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ADAMTS4 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(2R,3R)-1-[4-[(2-Chloro-4-fluorophenyl)methoxy]phenyl]sulfonyl-N,3-dihydroxy-3-methylpiperidine-2-carboxamideIC501.0 [1], 3.0 [2]
(2R)-3-Methyl-2-[(4-phenylphenyl)sulfonylamino]butanoic acidIC503000.0 [1]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi6700.0 [1]
(2S,3R)-2-(Cyclopropylmethylamino)-N-hydroxy-N'-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(3-hydroxyphenyl)methyl]butanediamideIC503.0 [1]
N-[4-[2-(Hydroxyamino)-2-oxoethyl]oxan-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamideKi4600.0 [1]
(2R)-2-[[4-[4-(1-Benzofuran-2-carbonyloxy)phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC50350.0 [1]
3-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-pyridin-2-yl-1,3-thiazol-5-yl]propanoic acidIC5023000.0 [1]
ADAMTS-5 inhibitorIC5044000.0 [1]
1'-Benzyl-5-(4-methoxyphenyl)-5'-methylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-oneIC5022000.0 [1]
(2R)-2-[[4-(3-Hydroxyphenyl)phenyl]sulfonylamino]-3-methylbutanoic acidIC509000.0 [1]
(2R)-2-[[4-(4-Hydroxyphenyl)phenyl]sulfonylamino]-3-methylbutanoic acidIC504600.0 [1]
N-((5-Chloro-8-hydroxyquinolin-7-yl)(2-chlorophenyl)methyl)-2-phenoxyacetamideIC502400.0 [1]
N-[(2S,4S)-1-[4-[2-(3,5-Dimethyl-1,2-oxazol-4-yl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamideIC500.69 [1], 25118864.32 [2]
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamideIC502.0 [1]
N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamideIC507.0 [1]
(2S)-2-Cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamideIC502.0 [1]
(2S)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-methyl-2-[[4-(trifluoromethyl)phenyl]methyl]butanamideIC5014.0 [1]
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamideIC501.0 [1], 2.0 [2]
IlomastatIC50480.0 [1]
MarimastatIC5010000.0 [1]
Mmp-2/mmp-9 inhibitor iIC504300.0 [1]
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic AcidIC5025000.0 [1]
(2S)-3-Methyl-2-[(4-phenylphenyl)sulfonylamino]butanoic acidIC50100000.0 [1]
(2S)-2-[[8-(Methoxycarbonylamino)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acidIC505.0 [1]
1-Benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-hydroxypiperidine-4-carboxamideIC501000.0 [1]
(2S)-2-[[4-[4-[(5-Bromo-4-methoxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC505600.0 [1]
(2R,5R)-1-[4-[(2,4-Dichlorophenyl)methoxy]phenyl]sulfonyl-N,5-dihydroxy-3,3-dimethylpiperidine-2-carboxamideIC501.1 [1]
N-Hydroxy-2-(4-phenoxy-benzenesulfonylamino)-acetamideIC50580.0 [1]
(2R)-2-[(4-Phenylphenyl)sulfonylamino]pentanedioic acidIC501100.0 [1]
CID 10160968Ki1834.0 [1]
(2S)-2-[[4-[4-[(5-Ethyl-4-hydroxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC504400.0 [1]
(2S)-2-[[4-[4-[(5-Chloro-3-methyl-4-propan-2-yloxy-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5014300.0 [1]
(2S)-2-[[4-[4-[(5-Iodo-4-methoxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5015000.0 [1]
(1S)-4-Methyl-1-[[5-[(3-oxo-4H-1,4-benzoxazin-6-yl)methylcarbamoyl]pyrazolo[1,5-a]pyrimidine-7-carbonyl]amino]-2,3-dihydro-1H-indene-5-carboxylic acidIC502400.0 [1]
2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetamideIC503300.0 [1]
(2R)-2-[[4-[4-(1-Benzofuran-2-carbonylamino)phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC507500.0 [1]
4-[[5-[2-[(4-Fluorophenyl)methylcarbamoyl]-6-methylpyridin-4-yl]tetrazol-2-yl]methyl]cyclohexane-1-carboxylic acidKi25000.0 [1]
L-Valine, N-((8-(2-oxo-3-oxazolidinyl)-3-dibenzofuranyl)sulfonyl)-IC5018000.0 [1]
(2S)-2-[[4-[4-[(4-Methoxy-3,5-dimethyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC508600.0 [1]
(2S)-2-[[4-[4-[(5-Ethyl-4-methoxy-3-methyl-1-benzofuran-2-carbonyl)amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5015000.0 [1]
(1S,2R,3R)-1-[[5-(4-Chloropyrazol-1-yl)thiophen-2-yl]sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acidIC504.0 [1]
CID 54585928IC501.2 [1]
N-Hydroxy-2-[(4-phenylmethoxyphenyl)sulfonylamino]acetamideIC503500.0 [1]
2-(4-Chlorophenoxy)-N-{[(4r)-4-Methyl-2,5-Dioxoimidazolidin-4-Yl]methyl}acetamideIC5074.0 [1]
N-[(2S,4S)-1-[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)pentan-2-yl]-N-hydroxyformamideIC501.4 [1]
(3S,4R)-4-[4-[(3-Chlorophenyl)methoxy]phenyl]sulfonyl-N,3-dihydroxyoxane-3-carboxamideIC501000.0 [1]
N-[[(4S)-4-(1-Methylimidazol-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-5-(trifluoromethyl)-1-benzofuran-2-carboxamideIC504.0 [1]
(3S,4R)-4-[4-[(4-Chlorophenyl)methoxy]phenyl]sulfonyl-N,3-dihydroxyoxane-3-carboxamideIC50330.0 [1]
(3S,4R)-N,3-Dihydroxy-4-[4-[(2-methylphenyl)methoxy]phenyl]sulfonyloxane-3-carboxamideIC5055.0 [1]
(3S,4R)-4-[4-[(2-Chlorophenyl)methoxy]phenyl]sulfonyl-N,3-dihydroxyoxane-3-carboxamideIC5040.0 [1]
N-[(2R,6S)-4-[2-(Hydroxyamino)-2-oxoethyl]-2,6-dimethylpiperidin-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamideKi4600.0 [1]
(2R)-3-Methyl-2-[[4-[4-(3-methyl-1-benzofuran-2-carbonyl)oxyphenyl]phenyl]sulfonylamino]butanoic acidIC5086.0 [1]
(2S)-2-[[4-[4-[[4-(Methanesulfonamido)-3-methyl-1-benzofuran-2-carbonyl]amino]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC502200.0 [1]
(2R)-2-[[4-[4-(Furan-2-carbonyloxy)phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5011600.0 [1]
(2R)-3-Methyl-2-[[4-[4-[(3-methyl-1-benzofuran-2-yl)methoxy]phenyl]phenyl]sulfonylamino]butanoic acidIC50700.0 [1]
(2R)-2-[[4-[4-[(3-Hydroxyphenoxy)methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC501100.0 [1]
(2R)-3-Methyl-2-[[4-[4-[(4-pyridin-2-yloxyphenoxy)methyl]phenyl]phenyl]sulfonylamino]butanoic acidIC50900.0 [1]
(2R)-2-[[4-[4-[[4-(Cyclohexanecarbonyl)phenoxy]methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5090.0 [1]
(2R)-2-[[4-[4-[(3-Fluorophenoxy)methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC501200.0 [1]
(2R)-2-[[4-[4-[(4-Methoxyphenoxy)methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC501600.0 [1]
(2R)-3-Methyl-2-[[4-[4-[[4-[(2-methylpropan-2-yl)oxycarbonylamino]phenoxy]methyl]phenyl]phenyl]sulfonylamino]butanoic acidIC50590.0 [1]
(2R)-3-Methyl-2-[[4-[4-[(5-oxo-7,8-dihydro-6H-naphthalen-2-yl)oxymethyl]phenyl]phenyl]sulfonylamino]butanoic acidIC50230.0 [1]
(2R)-3-Methyl-2-[[4-[4-[(4-phenoxyphenoxy)methyl]phenyl]phenyl]sulfonylamino]butanoic acidIC50400.0 [1]
(2R)-2-[[4-[4-[(3-Acetylphenoxy)methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC501000.0 [1]
(2R)-2-[[4-[4-[[4-(4-Fluorobenzoyl)phenoxy]methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC5080.0 [1]
(2R)-3-Methyl-2-[[4-[4-[[4-(6-methylpyridin-2-yl)oxyphenoxy]methyl]phenyl]phenyl]sulfonylamino]butanoic acidIC50730.0 [1]
(2R)-2-[[4-[4-[(4-Acetylphenoxy)methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC50430.0 [1]
(2R)-2-[[4-[4-[(4-Fluorophenoxy)methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC501700.0 [1]
(2R)-2-[[4-[4-[(4-Benzoylphenoxy)methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC50230.0 [1]
(2R)-2-[[2-Fluoro-4-[4-[(5-oxo-7,8-dihydro-6H-naphthalen-2-yl)oxymethyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC50180.0 [1]
N-({4'-[(4-Isobutyrylphenoxy)methyl]biphenyl-4-Yl}sulfonyl)-D-ValineIC50100.0 [1]
(2R)-3-Methyl-2-[[4-[4-[[4-(pyrrolidine-1-carbonyl)phenoxy]methyl]phenyl]phenyl]sulfonylamino]butanoic acidIC501900.0 [1]
5-Chloro-N-[[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC50110.0 [1]
5-Chloro-N-[[(4R)-2,5-dioxo-4-phenylimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC5012.0 [1]
5-Chloro-N-[[(4S)-4-(3-methylpyridin-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC5017.0 [1]
5-Chloro-N-[[(4S)-4-(2-methylpyrazol-3-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC5022.0 [1]
(1S)-1-[[3-Fluoro-5-[[4-fluoro-3-(trifluoromethyl)phenyl]methylcarbamoyl]pyrazolo[1,5-a]pyrimidine-7-carbonyl]amino]-4-methyl-2,3-dihydro-1H-indene-5-carboxylic acidIC507000.0 [1]
4-[[[4-(3,4-Dihydro-2H-quinolin-1-yl)-6-[(4-methylpiperazin-1-yl)methylamino]-1,3,5-triazin-2-yl]amino]methyl]-N-ethyl-N-(3-methylphenyl)benzamideIC506500.0 [1]
4-[[[4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6-oxo-1H-1,3,5-triazin-2-yl]amino]methyl]-N-ethyl-N-(3-methylphenyl)benzamideIC5022.0 [1]
2-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-phenyl-1,3-thiazol-5-yl]acetic acidIC5010000.0 [1]
(2E)-2-(1H-Benzimidazol-2-ylmethylidene)-5-propyl-1,3-thiazolidin-4-oneIC5021000.0 [1]
(2S)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamideIC5012.0 [1]
N-[4-[[4-(4-Fluorophenyl)piperazin-1-yl]sulfonylmethyl]oxan-4-yl]-N-hydroxyformamideIC5021.0 [1]
1'-Benzyl-5-(4-methoxyphenyl)spiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-oneIC5022000.0 [1]
5'-(4-Methoxyphenyl)-6-propylspiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-oneIC5022000.0 [1]
5-(4-Methoxyphenyl)-5'-methyl-1'-(2-methylphenyl)spiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-oneIC5010500.0 [1]
(2R)-3-Methyl-2-[(3-phenylphenyl)sulfonylamino]butanoic acidIC50100000.0 [1]
(2R)-2-[(3-Amino-4-phenylphenyl)sulfonylamino]-3-methylbutanoic acidIC5030000.0 [1]
(2R)-3-Methyl-2-[[4-(2-nitrophenyl)phenyl]sulfonylamino]butanoic acidIC5050000.0 [1]
(2R)-2-[[4-(2-Hydroxyphenyl)phenyl]sulfonylamino]-3-methylbutanoic acidIC5020000.0 [1]
4-Methyl-3-[(4-phenylphenyl)sulfonylamino]pentanoic acidIC50100000.0 [1]
(2R)-2-[(4-Phenylphenyl)sulfonylamino]propanoic acidIC505500.0 [1]
(2R)-3-(1H-Indol-2-yl)-2-[(4-phenylphenyl)sulfonylamino]propanoic acidIC502800.0 [1]
(2R)-3-Methyl-2-[methyl-(4-phenylphenyl)sulfonylamino]butanoic acidIC501600.0 [1]
(2R)-3-Methyl-2-[(4-phenylphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]butanoic acidIC5012000.0 [1]
N-{4'-[(1-Benzofuran-2-yl)methoxy][1,1'-biphenyl]-4-sulfonyl}-D-valineIC501400.0 [1]
(2R)-2-[[4-[4-[2-(1-Benzofuran-2-yl)-2-oxoethyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC503800.0 [1]
(2R)-2-[[4-[4-[(E)-2-(1-Benzofuran-2-yl)ethenyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC50400.0 [1]
2-(N-Methyl-N-phenylamino)-N-((5-chloro-8-hydroxyquinolin-7-yl)(3-nitrophenyl)methyl)acetamideIC5022000.0 [1]
N-((5-Chloro-8-hydroxyquinolin-7-yl)(3-nitrophenyl)methyl)-2-phenoxyacetamideIC501900.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ ADAMTS4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/adamts4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ ADAMTS4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/adamts4-inhibitors-ic50-ki.
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