Acetylcholine receptor; alpha1/beta1/delta/gamma Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nicotine	IC50	1000.0 [1]
	Nicotine	Ki	1480.0 [1], 5500.0 [2], 6270.0 [3]
	Bupropion	IC50	7.9 [1], 7900.0 [2]
	Varenicline	IC50	1000.0 [1]
	Varenicline	Ki	8200.0 [1]
	3-(2,4-Dimethoxybenzylidene)anabaseine	Ki	3900.0 [1]
	Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-	IC50	60000.0 [1]
	Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-	Ki	60000.0 [1]
	(S)-3-(Azetidin-2-ylmethoxy)pyridine	Ki	314.0 [1]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide	IC50	100000.0 [1]
	Philanthotoxin 343	IC50	11800.0 [1], 56700.0 [2]
	Dideaza-philanthotoxin-12	IC50	790.0 [1], 15100.0 [2]
	(2S)-N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-2-[(2-cyclohexylacetyl)amino]-3-(4-hydroxyphenyl)propanamide	IC50	13200.0 [1], 86900.0 [2]
	(2S)-N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-3-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamide	IC50	22300.0 [1], 249000.0 [2]
	N-[(2S)-1-(12-Aminododecylamino)-3-(3-hydroxyphenyl)-1-oxopropan-2-yl]butanamide	IC50	2430.0 [1], 104000.0 [2]
	(2S)-N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-2-[(2-cyclohexylacetyl)amino]-3-(3-hydroxyphenyl)propanamide	IC50	5330.0 [1], 59800.0 [2]
	(2S)-N-[3-[4-(3-Aminopropylamino)butylamino]propyl]-3-(3-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamide	IC50	10100.0 [1], 98200.0 [2]
	(2S)-N-[3-[4-(3-Aminopropoxy)butoxy]propyl]-3-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamide	IC50	12600.0 [1], 35000.0 [2]
	N-[(2S)-1-[3-[4-(3-Aminopropylamino)butylamino]propylamino]-3-(3-hydroxyphenyl)-1-oxopropan-2-yl]butanamide	IC50	117000.0 [1], 1000000.0 [2]
	(2S)-N-[3-[4-(3-Aminopropoxy)butoxy]propyl]-2-[(2-cyclohexylacetyl)amino]-3-(4-hydroxyphenyl)propanamide	IC50	5690.0 [1], 25900.0 [2]
	(2S)-N-(12-Aminododecyl)-2-[(2-cyclohexylacetyl)amino]-3-(4-hydroxyphenyl)propanamide	IC50	151000.0 [1], 1000000.0 [2]
	N-[(2S)-1-[3-[4-(3-Aminopropoxy)butoxy]propylamino]-3-(3-hydroxyphenyl)-1-oxopropan-2-yl]butanamide	IC50	42600.0 [1], 110000.0 [2]
	(2S)-N-(12-Aminododecyl)-3-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamide	IC50	17200.0 [1], 388000.0 [2]
	(2S)-N-[3-[4-(3-Aminopropoxy)butoxy]propyl]-3-(3-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamide	IC50	25300.0 [1], 50900.0 [2]
	N-[(2S)-1-[3-[4-(3-Aminopropoxy)butoxy]propylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide	IC50	10900.0 [1], 72700.0 [2]
	(2S)-N-(12-Aminododecyl)-3-(3-hydroxyphenyl)-2-[(2-phenylacetyl)amino]propanamide	IC50	8050.0 [1], 105000.0 [2]
	(2S)-N-[3-[4-(3-Aminopropoxy)butoxy]propyl]-2-[(2-cyclohexylacetyl)amino]-3-(3-hydroxyphenyl)propanamide	IC50	4470.0 [1], 30700.0 [2]
	Tropisetron	Ki	27000.0 [1]
	Cytisine	Ki	250.0 [1]
	Benzamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-4-chloro-, monohydrochloride	IC50	60000.0 [1]
	Radafaxine	IC50	7600.0 [1]
	3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane	Ki	3000.0 [1]
	(S)-1-(2-Fluorophenyl)ethyl (S)-quinuclidin-3-ylcarbamate	IC50	125892.54 [1]
	(1R,2R,4S)-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine	IC50	300.0 [1]
	Rac-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane	Ki	5700.0 [1]
	1H-1,4-Diazepine-1-pentanamide, 4-acetylhexahydro-N-(5-(4-methoxyphenyl)-1H-pyrazol-3-yl)-	IC50	30000.0 [1]
	3-(4-Chlorophenyl)-5-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-1,2-oxazole	IC50	95000.0 [1]
	CID 10107234	IC50	100000.0 [1]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-6-carboxamide	IC50	100000.0 [1]
	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-1-benzothiophene-6-carboxamide	IC50	100000.0 [1]
	2-(Tert-butyl(methyl)amino)-1-(3-chlorophenyl)propan-1-one	IC50	16.0 [1]
	2-(Tert-butylamino)-1-(3-fluorophenyl)propan-1-one	IC50	32.0 [1]
	Laburnamine	Ki	10000.0 [1]
	2-(Tert-butylamino)-1-(3-chlorophenyl)butan-1-one	IC50	3.9 [1]
	2-(Tert-butylamino)-1-(3-chlorophenyl)pentan-1-one	IC50	2.0 [1]
	1-(3-Bromophenyl)-2-(tert-butylamino)propan-1-one	IC50	10.0 [1]
	2-(Tert-butylamino)-1-(4-chlorophenyl)propan-1-one	IC50	14.0 [1]
	1-(3-Chlorophenyl)-2-(piperidin-1-yl)propan-1-one	IC50	28.0 [1]
	1-(3-Chlorophenyl)-2-(dimethylamino)propan-1-one	IC50	100.0 [1]
	3-(Tert-butylamino)-1-(3-chlorophenyl)-2-methylpropan-1-one	IC50	16.0 [1]
	1-(4-Bromophenyl)-2-(tert-butylamino)propan-1-one	IC50	7.6 [1]
	2-(Tert-butylamino)-1-(3-chloro-4-methylphenyl)propan-1-one	IC50	5.7 [1]
	2-(Tert-butylamino)-1-(3,5-dichlorophenyl)propan-1-one	IC50	17.0 [1]
	2-(Tert-butylamino)-1-(3,4-dichlorophenyl)butan-1-one	IC50	2.7 [1]
	2-(N-Tert-Butylamino)-1-(2'-thienyl)-1-propanone	IC50	69.0 [1]
	2-(Tert-butylamino)-1-m-tolylpropan-1-one	IC50	11.0 [1]
	2-(Tert-butylamino)-1-(3,4-difluorophenyl)propan-1-one	IC50	24.0 [1]
	1-(4-Bromo-3-methylphenyl)-2-(tert-butylamino)propan-1-one	IC50	12.0 [1]
	1-(3-Chlorophenyl)-2-(cyclopentylamino)propan-1-one	IC50	100.0 [1]
	2-(Tert-butylamino)-1-(3,4-dichlorophenyl)pentan-1-one	IC50	1.5 [1]
	2-(Tert-butylamino)-1-(3,4-dichlorophenyl)propan-1-one	IC50	9.8 [1]
	2-(Tert-butylamino)-1-p-tolylpropan-1-one	IC50	12.0 [1]
	(2S,3S)-2-(3-Fluorophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	100000.0 [1]
	(2S,3S)-2-(3-Bromophenyl)-3,5,5-trimethylmorpholin-2-ol	IC50	18000.0 [1]
	(2S,3S)-2-(3-Chlorophenyl)-3-ethyl-5,5-dimethylmorpholin-2-ol	IC50	14000.0 [1]
	(2S,3S)-2-(3-Chlorophenyl)-5,5-dimethyl-3-propyl-morpholin-2-ol	IC50	10000.0 [1]
	(2S,3S)-2-(3-Chlorophenyl)-3,4,5,5-tetramethylmorpholin-2-ol	IC50	57000.0 [1]
	N-[(3R)-1-Azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-5-carboxamide	IC50	100000.0 [1]
	(R,R)-Hydroxy Bupropion	IC50	28000.0 [1]
	1'-Pyridin-3-ylspiro[1-azabicyclo[2.2.1]heptane-7,3'-pyrrolidine]	Ki	580.0 [1]
	1-(10-Azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-4-yl)ethanone	Ki	650.0 [1]
	10-Azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene-4-carbonitrile	Ki	520.0 [1]
	1'-Pyridin-3-ylspiro[1-azabicyclo[2.2.2]octane-2,3'-pyrrolidine]	Ki	11000.0 [1]
	1'-Pyridin-3-ylspiro[1-azabicyclo[2.2.1]heptane-2,3'-pyrrolidine]	Ki	9900.0 [1]
	3-Ethyl-5-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-1,2-oxazole	IC50	9900.0 [1]
	Methyl (1R,2S,3R,5S)-3-(3-fluoro-4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate	IC50	7300.0 [1]
	5-[(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-3-(4-methoxyphenyl)-1,2-oxazole	IC50	19000.0 [1]
	Dexmecamylamine	IC50	600.0 [1]
	1-[5-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-4-methyl-1,4-diazepane	IC50	10000.0 [1]
	2-[5-[5-(4-Methyl-1,4-diazepan-1-yl)pyridin-3-yl]-1,2-oxazol-3-yl]ethanol	IC50	10000.0 [1]
	1-[5-[(1R,2S)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-1,4-diazepane	IC50	10000.0 [1]
	(1S,4S)-2-[5-[(1R,2S)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-2,5-diazabicyclo[2.2.1]heptane	IC50	10000.0 [1]
	(1S,4S)-2-[5-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-2,5-diazabicyclo[2.2.1]heptane	IC50	10000.0 [1]
	1-[5-[(1S,2R)-2-(2-Methoxyethyl)cyclopropyl]pyridin-3-yl]-1,4-diazepane	IC50	10000.0 [1]
	2-[5-[5-(1,4-Diazepan-1-yl)pyridin-3-yl]-1,2-oxazol-3-yl]ethanol	IC50	10000.0 [1]
	N-[5-(4-Fluorophenyl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide	IC50	30000.0 [1]
	N-[5-(4-Methoxyphenyl)-1H-pyrazol-3-yl]-5-morpholin-4-ylpentanamide	IC50	30000.0 [1]
	N-[5-(4-Methoxyphenyl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutanamide	IC50	31622.78 [1]
	cis-1-Methyl-5-(phenylethynyl)-3-(piperidin-1-ylmethyl)pyrrolidin-2-one	IC50	12589.25 [1]
	(3R,5S)-5-[2-(1-Benzofuran-5-yl)ethynyl]-1-methyl-3-(piperidin-1-ylmethyl)pyrrolidin-2-one	IC50	100000.0 [1]
	(3R,5S)-1-Methyl-5-[2-(1-methylindol-5-yl)ethynyl]-3-(piperidin-1-ylmethyl)pyrrolidin-2-one	IC50	3981.07 [1]
	(3R,5S)-5-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethynyl]-1-methyl-3-(piperidin-1-ylmethyl)pyrrolidin-2-one	IC50	6309.57 [1]
	2-(Tert-butylamino)-1-(3-methoxyphenyl)propan-1-one	IC50	16.0 [1]
	2-(Tert-butylamino)-1-(3-nitrophenyl)propan-1-one	IC50	41.0 [1]
	2-(Cyclopentylamino)-1-(3-fluorophenyl)propan-1-one	IC50	26.0 [1]
	1-(3-Bromophenyl)-2-(cyclopentylamino)propan-1-one	IC50	6.5 [1]
	2-(Cyclopentylamino)-1-(3-methylphenyl)propan-1-one	IC50	5.8 [1]
	2-(Cyclopentylamino)-1-(3-methoxyphenyl)propan-1-one	IC50	9.2 [1]
	2-(Cyclopentylamino)-1-(3-nitrophenyl)propan-1-one	IC50	19.0 [1]
	1-(3-Fluorophenyl)-2-piperidin-1-ylpropan-1-one	IC50	100.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

---

---

References

This online tool may be cited as follows

MLA	"Quest Database™ Acetylcholine receptor; alpha1/beta1/delta/gamma Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/acetylcholine-receptor-alpha1-beta1-delta-gamma-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Acetylcholine receptor; alpha1/beta1/delta/gamma Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acetylcholine-receptor-alpha1-beta1-delta-gamma-inhibitors-ic50-ki.
BibTeX	EndNote	RefMan