6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	IC50	22900.0 [1], 25000.0 [2], 100000.0 [3]
	3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	Ki	25100.0 [1]
	2-Amino-N-[4-(2-amino-3-cyano-1-ethylindol-5-yl)oxyphenyl]acetamide	IC50	514.0 [1], 30000.0 [2]
	2-Amino-N-[4-[2-amino-3-cyano-1-[2-(dimethylamino)-2-oxoethyl]indol-5-yl]oxyphenyl]acetamide	IC50	343.0 [1], 30000.0 [2]
	(2s)-2-Amino-N-[4-[(2-Amino-3-Cyano-1h-Indol-5-Yl)oxy]phenyl]-3-Hydroxy-Propanamide	IC50	575.0 [1], 30000.0 [2]
	(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)indol-5-yl]-methylamino]phenyl]pyrrolidine-2-carboxamide	IC50	75.0 [1], 13700.0 [2], 30000.0 [3]
	(2S)-N-[4-[3-Cyano-1-(2-methylpropyl)indol-5-yl]sulfonylphenyl]pyrrolidine-2-carboxamide	IC50	24700.0 [1], 30000.0 [2], 37700.0 [3]
	(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)indol-5-yl]methyl]phenyl]pyrrolidine-2-carboxamide	IC50	199.0 [1], 30000.0 [2]
	AZ Pfkfb3 26	IC50	23.0 [1], 343.0 [2], 5770.0 [3]
	2-Amino-N-[4-[2-amino-3-cyano-1-(2-methylpropyl)indol-5-yl]oxyphenyl]acetamide	IC50	177.0 [1], 16400.0 [2], 30000.0 [3]
	(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]pyrrolidine-2-carboxamide	IC50	112.0 [1], 3050.0 [2], 12000.0 [3]
	(2S)-N-[4-[3-Cyano-1-[2-(methylamino)-2-oxoethyl]indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide	IC50	111.0 [1], 14000.0 [2], 30000.0 [3]
	(2S)-N-[4-[3-Cyano-1-[2-(dimethylamino)ethyl]indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide	IC50	256.0 [1], 7480.0 [2], 30000.0 [3]
	(2S)-N-[4-[3-Cyano-1-(oxan-4-ylmethyl)indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide	IC50	48.0 [1], 633.0 [2], 30000.0 [3]
	(2S)-N-[4-[3-Cyano-1-(2-methyl-1-oxo-3H-isoindol-5-yl)indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide	IC50	8.0 [1], 140.0 [2], 2180.0 [3]
	(2S)-N-[4-[3-Cyano-1-(2-methylpropyl)indazol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide	IC50	4.0 [1], 297.0 [2], 15400.0 [3]
	2-Amino-N-[4-[[3-(1-methylpyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]acetamide	IC50	496.0 [1], 30000.0 [2]
	(2S)-N-[4-[[3-(1-Methylpyrazol-4-yl)-1H-indol-5-yl]oxy]phenyl]pyrrolidine-2-carboxamide	IC50	114.0 [1], 30000.0 [2]
	2-Amino-N-[4-(2-Amino-1-Benzyl-3-Cyano-Indol-5-Yl)oxyphenyl]acetamide	IC50	104.0 [1], 12600.0 [2], 30000.0 [3]
	CID 91668554	IC50	11.0 [1], 281.0 [2], 30000.0 [3]
	(2s)-N-[4-[1-Methyl-3-(1-Methylpyrazol-4-Yl)indol-5-Yl]oxyphenyl]pyrrolidine-2-Carboxamide	IC50	21.0 [1], 979.0 [2], 9710.0 [3]
	5,6,7,8,4'-Pentahydroxyflavone	IC50	2970.0 [1]
	5,6,7,8,4'-Pentahydroxyflavone	Ki	1290.0 [1]
	1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one	IC50	207.0 [1], 1000000.0 [2]
	2-Amino-N-[4-(2-amino-3-cyano-1-methylindol-5-yl)oxyphenyl]acetamide	IC50	815.0 [1], 30000.0 [2]
	2-Amino-N-[4-(3-cyano-1-ethylindol-5-yl)oxyphenyl]acetamide	IC50	562.0 [1], 30000.0 [2]
	5-(4-Acetyl-5-methyltriazol-1-yl)-4-bromo-2-phenylpyridazin-3-one	IC50	7400.0 [1]
	(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)indol-5-yl]amino]phenyl]pyrrolidine-2-carboxamide	IC50	1570.0 [1], 30000.0 [2]
	(2S)-N-[4-[3-Cyano-1-(2-methylpropyl)indol-5-yl]sulfanylphenyl]pyrrolidine-2-carboxamide	IC50	111.0 [1], 14000.0 [2]
	N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]-2-(methylamino)acetamide	IC50	830.0 [1], 30000.0 [2]
	N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]-2-(dimethylamino)acetamide	IC50	9830.0 [1], 30000.0 [2]
	(2R)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]pyrrolidine-2-carboxamide	IC50	30000.0 [1], 70900.0 [2]
	(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]-N-methylpyrrolidine-2-carboxamide	IC50	23100.0 [1], 30000.0 [2]
	(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]azetidine-2-carboxamide	IC50	86.0 [1], 19600.0 [2]
	(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]piperidine-2-carboxamide	IC50	2200.0 [1], 30000.0 [2]
	(2S)-N-[4-(3-Cyano-1-ethylindol-5-yl)oxyphenyl]-N-methyl-5-oxopyrrolidine-2-carboxamide	IC50	531.0 [1], 30000.0 [2]
	(2S)-N-[4-(3-Cyano-1-phenylindol-5-yl)oxyphenyl]pyrrolidine-2-carboxamide	IC50	27.0 [1], 8710.0 [2]
	(2S)-N-[4-(1-Benzyl-3-cyanoindol-5-yl)oxyphenyl]pyrrolidine-2-carboxamide	IC50	20.0 [1], 6950.0 [2]
	(2S)-N-[4-[3-Cyano-1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]indazol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide	IC50	3.0 [1], 67.0 [2]
	2-Hydroxy-4-(naphthalen-1-ylsulfonylamino)benzoic acid	IC50	490.0 [1], 27000.0 [2]
	6-(2-Chloro-3-methoxyphenyl)-N-[1-[3-[(2,5-dimethylpyrazol-3-yl)methoxy]phenyl]ethyl]-2-methylpyrimidin-4-amine	IC50	0.0 [1]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-(2-pyrazol-1-ylethoxy)phenyl]ethyl]pyrimidin-4-amine	IC50	500.0 [1], 1000.0 [2]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]ethyl]pyrimidin-4-amine	IC50	0.0 [1], 500.0 [2]
	N-[1-[3-(Furan-3-yl)phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1], 500.0 [2]
	N-[1-[3-[3-(Dimethylamino)propoxy]phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1]
	4-[2-Methyl-6-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]benzamide	IC50	0.0 [1]
	Methyl 2-[[3-[1-[[6-(1,3-benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]methyl]-1,3-oxazole-4-carboxylate	IC50	1000.0 [1]
	6-(1,3-Benzothiazol-6-yl)-N-[1-[5-[(2,5-dimethylpyrazol-3-yl)methoxy]pyridin-3-yl]ethyl]-2-methylpyrimidin-4-amine	IC50	0.0 [1]
	N-[1-[3-[(2,5-Dimethylpyrazol-3-yl)methoxy]phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1]
	N-[1-(2-Fluorophenyl)ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1]
	1-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]-3-carbamoylurea	IC50	500.0 [1], 1000.0 [2]
	6-(1,3-Benzothiazol-6-yl)-N-[1-[3-(6-fluoro-2-methylpyridin-3-yl)phenyl]ethyl]-2-methylpyrimidin-4-amine	IC50	0.0 [1], 500.0 [2]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-(methylsulfonylmethoxy)phenyl]ethyl]pyrimidin-4-amine	IC50	0.0 [1]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-(3-thiophen-3-ylphenyl)ethyl]pyrimidin-4-amine	IC50	1000.0 [1]
	6-(1,3-Benzothiazol-6-yl)-N-[1-(3-bromophenyl)ethyl]-2-methylpyrimidin-4-amine	IC50	0.0 [1], 500.0 [2]
	[3-[[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]methyl]piperidin-1-yl]-cyclopentylmethanone	IC50	500.0 [1], 1000.0 [2]
	Tert-butyl 3-[[3-[1-[[2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-yl]amino]ethyl]phenoxy]methyl]piperidine-1-carboxylate	IC50	500.0 [1], 1000.0 [2]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[(3-methyl-1,2-oxazol-5-yl)methoxy]phenyl]ethyl]pyrimidin-4-amine	IC50	0.0 [1]
	3-[1-[[6-(2-Fluoro-3-methoxyphenyl)-2-methylpyrimidin-4-yl]amino]ethyl]phenol	IC50	1000.0 [1]
	N-[1-[3-[(2,5-Dimethylpyrazol-3-yl)methoxy]phenyl]ethyl]-6-(3-ethyl-1-benzofuran-5-yl)-2-methylpyrimidin-4-amine	IC50	0.0 [1], 1000.0 [2]
	[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]urea	IC50	1000.0 [1]
	6-(1,3-Benzothiazol-6-yl)-N-[1-[3-(2-fluoropyrimidin-5-yl)phenyl]ethyl]-2-methylpyrimidin-4-amine	IC50	0.0 [1]
	N-[1-[3-(2-Imidazol-1-ylethoxy)phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1]
	3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]-N-but-2-ynylbenzenesulfonamide	IC50	0.0 [1]
	Methyl 2-[3-[[[6-(1,3-benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]methyl]-4-fluorophenoxy]acetate	IC50	1000.0 [1]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[[3-[(4-methylphenoxy)methyl]-1,2,4-oxadiazol-5-yl]methoxy]phenyl]ethyl]pyrimidin-4-amine	IC50	1000.0 [1]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-(3-nitrophenyl)ethyl]pyrimidin-4-amine	IC50	500.0 [1]
	N-[1-[3-[(2,5-Dimethylpyrazol-3-yl)methoxy]phenyl]ethyl]-6-(3-methoxy-4-methylphenyl)-2-methylpyrimidin-4-amine	IC50	0.0 [1]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-(2-methylsulfonylethoxy)phenyl]ethyl]pyrimidin-4-amine	IC50	1000.0 [1]
	N-[5-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]pyrimidin-2-yl]-N',N'-dimethylethane-1,2-diamine	IC50	0.0 [1]
	6-(1,3-Benzothiazol-6-yl)-N-[1-[3-(2-imidazol-1-ylethoxy)phenyl]ethyl]-2-methylpyrimidin-4-amine	IC50	0.0 [1]
	Ethyl 5-[3-[1-[[6-(1,3-benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]pyridine-3-carboxylate	IC50	500.0 [1], 1000.0 [2]
	N-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenyl]-1-methylimidazole-4-sulfonamide	IC50	1000.0 [1]
	2-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]-1-pyrrolidin-1-ylethanone	IC50	500.0 [1], 1000.0 [2]
	2-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]-N-[2-(dimethylamino)ethyl]acetamide	IC50	0.0 [1], 500.0 [2]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-(1H-pyrazol-5-ylmethoxy)phenyl]ethyl]pyrimidin-4-amine	IC50	0.0 [1], 500.0 [2]
	2-Methoxy-4-[2-methyl-6-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]benzamide	IC50	0.0 [1]
	2-Methyl-6-(3-methyl-1-benzofuran-5-yl)-N-[1-(3-methylphenyl)ethyl]pyrimidin-4-amine	IC50	0.0 [1], 500.0 [2]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-(3-prop-2-ynoxyphenyl)ethyl]pyrimidin-4-amine	IC50	500.0 [1]
	6-(1,3-Benzothiazol-6-yl)-N-[(2-fluorophenyl)methyl]-2-methylpyrimidin-4-amine	IC50	500.0 [1], 1000.0 [2]
	2-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]-N-(2-hydroxypropyl)acetamide	IC50	500.0 [1], 1000.0 [2]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[(5-methyl-1,2-oxazol-3-yl)methoxy]phenyl]ethyl]pyrimidin-4-amine	IC50	500.0 [1]
	2-[3-[1-[[2-Methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-yl]amino]ethyl]phenoxy]-1-morpholin-4-ylethanone	IC50	0.0 [1]
	2-Methyl-6-(3-methyl-1-benzofuran-5-yl)-N-[1-(2-methylphenyl)ethyl]pyrimidin-4-amine	IC50	1000.0 [1]
	4-[3-[1-[[6-(1,3-Benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]butan-1-ol	IC50	0.0 [1]
	6-(1-Ethylindol-6-yl)-2-methyl-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrimidin-4-amine	IC50	0.0 [1]
	3-[1-[[6-(3-Ethyl-1-benzofuran-5-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenol	IC50	0.0 [1], 1000.0 [2]
	N-[1-[3-(2-Aminopyrimidin-5-yl)-4-fluorophenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1]
	6-(1,3-Benzothiazol-6-yl)-N-[1-(2-methoxypyridin-4-yl)ethyl]-2-methylpyrimidin-4-amine	IC50	500.0 [1]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-(3-propoxyphenyl)ethyl]pyrimidin-4-amine	IC50	0.0 [1], 1000.0 [2]
	6-(1,3-Benzothiazol-6-yl)-N-[1-[3-[2-(dimethylamino)ethoxy]phenyl]ethyl]-2-methylpyrimidin-4-amine	IC50	0.0 [1], 500.0 [2]
	Methyl 2-[3-[1-[[6-(1,3-benzothiazol-6-yl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]acetate	IC50	1000.0 [1]
	6-(1,3-Benzothiazol-6-yl)-2-methyl-N-[1-[3-[(1-methylpiperidin-3-yl)methoxy]phenyl]ethyl]pyrimidin-4-amine	IC50	0.0 [1]
	N,N-Diethyl-2-[3-[1-[[6-(2-fluoro-3-methoxyphenyl)-2-methylpyrimidin-4-yl]amino]ethyl]phenoxy]acetamide	IC50	1000.0 [1]
	N-[1-[2-(2-Aminopyrimidin-5-yl)pyridin-4-yl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1]
	N-[(1S)-1-[3-(6-Chloropyridin-3-yl)phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1]
	N-[1-[3-[2-(Dimethylamino)ethoxy]phenyl]ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1], 1000.0 [2]
	6-(1,3-Benzothiazol-6-yl)-N-[(2-chloro-6-fluorophenyl)methyl]-2-methylpyrimidin-4-amine	IC50	0.0 [1]
	2-[2-Methyl-5-[2-methyl-6-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrimidin-4-yl]phenoxy]acetonitrile	IC50	0.0 [1]
	N-[(1S)-1-(4-Methoxyphenyl)ethyl]-2-methyl-6-(3-methyl-1-benzofuran-5-yl)pyrimidin-4-amine	IC50	0.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/6-phosphofructo-2-kinase-fructose-2-6-bisphosphatase-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/6-phosphofructo-2-kinase-fructose-2-6-bisphosphatase-3-inhibitors-ic50-ki.
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