4-hydroxyphenylpyruvate dioxygenase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nitisinone	Ki	37.0 [1]
	3-(3-Chlorophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	10.0 [1]
	3-(2-Bromo-4-methylphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	11.0 [1]
	3-(2-Chlorophenyl)-6-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4-one	Ki	86.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methyl-3-(2-methylphenyl)quinazolin-4-one	Ki	248.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(2-methoxyphenyl)-2-methylquinazolin-4-one	Ki	207.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(2-fluorophenyl)-2-methylquinazolin-4-one	Ki	79.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methyl-3-(3-methylphenyl)quinazolin-4-one	Ki	74.0 [1]
	3-(3-Chlorophenyl)-6-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4-one	Ki	173.0 [1]
	3-(3-Bromophenyl)-6-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4-one	Ki	93.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(3-fluorophenyl)-2-methylquinazolin-4-one	Ki	90.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(4-fluorophenyl)-2-methylquinazolin-4-one	Ki	247.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(4-methoxyphenyl)-2-methylquinazolin-4-one	Ki	238.0 [1]
	3-(4-Bromophenyl)-6-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4-one	Ki	130.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methyl-3-(4-methylphenyl)quinazolin-4-one	Ki	156.0 [1]
	3-(4-Chlorophenyl)-6-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4-one	Ki	237.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(2,4-dimethylphenyl)-2-methylquinazolin-4-one	Ki	161.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(2-fluoro-4-methylphenyl)-2-methylquinazolin-4-one	Ki	81.0 [1]
	6-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(4-fluoro-2-methylphenyl)-2-methylquinazolin-4-one	Ki	219.0 [1]
	3-(2-Bromo-4-methylphenyl)-6-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4-one	Ki	87.0 [1]
	3-(4-Chloro-2-methylphenyl)-6-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4-one	Ki	177.0 [1]
	3-(2-Chloro-4-methylphenyl)-6-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4-one	Ki	109.0 [1]
	2-Methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-phenylquinazolin-4-one	Ki	19.0 [1]
	3-(2-Fluorophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	15.0 [1]
	3-(2-Chlorophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	22.0 [1]
	3-(2-Bromophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	24.0 [1]
	2-Methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(2-methylphenyl)quinazolin-4-one	Ki	58.0 [1]
	3-(2-Methoxyphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	38.0 [1]
	3-(3-Fluorophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	20.0 [1]
	3-(3-Bromophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	14.0 [1]
	2-Methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(3-methylphenyl)quinazolin-4-one	Ki	13.0 [1]
	3-(3-Methoxyphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	34.0 [1]
	2-Methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-[3-(trifluoromethoxy)phenyl]quinazolin-4-one	Ki	31.0 [1]
	3-(4-Fluorophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	34.0 [1]
	3-(4-Chlorophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	22.0 [1]
	3-(4-Bromophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	18.0 [1]
	2-Methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(4-methylphenyl)quinazolin-4-one	Ki	25.0 [1]
	3-(4-Methoxyphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	60.0 [1]
	2-Methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-[4-(trifluoromethoxy)phenyl]quinazolin-4-one	Ki	160.0 [1]
	3-(4-Chloro-2-methylphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	32.0 [1]
	3-(4-Fluoro-2-methylphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	40.0 [1]
	3-(3,4-Dichlorophenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	25.0 [1]
	3-(2-Fluoro-4-methylphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	170.0 [1]
	3-(2-Chloro-4-methylphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	90.0 [1]
	3-(2,4-Dimethylphenyl)-2-methyl-6-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)quinazolin-4-one	Ki	59.0 [1]
	3-[2-Nitro-4-(trifluoromethyl)benzoyl]hexane-2,4-dione	IC50	68.0 [1]
	1-Methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-propylbenzimidazol-2-one	IC50	59.0 [1]
	3-Butyl-1-methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	170.0 [1]
	1-Methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(2-methylpropyl)benzimidazol-2-one	IC50	140.0 [1]
	3-Cyclopentyl-1-methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	130.0 [1]
	1-Methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-propan-2-ylbenzimidazol-2-one	IC50	61.0 [1]
	3-Ethyl-1-methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	22.0 [1]
	3-Tert-butyl-1-methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	100.0 [1]
	1-Methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-(4-methylphenyl)benzimidazol-2-one	IC50	250.0 [1]
	3-Benzyl-1-methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	130.0 [1]
	3-Cyclopropyl-1-methyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	100.0 [1]
	1-Ethyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-propylbenzimidazol-2-one	IC50	22.0 [1]
	1,3-Diethyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	21.0 [1]
	1-Ethyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-3-propan-2-ylbenzimidazol-2-one	IC50	64.0 [1]
	3-Tert-butyl-1-ethyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	150.0 [1]
	3-Cyclopropyl-1-ethyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)benzimidazol-2-one	IC50	220.0 [1]
	3-Ethyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-1-propylbenzimidazol-2-one	IC50	39.0 [1]
	5-(2-Methyl-3-oxo-1H-pyrazole-4-carbonyl)-1,3-dipropylbenzimidazol-2-one	IC50	40.0 [1]
	3-Tert-butyl-5-(2-methyl-3-oxo-1H-pyrazole-4-carbonyl)-1-propylbenzimidazol-2-one	IC50	77.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-methyl-3-propylbenzimidazol-2-one	IC50	1030.0 [1]
	3-Butyl-5-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-methylbenzimidazol-2-one	IC50	640.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-methyl-3-(2-methylpropyl)benzimidazol-2-one	IC50	2710.0 [1]
	3-Cyclopentyl-5-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-methylbenzimidazol-2-one	IC50	930.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-methyl-3-propan-2-ylbenzimidazol-2-one	IC50	940.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-ethyl-1-methylbenzimidazol-2-one	IC50	970.0 [1]
	3-Tert-butyl-5-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-methylbenzimidazol-2-one	IC50	990.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-methyl-3-(4-methylphenyl)benzimidazol-2-one	IC50	990.0 [1]
	3-Benzyl-5-(2,5-dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-methylbenzimidazol-2-one	IC50	670.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-ethyl-3-propylbenzimidazol-2-one	IC50	880.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1,3-diethylbenzimidazol-2-one	IC50	940.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1-ethyl-3-propan-2-ylbenzimidazol-2-one	IC50	970.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-ethyl-1-propylbenzimidazol-2-one	IC50	740.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-1,3-dipropylbenzimidazol-2-one	IC50	720.0 [1]
	5-(2,5-Dimethyl-3-oxo-1H-pyrazole-4-carbonyl)-3-propan-2-yl-1-propylbenzimidazol-2-one	IC50	1190.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 79 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ 4-hydroxyphenylpyruvate dioxygenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/4-hydroxyphenylpyruvate-dioxygenase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ 4-hydroxyphenylpyruvate dioxygenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/4-hydroxyphenylpyruvate-dioxygenase-inhibitors-ic50-ki.
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