Aldo-keto-reductase family 1 member C3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(E)-3-[3-(3-Methylbut-2-enyl)-4-(3-phenylpropanoyloxy)phenyl]prop-2-enoic acid	IC50	110.0 [1], 20000.0 [2], 30000.0 [3]
	(E)-3-[3-(3-Methylbut-2-enyl)-4-(3-phenylpropanoyloxy)phenyl]prop-2-enoic acid	Ki	105.0 [1]
	Flufenamic acid	IC50	410.0 [1]
	Indomethacin	IC50	100.0 [1], 730.0 [2], 2300.0 [3], 4100.0 [4]
	Indomethacin	Ki	8200.0 [1]
	1-[4-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)phenyl]pyrrolidin-2-one	IC50	24.0 [1], 42.0 [2], 52.0 [3]
	Meclofenamic acid	IC50	512.0 [1], 540.0 [2]
	N-Phenylanthranilic acid	IC50	1500.0 [1], 1520.0 [2]
	4-(Phenylamino)benzoic acid	IC50	2790.0 [1], 2800.0 [2]
	Artepillin C	IC50	1000.0 [1]
	Artepillin C	Ki	680.0 [1]
	3-[(2-Phenylethyl)sulfamoyl]benzoic acid	IC50	218.78 [1], 220.0 [2], 1000.0 [3]
	3-(1,3-Dihydro-isoindole-2-sulfonyl)-benzoic acid	IC50	46.77 [1], 47.0 [2], 884.0 [3]
	4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoic acid	IC50	1000.0 [1], 1230.27 [2], 1240.0 [3]
	3-((4-(Trifluoromethyl)Phenyl)Amino)Benzoic Acid	IC50	60.0 [1], 62.0 [2]
	3-Carboxamido-1,3,5(10)-Estratrien-17(R)-Spiro-2'(5',5'-Dimethyl-6'oxo)tetrahydropyran	IC50	3.2 [1]
	3-Carboxamido-1,3,5(10)-Estratrien-17(R)-Spiro-2'(5',5'-Dimethyl-6'oxo)tetrahydropyran	Ki	6.9 [1]
	3-[(4-Nitrophenyl)amino]benzoic Acid	IC50	30.0 [1], 36.0 [2]
	3-(4-Acetylanilino)benzoic acid	IC50	50.0 [1], 54.0 [2]
	3-((4-Methoxyphenyl)amino)benzoic acid	IC50	490.0 [1]
	3-(3,4-Dihydroisoquinolin-2(1h)-Ylsulfonyl)-N-Methylbenzamide	IC50	13.0 [1], 50.0 [2], 50.12 [3]
	3-(Phenylamino)benzoic acid	IC50	940.0 [1]
	5-Hydroxy-3-[(4-methoxyphenyl)methyl]-N-[3-(trifluoromethyl)phenyl]triazole-4-carboxamide	IC50	310.0 [1], 3560.0 [2]
	1-(4-Bromophenyl)sulfonylindole-3-carboxylic acid	IC50	67.61 [1], 68.0 [2], 407.0 [3]
	3-(3,4-Dihydro-2H-quinoline-1-sulfonyl)-benzoic acid	IC50	199.53 [1], 200.0 [2], 1000.0 [3]
	2-Methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol	IC50	0.34 [1], 1.9 [2], 24.0 [3]
	3-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N,N-dimethylbenzamide	IC50	14.0 [1], 52.48 [2], 53.0 [3]
	3-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	158.49 [1], 160.0 [2], 1000.0 [3]
	3a-Phenyl-3,4-dihydro-2H-pyrrolo[1,2-a]benzimidazol-1-one	IC50	5460.0 [1]
	3a-Phenyl-3,4-dihydro-2H-pyrrolo[1,2-a]benzimidazol-1-one	Ki	2730.0 [1], 32000.0 [2]
	3-(2,3-Dihydro-indole-1-sulfonyl)-benzoic acid	IC50	210.0 [1], 1000.0 [2]
	3-[2-(4-Chlorophenyl)ethylsulfamoyl]benzoic acid	IC50	140.0 [1], 141.25 [2], 1000.0 [3]
	3-[2-(3-Chlorophenyl)ethylsulfamoyl]benzoic acid	IC50	208.93 [1], 210.0 [2], 1000.0 [3]
	3-[(4-Bromophenyl)Amino]Benzoic Acid	IC50	120.0 [1], 130.0 [2]
	3-(4-Tert-butylanilino)benzoic acid	IC50	280.0 [1]
	3-[(4-Methylphenyl)Amino]Benzoic Acid	IC50	700.0 [1]
	3-[(4-Chlorophenyl)Amino]Benzoic Acid	IC50	130.0 [1], 140.0 [2]
	(S)-1-(Naphthalene-2-sulfonyl)-piperidine-3-carboxylic acid	IC50	398.11 [1], 400.0 [2], 1000.0 [3]
	(R)-1-(Naphthalene-2-sulfonyl)-piperidine-3-carboxylic acid	IC50	31.62 [1], 32.0 [2], 1000.0 [3]
	3-[(7-Iodo-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	14.0 [1], 14.13 [2], 45.0 [3]
	3-[(3-Methyl-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	8.51 [1], 8.6 [2], 176.0 [3]
	3-[(5-Bromo-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	10.96 [1], 11.0 [2], 14.0 [3]
	3-[(7-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	19.95 [1], 20.0 [2], 1000.0 [3]
	3-[(5-Hydroxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	15.85 [1], 16.0 [2], 453.0 [3]
	3-[(6-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	21.88 [1], 22.0 [2], 1000.0 [3]
	3-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-(2-pyridin-4-ylethyl)benzamide	IC50	35.0 [1], 57.54 [2], 58.0 [3]
	3-[(5-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	8.9 [1], 8.91 [2], 29.0 [3]
	3-[(5-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	10.96 [1], 11.0 [2], 16.0 [3]
	3-[(5-Iodo-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	14.0 [1], 14.13 [2], 20.0 [3]
	3-[(6-Methyl-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	16.98 [1], 17.0 [2], 52.0 [3]
	3-[(6-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	38.0 [1], 38.02 [2], 390.0 [3]
	3-[(7-Bromo-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	12.0 [1], 12.02 [2], 20.0 [3]
	3-[(1-Methyl-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	24.0 [1], 26.92 [2], 27.0 [3]
	3-[(6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	8.7 [1], 8.71 [2], 39.0 [3]
	3-[(6-Bromo-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	6.03 [1], 6.1 [2], 12.0 [3]
	3-[(7-Nitro-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	16.98 [1], 17.0 [2], 72.0 [3]
	3-[(6-Hydroxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	26.92 [1], 27.0 [2], 1000.0 [3]
	2-[3-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)anilino]-2-oxoacetic acid	IC50	61.66 [1], 62.0 [2], 1000.0 [3]
	3-[(8-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	19.0 [1], 19.05 [2], 28.0 [3]
	3-[(5-Amino-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	52.48 [1], 53.0 [2], 193.0 [3]
	3-[(7-Cyano-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	33.88 [1], 34.0 [2], 266.0 [3]
	3-[(7-Methyl-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	12.88 [1], 13.0 [2], 29.0 [3]
	3-[(7-Fluoro-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	20.89 [1], 21.0 [2], 24.0 [3]
	3-[(5-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	15.85 [1], 16.0 [2], 39.0 [3]
	2-(2,4-Dioxo-1,3-thiazolidin-5-yl)-N-(2-hydroxyphenyl)acetamide	IC50	213.0 [1]
	2-(2,4-Dioxo-1,3-thiazolidin-5-yl)-N-(2-hydroxyphenyl)acetamide	Ki	107.0 [1], 2000.0 [2]
	Ibuprofen	IC50	10000.0 [1], 33000.0 [2]
	Medroxyprogesterone acetate	IC50	280.0 [1], 300.0 [2]
	Naproxen	IC50	480.0 [1], 1100.0 [2]
	Jasmonic acid	Ki	21000.0 [1], 162000.0 [2]
	Mefenamic acid	IC50	560.0 [1]
	Mefenamic acid	Ki	300.0 [1]
	3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acid	IC50	13.0 [1], 27.0 [2]
	1-(4-Chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid	IC50	0.96 [1], 960.0 [2]
	1-{4-[(2-Methylpiperidin-1-yl)sulfonyl]phenyl}pyrrolidin-2-one	IC50	11.0 [1], 94.0 [2]
	[4-(4-Chlorophenyl)piperazin-1-yl](morpholin-4-yl)methanone	IC50	18.0 [1], 110.0 [2]
	3-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]propanoic acid	IC50	0.22 [1], 220.0 [2]
	2-[5-Methoxy-2-methyl-1-(4-methylbenzoyl)indol-3-yl]acetic acid	IC50	0.16 [1], 160.0 [2]
	9-(4-Chlorobenzoyl)-6-methoxy-1,2,3,4-tetrahydrocarbazole-3-carboxylic acid	IC50	0.16 [1], 160.0 [2]
	1-Naphthalen-2-ylsulfonylpyrrolidine-3-carboxylic acid	IC50	380.0 [1], 380.19 [2]
	3-(Naphthalen-2-ylsulfamoyl)benzoic acid	IC50	600.0 [1], 602.56 [2]
	3-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)benzamide	IC50	169.82 [1], 170.0 [2]
	3-[2-(4-Methoxyphenyl)ethylsulfamoyl]benzoic acid	IC50	1440.0 [1], 1445.44 [2]
	3-[2-(2-Fluorophenyl)ethylsulfamoyl]benzoic acid	IC50	330.0 [1], 331.13 [2]
	1-[3-(2-Chlorophenyl)phenyl]sulfonylpiperidine-3-carboxylic acid	IC50	740.0 [1], 741.31 [2]
	1-[4-(3-Phenylphenyl)phenyl]sulfonylpiperidine-3-carboxylic acid	IC50	24400.0 [1], 24547.09 [2]
	1-Anthracen-2-ylsulfonylpiperidine-3-carboxylic acid	IC50	389.05 [1], 390.0 [2]
	3-[2-(4-Methylphenyl)ethylsulfamoyl]benzoic acid	IC50	640.0 [1], 645.65 [2]
	3-[(6-Iodo-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	38.9 [1], 39.0 [2]
	3-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)-N-[2-(dimethylamino)ethyl]benzamide	IC50	891.25 [1], 900.0 [2]
	5-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)pyridine-3-carboxylic acid	IC50	41.69 [1], 42.0 [2]
	3-[(6-Cyano-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	28.84 [1], 29.0 [2]
	1-[4-(2-Chlorophenyl)phenyl]sulfonylpiperidine-3-carboxylic acid	IC50	549.54 [1], 550.0 [2]
	3-[(7-Methoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	28.84 [1], 29.0 [2]
	3-[2-(3-Methylphenyl)ethylsulfamoyl]benzoic acid	IC50	218.78 [1], 220.0 [2]
	3-[(7-Ethynyl-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]benzoic acid	IC50	41.69 [1], 42.0 [2]
	[3-(3,4-Dihydro-1H-isoquinolin-2-ylsulfonyl)phenyl]-(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone	IC50	346.74 [1], 350.0 [2]
	3-[2-(3-Phenoxyphenyl)ethylsulfamoyl]benzoic acid	IC50	524.81 [1], 530.0 [2]
	1-Naphthalen-2-ylsulfonylpyrazole-3-carboxylic acid	IC50	500.0 [1], 501.19 [2]
	3-[2-(3-Methoxyphenyl)ethylsulfamoyl]benzoic acid	IC50	740.0 [1], 741.31 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Aldo-keto-reductase family 1 member C3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/aldo-keto-reductase-family-1-member-c3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Aldo-keto-reductase family 1 member C3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/aldo-keto-reductase-family-1-member-c3-inhibitors-ic50-ki.
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