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Acyl coenzyme A:cholesterol acyltransferase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamideIC50926.0 [1]
1-[5-[(4,5-Diphenyl-1H-imidazol-2-yl)sulfanyl]pentyl]-3,5-dimethylpyrazoleIC5053.0 [1]
(5E,8E,11E,14E,17E,20E)-N-[2,6-Di(propan-2-yl)phenyl]docosa-5,8,11,14,17,20-hexaenamideIC5036.0 [1]
N-[2,6-Di(propan-2-yl)phenyl]tetradecanethioamideIC50130.0 [1]
AvasimibeIC5025.0 [1], 479.0 [2], 1500.0 [3], 4100.0 [4], 23500.0 [5]
3-(2,4-Difluorophenyl)-1-[4-(2,2-dimethylpropyl)benzyl]-1-heptylureaIC50140.0 [1], 740.0 [2], 810.0 [3], 1090.0 [4], 6060.0 [5]
OleanilideIC50140.0 [1], 170.0 [2]
(5,9-Diacetyloxy-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-8,12,17-trien-6-yl)methyl acetateIC50640.0 [1], 80000.0 [2], 1000000.0 [3]
1-(5-((4,5-Diphenyl-1H-imidazol-2-yl)sulfinyl)pentyl)-3,5-dimethyl-1H-pyrazoleIC50108.0 [1], 164.0 [2], 240.0 [3], 300.0 [4]
PactimibeIC50300.0 [1], 1800.0 [2], 4900.0 [3]
Nonanoic acid biphenyl-2-ylamideIC5064600.0 [1], 65000.0 [2]
Octanoic acid biphenyl-2-ylamideIC5060900.0 [1], 61000.0 [2]
Oleic acidIC501000000.0 [1]
Linoleic acidIC501000000.0 [1]
OleamideIC5063000.0 [1], 85000.0 [2]
Beauveriolide IIIIC50410.0 [1], 900.0 [2]
1-(3,4-Dimethoxyphenyl)-2-[4-[(2S,3R,4R,5S)-5-[4-[1-(3,4-dimethoxyphenyl)-1-hydroxypropan-2-yl]oxy-3-methoxyphenyl]-3,4-dimethyloxolan-2-yl]-2-methoxyphenoxy]propan-1-olIC508000.0 [1], 39000.0 [2]
EflucimibeIC5039.0 [1]
LinoleamideIC5045000.0 [1], 53000.0 [2]
CID 9892288IC50450.0 [1]
IsovalerylshikoninIC50600.0 [1], 13800.0 [2]
1-(1,3-Benzodioxol-5-yl)-2-[4-[(2S,3R,4R,5S)-5-[4-[1-(3,4-dimethoxyphenyl)-1-hydroxypropan-2-yl]oxy-3-methoxyphenyl]-3,4-dimethyloxolan-2-yl]-2-methoxyphenoxy]propan-1-olIC5082000.0 [1]
4-[1-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]piperidin-4-yl]oxycyclohexane-1-carboxylic acidIC5010000.0 [1]
[(1S,2S,5S,6R,7R,9S,10S,18R)-5-Acetyloxy-6-(acetyloxymethyl)-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-9-yl] 4-cyanobenzoateIC504160.0 [1]
Beauveriolide IIC50600.0 [1], 780.0 [2]
2-[4-[2-(1H-Benzimidazol-2-ylsulfanyl)ethyl]piperazin-1-yl]-N-[6-methyl-2,4-bis(methylsulfanyl)pyridin-3-yl]acetamide;hydrochlorideIC5026.0 [1], 450.0 [2]
1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-butyl}-3,5-dimethyl-1H-pyrazoleIC5075.0 [1], 500.0 [2]
4-[1-[5-(6-Fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl]oxycyclohexane-1-carboxylic acidIC5010000.0 [1]
4-[1-[5-(6-Chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl]oxycyclohexane-1-carboxylic acidIC5010000.0 [1]
4-[3-Fluoro-4-[[5-(2,4,5-trifluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenoxy]cyclohexane-1-carboxylic acidIC50310.0 [1], 6500.0 [2]
4-[4-[[5-(2,4,5-Trifluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenoxy]cyclohexane-1-carboxylic acidIC50450.0 [1], 1300.0 [2]
ProgesteroneIC5017000.0 [1]
Diethyl pyrocarbonateIC5044000.0 [1]
ShikoninIC5070400.0 [1]
Unii-ST04094S3XIC50128900.0 [1]
KurarinoneIC5010900.0 [1]
1,4-Bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinoneIC5026000.0 [1]
Territrem BIC5050000.0 [1]
Manassantin BIC5082000.0 [1]
beta-HydroxyisovalerylshikoninIC50186900.0 [1]
[(1S,2S)-2-[[2,2-Dimethylpropyl(nonyl)carbamoyl]amino]cyclohexyl] 3-[[(4R)-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl]amino]propanoateIC5032.0 [1]
CID 42636350IC5034000.0 [1]
PipercideIC503700.0 [1]
DGAT-1 inhibitorIC5012000.0 [1]
Arisugacin AIC5050000.0 [1]
Macluraxanthone BIC5096000.0 [1]
Cudraxanthone LIC5068000.0 [1]
Cudraflavanone AIC5082400.0 [1]
2-[4-[4-[[5-(3,4-Difluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenyl]cyclohexyl]acetic acidIC5080.0 [1]
Cudraxanthone DIC5057600.0 [1]
2-Methylthio-1,4-naphthoquinoneIC502820.0 [1]
Unii-G3MY6fge1JIC5010000.0 [1]
Cudraxanthone MIC5056800.0 [1]
DGAT-1 inhibitor 2IC505200.0 [1]
[(1S,2S,5S,6R,7R,9S,10S,18R)-9-Acetyloxy-6-(acetyloxymethyl)-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-5-yl] propanoateIC5027300.0 [1]
ButylshikoninIC5077600.0 [1]
5,8,10-Trihydroxy-3,3-dimethyl-11-(2-methylbut-3-en-2-yl)pyrano[2,3-c]xanthen-7-oneIC5040000.0 [1]
(3R,4R)-3-Ethyl-1-(4-methoxyphenyl)-4-phenyl-3-(3-phenylpropyl)azetidin-2-oneIC5010000.0 [1]
Isocudraniaxanthone BIC50148000.0 [1]
Diethyl 2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[2,1-f][1,2,4]triazine-5,6-dicarboxylateIC50500.0 [1]
PropionylshikoninIC5022400.0 [1]
2-Ethylsulfanylnaphthalene-1,4-dioneIC507510.0 [1]
Cudraxanthone CIC5020000.0 [1]
(3S,4R)-3-Ethyl-4-phenyl-3-(3-phenylpropyl)-1-(2,4,6-trimethoxyphenyl)azetidin-2-oneIC501700.0 [1]
(3S,4R)-1-(4-Methoxy-phenyl)-3,4-diphenyl-3-phenylacetyl-azetidin-2-oneIC507500.0 [1]
(3S,4R)-1-(4-Methoxy-phenyl)-3,4-diphenyl-3-(3-phenyl-propyl)-azetidin-2-oneIC506000.0 [1]
[(1R)-1-(5,8-Dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] pentanoateIC5094800.0 [1]
2-[(R)-1-(Benzoyloxy)-4-methyl-3-pentenyl]-5,8-dihydroxy-1,4-naphthoquinoneIC5053700.0 [1]
[(1S,2S,5S,6R,7R,9S,10S,18R)-5-Acetyloxy-6-(acetyloxymethyl)-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-9-yl] benzoateIC50680.0 [1]
(3R,6S,9S,13S)-9-Benzhydryl-3-[(2S)-butan-2-yl]-13-[(2S)-hexan-2-yl]-6-methyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetroneIC5040.0 [1]
(5As,7S)-7-[1-(6-imino-7H-purin-3-yl)propan-2-yl]-3-methyl-6,7,8,9-tetrahydro-5aH-pyrano[4,3-b]chromen-1-oneIC501200.0 [1]
SMP-797 hydrochloride monohydrateIC5031.0 [1]
4-[4-[4-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]piperidine-1-carbonyl]cyclohexane-1-carboxylic acidIC5068400.0 [1]
(3R,4S)-1-(4-Methoxyphenyl)-4-phenyl-3-(3-phenylpropyl)azetidin-2-oneIC5010000.0 [1]
(2S)-5,7-Dihydroxy-2-(7-hydroxy-2,2-dimethylchromen-6-yl)-8-(3-hydroxy-3-methylbutyl)-2,3-dihydrochromen-4-oneIC5059200.0 [1]
(3R,6R,9S,13S)-9-Benzhydryl-3-[(2S)-butan-2-yl]-13-[(2S)-hexan-2-yl]-6-methyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetroneIC5020.0 [1]
1-(2,6-Diisopropylphenyl)-3-((4-(3-methoxyphenyl)-1-phenylpiperidin-4-yl)methyl)ureaIC5035.0 [1]
6-[[7-(Dimethylamino)-1,3-benzoxazol-2-yl]sulfanyl]-N-[2,6-di(propan-2-yl)phenyl]hexanamideIC50820.0 [1]
6-[[7-[(Dimethylamino)methyl]-1,3-benzoxazol-2-yl]sulfanyl]-N-[2,6-di(propan-2-yl)phenyl]hexanamideIC505600.0 [1]
ACAT-IN-1 cis isomerIC5040.0 [1]
9-(1,3-Benzoxazol-2-ylsulfanyl)-N-[2,6-di(propan-2-yl)phenyl]nonanamideIC507.0 [1]
N-[2-(4-Amino-phenyl)-1-phenyl-ethyl]-2,2-diphenyl-acetamideIC50900.0 [1]
N-(4,6-Dimethyl-1-octylindolin-7-yl)-2,2-dimethylpropanamideIC50640.0 [1]
[(1R)-1-(5,8-Dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] pent-4-enoateIC5030700.0 [1]
[(1S,2S,3R,11S,12S,14R,15R,18R,20S)-3-Hydroxy-1,11,15-trimethyl-5-oxo-18-phenyl-7-pyridin-3-yl-6,10,17,19-tetraoxapentacyclo[12.8.0.02,11.04,9.015,20]docosa-4(9),7-dien-12-yl] pentanoateIC504000.0 [1]
N-Octyl-5,6-diphenylpyridazine-3-amineIC503200.0 [1]
1-{5-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-pentyl}-3,5-dimethyl-1H-pyrazoleIC5060.0 [1]
4-[4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl]butyl]thiomorpholineIC5070.0 [1]
2-[5-Methyl-5-(4-phenylmethoxybutyl)-1,3-dioxan-2-yl]-4,5-diphenyl-1H-imidazoleIC50300.0 [1]
1-Benzyl-4-[4-[2-(4,5-diphenyl-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl]butyl]piperazineIC5090.0 [1]
[(1S,2S,3R,11S,12S,14R,15R,18R,20S)-3-Hydroxy-1,11,15-trimethyl-18-(2-methylphenyl)-5-oxo-7-pyridin-3-yl-6,10,17,19-tetraoxapentacyclo[12.8.0.02,11.04,9.015,20]docosa-4(9),7-dien-12-yl] pentanoateIC503200.0 [1]
1-[4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl]butyl]-4-phenylpiperazineIC5070.0 [1]
2-[4-[4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl]butyl]piperazin-1-yl]pyrimidineIC5075.0 [1]
[(1S,2S,5S,6R,7R,9S,10S,18R)-9-Acetyloxy-6-(acetyloxymethyl)-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-5-yl] 2-methylpropanoateIC5013600.0 [1]
2-(5,5-Diethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-imidazoleIC501300.0 [1]
1-[4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl]butyl]indazoleIC50130.0 [1]
[(1S,2S,5S,6R,7R,9S,10S,18R)-5,9-Diacetyloxy-18-hydroxy-2,6,10-trimethyl-16-oxo-14-pyridin-3-yl-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-12(17),13-dien-6-yl]methyl 2-methylpropanoateIC5028000.0 [1]
N-Benzyl-4-[2-(4,5-diphenyl-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl]-N-methylbutan-1-amineIC50220.0 [1]
2-[4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl]butyl]-3,4-dihydro-1H-isoquinolineIC5060.0 [1]
1-[4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-1,3-dioxan-5-yl]butyl]-4-(4-methoxyphenyl)piperazineIC5010.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Acyl coenzyme A:cholesterol acyltransferase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/acyl-coenzyme-a-cholesterol-acyltransferase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Acyl coenzyme A:cholesterol acyltransferase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acyl-coenzyme-a-cholesterol-acyltransferase-1-inhibitors-ic50-ki.
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