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Acetyl-CoA carboxylase 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(3R)-1'-(9-Anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidineIC50410.0 [1], 456.0 [2], 550.0 [3], 910.0 [4]
N-(4-(2-(4-Isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5030000.0 [1]
N-(3-(2-(4-Isopropoxyphenoxy)thiazol-5-yl)prop-2-ynyl)acetamideIC5030000.0 [1]
1-(4-(2-(4-Isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)-3-methylureaIC5030000.0 [1]
2-Tert-butyl-1'-(1H-indazole-5-carbonyl)spiro[6H-pyrano[3,2-c]pyrazole-5,4'-piperidine]-7-oneIC5019.0 [1], 111.0 [2]
PF-05175157IC5027.0 [1], 98.0 [2]
Methyl 4-(2-(4-isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-ylcarbamateIC5030000.0 [1]
(S)-Methyl 4-(2-(4-isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-ylcarbamateIC5030000.0 [1]
N-[1-Methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-YL]prop-2-ynyl]acetamideIC50260.0 [1]
N-(4-(2-(4-Propoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC50140.0 [1]
1-Hydroxy-1-[4-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]but-3-yn-2-yl]ureaIC501000.0 [1]
N-(4-(2-(4-(Isopropylthio)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC50370.0 [1]
N-(1-Cyclopropyl-3-(2-(4-isopropoxyphenoxy)thiazol-5-yl)prop-2-ynyl)acetamideIC5030000.0 [1]
N-(4-(2-(4-(Isopropylamino)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5030000.0 [1]
N-(3-(2-(4-Isopropoxyphenoxy)thiazol-5-yl)-1-phenylprop-2-ynyl)acetamideIC5030000.0 [1]
N-(4-(2-(4-(Cyclopropylmethoxy)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC50940.0 [1], 1300.0 [2]
N-(4-(2-(3-Isobutoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5072.0 [1]
N-[4-[2-[4-(Oxolan-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamideIC50760.0 [1]
N-(4-(2-(4-Isobutoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC50230.0 [1]
N-(4-(2-(4-(Cyclohexyloxy)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC50120.0 [1]
N-(4-(2-(4-(Cyclohexylmethoxy)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5086.0 [1]
1-[4-[4-[4-[2,6-Bis(4-methylphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC50101.0 [1]
1-[3-[4-[(5S)-3,3-Dimethyl-1-oxo-2-oxa-9-azaspiro[4.5]decan-9-yl]piperidine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC5032.0 [1]
CID 56968001IC5010.0 [1], 20.0 [2]
N-[1-[2-[5-[3-(Cyclopropylmethoxy)phenoxy]pyridin-2-yl]-1,3-benzoxazol-6-yl]ethyl]acetamideIC507.1 [1], 9.9 [2]
N-[1-[2-[4-[3-(Cyclopropylmethoxy)phenoxy]phenyl]-1,3-benzoxazol-6-yl]ethyl]acetamideIC502.2 [1], 5.3 [2]
N-[1-[2-[3-[3-(Cyclopropylmethoxy)phenoxy]azetidin-1-yl]-1,3-benzoxazol-6-yl]ethyl]acetamideIC5023.0 [1], 51.0 [2]
N-[1-[2-[4-[3-(Cyclopropylmethoxy)phenoxy]phenyl]-1-benzothiophen-5-yl]ethyl]acetamideIC5011.0 [1], 26.0 [2]
N-[1-[2-[4-[3-(Cyclopropylmethoxy)phenoxy]piperidin-1-yl]-1,3-benzoxazol-6-yl]ethyl]acetamideIC50230.0 [1], 400.0 [2]
N-[1-[2-[3-(3-Pentylphenoxy)azetidin-1-yl]-1,3-benzoxazol-6-yl]ethyl]acetamideIC50100.0 [1], 220.0 [2]
N-[1-[2-[6-[3-(Cyclopropylmethoxy)phenoxy]pyridin-3-yl]-1,3-benzoxazol-6-yl]ethyl]acetamideIC500.76 [1], 1.8 [2]
N-[1-[2-[6-[3-(Cyclopropylmethoxy)phenoxy]pyridin-3-yl]-1,3-benzothiazol-5-yl]ethyl]acetamideIC507.4 [1], 14.0 [2]
N-[(2S)-1-[[2-[4-[3-(Cyclopropylmethoxy)phenoxy]phenyl]-1,3-oxazol-5-yl]oxy]propan-2-yl]acetamideIC500.96 [1], 3.4 [2]
[(2S)-1-[[2-[4-[3-(Cyclopropylmethoxy)phenoxy]phenyl]-1,3-oxazol-5-yl]oxy]propan-2-yl]ureaIC500.58 [1], 6.4 [2]
N-[4-[2-[4-[3-(Cyclopropylmethoxy)phenoxy]phenyl]-1,3-oxazol-5-yl]butan-2-yl]acetamideIC504.9 [1], 8.6 [2]
N-[1-[3-[[4-[3-(Cyclopropylmethoxy)phenoxy]phenyl]methoxy]phenyl]ethyl]acetamideIC50140.0 [1], 1000.0 [2]
N-[(2S)-1-[[2-[5-[3-(Cyclopropylmethoxy)phenoxy]pyridin-2-yl]-1,3-oxazol-5-yl]oxy]propan-2-yl]acetamideIC505.8 [1], 51.0 [2]
N-[(2R)-1-[[2-[4-[3-(Cyclopropylmethoxy)phenoxy]phenyl]-1,3-oxazol-5-yl]oxy]propan-2-yl]acetamideIC50240.0 [1], 710.0 [2]
N-[(2S)-1-[[2-[6-[3-(Cyclopropylmethoxy)phenoxy]pyridin-3-yl]-1,3-oxazol-5-yl]oxy]propan-2-yl]acetamideIC500.96 [1], 2.8 [2]
N-[(2S)-4-[4-(6-Propan-2-yloxypyridin-3-yl)oxyphenyl]butan-2-yl]acetamideIC50190.0 [1]
1-Tert-butyl-1'-(3,7-dimethyl-2H-indazole-5-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5027.0 [1], 65.0 [2]
2-Tert-butyl-1'-(3-chloro-1H-indole-5-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5013.0 [1], 27.0 [2]
2-Tert-butyl-1'-(3-chloro-1H-indole-6-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC507.0 [1], 18.0 [2]
2-Tert-butyl-1'-[2-(methylamino)quinoline-7-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC505.6 [1], 6.0 [2]
2-Tert-butyl-1'-[1-(methylamino)isoquinoline-7-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5018.0 [1], 21.0 [2]
1'-(3,7-Dimethyl-2H-indazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5024.2 [1], 86.0 [2]
2-Tert-butyl-1'-(3-methoxyisoquinoline-6-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5074.0 [1], 78.0 [2]
2-Tert-butyl-1'-[2-(dimethylamino)quinoline-7-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC505.0 [1], 7.4 [2]
2-Cyclobutyl-1'-(3,7-dimethyl-2H-indazole-5-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5049.0 [1], 50.0 [2]
2-Tert-butyl-1'-[3-(trifluoromethyl)-2H-indazole-5-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5042.0 [1], 78.0 [2]
2-Tert-butyl-1'-(3-chloro-2H-indazole-5-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5017.0 [1], 23.0 [2]
2-Tert-butyl-1'-(3-chloro-1H-pyrrolo[3,2-b]pyridine-6-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5011.0 [1], 19.0 [2]
2-Tert-butyl-1'-(1-methoxyisoquinoline-7-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5011.0 [1], 14.0 [2]
2-Tert-butyl-1'-[2-(propylamino)quinoline-7-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC501.8 [1], 5.6 [2]
3-[5-(4-Chloro-3-fluorophenyl)-2-methylphenyl]-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-oneIC50102.0 [1], 129.0 [2]
3-[5-(4-Chlorophenyl)-2-methylphenyl]-8-methoxy-1-azaspiro[4.5]dec-3-en-2-oneIC5084.0 [1], 280.0 [2]
3-[5-(3,4-Dichlorophenyl)-2-methylphenyl]-8-methoxy-1-azaspiro[4.5]dec-3-en-2-oneIC50327.0 [1], 428.0 [2]
FirsocostatIC502.6 [1]
3,5-Dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamideIC506000.0 [1]
N-[1-[2-[2-(4-Propan-2-yloxyphenoxy)-1,3-thiazol-5-yl]-1,3-thiazol-5-yl]ethyl]acetamideIC50210.0 [1]
N-[4-[4-(4-Propan-2-yloxyphenoxy)phenyl]but-3-yn-2-yl]acetamideIC5029.0 [1]
(R)-Methyl 4-(2-(4-isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-ylcarbamateIC5030000.0 [1]
N-[(E,2S)-4-[6-[(7-Chloro-2-ethoxy-1,3-benzothiazol-6-yl)oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC501950.0 [1]
1-[3-[4-(3,3-Dimethyl-1-oxo-2-oxa-9-azaspiro[4.5]decan-9-yl)piperidine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC5063.0 [1]
2-Tert-butyl-1'-(7-methyl-1H-indazole-5-carbonyl)spiro[6H-pyrano[3,2-c]pyrazole-5,4'-piperidine]-7-oneIC5032.0 [1]
2-[[2-(4-Propan-2-yloxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]methylsulfanyl]-[1,3]oxazolo[4,5-b]pyridineIC50100000.0 [1]
N-{3-[2-(4-Isopropoxy-phenylsulfanyl)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamideIC5030000.0 [1]
N-[4-[2-(6-Propan-2-yloxypyridin-3-yl)oxy-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamideIC50390.0 [1]
1-Methyl-3-[2-(4-phenoxy-phenoxy)-thiazol-5-yl]-prop-2-ynylamineIC5030000.0 [1]
4-[2-(4-Phenoxy-phenoxy)-thiazol-5-yl]-but-3-yn-2-olIC5030000.0 [1]
N-[4-[2-(4-Propan-2-yloxyphenoxy)-1,3-thiazol-4-yl]but-3-yn-2-yl]acetamideIC5030000.0 [1]
N-[4-[2-(4-Propan-2-ylphenoxy)-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamideIC501250.0 [1]
{1-Methyl-3-[2-(4-phenoxy-phenoxy)-thiazol-5-yl]-prop-2-ynyl}-ureaIC5030000.0 [1]
N-[(E,2S)-4-[2-(4-Ethoxyphenoxy)-1,3-thiazol-5-yl]but-3-en-2-yl]acetamideIC50100000.0 [1]
N-[(E,2S)-4-[6-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC50964.0 [1]
N-[(E,2S)-4-[6-[2-Chloro-4-(2-fluoroethoxy)phenoxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC50100000.0 [1]
N-[(E,2S)-4-[6-(2-Chloro-4-ethoxyphenoxy)pyridin-3-yl]but-3-en-2-yl]acetamideIC50100000.0 [1]
N-[(E,2S)-4-[6-[2-Chloro-4-(2,2-difluoroethoxy)phenoxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC50100000.0 [1]
N-[(E,2S)-4-[2-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]pyrimidin-5-yl]but-3-en-2-yl]acetamideIC50100000.0 [1]
N-[(E,2S)-4-[6-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]pyridazin-3-yl]but-3-en-2-yl]acetamideIC50100000.0 [1]
Methyl N-[(E,2S)-4-[2-(4-propan-2-yloxyphenoxy)-1,3-thiazol-5-yl]but-3-en-2-yl]carbamateIC50100000.0 [1]
N-[(E,2S)-4-[2-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]-3-methylimidazol-4-yl]but-3-en-2-yl]acetamideIC5037200.0 [1]
N-[(E,2S)-4-[6-[(7-Chloro-2-methyl-1,3-benzothiazol-6-yl)oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC5012200.0 [1]
N-[(E,2S)-4-[6-[(7-Chloro-2-propan-2-yl-1,3-benzothiazol-6-yl)oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC50303.0 [1]
N-[(E,2S)-4-[6-[(5-Chloro-2-methyl-1,3-benzothiazol-6-yl)oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC5052100.0 [1]
2-Tert-butyl-1'-(1H-indazole-5-carbonyl)-6-methylspiro[6H-pyrano[3,2-c]pyrazole-5,4'-piperidine]-7-oneIC50676.0 [1]
2'-Tert-butyl-1-(1H-indazole-5-carbonyl)-6',6'-dimethylspiro[piperidine-4,5'-pyrano[3,2-c]pyrazole]-7'-oneIC503900.0 [1]
1-Ethyl-1'-(1H-indazole-5-carbonyl)spiro[4,6-dihydroindazole-5,4'-piperidine]-7-oneIC50317.0 [1]
N-[1-[2-[3-(3-Methylphenoxy)azetidin-1-yl]-1,3-benzoxazol-6-yl]ethyl]acetamideIC5010000.0 [1]
N-[1-[2-[3-(3-Butoxyphenoxy)azetidin-1-yl]-1,3-benzoxazol-6-yl]ethyl]acetamideIC50210.0 [1]
N-[(E,2S)-4-[6-[[2-Propan-2-yl-7-(trifluoromethyl)-1,3-benzothiazol-6-yl]oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC507450.0 [1]
N-[(E,2S)-4-[2-(4-Propan-2-yloxyphenoxy)-1,3-thiazol-5-yl]but-3-en-2-yl]acetamideIC5053400.0 [1]
N-[(E,2S)-4-[5-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]pyrazin-2-yl]but-3-en-2-yl]acetamideIC50750.0 [1]
N-[(E,2S)-4-[6-[[7-Chloro-2-(2-hydroxypropan-2-yl)-1,3-benzothiazol-6-yl]oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC503150.0 [1]
N-[(E,2S)-4-[5-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]-1,3,4-thiadiazol-2-yl]but-3-en-2-yl]acetamideIC50100000.0 [1]
8-(7-Methyl-1H-indazole-5-carbonyl)-2-[4-(trifluoromethyl)phenyl]-2,8-diazaspiro[4.5]decan-3-oneIC501202.0 [1]
4-[8-(7-Methyl-1H-indazole-5-carbonyl)-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzonitrileIC503990.0 [1]
8-(2-Methyl-3H-benzimidazole-5-carbonyl)-2-[4-(trifluoromethyl)phenyl]-2,8-diazaspiro[4.5]decan-3-oneIC502221.0 [1]
8-(Quinoline-3-carbonyl)-2-[4-(trifluoromethyl)phenyl]-2,8-diazaspiro[4.5]decan-3-oneIC505000.0 [1]
8-[2-(4-Propan-2-ylphenyl)-3H-benzimidazole-5-carbonyl]-2-[4-(trifluoromethyl)phenyl]-2,8-diazaspiro[4.5]decan-3-oneIC501147.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Acetyl-CoA carboxylase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/acetyl-coa-carboxylase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Acetyl-CoA carboxylase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acetyl-coa-carboxylase-1-inhibitors-ic50-ki.
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