Acyl coenzyme A:cholesterol acyltransferase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Benzil	IC50	27.0 [1], 43.0 [2], 370.0 [3]
	Benzil	Ki	45.0 [1]
	CID 10427006	IC50	600.0 [1]
	3-Octylthio-1,1,1-trifluoro-2-propanone	IC50	13.0 [1], 24.0 [2]
	3-Octylthio-1,1,1-trifluoro-2-propanone	Ki	4.17 [1], 190.55 [2]
	Diclofenac acyl glucuronide	IC50	1960.0 [1], 2270.0 [2], 2510.0 [3]
	Diclofenac acyl glucuronide	Ki	4320.0 [1]
	1-(Oxazol-2-yl)-7-phenylheptan-1-one	IC50	20.0 [1]
	1,2-Bis(3,5-difluorophenyl)ethane-1,2-dione	Ki	73.5 [1], 74.0 [2], 74.13 [3], 97.2 [4]
	1,4-Bis(phenylglyoxaloyl)benzene	Ki	2.1 [1], 7.94 [2], 8.0 [3]
	1,1,1-Trifluorododecan-2-one	IC50	30.0 [1], 65.0 [2]
	1,1,1-Trifluorododecan-2-one	Ki	2.29 [1], 151.36 [2]
	4,4'-Dichlorobenzil	Ki	1.6 [1], 181.97 [2], 182.0 [3]
	1-(3,4-Dimethylphenyl)-2-phenylethane-1,2-dione	Ki	18.8 [1], 99.1 [2], 100.0 [3]
	1-(4-Methyl-3-nitro-phenyl)-2-phenyl-ethane-1,2-dione	Ki	7.5 [1], 295.0 [2], 295.12 [3]
	1-(4-Chlorophenyl)-2-phenylethane-1,2-dione	Ki	5.4 [1], 47.4 [2], 47.86 [3]
	Benzoin	Ki	7210.0 [1], 7250.0 [2], 100000.0 [3]
	2-(7-Phenylheptanoyl)oxazole-5-carbonitrile	IC50	20.0 [1]
	2-(7-Phenylheptanoyl)oxazole-5-carboxylic acid	IC50	2000.0 [1], 100000.0 [2]
	4,4'-Difluorobenzil	Ki	229.09 [1], 230.0 [2], 231.0 [3]
	6-[2-(7-Phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid	IC50	100000.0 [1]
	1,2-Bis(3,4,5-trifluorophenyl)ethane-1,2-dione	Ki	371.54 [1], 372.0 [2], 470.0 [3]
	4-(N-Methyl-4-methoxyanilino)naphthalene-1,2-dione	Ki	17.7 [1], 81.6 [2], 87.5 [3]
	4-(4-Fluoro-N-methylanilino)naphthalene-1,2-dione	Ki	15.6 [1], 37.6 [2], 163.0 [3]
	4,4'-Dibromobenzil	Ki	0.03 [1], 100000.0 [2]
	2,3-Butanedione	Ki	100000.0 [1]
	Bis(4-nitrophenyl) hydrogen phosphate	IC50	140.0 [1], 210.0 [2]
	9,10-Phenanthrenequinone	Ki	2.5 [1]
	1-Phenyl-1,2-propanedione	Ki	5270.0 [1]
	Miltirone	Ki	2530.0 [1]
	Acenaphthenequinone	Ki	31.0 [1]
	1-Phenylisatin	Ki	23.0 [1]
	1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one	IC50	1.0 [1]
	1-([1,3]Oxazolo[4,5-b]pyridin-2-yl)-7-phenylheptan-1-one	IC50	3.0 [1]
	1-(Oxazol-2-yl)octadec-9-en-1-one	IC50	9000.0 [1]
	Furil	Ki	1174.9 [1], 8480.0 [2]
	Oleoyl oxazolopyridine	IC50	1000.0 [1]
	1,1,1-Trifluorononan-2-one	IC50	2.0 [1]
	4-(2-Oxo-2-phenylacetyl)benzoic acid	Ki	524.0 [1], 524.81 [2]
	4,4'-Dimethylbenzil	Ki	532.0 [1], 537.03 [2]
	(Z)-1-(Benzo[d]oxazol-2-yl)octadec-9-en-1-one	IC50	10000.0 [1]
	1-(5-(Pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one	IC50	50000.0 [1], 100000.0 [2]
	7-Phenyl-1-[5-(Pyridin-2-Yl)-1,3,4-Oxadiazol-2-Yl]heptan-1-One	IC50	140.0 [1]
	1,1,1-Trifluorotridecan-2-one	IC50	60.0 [1], 70.0 [2]
	2-Nonadecanone, 1,1,1-trifluoro-	IC50	4600.0 [1]
	1,1,1-Trifluoro-8-phenyl-octan-2-one	IC50	1.0 [1]
	1,1,1-Trifluoro-3-hexylsulfanylpropan-2-one	Ki	5.25 [1], 331.13 [2]
	1,1,1-Trifluoro-undecan-2-one	IC50	10.0 [1]
	7-Phenyl-1-(5-(trifluoromethyl)oxazol-2-yl)heptan-1-one	IC50	200.0 [1]
	3-Decylsulfanyl-1,1,1-trifluoropropan-2-one	Ki	3.98 [1], 128.82 [2]
	1,2-Di(thiophen-2-yl)ethane-1,2-dione	Ki	213.8 [1], 874.0 [2]
	2,2'-Pyridil	Ki	125.89 [1], 484.0 [2]
	4,4'-Dimethoxybenzil	Ki	3388.44 [1], 3410.0 [2]
	1,1,1-Trifluoro-9-phenyl-nonan-2-one	IC50	5.0 [1]
	2-Propanone, 3-(dodecylthio)-1,1,1-trifluoro-	Ki	7.41 [1], 70.79 [2]
	Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate	IC50	300.0 [1]
	1-Benzooxazol-2-yl-6-phenyl-hexan-1-one	IC50	20.0 [1]
	1,1,1-Trifluoro-7-phenyl-heptan-2-one	IC50	0.5 [1]
	1,1,1-Trifluoro-3-(decylsulfonyl)propane-2,2-diol	Ki	0.3 [1], 794.33 [2]
	3-Butylsulfanyl-1,1,1-trifluoropropan-2-one	Ki	5.37 [1], 794.33 [2]
	1-(4-Chlorobenzyl)-1H-indole-2,3-dione	Ki	25.0 [1]
	1,1,1-Trifluoro-3-(octane-1-sulfonyl)propane-2,2-diol	Ki	0.6 [1], 1513.56 [2]
	1,1,1-Trifluoro-3-[(2-phenylethyl)sulfanyl]propan-2-one	Ki	6.46 [1], 120.23 [2]
	2-Chloro-3',4'-dimethoxybenzil	Ki	3300.0 [1], 3311.31 [2]
	Benzil, 3,5'-dinitro-	Ki	18100.0 [1], 18197.01 [2]
	Phenyl-1,2-Heptanedione	Ki	6.65 [1], 6.7 [2]
	8,9-Hexadecanedione	Ki	7.6 [1]
	1,2-Bis(4-bromothiophen-2-yl)ethane-1,2-dione	Ki	2.2 [1], 30.2 [2]
	1,2-Bis(5-bromothiophen-2-yl)ethane-1,2-dione	Ki	7.0 [1], 208.93 [2]
	1,2-Di(3-thienyl)-1,2-ethanedione	Ki	363.08 [1], 2410.0 [2]
	1-Phenylhexane-1,2-dione	Ki	26.0 [1], 26.1 [2]
	Ethanedione, dicyclohexyl-	Ki	5.0 [1], 72.0 [2]
	Ethanedione, bis(3-methoxyphenyl)-	Ki	1540.0 [1], 1548.82 [2]
	4-(N,4-Dimethylanilino)naphthalene-1,2-dione	Ki	4.9 [1], 11.1 [2]
	Tetradecane-7,8-dione	Ki	4.8 [1]
	4-[Methyl(phenyl)amino]naphthalene-1,2-dione	Ki	32.1 [1], 90.0 [2]
	1-(4-Chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione	Ki	158.49 [1], 160.0 [2]
	1-(4-Nitrophenyl)-2-phenylethane-1,2-dione	Ki	213.8 [1], 215.0 [2]
	4-Methoxybenzil	Ki	173.78 [1], 175.0 [2]
	1,2-Di(naphthalen-2-yl)ethane-1,2-dione	Ki	255.0 [1], 257.04 [2]
	1-(Perchlorophenyl)-2-(perfluorophenyl)ethane-1,2-dione	Ki	1690.0 [1], 1698.24 [2]
	1,1,1-Trifluoro-3-octylsulfonylpropan-2-one	IC50	5.4 [1], 18.0 [2]
	1,1,1-Trifluoro-3-octylsulfinylpropan-2-one	IC50	5.5 [1], 30.0 [2]
	3-Dodecylsulfonyl-1,1,1-trifluoropropane-2,2-diol	Ki	0.4 [1], 741.31 [2]
	1,1,1-Trifluoro-3-hexylsulfonylpropane-2,2-diol	Ki	0.71 [1], 9772.37 [2]
	p-Methylbenzil	Ki	125.0 [1], 125.89 [2]
	4-(Bromomethyl)benzil	Ki	77.6 [1], 77.62 [2]
	2,2'-Dichlorobenzil	Ki	1650.0 [1], 1659.59 [2]
	4-(4-Iodo-N-methylanilino)naphthalene-1,2-dione	Ki	148.0 [1], 400.0 [2]
	4-(4-Chloro-N-methylanilino)naphthalene-1,2-dione	Ki	12.9 [1], 19.2 [2]
	4-(4-Bromo-N-methylanilino)naphthalene-1,2-dione	Ki	16.1 [1], 17.2 [2]
	3-Dodecylsulfinyl-1,1,1-trifluoropropane-2,2-diol	Ki	0.4 [1], 1905.46 [2]
	3-Decylsulfinyl-1,1,1-trifluoropropane-2,2-diol	Ki	0.5 [1], 5248.07 [2]
	1,1,1-Trifluoro-3-octylsulfinylpropane-2,2-diol	Ki	0.6 [1], 14791.08 [2]
	1,1,1-Trifluoro-3-hexylsulfinylpropane-2,2-diol	Ki	3.31 [1], 79432.82 [2]
	1,1,1-Trifluoro-3-hexoxypropane-2,2-diol	Ki	1.0 [1], 3311.31 [2]
	1,1,1-Trifluoro-3-(2-phenylethylsulfanyl)propane-2,2-diol	Ki	6.03 [1], 13803.84 [2]
	Valproic acid	Ki	363000.0 [1]
	1,4-Benzoquinone	Ki	100000.0 [1]
	Donepezil	IC50	100000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Acyl coenzyme A:cholesterol acyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/acyl-coenzyme-a-cholesterol-acyltransferase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 10). Quest Database™ Acyl coenzyme A:cholesterol acyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/acyl-coenzyme-a-cholesterol-acyltransferase-inhibitors-ic50-ki.
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