Alkaline phosphatase, tissue-nonspecific isozyme Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2,5-Dimethoxy-N-(3-quinolinyl)benzenesulfonamide	IC50	230.0 [1]
	2,5-Dimethoxy-N-(3-quinolinyl)benzenesulfonamide	Ki	340.0 [1], 590.0 [2]
	Levamisole	IC50	5000.0 [1], 19200.0 [2], 20200.0 [3], 20210.0 [4]
	Levamisole	Ki	16000.0 [1]
	Phenylalanine	IC50	5000.0 [1], 100100.0 [2], 200000.0 [3]
	Theophylline	IC50	5000.0 [1], 100000.0 [2]
	Theophylline	Ki	82000.0 [1]
	5-Bromo-2-methoxy-N-(quinolin-3-yl)benzenesulfonamide	IC50	6.0 [1], 120.0 [2], 20000.0 [3]
	Levamisole hydrochloride	Ki	16000.0 [1], 93000.0 [2]
	3-Pyridinecarboxamide, 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-	IC50	16.0 [1], 105.0 [2]
	5-[(5-Chloro-2-methoxyphenyl)sulfonylamino]pyridine-3-carboxylic acid	IC50	134.0 [1], 20000.0 [2]
	[(5-Chloro-2-methoxyphenyl)sulfonyl]-3-pyridylamine	IC50	84.0 [1], 795.0 [2]
	5-Chloro-2-methoxy-N-quinolin-3-ylbenzenesulfonamide	IC50	6.0 [1], 4510.0 [2]
	[(2-Methoxy-4-methylphenyl)sulfonyl]-3-pyridylamine	IC50	896.0 [1], 3550.0 [2]
	5-[[5-Chloro-2-(trifluoromethoxy)phenyl]sulfonylamino]pyridine-3-carboxamide	IC50	432.0 [1], 18700.0 [2]
	2-Methoxy-5-phenyl-N-pyridin-3-ylbenzenesulfonamide	IC50	876.0 [1], 20000.0 [2]
	5-Bromo-2-methoxy-N-pyridin-3-ylbenzenesulfonamide	IC50	43.0 [1], 543.0 [2]
	5-Chloro-2-methoxy-N-(5-pyridin-4-ylpyridin-3-yl)benzenesulfonamide	IC50	73.0 [1], 20000.0 [2]
	Methyl 5-[(5-chloro-2-methoxyphenyl)sulfonylamino]pyridine-3-carboxylate	IC50	65.0 [1], 20000.0 [2]
	2-Methoxy-N-quinolin-3-yl-5-(trifluoromethyl)benzenesulfonamide	IC50	26.0 [1], 20000.0 [2]
	3-Pyridinecarboxamide, 5-[[(5-fluoro-2-methoxyphenyl)sulfonyl]amino]-	IC50	19.0 [1], 109.0 [2]
	3-Pyridinecarboxamide, 5-[[(5-bromo-2-methoxyphenyl)sulfonyl]amino]-	IC50	14.0 [1], 121.0 [2]
	5-[(5-Chloro-2-methoxyphenyl)sulfonylamino]-N-methylpyridine-3-carboxamide	IC50	109.0 [1], 20000.0 [2]
	5-[(5-Chloro-2-methoxyphenyl)sulfonylamino]-N-ethylpyridine-3-carboxamide	IC50	193.0 [1], 20000.0 [2]
	5-Chloro-2-methoxy-N-[5-(4-methoxyphenyl)pyridin-3-yl]benzenesulfonamide	IC50	23.0 [1], 16000.0 [2]
	5-[[2-Methoxy-5-(trifluoromethoxy)phenyl]sulfonylamino]pyridine-3-carboxamide	IC50	131.0 [1], 1560.0 [2]
	2-Methoxy-N-pyridin-3-yl-5-(trifluoromethyl)benzenesulfonamide	IC50	183.0 [1], 3010.0 [2]
	2,5-Dimethoxy-N-(5-pyridin-4-ylpyridin-3-yl)benzenesulfonamide	IC50	73.0 [1], 20000.0 [2]
	Tryptophan	IC50	5000.0 [1]
	Leucine	IC50	5000.0 [1]
	L-Homoarginine	IC50	5000.0 [1]
	(S)-2-Amino-4-methylpentanamide	IC50	5000.0 [1]
	1-(3,4-Dihydroxyphenyl)-2-{[1-(4-methoxyphenyl)-1H-tetrazol-5-yl]thio}ethanone	IC50	8000.0 [1]
	2-{[2-(3,4-Dihydroxyphenyl)-2-oxoethyl]thio}-4-(methoxymethyl)-6-methylnicotinonitrile	IC50	4800.0 [1]
	1-(3,4-Dihydroxyphenyl)-2-(1-imidazolyl)ethanone	IC50	100000.0 [1]
	Methyl 5-(2,4-dichlorophenyl)pyrazole-3-carboxylate	IC50	500.0 [1]
	1-(3,4-Dihydroxyphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]ethanone	IC50	8600.0 [1]
	1,4-Dihydrochromeno[4,3-c]pyrazole-3-carboxylic acid	IC50	1300.0 [1]
	CID 24790972	IC50	100000.0 [1]
	N-Benzyl-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide	IC50	100000.0 [1]
	CID 24790974	IC50	100000.0 [1]
	CID 24790980	IC50	100000.0 [1]
	CID 24790981	IC50	100000.0 [1]
	N-(3,4-Dimethylphenyl)-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide	IC50	100000.0 [1]
	N-[(4-Fluorophenyl)methyl]-3-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]propanamide	IC50	100000.0 [1]
	3-[2-(3,4-Dihydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one	IC50	29200.0 [1]
	1H-Pyrazole, 3,5-dimethyl-1-(4-pyridinylcarbonyl)-	IC50	6510.0 [1]
	2-Methoxy-5-methyl-N-pyridin-3-yl-benzenesulfonamide	IC50	1850.0 [1]
	5-(2-Chlorophenyl)-1H-pyrazole-3-carboxylic acid	IC50	980.0 [1]
	1-(4-Chlorobenzoyl)-3,5-dimethyl-1H-pyrazole	IC50	5710.0 [1]
	2,5-Dimethoxy-N-3-pyridinylbenzenesulfonamide	IC50	1060.0 [1]
	N-(2,5-Dimethylphenyl)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)sulfonylamino]acetamide	IC50	35000.0 [1]
	2-Ethoxy-5-methyl-N-pyridin-3-ylbenzenesulfonamide	IC50	1130.0 [1]
	4-Methyl-7,8-bis[(methylsulfonyl)oxy]-2H-1-benzopyran-2-one	IC50	2160.0 [1]
	4-Bromo-2,5-dimethoxy-N-(pyridin-3-yl)benzenesulfonamide	IC50	1550.0 [1]
	(4-Chloro-3,5-dimethyl-1H-pyrazol-1-yl)(4-chlorophenyl)methanone	IC50	910.0 [1]
	4-Chloro-3,5-dimethylpyrazolyl 4-pyridyl ketone	IC50	42000.0 [1]
	Methanone, (4-aminophenyl)(3,5-dimethyl-1H-pyrazol-1-yl)-	IC50	3580.0 [1]
	(E)-1-(4-Chloro-3,5-dimethylpyrazol-1-yl)-3-phenylprop-2-en-1-one	IC50	13300.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) 4-chloro-3-nitrobenzenesulfonate	IC50	1420.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) ethanesulfonate	IC50	9370.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) 4-nitrobenzenesulfonate	IC50	1330.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) butane-1-sulfonate	IC50	850.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) 4-chlorobenzenesulfonate	IC50	2520.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) 4-propylbenzenesulfonate	IC50	17600.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) methanesulfonate	IC50	2510.0 [1]
	[8-(4-Methoxyphenyl)sulfonyloxy-4-methyl-2-oxochromen-7-yl] 4-methoxybenzenesulfonate	IC50	2590.0 [1]
	(4-Methyl-8-nitro-2-oxochromen-7-yl) 4-chloro-3-nitrobenzenesulfonate	IC50	7710.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) 3-nitrobenzenesulfonate	IC50	2420.0 [1]
	[8-(2,5-Dichlorophenyl)sulfonyloxy-4-methyl-2-oxochromen-7-yl] 2,5-dichlorobenzenesulfonate	IC50	1330.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) benzenesulfonate	IC50	3530.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) octane-1-sulfonate	IC50	920.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) butane-1-sulfonate	IC50	1640.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) 4-propylbenzenesulfonate	IC50	9230.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) 2,5-dichlorobenzenesulfonate	IC50	2470.0 [1]
	(4-Methyl-8-nitro-2-oxochromen-7-yl) 4-octylbenzenesulfonate	IC50	2540.0 [1]
	[4-Methyl-8-(4-nitrophenyl)sulfonyloxy-2-oxochromen-7-yl] 4-nitrobenzenesulfonate	IC50	1170.0 [1]
	(8-Ethylsulfonyloxy-4-methyl-2-oxochromen-7-yl) ethanesulfonate	IC50	1940.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) 2-nitrobenzenesulfonate	IC50	1070.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) 2-nitrobenzenesulfonate	IC50	1250.0 [1]
	(4-Methyl-8-octylsulfonyloxy-2-oxochromen-7-yl) octane-1-sulfonate	IC50	920.0 [1]
	[8-(4-Chlorophenyl)sulfonyloxy-4-methyl-2-oxochromen-7-yl] 4-chlorobenzenesulfonate	IC50	3690.0 [1]
	(4-Methyl-2-oxochromen-7-yl) 4-chloro-3-nitrobenzenesulfonate	IC50	2310.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) 2,5-dichlorobenzenesulfonate	IC50	1830.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) 4-methoxybenzenesulfonate	IC50	580.0 [1]
	(4-Methyl-2-oxochromen-7-yl) 2,4,5-trichlorobenzenesulfonate	IC50	8370.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) 4-methoxybenzenesulfonate	IC50	9010.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) octane-1-sulfonate	IC50	2560.0 [1]
	(3-Chloro-4-methyl-2-oxochromen-7-yl) 4-chlorobenzenesulfonate	IC50	6380.0 [1]
	(3-Cyano-4-methyl-2-oxochromen-7-yl) methanesulfonate	IC50	1990.0 [1]
	(4-Chloro-3,5-dimethylpyrazol-1-yl)-(4-methylphenyl)methanone	IC50	17700.0 [1]
	2-(3,4-Dimethylphenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one	IC50	540.0 [1]
	(3Z)-3-[(2-Methylphenyl)methylidene]-1,1-dioxo-1lambda6,2-benzothiazin-4-one	IC50	2360.0 [1]
	2-(Prop-2-enylamino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one	IC50	290.0 [1]
	2-(Butylamino)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one	IC50	880.0 [1]
	(3Z)-3-[(3-Fluorophenyl)methylidene]-1,1-dioxo-1lambda6,2-benzothiazin-4-one	IC50	3190.0 [1]
	2-[Amino(methyl)amino]-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one	IC50	2020.0 [1]
	(3Z)-3-[(4-Chlorophenyl)methylidene]-1,1-dioxo-1lambda6,2-benzothiazin-4-one	IC50	250.0 [1]
	2-(3-Fluorophenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one	IC50	1390.0 [1]
	2-(3-Nitrophenyl)-7-(trifluoromethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one	IC50	620.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Alkaline phosphatase, tissue-nonspecific isozyme Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/alkaline-phosphatase-tissue-nonspecific-isozyme-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Alkaline phosphatase, tissue-nonspecific isozyme Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/alkaline-phosphatase-tissue-nonspecific-isozyme-inhibitors-ic50-ki.
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