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ADAM10 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Benzyl N-[(4R)-4-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamateIC5010000.0 [1]
N^2^-[(2R)-2-{(1S)-1-[Formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl]-N,3-dimethyl-L-valinamideIC5010000.0 [1]
(4s)-3-{[4-(4-Cyano-2-Methylphenyl)piperazin-1-Yl]sulfonyl}-N-Hydroxy-1,3-Thiazolidine-4-CarboxamideIC507000.0 [1]
Benzyl N-[(4R)-4-[[4-(4-cyano-2-methylphenyl)piperazin-1-yl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamateIC5010000.0 [1]
(6S,7S)-N-Hydroxy-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamideIC5018.0 [1], 33.0 [2]
(6S,7S)-N-Hydroxy-6-[(4-phenylpiperazin-1-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC5052.0 [1], 118.0 [2], 120.0 [3]
CID 44446843IC5092.0 [1], 97.0 [2], 323.0 [3]
Unii-Q56UE7E40YIC5022.0 [1], 59.0 [2]
(6S,7S)-N-Hydroxy-6-[(4-phenylpiperidin-1-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC50137.0 [1], 320.0 [2], 324.0 [3]
(6S,7S)-N-Hydroxy-6-(3-phenyl-2,5-dihydropyrrole-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamideIC5013.0 [1], 23.0 [2]
IlomastatIC508.1 [1], 263.0 [2]
ApratastatIC5071.0 [1]
Grassystatin AIC5010000.0 [1], 100000.0 [2]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi10000.0 [1]
(6S,7S)-N-Hydroxy-6-{[(3R)-3-phenylpyrrolidin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamideIC5097.0 [1]
(6S,7S)-N-Hydroxy-5-methyl-6-[(4-phenylpiperazin-1-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC50310.0 [1]
CID 44447430IC506.2 [1], 16.0 [2]
(2R,3R)-4-[(2R)-2-(3-Chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamideKi166.0 [1]
[(3S)-Oxolan-3-yl] 4-[[4-(4-fluoro-2-methylphenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5092.0 [1], 141.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC5018.0 [1], 41.0 [2]
[(3S)-Oxolan-3-yl] 4-[[4-(4-cyanophenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5039.0 [1], 77.0 [2]
Pyrrolidin-3-yl 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC5016.0 [1], 18.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[(4-phenylpiperidin-1-yl)sulfonylmethyl]piperidine-1-carboxylateIC5022.0 [1], 28.0 [2]
[(3S)-Oxolan-3-yl] 4-[[4-(4-cyano-2-methylphenyl)-3,6-dihydro-2H-pyridin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5045.0 [1], 107.0 [2]
[(2S)-Pyrrolidin-2-yl]methyl 4-[[4-(4-cyano-2-methylphenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC506.5 [1], 9.1 [2]
[(3S)-Oxolan-3-yl] 4-[[4-(2-fluorophenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5044.0 [1], 76.0 [2]
[(2S)-Pyrrolidin-2-yl]methyl 4-[[4-(4-cyano-2-methylphenyl)-3,6-dihydro-2H-pyridin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5027.0 [1], 34.0 [2]
[(2R)-Pyrrolidin-2-yl]methyl 4-[[4-(4-cyano-2-methylphenyl)-3,6-dihydro-2H-pyridin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5019.0 [1], 24.0 [2]
(3-Methyloxolan-3-yl) 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC5011.0 [1], 36.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[[4-[2-(trifluoromethyl)phenyl]piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC501000.0 [1], 1036.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)sulfonylmethyl]piperidine-1-carboxylateIC507.1 [1], 10.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)-3,6-dihydro-2H-pyridin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC5018.0 [1], 133.0 [2]
[(3S)-Oxolan-3-yl] 4-[[4-(4-cyano-2-methylphenyl)piperazin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5025.0 [1], 26.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperazin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC50107.0 [1], 217.0 [2]
[(3S)-Oxolan-3-yl] 4-[[4-(2-cyanophenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC501000.0 [1], 2000.0 [2]
(4,4-Dimethyloxolan-3-yl) 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC5014.0 [1], 22.0 [2]
[(2S)-Pyrrolidin-2-yl]methyl 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC5023.0 [1], 34.0 [2]
[(3S)-Oxolan-3-yl] 4-[[4-(4-cyano-2-methylphenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5012.0 [1], 14.0 [2]
[(3S)-Oxolan-3-yl] 4-[[4-[4-(dimethylcarbamoyl)-2-methylphenyl]piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC501000.0 [1], 2000.0 [2]
[(2R)-Pyrrolidin-2-yl]methyl 4-[[4-(4-cyano-2-methylphenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5011.0 [1], 23.0 [2]
[(3S)-Oxolan-3-yl] 4-[[4-(4-cyano-3,5-dimethylphenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC5057.0 [1], 96.0 [2]
[(3S)-Oxolan-3-yl] 4-[[4-(3,5-dimethylphenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC50286.0 [1], 833.0 [2]
Methyl (6S,7S)-7-(hydroxycarbamoyl)-6-(3-phenyl-2,5-dihydropyrrole-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylateIC5026.0 [1], 34.0 [2]
(6S,7S)-N-Hydroxy-6-[4-(3-methylphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC5025.0 [1], 42.0 [2]
(6S,7S)-6-[4-(3-Ethylphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-N-hydroxy-5-azaspiro[2.5]octane-7-carboxamideIC5033.0 [1], 240.0 [2]
(6S,7S)-N-Hydroxy-6-[4-(3-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC5040.0 [1], 194.0 [2]
(6S,7S)-N-Hydroxy-6-[4-(3-propan-2-ylphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC5073.0 [1], 229.0 [2]
(6S,7S)-6-[4-(3-Cyclopropylphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-N-hydroxy-5-azaspiro[2.5]octane-7-carboxamideIC5048.0 [1], 162.0 [2]
(6S,7S)-6-[4-(3,5-Dimethylphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-N-hydroxy-5-azaspiro[2.5]octane-7-carboxamideIC5085.0 [1], 86.0 [2]
(6S,7S)-6-[4-(4-Cyano-3-propan-2-ylphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-N-hydroxy-5-azaspiro[2.5]octane-7-carboxamideIC50154.0 [1], 902.0 [2]
(6S,7S)-6-[4-(4-Cyano-3,5-dimethylphenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-N-hydroxy-5-azaspiro[2.5]octane-7-carboxamideIC5028.0 [1], 129.0 [2]
(6S,7S)-6-[4-(3,5-Difluorophenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-N-hydroxy-5-azaspiro[2.5]octane-7-carboxamideIC5015.0 [1], 24.0 [2]
(6S,7S)-N-Hydroxy-6-[4-(3-methylphenyl)piperazine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC50184.0 [1], 187.0 [2]
(6S,7S)-6-[4-(4-Cyano-3-methylphenyl)piperazine-1-carbonyl]-N-hydroxy-5-azaspiro[2.5]octane-7-carboxamideIC5038.0 [1], 594.0 [2]
(6S,7S)-6-[4-(3-Chlorophenyl)piperazine-1-carbonyl]-N-hydroxy-5-azaspiro[2.5]octane-7-carboxamideIC5014.0 [1], 42.0 [2]
(6S,7S)-N-Hydroxy-6-[4-(3-methylphenyl)piperidine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC50194.0 [1], 689.0 [2]
(6S,7S)-N-Hydroxy-6-[4-(3-propan-2-ylphenyl)piperidine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC5016.0 [1], 139.0 [2]
Methyl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylateIC5059.0 [1], 68.0 [2]
2-Methylpropyl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylateIC5019.0 [1], 150.0 [2]
Benzyl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylateIC5034.0 [1], 431.0 [2]
(6S,7S)-5-Acetyl-N-hydroxy-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamideIC5040.0 [1], 72.0 [2]
(6S,7S)-N-Hydroxy-5-methylsulfonyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamideIC5051.0 [1], 93.0 [2]
Methyl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenylpiperidine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylateIC5019.0 [1], 169.0 [2]
Oxan-4-yl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylateIC5026.0 [1], 37.0 [2]
(6S,7S)-N-Hydroxy-5-methylsulfonyl-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamideIC5027.0 [1], 45.0 [2]
Methyl (6S,7S)-7-(hydroxycarbamoyl)-6-(3-phenylpyrrolidine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylateIC5081.0 [1], 289.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[(3-phenyl-2,5-dihydropyrrol-1-yl)sulfonylmethyl]piperidine-1-carboxylateIC50102.0 [1], 332.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[(3-phenylpyrrolidin-1-yl)sulfonylmethyl]piperidine-1-carboxylateIC50261.0 [1], 358.0 [2]
[(3S)-Oxolan-3-yl] 4-(hydroxycarbamoyl)-4-[(4-phenylpiperazin-1-yl)sulfonylmethyl]piperidine-1-carboxylateIC5013.0 [1], 15.0 [2]
[(2R)-Pyrrolidin-2-yl]methyl 4-(hydroxycarbamoyl)-4-[[4-(2-methylphenyl)piperidin-1-yl]sulfonylmethyl]piperidine-1-carboxylateIC5019.0 [1], 30.0 [2]
Pyrrolidin-3-yl 4-[[4-(4-cyano-2-methylphenyl)piperidin-1-yl]sulfonylmethyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylateIC507.8 [1], 13.0 [2]
(2R)-N-Hydroxy-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]-3-methylbutanamide;hydrochlorideIC50890.0 [1]
CID 9847838IC50480.0 [1]
2-{2-[(Furan-2-carbonyl)-amino]-3-furan-2-yl-acryloylamino}-propionic acidIC5010500.0 [1]
(2R,3S)-2-[(4-But-2-ynoxyphenyl)sulfonylamino]-N,3-dihydroxybutanamideIC501090.0 [1]
(1R,2S)-2-N-Hydroxy-1-[[4-[(2-methylquinolin-4-yl)methoxy]phenyl]methyl]cyclopropane-1,2-dicarboxamideKi10000000.0 [1]
3-[[[2-(Hydroxyamino)-2-oxoethyl]-(4-methoxyphenyl)sulfonylamino]methyl]benzoic acidIC5011700.0 [1]
(R)-5-((6-Methoxy-1-oxoisoindolin-2-yl)methyl)-5-(pyridin-3-ylethynyl)imidazolidine-2,4-dioneIC5022.0 [1]
(1R,2S)-1-[[3-Fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl]methyl]-2-N-hydroxycyclopropane-1,2-dicarboxamideKi10000000.0 [1]
Grassystatin BIC5087200.0 [1]
(6S,7S)-N-Hydroxy-5-methyl-6-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl]-5-azaspiro[2.5]octane-7-carboxamideIC5097.0 [1]
[(R)-3-(Hydroxycarbamoyl)-3-[4-(2-butynyloxy)phenylsulfonylamino]propyl]carbamic acid benzyl esterIC50240.0 [1]
(5S)-1-[(2R)-1-[(2S)-2-[[(6S)-6-Benzyl-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-cyclohexylpropan-2-yl]-5-[(4-hydroxyphenyl)methyl]-4-(2-phenylethyl)piperazine-2,3-dioneIC50100000.0 [1]
(5S)-4-[2-(1-Adamantyl)ethyl]-1-[(2S)-1-[(2S)-2-[[(6S)-6-benzyl-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-phenylpropan-2-yl]-5-[(4-hydroxyphenyl)methyl]piperazine-2,3-dioneIC50100000.0 [1]
N-[(2R,6S)-4-[2-(Hydroxyamino)-2-oxoethyl]-2,6-dimethylpiperidin-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamideKi3000.0 [1]
(1S,2S)-N-Hydroxy-5-(2-morpholin-4-yl-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamideIC5083.0 [1]
(1S,2S)-N-Hydroxy-5-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamideIC5030.0 [1]
(1S,2S)-N-Hydroxy-5-(2-oxo-2-piperidin-1-ylethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamideIC5058.0 [1]
(2S,3S)-5-[2-(5-Aminopentylamino)-2-oxoethyl]-N-hydroxy-2-(3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamideIC50161.0 [1]
(1S,2S)-N-Hydroxy-5-[2-[(3R)-3-hydroxypyrrolidin-1-yl]-2-oxoethyl]-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamideIC50111.0 [1]
(2R,3R)-N-(Benzofuran-2-ylmethyl)-2,3-dihydroxy-4-oxo-4-(2-phenylpyrrolidin-1-yl)butanamideKi734.0 [1]
(1S,2R)-2-Cyano-N-hydroxy-2-[[4-[(2-phenylquinolin-4-yl)methoxy]phenyl]methyl]cyclopropane-1-carboxamideKi10000000.0 [1]
(2r,3r)-4-[4-(2-Chlorophenyl)piperazin-1-Yl]-2,3-Dihydroxy-4-Oxo-N-(2-Thiophen-2-Ylethyl)butanamideKi400.0 [1]
(2R,3R)-4-[2-(3-Chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-(2-thiophen-2-ylethyl)butanamideKi29.0 [1]
(1S,2S)-N-Hydroxy-5-(2-oxo-2-pyrrolidin-1-ylethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamideIC5064.0 [1]
(5S)-4-[(4-Tert-butylcyclohexyl)methyl]-1-[(2S)-1-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)propan-2-yl]-5-[(4-hydroxyphenyl)methyl]piperazine-2,3-dioneIC50100000.0 [1]
(5S)-4-(1-Adamantylmethyl)-1-[(2S)-1-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)propan-2-yl]-5-[(4-hydroxyphenyl)methyl]piperazine-2,3-dioneIC50100000.0 [1]
(5S)-4-(Cyclohexylmethyl)-1-[(2S)-1-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)propan-2-yl]-5-[(4-hydroxyphenyl)methyl]piperazine-2,3-dioneIC50100000.0 [1]
(5S)-4-(Cyclobutylmethyl)-1-[(2S)-1-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)propan-2-yl]-5-[(4-hydroxyphenyl)methyl]piperazine-2,3-dioneIC50100000.0 [1]
(5S)-1-[(2S)-1-[(2S)-2-[[(6S)-2,3-Dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)propan-2-yl]-5-[(4-hydroxyphenyl)methyl]-4-(2-phenylbutyl)piperazine-2,3-dioneIC50100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ ADAM10 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/adam10-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ ADAM10 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/adam10-inhibitors-ic50-ki.
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