 | 3-(3-(Tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid | IC50 | 26.0 [1] |
 | Quiflapon sodium | IC50 | 12.0 [1] |
 | Fiboflapon | IC50 | 2.9 [1] |
 | AM-103 free acid | IC50 | 10.0 [1] |
 | Quiflapon | IC50 | 1.6 [1], 2.0 [2] |
 | 3-[1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-amine | IC50 | 20.0 [1], 440.0 [2] |
 | 5-[4-[1-[5-[1-(2-Methoxyethyl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine | IC50 | 2.4 [1], 65.0 [2] |
 | 1-[4-[3-[1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-2-ol | IC50 | 3.5 [1], 69.0 [2] |
 | 5-[4-[1-[5-(1-Methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine | IC50 | 1.9 [1], 45.0 [2] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-ethylpyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.6 [1], 10.1 [2], 1200.0 [3], 1390.0 [4] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.8 [1], 5.3 [2], 194.0 [3], 502.0 [4] |
 | 3-[3-Tert-butylsulfanyl-5-[(6-fluoroquinolin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.7 [1], 7.6 [2], 289.0 [3], 747.0 [4] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methyl-1-oxidopyridin-1-ium-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 4.6 [1], 89.5 [2], 873.0 [3], 1394.0 [4] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[[4-(6-oxo-1H-pyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 8.3 [1], 94.0 [2], 1280.0 [3], 10000.0 [4] |
 | AM-643 free acid | IC50 | 0.6 [1], 2.0 [2], 81.0 [3], 161.0 [4] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.5 [1], 1.7 [2], 87.0 [3], 328.0 [4] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-(quinoxalin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.7 [1], 11.4 [2], 456.0 [3], 542.0 [4] |
 | 3-[3-Tert-butylsulfanyl-5-(imidazo[1,2-a]pyridin-2-ylmethoxy)-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 1.4 [1], 8.9 [2], 552.0 [3], 980.0 [4] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(6-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.5 [1], 3.1 [2], 359.0 [3], 535.0 [4] |
 | 3-[3-Tert-butylsulfanyl-5-[(5,6-dimethylpyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.6 [1], 3.4 [2], 225.0 [3], 570.0 [4] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methoxypyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.7 [1], 8.0 [2], 652.0 [3], 688.0 [4] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyrazin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 3.3 [1], 5.4 [2], 208.0 [3], 281.0 [4] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[[4-[6-(trifluoromethyl)pyridin-3-yl]phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.4 [1], 3.2 [2], 180.0 [3], 401.0 [4] |
 | 3-[3-(3,3-Dimethylbutanoyl)-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 1.5 [1], 29.3 [2], 1580.0 [3], 2000.0 [4] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.5 [1], 2.7 [2], 202.0 [3], 435.0 [4] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[[4-(5-methylpyridin-2-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.5 [1], 2.2 [2], 130.0 [3], 283.0 [4] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(5-fluoropyridin-2-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.4 [1], 1.5 [2], 75.0 [3], 194.0 [4] |
 | Zileuton | IC50 | 580.0 [1], 2200.0 [2], 4200.0 [3] |
 | 1-[(2-Chlorophenyl)methyl]-2-[1-[4-(2-methylpropyl)phenyl]ethyl]benzimidazole-5-carbonitrile | IC50 | 12.0 [1], 26.0 [2], 35.0 [3] |
 | 2-[4-(4-Chlorophenyl)-3-methylisoxazol-5-yl]-5-[(2-methylphenyl)methoxy]phenol | IC50 | 4400.0 [1] |
 | 3-[3-Tert-butylsulfanyl-5-[(3,5-dimethylpyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 1.2 [1], 59.3 [2], 1790.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.5 [1], 1.8 [2], 504.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-2-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.3 [1], 1.3 [2], 233.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(2-ethoxy-1,3-thiazol-4-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.4 [1], 1.4 [2], 419.0 [3] |
 | 3-[3-Tert-butylsulfinyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 253.0 [1], 559.0 [2], 33200.0 [3] |
 | 3-[1-[[4-(6-Ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 22.6 [1], 219.0 [2], 22300.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(7-fluoroquinolin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 2.1 [1], 327.0 [2], 3220.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(6-methylquinolin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 1.7 [1], 148.0 [2], 3880.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-(1H-indol-2-ylmethoxy)-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 11.1 [1], 1250.0 [2], 11800.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(3-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 1.1 [1], 17.4 [2], 1290.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(4-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 1.8 [1], 21.8 [2], 3300.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-chloropyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.7 [1], 26.5 [2], 1160.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-carbamoylpyridin-2-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 229.0 [1], 3270.0 [2], 39000.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]-5-[(5-methyl-1,2-oxazol-3-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 2.4 [1], 114.0 [2], 2424.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(1,5-dimethylpyrazol-3-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 26.8 [1], 1600.0 [2], 26300.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(2,5-dimethylpyrazol-3-yl)methoxy]-1-[[4-(6-methoxypyridin-3-yl)phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 19.7 [1], 2470.0 [2], 16600.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(3-methoxypyridin-2-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.8 [1], 4.6 [2], 1460.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[[4-[4-(trifluoromethyl)pyridin-2-yl]phenyl]methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.4 [1], 2.1 [2], 452.0 [3] |
 | 3-[1-[[4-(6-Ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]-3-(2-phenylacetyl)indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 64.0 [1], 22500.0 [2], 32600.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-2-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.6 [1], 1.4 [2], 556.0 [3] |
 | 3-[3-Tert-butylsulfanyl-1-[[4-(5-fluoropyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.6 [1], 2.1 [2], 225.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[(4-pyridin-3-ylphenyl)methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.5 [1], 2.6 [2], 268.0 [3] |
 | 3-[3-Tert-butylsulfanyl-5-[(5-methylpyridin-2-yl)methoxy]-1-[(4-pyridin-2-ylphenyl)methyl]indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 0.6 [1], 1.3 [2], 285.0 [3] |
 | 3-[1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-N,N-dimethyl-1,2,4-oxadiazol-5-amine | IC50 | 280.0 [1], 2600.0 [2] |
 | 5-[5-[1-[5-[1-(2-Methoxyethyl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]pyridin-2-yl]pyrimidin-2-amine | IC50 | 17.0 [1], 213.0 [2] |
 | 2-[4-[3-[1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-1-ol | IC50 | 33.0 [1], 403.0 [2] |
 | 1-[4-[3-[1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-2-ol | IC50 | 28.0 [1], 124.0 [2] |
 | 5-[5-[1-[5-[1-(Oxetan-3-yl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]pyridin-2-yl]pyrimidin-2-amine | IC50 | 13.0 [1], 71.0 [2] |
 | 5-[5-[1-[5-(1-Ethylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]pyridin-2-yl]pyrimidin-2-amine | IC50 | 8.8 [1], 192.0 [2] |
 | 5-[5-[1-[5-(5-Methyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]pyridin-2-yl]pyrimidin-2-amine | IC50 | 5.5 [1], 164.0 [2] |
 | 2-[4-[3-[1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropanenitrile | IC50 | 18.0 [1], 94.0 [2] |
 | 1-[3-[1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-1,2,4-oxadiazol-5-yl]piperidin-4-ol | IC50 | 170.0 [1], 173.0 [2], 595.0 [3] |
 | 5-[5-[1-(5-Pyrrolidin-1-yl-1,2,4-oxadiazol-3-yl)cyclobutyl]pyridin-2-yl]pyrimidin-2-amine | IC50 | 92.0 [1], 917.0 [2] |
 | 2-[4-[3-[1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N-tert-butylacetamide | IC50 | 14.0 [1], 195.0 [2] |
 | 2-[4-[3-[1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N-tert-butyl-N-methylacetamide | IC50 | 14.0 [1], 262.0 [2] |
 | 5-[5-[1-[5-(1-Methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]pyridin-2-yl]pyrimidin-2-amine | IC50 | 13.0 [1], 270.0 [2] |
 | 5-[6-[1-[5-(1-Methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]pyridin-3-yl]pyrimidin-2-amine | IC50 | 81.0 [1], 787.0 [2] |
 | 5-[6-[1-[5-(5-Methyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]pyridin-3-yl]pyrimidin-2-amine | IC50 | 43.0 [1], 342.0 [2] |
 | CID 11526708 | IC50 | 1000.0 [1] |
 | 3-(1-(4-Chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid | IC50 | 1000.0 [1] |
 | 1-(2-Chlorobenzyl)-2-{1-[4-(2-methylpropyl)phenyl]ethyl}-1H-benzimidazole | IC50 | 310.0 [1] |
 | 2-[4-[3-[(1R)-1-[4-(2-Aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide | IC50 | 1.7 [1], 45.0 [2] |
 | 3-[3-Tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(pyridin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid | IC50 | 1.7 [1], 3.0 [2] |
 | 5-[4-[[5-(1-Methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]methyl]phenyl]pyrimidin-2-amine | IC50 | 1000.0 [1], 5000.0 [2] |
 | 5-[4-[1-[5-(1H-Pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine | IC50 | 2.3 [1], 110.0 [2] |
 | 5-[4-[1-[5-(1H-Imidazol-5-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine | IC50 | 2.5 [1], 270.0 [2] |
 | 3-[3-[1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]-1H-pyridin-2-one | IC50 | 2.9 [1], 5000.0 [2] |
 | 1-[4-[3-[(1R)-1-[4-(2-Aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]piperazin-1-yl]-2-methylpropan-2-ol | IC50 | 53.0 [1], 99.0 [2] |
 | 5-[4-[1-[5-[4-(Oxolan-2-ylmethyl)piperazin-1-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine | IC50 | 92.0 [1], 182.0 [2] |
 | 4-[3-[(1R)-1-[4-(2-Aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-N,N-dimethylpiperazine-1-carboxamide | IC50 | 12.0 [1], 58.0 [2] |
 | [1-[3-[1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]piperidin-4-yl]methanol | IC50 | 46.0 [1], 173.0 [2] |
 | 3-[4-[3-[1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]propanenitrile | IC50 | 11.0 [1], 85.0 [2] |
 | 1-[3-[(1R)-1-[4-(2-Aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-3-methylazetidin-3-ol | IC50 | 16.0 [1], 72.0 [2] |
 | 1-[3-[1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]azetidin-3-ol | IC50 | 160.0 [1], 315.0 [2] |
 | 3-[4-[3-[1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]propanenitrile | IC50 | 1.0 [1], 37.0 [2] |
 | 1-[3-[1-[4-(2-Aminopyrimidin-5-yl)phenyl]cyclobutyl]-1,2,4-oxadiazol-5-yl]-4-methylpiperidin-4-ol | IC50 | 17.0 [1], 87.0 [2] |
 | 3-[(1R)-1-[4-(2-Aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-N-methyl-N-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-5-amine | IC50 | 29.0 [1], 92.0 [2] |
 | 1-[3-[(1R)-1-[4-(2-Aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-4-methylpiperidin-4-ol | IC50 | 5.6 [1], 13.0 [2] |
 | 1-[3-[(1R)-1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-4-methylpiperidin-4-ol | IC50 | 97.0 [1], 115.0 [2] |
 | 1-[3-[(1R)-1-[6-(2-Aminopyrimidin-5-yl)pyridin-3-yl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]piperidin-4-ol | IC50 | 324.0 [1], 434.0 [2] |
 | 5-[4-[1-[5-(4-Propan-2-yloxypiperidin-1-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine | IC50 | 48.0 [1], 174.0 [2] |
 | 3-[1-[(2-Chlorophenyl)methyl]-2-[1-[4-(2-methylpropyl)phenyl]ethyl]benzimidazol-5-yl]propanoic acid | IC50 | 50.0 [1], 70.0 [2] |
 | 3-[2-[(4-Chlorophenyl)methyl]-6-methyl-9-(quinolin-2-ylmethoxy)-5-thia-2-azatricyclo[6.3.1.04,12]dodeca-1(12),3,8,10-tetraen-3-yl]-2,2-dimethylpropanoic acid | IC50 | 19.0 [1] |
 | 5-[4-[(1S)-1-Cyclobutyl-1-[5-(1-methylpyrazol-4-yl)-1,2,4-oxadiazol-3-yl]ethyl]phenyl]pyrimidin-2-amine | IC50 | 140.0 [1], 3200.0 [2] |
 | 2-[4-[3-[(1R)-1-Cyclopropyl-1-[4-[2-(propan-2-ylamino)pyrimidin-5-yl]phenyl]ethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide | IC50 | 1000.0 [1], 50000.0 [2] |
 | 1-[4-[3-[(1R)-1-[4-(2-Aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-2-methylpropan-2-ol | IC50 | 2.1 [1], 20.0 [2] |
 | 5-[4-[(1R)-1-Cyclopropyl-1-[5-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]ethyl]phenyl]pyrimidin-2-amine | IC50 | 3.1 [1], 14.0 [2] |
 | 2-[4-[3-[(1R)-1-Cyclopropyl-1-[4-[2-(methylamino)pyrimidin-5-yl]phenyl]ethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide | IC50 | 2.9 [1], 30.0 [2] |
 | 2-[4-[3-[1-Cyclopropyl-1-[4-[2-(ethylamino)pyrimidin-5-yl]phenyl]ethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide | IC50 | 370.0 [1], 1000.0 [2] |
 | 5-[4-[1-[5-[1-(Oxetan-3-yl)pyrazol-4-yl]-1,2,4-oxadiazol-3-yl]cyclobutyl]phenyl]pyrimidin-2-amine | IC50 | 1.9 [1], 43.0 [2] |
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