85.0 [2], 102.0 [3]
	N-[(3R,5R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-5-methylpiperidin-3-yl]-N,3,3-trimethylbutanamide	IC50	0.63 [1], 22.0 [2], 116.0 [3]
	(3R,6S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-6-methyl-N-phenylpiperidine-3-carboxamide	IC50	1258.93 [1], 29300.0 [2]
	(3S,6R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide	IC50	7.94 [1], 316.0 [2], 472.0 [3]
	Tert-butyl N-[(3R,5R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-5-methylpiperidin-3-yl]-N-methylcarbamate	IC50	0.79 [1], 9.0 [2], 19.0 [3]
	2-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2-chloroanilino)ethanol	IC50	2.6 [1], 4.7 [2]
	4-N-(3-Fluorophenyl)-4-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine	IC50	34.0 [1], 280.0 [2]
	4-[5-(1-Methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-(2-phenylpropan-2-yl)pyrimidin-2-amine	IC50	65.0 [1], 140.0 [2]
	4-[5-(1-Methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-(1-phenylcyclopropyl)pyrimidin-2-amine	IC50	59.5 [1], 110.0 [2]
	2-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)ethanol	IC50	13.0 [1], 250.0 [2]
	(2S)-3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-4-methoxyanilino)propane-1,2-diol	IC50	24.0 [1], 6800.0 [2]
	4-[5-(1-Methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-6-(1-phenylcyclopentyl)pyrimidin-2-amine	IC50	130.0 [1], 625.0 [2]
	4-[1-(4-Chlorophenyl)cyclopentyl]-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine	IC50	870.0 [1], 1400.0 [2]
	4-N-(3-Chlorophenyl)-4-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine	IC50	51.0 [1], 200.0 [2]
	4-N-(2-Fluorophenyl)-4-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine	IC50	9.7 [1], 27.0 [2]
	4-N-(2-Chlorophenyl)-4-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine	IC50	7.6 [1], 26.0 [2]
	4-N-Methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-phenylpyrimidine-2,4-diamine	IC50	16.5 [1], 800.0 [2]
	4-N-Ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-phenylpyrimidine-2,4-diamine	IC50	12.0 [1], 690.0 [2]
	4-N-(4-Chlorophenyl)-4-N-ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine	IC50	46.0 [1], 120.0 [2]
	4-N-Benzyl-4-N-ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine	IC50	51.0 [1], 530.0 [2]
	2-(N-[2-Amino-6-[5-(1-propan-2-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2-chloroanilino)ethanol	IC50	17.0 [1], 2100.0 [2]
	4-(5-Fluoro-2,3-dihydroindol-1-yl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine	IC50	200.0 [1], 10000.0 [2]
	4-(5-Fluoro-2,3-dihydroindol-1-yl)-6-[5-(1-propan-2-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine	IC50	5900.0 [1], 10000.0 [2]
	4-N-(2-Chlorophenyl)-4-N-methyl-6-[5-(1-propan-2-ylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine	IC50	30.0 [1], 400.0 [2]
	4-N-Ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-(1,3,4-thiadiazol-2-yl)pyrimidine-2,4-diamine	IC50	155.0 [1], 10000.0 [2]
	1-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)-3-methoxypropan-2-ol	IC50	11.0 [1], 520.0 [2]
	3-[[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-(2,3-dihydroxypropyl)amino]benzonitrile	IC50	90.0 [1], 10000.0 [2]
	3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2-chloroanilino)propanoic acid	IC50	4.8 [1], 10000.0 [2]
	2-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2,4-difluoroanilino)ethanol	IC50	6.5 [1], 35.0 [2]
	2-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]-2-fluoroanilino)ethanol	IC50	5.0 [1], 23.0 [2]
	4-(2,3-Dihydro-1,4-benzoxazin-4-yl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine	IC50	5.0 [1], 10000.0 [2]
	4-N-(3-Fluorophenyl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-(2-morpholin-4-ylethyl)pyrimidine-2,4-diamine	IC50	89.0 [1], 9700.0 [2]
	4-N-(2-Chlorophenyl)-4-N-(2-methoxyethyl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidine-2,4-diamine	IC50	7.0 [1], 25.5 [2]
	3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)propanenitrile	IC50	7.1 [1], 7.9 [2]
	4-N-(3-Aminopropyl)-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-N-phenylpyrimidine-2,4-diamine	IC50	8.7 [1], 6800.0 [2]
	3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)propanamide	IC50	17.0 [1], 23000.0 [2]
	4-[1-(2-Fluorophenyl)cyclopropyl]-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine	IC50	20.0 [1], 45.5 [2]
	N-[3-(N-[2-Amino-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]anilino)propyl]acetamide	IC50	22.0 [1], 430.0 [2]
	N-(3-Fluorophenyl)-N-methyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-amine	IC50	190.0 [1], 660.0 [2]
	Staurosporine	IC50	5.2 [1], 10.0 [2]
	PDK1 inhibitor AR-12	IC50	5000.0 [1]
	(Z)-3-((1H-Pyrrol-2-yl)methylene)indolin-2-one	IC50	520.0 [1], 1800.0 [2]
	2-(4-(8-(2-(Pyridin-3-yl)ethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)acetonitrile	IC50	34.0 [1]
	N-Methyl-1(R)-aminoindan	IC50	200.0 [1]
	[(3Z)-2-Oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-5-yl]urea	IC50	18.0 [1], 3000.0 [2]
	4-[2-(3-Chloroanilino)-7H-purin-6-yl]phenol	IC50	1600.0 [1]
	6-(2-Aminopyrimidin-4-Yl)-1h-Indazol-3-Amine	IC50	370.0 [1], 398.11 [2]
	1-(3-Aminopropyl)-8-[3-[2-(dimethylamino)-2-oxoethyl]anilino]-N-[(2-methylpyridin-4-yl)methyl]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	85.0 [1]
	(10E)-13-Methyl-7-oxa-13,20,22,24,26,28-hexazapentacyclo[19.6.1.12,6.115,19.023,27]triaconta-1(27),2(30),3,5,10,15(29),16,18,21(28),22,24-undecaene	IC50	390.0 [1]
	2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-[(3Z)-3-(1H-imidazol-5-ylmethylidene)-2-oxo-1H-indol-5-yl]acetamide	IC50	980.0 [1], 998.0 [2]
	2-[4-[5-Phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]guanidine	IC50	2000.0 [1]
	3-(6-Ethylpyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridine	IC50	10000.0 [1], 30000.0 [2]
	3-(1H-Benzo[d]imidazol-2-yl)-5-bromo-1H-indazole	IC50	10900.0 [1]
	2,2-Difluoro-N-[3-[6-(4-methylpiperidin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-5-yl]cyclopropane-1-carboxamide	IC50	780.0 [1], 800.0 [2]
	1-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-3-(2,4-difluorophenyl)urea	IC50	100000.0 [1]
	N-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-1-pyridin-4-ylpiperidine-4-carboxamide	IC50	100000.0 [1]
	2,2-Difluoro-N-[3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-indazol-6-yl]cyclopropane-1-carboxamide	IC50	100000.0 [1]
	4-Butyl-6-(1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-Amine	IC50	1100.0 [1], 10000.0 [2]
	4-Ethyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamine	IC50	1200.0 [1], 30000.0 [2]
	4-Pentyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	IC50	2200.0 [1], 30000.0 [2]
	4-(3-Aminopropyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	IC50	390.0 [1], 30000.0 [2]
	4-(4-Aminobutyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	IC50	1000.0 [1], 30000.0 [2]
	4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-6-ethylpyrimidin-2-amine	IC50	480.0 [1], 30000.0 [2]
	4-Ethyl-6-[5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine	IC50	85.0 [1], 11000.0 [2]
	4-Ethyl-6-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	IC50	500.0 [1], 30000.0 [2]
	4-Ethyl-6-(5-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	IC50	450.0 [1], 30000.0 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ 3-phosphoinositide dependent protein kinase-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 7 May. 2024, https://www.aatbio.com/data-sets/3-phosphoinositide-dependent-protein-kinase-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 7). Quest Database™ 3-phosphoinositide dependent protein kinase-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/3-phosphoinositide-dependent-protein-kinase-1-inhibitors-ic50-ki.
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