 | 1'-[6-[5-(Pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]-5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 0.03 [1], 0.06 [2], 0.8 [3] |
 | MK-8245 | IC50 | 1.0 [1], 5.0 [2], 1066.0 [3], 1070.0 [4] |
 | N-(2-Hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide | IC50 | 28.0 [1], 43.0 [2] |
 | N-[5-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 0.2 [1], 0.3 [2], 26.0 [3] |
 | N-[(2R)-2-Hydroxy-2-phenylethyl]-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 15.0 [1], 25.0 [2], 71.0 [3] |
 | N-[(2S)-2-Hydroxy-2-phenylethyl]-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 60.0 [1], 81.0 [2], 90.0 [3] |
 | N-(2-Hydroxy-2-phenylethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide | IC50 | 7.0 [1], 15.0 [2], 51.0 [3] |
 | N-(2-Hydroxy-2-phenylethyl)-6-(4-oxospiro[3H-chromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide | IC50 | 0.69 [1], 50.0 [2], 250.0 [3] |
 | 2-(4-(2-(Trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxamide | IC50 | 254.0 [1], 300.0 [2] |
 | 3-(2-Hydroxyethoxy)-4-methoxy-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)benzamide | IC50 | 3.0 [1] |
 | N-Phenethyl-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide | IC50 | 9.0 [1], 18.0 [2] |
 | 5-Fluoro-1'-[6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 0.3 [1], 0.7 [2] |
 | N-Benzyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 41.0 [1], 750.0 [2] |
 | N-(2-(7-(3,4-Dichlorobenzylamino)-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl)ethyl)acetamide | IC50 | 8.6 [1] |
 | N-[2-[3-(4-Methoxyphenyl)-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide | IC50 | 3.3 [1], 33.0 [2] |
 | 1'-[6-[5-(Pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 1.0 [1], 4.0 [2] |
 | N-(3-(4-Chloro-3-(trifluoromethyl)benzyl)-4-oxo-3,4-dihydroquinazolin-6-yl)-2-hydroxyacetamide | IC50 | 110.0 [1] |
 | N-[2-[7-[[4-Chloro-3-(trifluoromethyl)phenyl]methylamino]-3-(4-methoxyphenyl)-2-oxoquinoxalin-1-yl]ethyl]acetamide | IC50 | 0.05 [1] |
 | 1'-[6-[5-(Pyridin-2-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 4.0 [1], 9.0 [2] |
 | 1'-[6-[5-(Pyridin-4-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 6.0 [1], 7.0 [2] |
 | 6-(5-Fluorospiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamide | IC50 | 6.0 [1], 7.0 [2] |
 | 5-Chloro-1'-[6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 0.06 [1], 1.0 [2] |
 | 6-(5-Chlorospiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamide | IC50 | 1.0 [1], 2.0 [2] |
 | N-(2-Hydroxy-2-pyridin-3-ylethyl)-6-[5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl]pyridazine-3-carboxamide | IC50 | 0.45 [1], 3.0 [2] |
 | 5-{6-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl}nicotinic acid | IC50 | 7.0 [1], 6030.0 [2] |
 | 2-[5-[3-[3-(2-Bromo-5-fluorophenoxy)propoxy]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid | IC50 | 41.0 [1], 7740.0 [2] |
 | N-[5-[(3-Chloro-4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 2.0 [1], 17.0 [2] |
 | 3-(2-Hydroxyethoxy)-4-methoxy-N-[5-[[3-(trifluoromethoxy)phenyl]methyl]-1,3-thiazol-2-yl]benzamide | IC50 | 4.0 [1], 59.0 [2] |
 | N-[5-[(3-Fluoro-4-methylphenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 82.0 [1], 639.0 [2] |
 | N-(5-(3-Chlorobenzyl)thiazol-2-yl)-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 4.0 [1], 9.0 [2] |
 | N-[5-[(3,4-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 1.0 [1], 13.0 [2] |
 | N-[5-[(3,5-Difluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 2.9 [1], 116.0 [2] |
 | N-[5-[(3,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 1.0 [1], 13.0 [2] |
 | N-[5-[[4-Fluoro-3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 0.6 [1], 8.0 [2] |
 | N-[5-[(3,4-Difluorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 9.0 [1], 34.0 [2] |
 | N-(5-(3-Fluorobenzyl)thiazol-2-yl)-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 11.0 [1], 34.0 [2] |
 | N-[5-[(2,5-Dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 125.0 [1], 429.0 [2] |
 | N-[2-(4-Fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 5.0 [1], 22.0 [2] |
 | N-(2-Hydroxy-2-thiophen-3-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 7.0 [1], 21.0 [2] |
 | 6-[4-(4-Fluorobenzoyl)piperidin-1-yl]-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide | IC50 | 80.0 [1], 118.0 [2] |
 | N-(2-Hydroxy-2-pyridin-2-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 180.0 [1], 390.0 [2] |
 | N-(2-Hydroxy-2-phenylethyl)-6-[4-(2-methoxybenzoyl)piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 311.0 [1], 1048.0 [2] |
 | N-[2-(2-Fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 22.0 [1], 60.0 [2] |
 | N-(2-Hydroxy-2-phenylethyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 7.0 [1], 14.0 [2] |
 | N-(2-Hydroxy-2-phenylethyl)-6-[4-[2-(trifluoromethoxy)benzoyl]piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 10.0 [1], 103.0 [2] |
 | N-(2-Hydroxy-2-thiophen-2-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 25.0 [1], 44.0 [2] |
 | N-(2-Hydroxy-2-pyridin-4-ylethyl)-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 144.0 [1], 187.0 [2] |
 | 6-(4-Benzoylpiperidin-1-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide | IC50 | 108.0 [1], 292.0 [2] |
 | N-[2-(3-Fluorophenyl)-2-hydroxyethyl]-6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxamide | IC50 | 6.0 [1], 11.0 [2] |
 | N-(2-Hydroxy-2-pyridin-3-ylethyl)-6-(5-methylspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide | IC50 | 1.0 [1], 6.0 [2] |
 | 6-(5,8-Difluorospiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamide | IC50 | 2.0 [1], 7.0 [2] |
 | 1-(Pyridin-3-ylmethyl)-3-[6-[5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl]pyridazin-3-yl]urea | IC50 | 10.0 [1], 106.0 [2] |
 | 1'-[6-[5-(Pyridin-3-ylmethyl)-1H-1,2,4-triazol-3-yl]pyridazin-3-yl]-5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 1.0 [1], 4.0 [2] |
 | 1'-[6-[2-Methyl-5-(pyridin-3-ylmethyl)-1,2,4-triazol-3-yl]pyridazin-3-yl]-5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 38.0 [1], 65.0 [2] |
 | 1'-[6-[5-(2-Pyridin-3-ylethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]-5-(trifluoromethyl)spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 16.0 [1], 35.0 [2] |
 | N-(2-Hydroxy-2-phenylethyl)-6-(4-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide | IC50 | 0.48 [1], 16.0 [2] |
 | N-(2-Hydroxy-2-phenylethyl)-6-(3-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide | IC50 | 0.56 [1], 49.0 [2] |
 | N-(2-Hydroxy-2-phenylethyl)-6-spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-ylpyridazine-3-carboxamide | IC50 | 0.07 [1], 2.7 [2] |
 | N-(2-Hydroxy-2-phenylethyl)-6-spiro[1,4-dihydroisochromene-3,4'-piperidine]-1'-ylpyridazine-3-carboxamide | IC50 | 76.0 [1], 400.0 [2] |
 | 6-(5-Fluoro-4-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide | IC50 | 17.0 [1], 157.0 [2] |
 | 2-[5-[3-[2-(2-Chloro-5-fluorophenyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid | IC50 | 27.0 [1], 9900.0 [2] |
 | 5,8-Difluoro-1'-[6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 0.1 [1], 1.0 [2] |
 | 5-Methyl-1'-[6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl]spiro[3,4-dihydrochromene-2,4'-piperidine] | IC50 | 0.2 [1], 0.7 [2] |
 | N-(Pyridin-3-ylmethyl)-6-spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-ylpyridazine-3-carboxamide | IC50 | 27.0 [1], 76.0 [2] |
 | 6-Fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole | IC50 | 15.0 [1], 39.0 [2] |
 | 6-Fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]indole | IC50 | 11.0 [1], 25.0 [2] |
 | 6-Fluoro-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]indazole | IC50 | 9.0 [1], 51.0 [2] |
 | 5-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]-N,N-dimethylpyridin-2-amine | IC50 | 12.0 [1], 30.0 [2] |
 | [1-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-4-yl]methanol | IC50 | 6.0 [1], 21.0 [2] |
 | 1-[1-[6-(1-Methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-6-(trifluoromethyl)-2,3-dihydroindole | IC50 | 16.0 [1], 42.0 [2] |
 | [4-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]phenyl]methanol | IC50 | 7.0 [1], 8.0 [2] |
 | 6-Fluoro-1-[1-[6-(6-methoxypyridin-3-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole | IC50 | 4.0 [1], 79.0 [2] |
 | 2-[4-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-1-yl]ethanol | IC50 | 17.0 [1], 21.0 [2] |
 | 2-[4-[6-[4-(6-Fluoro-2,3-dihydroindol-1-yl)piperidin-1-yl]pyridazin-3-yl]pyrazol-1-yl]-N-methylacetamide | IC50 | 11.0 [1], 12.0 [2] |
 | 6-Methyl-1-[1-[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole | IC50 | 241.0 [1], 422.0 [2] |
 | 6-Fluoro-1-[1-[6-[4-(trifluoromethyl)phenyl]pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole | IC50 | 31.0 [1], 54.0 [2] |
 | 6-Fluoro-1-[1-[6-(4-methylpyrazol-1-yl)pyridazin-3-yl]piperidin-4-yl]-2,3-dihydroindole | IC50 | 11.0 [1], 23.0 [2] |
 | Sterculic acid | IC50 | 300.0 [1] |
 | Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-(4-(2-(trifluoromethyl)phenoxy)-1-piperidinyl)- | IC50 | 21.0 [1] |
 | 2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole | IC50 | 670.0 [1] |
 | [5-[6-[4-(Trifluoromethyl)-4-[4-(trifluoromethyl)phenyl]piperidin-1-yl]pyridazin-3-yl]-1,3,4-oxadiazol-2-yl]methanol | IC50 | 4.7 [1] |
 | N-(2-Cyclopropylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide | IC50 | 39.0 [1] |
 | N-(2-Cyclopropylethyl)-6-[4-[5-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 12.0 [1] |
 | N-(3-(3,4-Dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl)-2-hydroxyacetamide | IC50 | 119.0 [1] |
 | N-(3-Methylbutyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 37.0 [1] |
 | 4-(Ethylamino)-3-(2-hydroxyethoxy)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)benzamide | IC50 | 0.04 [1] |
 | 6-[5-(Cyclopropylmethyl)spiro[3,4-dihydro-1,5-benzoxazepine-2,4'-piperidine]-1'-yl]-N-(2-hydroxy-2-pyridin-3-ylethyl)pyridazine-3-carboxamide | IC50 | 10.0 [1] |
 | N-Phenyl-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 125.0 [1] |
 | 3-(4-Methoxyphenyl)-N-(5-(3-(trifluoromethyl)benzyl)thiazol-2-yl)acrylamide | IC50 | 3.0 [1] |
 | 6-[4-[2-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl]piperazin-1-yl]-N-(2-cyclopropylethyl)pyridazine-3-carboxamide | IC50 | 5870.0 [1] |
 | N-(2-Cyclopropylethyl)-6-[4-[3-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 66.0 [1] |
 | N-(4-Cyclopropylbutyl)-6-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 100.0 [1] |
 | N-(2-Cyclopropylethyl)-6-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 24.0 [1] |
 | N-Hexyl-5-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyrimidine-2-carboxamide | IC50 | 6400.0 [1] |
 | 6-[4-[5-Chloro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-N-(2-cyclopropylethyl)pyridazine-3-carboxamide | IC50 | 18.0 [1] |
 | N-(3-Methylbutyl)-5-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]pyridine-2-carboxamide | IC50 | 2400.0 [1] |
 | N-(2-Cyclopropylethyl)-6-[4-[5-methyl-2-(trifluoromethyl)furan-3-carbonyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 62.0 [1] |
 | N-Phenethyl-5-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)picolinamide | IC50 | 250.0 [1] |
 | N-(2-Cyclopropylethyl)-6-[4-(2,5-dichlorobenzoyl)piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 101.0 [1] |
 | N-(2-Cyclopropylethyl)-6-[4-[2-(trifluoromethyl)furan-3-carbonyl]piperazin-1-yl]pyridazine-3-carboxamide | IC50 | 290.0 [1] |
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