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Aldose reductase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SorbinilIC50700.0 [1]
ZopolrestatIC504.8 [1]
ZopolrestatKi19.0 [1]
TolrestatIC5023.9 [1]
FidarestatIC509.0 [1]
EpalrestatIC5085.0 [1]
QuercetinIC5014.8 [1], 2200.0 [2], 2850.0 [3], 2900.0 [4]
AlrestatinIC506500.0 [1], 22000.0 [2], 34000.0 [3], 79000.0 [4], 140000.0 [5]
3-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acidIC504500.0 [1], 5000.0 [2], 7200.0 [3], 7300.0 [4], 19000.0 [5]
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(4,5,6-trihydroxy-2-methyloxan-3-yl)oxychromen-4-oneIC507100.0 [1], 9000.0 [2], 14000.0 [3], 16000.0 [4]
3-[2-Ethoxy(oxo)acetamido]-2-hydroxy-5-nitrobenzoic acidIC503200.0 [1], 4000.0 [2], 4500.0 [3], 7300.0 [4], 8300.0 [5]
4H-1-Benzopyran-4-one, 3-chloro-2-(1H-tetrazol-5-yl)-IC504100.0 [1], 38000.0 [2], 39000.0 [3], 200000.0 [4], 280000.0 [5]
7-Hydroxy-4-oxo-4a,8a-dihydrochromene-2-carboxylic acidIC501800.0 [1], 3100.0 [2], 3900.0 [3], 4700.0 [4], 5900.0 [5]
MinalrestatIC5012.2 [1], 25.0 [2], 70.0 [3], 73.0 [4]
6-[(5-Chloro-3-methyl-1-benzofuran-2-YL)sulfonyl]pyridazin-3(2H)-oneIC500.84 [1], 1.0 [2]
(6,7-Dichloro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acidIC5050.9 [1], 140.0 [2], 156.0 [3], 5620.0 [4]
PonalrestatIC5021.0 [1], 56.5 [2], 66.5 [3]
ZenarestatIC508.0 [1], 42.4 [2], 44.0 [3]
LidorestatIC505.0 [1], 27000.0 [2]
6-(1-Benzofuran-2-sulfonyl)-2,3-dihydropyridazin-3-oneIC5025.0 [1], 150.0 [2]
2-(2,4-Dioxo-5-(4-phenoxybenzylidene)thiazolidin-3-yl)acetic acidIC500.17 [1], 130.0 [2], 820.0 [3]
7-Chloro-6-fluoro-4-hydroxy-2-methylchroman-4-acetic acidIC5012.0 [1], 49.3 [2], 60.0 [3]
LuteolinIC50600.0 [1], 3200.0 [2]
Chlorogenic acidIC50300.0 [1], 1800.0 [2]
EmodinIC502690.0 [1]
EmodinKi2113.0 [1]
Flufenamic acidIC5041000.0 [1], 100000.0 [2]
ChrysinIC507780.0 [1], 8500.0 [2]
4-Hydroxycinnamic acidIC50140.0 [1], 76000.0 [2]
QuercitrinIC50150.0 [1], 2000.0 [2]
7-MethoxycoumarinIC5067500.0 [1], 131000.0 [2]
(2R,4S)-2-Aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dioneIC50570.0 [1]
5-(4-Hydroxybenzylidene)thiazolidine-2,4-dioneIC5020.2 [1], 8960.0 [2]
Idd594IC5030.0 [1]
3-((4-(Trifluoromethyl)Phenyl)Amino)Benzoic AcidIC5050000.0 [1]
(2Z)-7-Hydroxy-2-[(4-methoxyphenyl)imino]-N-(pyridin-2-yl)-2H-chromene-3-carboxamideIC5011.0 [1]
3-[(4-Nitrophenyl)amino]benzoic AcidIC5050000.0 [1]
6-(2,4-Dichloro-benzenesulfonyl)-2H-pyridazin-3-oneIC50190.0 [1]
3-(2-Phenylphenyl)sulfonyl-1H-pyridazin-6-oneIC502200.0 [1]
6-(Benzothiazole-2-sulfonyl)-2H-pyridazin-3-oneIC50450.0 [1]
3-[(5-Chloro-1-benzofuran-2-yl)sulfonyl]-1H-pyridazin-6-oneIC5025.0 [1]
3-(4-Acetylanilino)benzoic acidIC5038600.0 [1]
3-[(5,7-Dichloro-1-benzofuran-2-yl)sulfonyl]-1H-pyridazin-6-oneIC5087.0 [1]
3-[(5-Methoxy-1-benzofuran-2-yl)sulfonyl]-1H-pyridazin-6-oneIC50230.0 [1]
6-(Benzenesulfonyl)-2,3-dihydropyridazin-3-oneIC50600.0 [1]
6-(1-Benzothiophene-2-sulfonyl)-2,3-dihydropyridazin-3-oneIC50150.0 [1], 180.0 [2]
N-Benzyl-7-hydroxy-2-(4-methoxyphenyl)iminochromene-3-carboxamideIC5024.0 [1]
3-[(2-Benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acidIC5019.0 [1]
3-[(6-Trifluoromethyl-2-benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acidIC503.1 [1], 70.0 [2]
2-[3-(1-Benzothiophen-2-ylmethyl)-4-oxophthalazin-1-yl]acetic acidIC50120.0 [1]
2-[3-[(5-Fluoro-1-benzothiophen-2-yl)methyl]-4-oxophthalazin-1-yl]acetic acidIC50150.0 [1]
6-Tosylpyridazin-3(2H)-oneIC501900.0 [1]
3-[(4-Bromophenyl)Amino]Benzoic AcidIC5050000.0 [1]
3-(4-Tert-butylanilino)benzoic acidIC5050000.0 [1]
(5Z)-5-(Naphthalen-1-ylmethylidene)-1,3-thiazolidine-2,4-dioneIC508.96 [1], 10700.0 [2]
3-(2-Chloro-4-fluorophenyl)sulfonyl-1H-pyridazin-6-oneIC50280.0 [1]
6-(1H-Indole-2-sulfonyl)-2,3-dihydropyridazin-3-oneIC50590.0 [1], 5000.0 [2]
3-(2-Bromophenyl)sulfonyl-1H-pyridazin-6-oneIC50210.0 [1]
6-[(4-Methoxyphenyl)sulfonyl]pyridazin-3(2H)-oneIC502000.0 [1]
3-(2-Chlorophenyl)sulfonyl-1H-pyridazin-6-oneIC50170.0 [1]
3-[(5-Chloro-1H-indol-2-yl)sulfonyl]-1H-pyridazin-6-oneIC501100.0 [1]
6-(4-Bromo-2-fluoro-benzenesulfonyl)-2H-pyridazin-3-oneIC50140.0 [1]
2-(2,4-Dioxo-5-(3-phenoxybenzylidene)thiazolidin-3-yl)acetic acidIC5010.7 [1], 130.0 [2]
2-(2-(Ethoxycarbonyl)-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acidIC5083.5 [1]
2-(2-(Ethoxycarbonyl)-8-methoxy-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acidKi66.1 [1]
5-(3-Phenoxybenzylidene)thiazolidine-2,4-dioneIC500.28 [1], 6140.0 [2]
(6-Fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acidIC50200.0 [1], 310.0 [2]
(6,7-Difluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acidIC50250.0 [1], 350.0 [2]
(7-Bromo-6-chloro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acidIC5050.0 [1], 70.0 [2]
(7-Bromo-6-fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acidIC5090.0 [1], 120.0 [2]
(6-Chloro-7-fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic acidIC50390.0 [1], 410.0 [2]
2-(5-(4-(Benzyloxy)benzylidene)-2,4-dioxothiazolidin-3-yl)acetic acidIC5010.7 [1], 280.0 [2]
IndomethacinIC506000.0 [1]
DiclofenacIC50100000.0 [1]
Salicylic acidIC501000000.0 [1]
GenisteinIC5020000.0 [1]
CoumarinIC50500000.0 [1]
Oleanolic acidIC50124000.0 [1]
KetoprofenIC50180000.0 [1]
ApigeninIC5011900.0 [1]
DaidzeinIC50161800.0 [1]
KaempferolIC5010000.0 [1]
EnoxoloneIC50280000.0 [1]
NaringeninIC5028870.0 [1]
Ursolic acidIC5041000.0 [1]
Ellagic acidIC50200.0 [1]
Caffeic acidIC5032000.0 [1]
GossypolKi500.0 [1]
4-MethylumbelliferoneIC5024500.0 [1]
Mefenamic acidIC5077000.0 [1]
SulindacIC50374.0 [1]
MyricetinIC5029000.0 [1]
Phenylacetic acidIC5096000.0 [1]
Betulinic acidIC5011000.0 [1]
TolmetinIC502390.0 [1]
Tanshinone IIAIC508690.0 [1]
GlyceraldehydeIC5010.0 [1]
Isolithocholic acidIC506900.0 [1]
Rosmarinic acidIC503910.0 [1]
UmbelliferoneIC5022900.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Aldose reductase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/aldose-reductase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Aldose reductase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/aldose-reductase-inhibitors-ic50-ki.
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