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Acetyl-CoA carboxylase 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(3R)-1'-(9-Anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidineIC5038.0 [1]
N-(4-(2-(4-Isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5019.0 [1]
2-Tert-butyl-1'-(1H-indazole-5-carbonyl)spiro[6H-pyrano[3,2-c]pyrazole-5,4'-piperidine]-7-oneIC509.8 [1], 10.0 [2], 11.0 [3]
N-(3-(2-(4-Isopropoxyphenoxy)thiazol-5-yl)prop-2-ynyl)acetamideIC501730.0 [1], 1860.0 [2]
1-(4-(2-(4-Isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)-3-methylureaIC5030.0 [1], 32.0 [2]
N-[(2S)-4-[4-(6-Propan-2-yloxypyridin-3-yl)oxyphenyl]butan-2-yl]acetamideIC5030.0 [1], 400.0 [2]
N-[3-[5-(4-Phenylmethoxyphenoxy)-1,3-dioxan-2-yl]propyl]acetamideIC50400.0 [1], 30000.0 [2]
PF-05175157IC5033.0 [1], 45.0 [2]
Methyl 4-(2-(4-isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-ylcarbamateIC5096.0 [1]
(S)-Methyl 4-(2-(4-isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-ylcarbamateIC5038.0 [1]
6,7-Dimethyl-1'-[(7-Methyl-1h-Indazol-5-Yl)carbonyl]spiro[chromene-2,4'-Piperidin]-4(3h)-OneIC5048.0 [1]
N-[1-Methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-YL]prop-2-ynyl]acetamideIC5011.0 [1]
N-(4-(2-(4-Propoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC504.0 [1]
N-[4-[4-(4-Propan-2-yloxyphenoxy)phenyl]but-3-yn-2-yl]acetamideIC506.0 [1], 11.0 [2]
1-Hydroxy-1-[4-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]but-3-yn-2-yl]ureaIC5075.0 [1], 80.0 [2]
N-(4-(2-(4-(Isopropylthio)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5055.0 [1]
N-(1-Cyclopropyl-3-(2-(4-isopropoxyphenoxy)thiazol-5-yl)prop-2-ynyl)acetamideIC50840.0 [1], 880.0 [2]
N-(4-(2-(4-(Isopropylamino)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC50150.0 [1]
N-(3-(2-(4-Isopropoxyphenoxy)thiazol-5-yl)-1-phenylprop-2-ynyl)acetamideIC5030000.0 [1]
N-(4-(2-(4-(Cyclopropylmethoxy)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC507.0 [1]
N-(4-(2-(3-Isobutoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5013.0 [1]
N-[4-[2-[4-(Oxolan-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamideIC5067.0 [1]
N-(4-(2-(4-Isobutoxyphenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5010.0 [1]
N-(4-(2-(4-(Cyclohexyloxy)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5016.0 [1]
N-(4-(2-(4-(Cyclohexylmethoxy)phenoxy)thiazol-5-yl)but-3-yn-2-yl)acetamideIC5027.0 [1]
1-[4-[4-[4-[2,6-Bis(4-methylphenyl)pyridine-4-carbonyl]piperazin-1-yl]piperidine-1-carbonyl]piperidin-1-yl]ethanoneIC5023.0 [1]
1-[3-[4-[(5S)-3,3-Dimethyl-1-oxo-2-oxa-9-azaspiro[4.5]decan-9-yl]piperidine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC505.4 [1]
2-Tert-butyl-1'-(7-methyl-1H-indazole-5-carbonyl)spiro[6H-pyrano[3,2-c]pyrazole-5,4'-piperidine]-7-oneIC506.9 [1], 8.0 [2]
CID 56968001IC504.0 [1], 5.2 [2]
2-[[2-(4-Propan-2-yloxyphenyl)-4,5-dihydro-1,3-oxazol-4-yl]methylsulfanyl]-[1,3]oxazolo[4,5-b]pyridineIC502800.0 [1]
5-Ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazoleIC50359.0 [1], 841.0 [2]
Tert-butyl {[trans-4-({[(2-phenylquinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamateIC50210.0 [1], 1000.0 [2]
N-[4-[4-(5-Cyclopentyloxypyridin-2-yl)oxyphenyl]butan-2-yl]acetamideIC50140.0 [1]
N-[3-[5-(4-Cyclopentyloxyphenoxy)-1,3-dioxan-2-yl]propyl]acetamideIC50190.0 [1], 200.0 [2]
N-[3-[4-(5-Cyclopentyloxypyridin-2-yl)oxyphenyl]propyl]acetamideIC501280.0 [1]
N-[4-[4-(5-Phenylmethoxypyridin-2-yl)oxyphenyl]butan-2-yl]acetamideIC50100.0 [1], 210.0 [2]
N-[4-[4-(5-Propan-2-yloxypyridin-2-yl)oxyphenyl]butan-2-yl]acetamideIC50150.0 [1], 200.0 [2]
N-[3-[5-(5-Phenylmethoxypyridin-2-yl)oxy-1,3-dioxan-2-yl]propyl]acetamideIC5050.0 [1], 70.0 [2]
N-[4-[4-(6-Propan-2-yloxypyridin-3-yl)oxyphenyl]butan-2-yl]formamideIC50670.0 [1]
Methyl {3-[4-(6-isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}carbamateIC50210.0 [1], 250.0 [2]
N-[4-[4-(6-Propan-2-yloxypyridin-3-yl)oxyphenyl]butan-2-yl]cyclopropanecarboxamideIC5090.0 [1], 190.0 [2]
{3-[4-(6-Isopropoxypyridin-3-yloxy)phenyl]-1-methylpropyl}ureaIC50150.0 [1]
N-[(2S)-4-[4-(5-Propan-2-yloxypyridin-2-yl)oxyphenyl]butan-2-yl]acetamideIC50200.0 [1]
N-[(2S)-4-[4-(6-Propan-2-yloxypyridin-3-yl)oxyphenyl]butan-2-yl]cyclopropanecarboxamideIC5080.0 [1]
N-[4-[4-(6-Phenylmethoxypyridin-3-yl)oxyphenyl]butan-2-yl]acetamideIC5070.0 [1], 80.0 [2]
N-[4-[4-(2-Propan-2-yloxypyrimidin-5-yl)oxyphenyl]butan-2-yl]acetamideIC50700.0 [1], 740.0 [2]
1-Tert-butyl-1'-(3,7-dimethyl-2H-indazole-5-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5018.0 [1], 68.0 [2]
2-Tert-butyl-1'-(3-chloro-1H-indole-5-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC505.9 [1], 6.8 [2]
2-Tert-butyl-1'-(3-chloro-1H-indole-6-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC503.0 [1], 4.1 [2]
2-Tert-butyl-1'-[2-(methylamino)quinoline-7-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC501.7 [1], 4.2 [2]
2-Tert-butyl-1'-[1-(methylamino)isoquinoline-7-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC506.0 [1], 6.4 [2]
1'-(3,7-Dimethyl-2H-indazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5019.0 [1], 55.0 [2]
2-Tert-butyl-1'-(3-methoxyisoquinoline-6-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5012.0 [1], 29.0 [2]
2-Tert-butyl-1'-[2-(dimethylamino)quinoline-7-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC501.5 [1], 2.3 [2]
N-[1-[3-[(2S)-4-(4-Ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl]acetamideIC508.2 [1], 54.0 [2]
2-Cyclobutyl-1'-(3,7-dimethyl-2H-indazole-5-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5013.0 [1], 16.0 [2]
2-Tert-butyl-1'-[3-(trifluoromethyl)-2H-indazole-5-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC5019.0 [1], 21.0 [2]
2-Tert-butyl-1'-(3-chloro-2H-indazole-5-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC504.0 [1], 6.7 [2]
2-Tert-butyl-1'-(3-chloro-1H-pyrrolo[3,2-b]pyridine-6-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC504.2 [1], 5.0 [2]
2-Tert-butyl-1'-(1-methoxyisoquinoline-7-carbonyl)spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC502.6 [1], 4.2 [2]
2-Tert-butyl-1'-[2-(propylamino)quinoline-7-carbonyl]spiro[4,6-dihydropyrazolo[3,4-c]pyridine-5,4'-piperidine]-7-oneIC501.1 [1], 1.7 [2]
N-[[3-[(2S)-4-(4-Ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl]acetamideIC5064.0 [1], 259.0 [2]
5-Ethyl-3-[4-(2-methyl-4-propoxyphenyl)piperazin-1-yl]-1,2,4-oxadiazoleIC50128.0 [1], 391.0 [2]
5-Ethyl-3-[4-(2-methyl-4-propoxyphenyl)phenyl]-1,2,4-oxadiazoleIC50103.0 [1], 126.0 [2]
3-[(2S)-4-(4-Ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-5-ethyl-1,2,4-oxadiazoleIC5037.0 [1], 39.0 [2]
N-[(1S)-1-[3-[(2S)-4-(4-Ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamideIC505.4 [1], 24.0 [2]
N-[(1R)-1-[3-[(2S)-4-(4-Ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamideIC5013.0 [1], 40.0 [2]
N-[2-[3-[(2S)-4-(4-Ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl]acetamideIC509.8 [1], 348.0 [2]
N-[(1S)-1-[4-[1-[5-[(2,2-Difluorocyclopropyl)methoxy]pyrimidin-2-yl]azetidin-3-yl]phenyl]ethyl]acetamideIC50180.0 [1]
N-[(1S)-1-[4-[[6-[(2,2-Difluorocyclopropyl)methoxy]-3,4-dihydro-1H-isoquinolin-2-yl]methyl]phenyl]ethyl]-3-fluorocyclobutane-1-carboxamideIC5028.0 [1], 50.0 [2]
N-[(2S)-1-[4-(4-Propan-2-yloxyphenoxy)phenoxy]propan-2-yl]acetamideIC50120.0 [1], 1500.0 [2]
3-[5-(4-Chloro-3-fluorophenyl)-2-methylphenyl]-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-oneIC50690.0 [1], 1380.0 [2]
3-[5-(4-Chlorophenyl)-2-methylphenyl]-8-methoxy-1-azaspiro[4.5]dec-3-en-2-oneIC50370.0 [1], 822.0 [2]
3-[5-(3,4-Dichlorophenyl)-2-methylphenyl]-8-methoxy-1-azaspiro[4.5]dec-3-en-2-oneIC501414.0 [1], 2610.0 [2]
FirsocostatIC501.7 [1]
3,5-Dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamideIC5012000.0 [1]
N-[1-[2-[2-(4-Propan-2-yloxyphenoxy)-1,3-thiazol-5-yl]-1,3-thiazol-5-yl]ethyl]acetamideIC5028.0 [1]
(R)-Methyl 4-(2-(4-isopropoxyphenoxy)thiazol-5-yl)but-3-yn-2-ylcarbamateIC501510.0 [1]
N-[(E,2S)-4-[6-[(7-Chloro-2-ethoxy-1,3-benzothiazol-6-yl)oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC501.9 [1]
1-[3-[4-(3,3-Dimethyl-1-oxo-2-oxa-9-azaspiro[4.5]decan-9-yl)piperidine-1-carbonyl]-1-benzothiophen-2-yl]-3-ethylureaIC5013.0 [1]
N-{3-[2-(4-Isopropoxy-phenylsulfanyl)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-acetamideIC5069.0 [1]
N-[4-[2-(6-Propan-2-yloxypyridin-3-yl)oxy-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamideIC5015.0 [1]
1-Methyl-3-[2-(4-phenoxy-phenoxy)-thiazol-5-yl]-prop-2-ynylamineIC502420.0 [1]
4-[2-(4-Phenoxy-phenoxy)-thiazol-5-yl]-but-3-yn-2-olIC50600.0 [1]
N-[4-[2-(4-Propan-2-yloxyphenoxy)-1,3-thiazol-4-yl]but-3-yn-2-yl]acetamideIC5030000.0 [1]
N-[4-[2-(4-Propan-2-ylphenoxy)-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamideIC5030000.0 [1]
{1-Methyl-3-[2-(4-phenoxy-phenoxy)-thiazol-5-yl]-prop-2-ynyl}-ureaIC5026.0 [1]
N-[(E,2S)-4-[2-(4-Ethoxyphenoxy)-1,3-thiazol-5-yl]but-3-en-2-yl]acetamideIC5079.0 [1]
N-[(E,2S)-4-[6-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC506.9 [1]
N-[(E,2S)-4-[6-[2-Chloro-4-(2-fluoroethoxy)phenoxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC50186.0 [1]
N-[(E,2S)-4-[6-(2-Chloro-4-ethoxyphenoxy)pyridin-3-yl]but-3-en-2-yl]acetamideIC5046.0 [1]
N-[(E,2S)-4-[6-[2-Chloro-4-(2,2-difluoroethoxy)phenoxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC5084.0 [1]
N-[(E,2S)-4-[2-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]pyrimidin-5-yl]but-3-en-2-yl]acetamideIC5048.0 [1]
N-[(E,2S)-4-[6-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]pyridazin-3-yl]but-3-en-2-yl]acetamideIC50306.0 [1]
Methyl N-[(E,2S)-4-[2-(4-propan-2-yloxyphenoxy)-1,3-thiazol-5-yl]but-3-en-2-yl]carbamateIC5076.0 [1]
N-[(E,2S)-4-[2-[2-Chloro-4-(cyclopropylmethoxy)phenoxy]-3-methylimidazol-4-yl]but-3-en-2-yl]acetamideIC50454.0 [1]
N-[(E,2S)-4-[6-[(7-Chloro-2-methyl-1,3-benzothiazol-6-yl)oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC5026.0 [1]
N-[(E,2S)-4-[6-[(7-Chloro-2-propan-2-yl-1,3-benzothiazol-6-yl)oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC504.3 [1]
N-[(E,2S)-4-[6-[(5-Chloro-2-methyl-1,3-benzothiazol-6-yl)oxy]pyridin-3-yl]but-3-en-2-yl]acetamideIC50473.0 [1]
2-Tert-butyl-1'-(1H-indazole-5-carbonyl)-6-methylspiro[6H-pyrano[3,2-c]pyrazole-5,4'-piperidine]-7-oneIC5063.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Acetyl-CoA carboxylase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/acetyl-coa-carboxylase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Acetyl-CoA carboxylase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acetyl-coa-carboxylase-2-inhibitors-ic50-ki.
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