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ADAMTS5 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(2R,3R)-1-[4-[(2-Chloro-4-fluorophenyl)methoxy]phenyl]sulfonyl-N,3-dihydroxy-3-methylpiperidine-2-carboxamideIC501.0 [1], 6.3 [2], 18.0 [3]
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamideIC502.0 [1], 20.0 [2]
N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanamideIC504.0 [1], 64.0 [2]
(2S)-2-Cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamideIC502.0 [1], 18.0 [2]
(2S)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-methyl-2-[[4-(trifluoromethyl)phenyl]methyl]butanamideIC508.0 [1], 150.0 [2]
(2R)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamideIC501.0 [1], 15.0 [2]
(3R,4R)-N-Hydroxy-4-[[4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl]benzoyl]amino]oxane-3-carboxamideKi1000.0 [1], 1900.0 [2]
(2S,3R)-2-(Cyclopropylmethylamino)-N-hydroxy-N'-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(3-hydroxyphenyl)methyl]butanediamideIC5012.0 [1], 17.0 [2]
N-[4-[2-(Hydroxyamino)-2-oxoethyl]oxan-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamideKi1900.0 [1]
3-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-pyridin-2-yl-1,3-thiazol-5-yl]propanoic acidIC50230.0 [1]
ADAMTS-5 inhibitorIC501100.0 [1]
1'-Benzyl-5-(4-methoxyphenyl)-5'-methylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-oneIC50640.0 [1]
N-((5-Chloro-8-hydroxyquinolin-7-yl)(2-chlorophenyl)methyl)-2-phenoxyacetamideIC50350.0 [1]
(1R,2S)-1-[[4-(4-Chlorophenyl)phenyl]sulfonyl-[2-(4-methoxycarbonylimidazol-1-yl)ethyl]amino]-2-phenylcyclopropane-1-carboxylic acid;hydrochlorideIC5073.0 [1]
(1S,2R,3R)-1-[[5-(4-Chloropyrazol-1-yl)thiophen-2-yl]sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acidIC507.4 [1]
(1S,2R,3R)-1-[[5-(4-Chlorophenyl)thiophen-2-yl]sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acidIC5021.0 [1]
2-(4-Chlorophenoxy)-N-{[(4r)-4-Methyl-2,5-Dioxoimidazolidin-4-Yl]methyl}acetamideIC50350.0 [1], 620.0 [2]
N-[[(4S)-4-(1-Methylimidazol-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-5-(trifluoromethyl)-1-benzofuran-2-carboxamideIC504.0 [1], 35.0 [2]
5-Chloro-N-[[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC50150.0 [1], 2400.0 [2]
5-Chloro-N-[[(4R)-2,5-dioxo-4-phenylimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC5022.0 [1], 420.0 [2]
5-Chloro-N-[[(4S)-4-(3-methylpyridin-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC5019.0 [1], 1700.0 [2]
5-Chloro-N-[[(4S)-4-(2-methylpyrazol-3-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC5019.0 [1], 530.0 [2]
(2S)-N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-2-methyl-3-[4-(trifluoromethyl)phenyl]propanamideIC5013.0 [1], 140.0 [2]
5-Chloro-N-{[(4r)-2,5-Dioxo-4-(1,3-Thiazol-2-Yl)imidazolidin-4-Yl]methyl}-1-Benzofuran-2-CarboxamideIC5017.0 [1], 330.0 [2]
5-Chloro-N-[[(4S)-4-(1-methylimidazol-2-yl)-2,5-dioxoimidazolidin-4-yl]methyl]-1-benzofuran-2-carboxamideIC509.0 [1], 110.0 [2]
N-[[(4R)-4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamideIC505.0 [1], 52.0 [2]
IlomastatIC50500.0 [1]
MarimastatIC5010000.0 [1]
5-Ethyl-5'-phenyl-3'H-spiro[indole-3,2'-[1,3,4]thiadiazol]-2(1H)-oneIC509600.0 [1]
10-Ethyl-5-(4-methylphenyl)spiro[1,3,4-thiadiazoline-2,3'-indoline]-7-oneIC501900.0 [1]
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic AcidIC5025000.0 [1]
3-(5-(3,4-Bis(benzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acidIC505300.0 [1]
LipofermataIC5013600.0 [1]
1-Benzyl-3-[[2-(4-chlorophenoxy)acetyl]amino]thioureaIC5012600.0 [1]
(2S)-2-[[8-(Methoxycarbonylamino)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acidIC5010.0 [1]
1-Benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-hydroxypiperidine-4-carboxamideIC50420.0 [1]
(2R,5R)-1-[4-[(2,4-Dichlorophenyl)methoxy]phenyl]sulfonyl-N,5-dihydroxy-3,3-dimethylpiperidine-2-carboxamideIC501.4 [1]
N-((5-Chloro-8-hydroxyquinolin-7-yl)(4-nitrophenyl)methyl)-2-phenoxyacetamideIC50460.0 [1]
N-((5-Chloro-8-hydroxyquinolin-7-yl)(4-methoxyphenyl)methyl)-2-phenoxyacetamideIC501000.0 [1]
5'-(4-Methylphenyl)-2-spiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]oneIC503700.0 [1]
N-Hydroxy-2-(4-phenoxy-benzenesulfonylamino)-acetamideIC50330.0 [1]
CID 10160968Ki97.0 [1]
5-(4-(Benzyloxy)-3-methoxybenzylidene)-2-thioxothiazolidin-4-oneIC5022000.0 [1]
4-Thiazolidinone, 2-(2-benzoxazolylmethylene)-, (2E)-IC505400.0 [1]
(2E)-2-(1H-Benzimidazol-2-ylmethylidene)-1,3-thiazolidin-4-oneIC50470.0 [1]
2-(4-Butoxy-benzenesulfonylamino)-N-hydroxy-acetamideIC503400.0 [1]
4-[[5-[2-[(4-Fluorophenyl)methylcarbamoyl]-6-methylpyridin-4-yl]tetrazol-2-yl]methyl]cyclohexane-1-carboxylic acidKi25000.0 [1]
N-((5-Chloro-8-hydroxyquinolin-7-yl)(4-chlorophenyl)methyl)-2-phenoxyacetamideIC50830.0 [1]
1'-Methyl-5-(4-methylphenyl)spiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-oneIC504600.0 [1]
5'-Phenylspiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-oneIC5024200.0 [1]
5-Methyl-5'-(4-methylphenyl)spiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-oneIC503000.0 [1]
L-Valine, N-((8-(2-oxo-3-oxazolidinyl)-3-dibenzofuranyl)sulfonyl)-IC5022600.0 [1]
N-[(2S,4S)-1-[4-[2-(3,5-Dimethyl-1,2-oxazol-4-yl)ethyl]piperidin-1-yl]sulfonyl-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamideIC5023.0 [1]
CID 54585928IC5020.0 [1]
N-Hydroxy-2-[(4-phenylmethoxyphenyl)sulfonylamino]acetamideIC50620.0 [1]
N-[(2R,6S)-4-[2-(Hydroxyamino)-2-oxoethyl]-2,6-dimethylpiperidin-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamideKi1900.0 [1]
(1S,2R)-1-(4'-Chlorobiphenyl-4-sulfonylamino)-2-phenylcyclopropanecarboxylic acidIC5084.0 [1]
(2R)-3-Methyl-2-[[4-[4-[(3-methyl-1-benzofuran-2-yl)methoxy]phenyl]phenyl]sulfonylamino]butanoic acidIC503700.0 [1]
(2R)-2-[[4-[4-[[4-(Cyclohexanecarbonyl)phenoxy]methyl]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acidIC502600.0 [1]
(2R)-3-Methyl-2-[[4-[4-[(5-oxo-7,8-dihydro-6H-naphthalen-2-yl)oxymethyl]phenyl]phenyl]sulfonylamino]butanoic acidIC506600.0 [1]
N-({4'-[(4-Isobutyrylphenoxy)methyl]biphenyl-4-Yl}sulfonyl)-D-ValineIC508400.0 [1]
2-(1,3-Benzothiazol-2-ylmethylidene)-1,3-thiazolidin-4-oneIC501300.0 [1]
(5E)-5-[3-(Benzyloxy)benzylidene]-2-thioxo-1,3-thiazolidin-4-oneIC5020100.0 [1]
N,N-Dimethyl-2-[2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-4-phenyl-1,3-thiazol-5-yl]acetamideIC502200.0 [1]
(2E)-2-[(4-Phenyl-5-propyl-1,3-thiazol-2-yl)methylidene]-1,3-thiazolidin-4-oneIC501400.0 [1]
(2E)-2-[(4-Phenyl-5-propan-2-yl-1,3-thiazol-2-yl)methylidene]-1,3-thiazolidin-4-oneIC50830.0 [1]
(2E)-2-[(5-Ethyl-4-phenyl-1,3-thiazol-2-yl)methylidene]-1,3-thiazolidin-4-oneIC501200.0 [1]
(2E)-2-[(5-Methyl-4-phenyl-1,3-thiazol-2-yl)methylidene]-1,3-thiazolidin-4-oneIC501200.0 [1]
(2E)-2-[(4-Phenyl-1,3-thiazol-2-yl)methylidene]-1,3-thiazolidin-4-oneIC507000.0 [1]
2-[4-(5-Bromopyridin-2-yl)-2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-1,3-thiazol-5-yl]acetic acidIC50840.0 [1]
2-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-pyridin-2-yl-1,3-thiazol-5-yl]acetic acidIC50400.0 [1]
2-[4-(3-Bromothiophen-2-yl)-2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-1,3-thiazol-5-yl]acetic acidIC50470.0 [1]
2-[4-(5-Bromothiophen-2-yl)-2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-1,3-thiazol-5-yl]acetic acidIC503000.0 [1]
2-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-thiophen-2-yl-1,3-thiazol-5-yl]acetic acidIC504000.0 [1]
2-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-(4-phenylphenyl)-1,3-thiazol-5-yl]acetic acidIC50430.0 [1]
2-[4-(4-Methoxyphenyl)-2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-1,3-thiazol-5-yl]acetic acidIC501000.0 [1]
2-[4-(4-Methylphenyl)-2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-1,3-thiazol-5-yl]acetic acidIC50720.0 [1]
2-[4-(4-Chlorophenyl)-2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-1,3-thiazol-5-yl]acetic acidIC506400.0 [1]
2-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-phenyl-1,3-thiazol-5-yl]acetic acidIC501200.0 [1]
4-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-phenyl-1,3-thiazol-5-yl]butanoic acidIC50500.0 [1]
3-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-phenyl-1,3-thiazol-5-yl]propanoic acidIC50420.0 [1]
2-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-phenyl-1,3-thiazol-5-yl]propanoic acidIC50730.0 [1]
2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-phenyl-1,3-thiazole-5-carboxylic acidIC501200.0 [1]
3-[4-(5-Bromopyridin-2-yl)-2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-1,3-thiazol-5-yl]propanoic acidIC50630.0 [1]
3-[4-(3-Bromothiophen-2-yl)-2-[(E)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-1,3-thiazol-5-yl]propanoic acidIC50420.0 [1]
3-[2-[(E)-(4-Oxo-1,3-thiazolidin-2-ylidene)methyl]-4-(4-phenylphenyl)-1,3-thiazol-5-yl]propanoic acidIC50430.0 [1]
(2E)-2-[(6-Methyl-1H-benzimidazol-2-yl)methylidene]-1,3-thiazolidin-4-oneIC502500.0 [1]
(2E)-2-(4H-Indeno[1,2-d][1,3]thiazol-2-ylmethylidene)-1,3-thiazolidin-4-oneIC501700.0 [1]
N-[[(2R)-1-[2-Oxo-6-[(2-thiophen-2-yl-1,3-thiazol-4-yl)methylamino]-1H-1,3,5-triazin-4-yl]pyrrolidin-2-yl]methyl]-4-(trifluoromethyl)benzenesulfonamideIC505300.0 [1]
(2E)-2-(1H-Benzimidazol-2-ylmethylidene)-5-(2-hydroxyethyl)-1,3-thiazolidin-4-oneIC50480.0 [1]
(2E)-2-(1H-Benzimidazol-2-ylmethylidene)-5-methyl-1,3-thiazolidin-4-oneIC50480.0 [1]
(2E)-2-(1H-Benzimidazol-2-ylmethylidene)-5-ethyl-1,3-thiazolidin-4-oneIC50420.0 [1]
(2E)-2-[(4-Methyl-1H-benzimidazol-2-yl)methylidene]-1,3-thiazolidin-4-oneIC502700.0 [1]
(2E)-2-[(5,6-Dimethyl-1H-benzimidazol-2-yl)methylidene]-1,3-thiazolidin-4-oneIC506000.0 [1]
(2E)-2-(1H-Benzimidazol-2-ylmethylidene)-5-propyl-1,3-thiazolidin-4-oneIC50170.0 [1]
(2E)-2-(1H-Benzimidazol-2-ylmethylidene)-5-butyl-1,3-thiazolidin-4-oneIC50410.0 [1]
(2E)-5-Propyl-2-[[6-(trifluoromethyl)-1H-benzimidazol-2-yl]methylidene]-1,3-thiazolidin-4-oneIC504000.0 [1]
(2E)-2-(4H-Thiochromeno[4,3-d][1,3]thiazol-2-ylmethylidene)-1,3-thiazolidin-4-oneIC50500.0 [1]
(2E)-2-[(4-Methyl-1H-benzimidazol-2-yl)methylidene]-5-propyl-1,3-thiazolidin-4-oneIC50500.0 [1]
(2E)-2-[(6-Methyl-1H-benzimidazol-2-yl)methylidene]-5-propyl-1,3-thiazolidin-4-oneIC501300.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ ADAMTS5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/adamts5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ ADAMTS5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/adamts5-inhibitors-ic50-ki.
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