 | (2-(2',6'-Dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane | IC50 | 1.0 [1] |
 | Tamsulosin | IC50 | 2.2 [1] |
 | Methyl 5-[3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | Ki | 1.3 [1] |
 | Risperidone | IC50 | 10.0 [1], 10.9 [2] |
| Risperidone | Ki | 2.3 [1], 2.8 [2], 10.0 [3] |
 | Aripiprazole | IC50 | 170.0 [1] |
| Aripiprazole | Ki | 26.0 [1], 100.0 [2] |
 | Doxazosin | Ki | 0.54 [1], 0.78 [2], 2.6 [3], 3.16 [4] |
 | Naftopidil | IC50 | 555.0 [1] |
| Naftopidil | Ki | 3.7 [1], 3.71 [2], 5.88 [3] |
 | 3-[1-[4-(5-Chloro-1,1,3-trioxo-1,2-benzothiazol-2-yl)butyl]piperidin-4-yl]-1,3-benzoxazol-2-one | Ki | 0.08 [1], 0.17 [2], 0.24 [3], 74.0 [4], 90.0 [5] |
 | Silodosin | IC50 | 1.8 [1], 1.9 [2] |
| Silodosin | Ki | 0.04 [1] |
 | Cyclazosin | Ki | 5.5 [1], 12.3 [2], 25.12 [3] |
 | 3-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione | Ki | 0.27 [1], 0.29 [2], 3.72e+18 [3] |
 | (4S,5S)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-5-methyl-2-oxo-1,3-oxazolidine-3-carboxamide | Ki | 0.17 [1], 0.23 [2] |
 | 8-[(2R)-1-[4-(2,4,5-Trifluorophenyl)piperazin-1-yl]propan-2-yl]-8-azaspiro[4.5]decane-7,9-dione | Ki | 290.0 [1], 294.0 [2], 14000.0 [3], 14900.0 [4] |
 | 5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-3-N,2,6-trimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide | Ki | 3.1 [1], 3.16 [2], 4.47 [3] |
 | 5-N-[3-(4,4-Diphenylpiperidin-1-yl)propyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide | Ki | 1.3 [1], 1.86 [2], 1.87 [3] |
 | N-((1r,4r)-4-(4-(2-Cyclopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide | Ki | 0.91 [1], 11.0 [2] |
 | N-((1r,4r)-4-(4-(2-Isopropoxyphenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide | Ki | 1.8 [1], 2.2 [2], 28.0 [3] |
 | 3,4-Dimethoxy-N-[4-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]benzenesulfonamide | Ki | 1.8 [1], 21.0 [2] |
 | N-((1r,4r)-4-(4-(2-(2-Fluoroethoxy)phenyl)piperidin-1-yl)cyclohexyl)-3,4-dimethoxybenzenesulfonamide | Ki | 8.5 [1], 11.0 [2], 69.0 [3] |
 | N-[4-[4-[2-(2,2-Difluoroethoxy)phenyl]piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide | Ki | 12.0 [1], 31.0 [2] |
 | 3,4-Dimethoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide | Ki | 1.6 [1], 2.0 [2], 23.0 [3] |
 | Clozapine | Ki | 10.0 [1], 19.0 [2] |
 | Olanzapine | Ki | 60.0 [1], 1000.0 [2] |
 | Phentolamine | Ki | 0.6 [1], 4.12 [2], 12.0 [3] |
 | Azelastine | Ki | 50.12 [1] |
 | 8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride | Ki | 42.66 [1], 251.19 [2], 380.19 [3] |
 | Niguldipine | Ki | 0.16 [1], 1.8 [2] |
 | Upidosin | Ki | 0.34 [1], 1.0 [2] |
 | 7-Chloro-2-ethenyl-3,4,5,6-tetrahydro-4-methylthieno(4,3,2-ef)(3)benzazepine | Ki | 25.12 [1], 36.0 [2] |
 | Benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate | IC50 | 590.0 [1] |
| Benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate | Ki | 420.0 [1] |
 | CID 9872515 | Ki | 1.0 [1], 1.26 [2], 1.3 [3] |
 | 2-[[(2R)-1-[4-[4-[3-(Azepan-1-yl)propoxy]phenyl]butyl]pyrrolidin-2-yl]methyl]-4-[(4-chlorophenyl)methyl]phthalazin-1-one | Ki | 39.81 [1] |
 | N-[[(3S)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride | Ki | 0.41 [1] |
 | N,N-Dimethyl-1-(3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7,9,11,14,16-hexaen-4-yl)methanamine | IC50 | 537.03 [1] |
 | Methyl 4-(3,4-difluorophenyl)-3-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate | Ki | 0.1 [1], 1.0 [2] |
 | 5-N-[4-(4,4-Diphenylpiperidin-1-yl)butyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide | Ki | 1.86 [1], 1.87 [2], 1.9 [3] |
 | Methyl 5-[4-(4,4-diphenylpiperidin-1-yl)butylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | Ki | 5.89 [1], 14.79 [2] |
 | Methyl 5-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | Ki | 3.55 [1], 3.58 [2], 3.6 [3] |
 | 1-(1,4-Dioxaspiro[4.5]decan-3-ylmethyl)-4-(2-methoxyphenyl)piperazine | Ki | 91.2 [1] |
 | N-[(2,2-Diphenyl-1,3-dioxolan-4-yl)methyl]-2-phenoxyethanamine;oxalic acid | Ki | 37.15 [1] |
 | Methyl 1-[3-[[5-carbamoyl-6-ethyl-4-(4-nitrophenyl)-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate | Ki | 0.19 [1], 0.5 [2], 1.9 [3] |
 | Clonidine | Ki | 512.86 [1], 977.24 [2] |
 | Quetiapine | Ki | 20.0 [1], 100.0 [2] |
 | Corynanthine | Ki | 29.0 [1], 142.0 [2] |
 | Mianserin | IC50 | 407.38 [1] |
 | Cyclohexanecarboxamide, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl- | Ki | 18.62 [1], 20.0 [2] |
 | Alfuzosin | Ki | 8.2 [1], 10.0 [2] |
 | Rilmenidine | Ki | 6025.6 [1], 8912.51 [2] |
 | 1-(2-Methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine | Ki | 0.26 [1], 2.0 [2] |
 | Indoramin | Ki | 3.7 [1], 3.98 [2] |
 | 5-Methylurapidil | Ki | 0.63 [1], 2.3 [2] |
 | Dexniguldipine | Ki | 0.16 [1], 4.7 [2] |
 | 1-(5-Chloro-1H-indol-3-yl)-N-[2-[2-(cyclopropylmethoxy)phenoxy]ethyl]-2-methylpropan-2-amine | Ki | 0.6 [1], 0.63 [2] |
 | 5-Methyl-3-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl]propyl]-1H-pyrimidine-2,4-dione | Ki | 0.25 [1] |
 | N,N-Diallyl-5-methoxytryptamine | Ki | 10000.0 [1] |
 | Methyl (4R)-5-[3-(4,4-diphenylpiperidin-1-yl)propylcarbamoyl]-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | Ki | 0.18 [1] |
 | 5-[2-[(3Ar,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-thia-3,5,13-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),10,12-tetraene-4,6-dione | Ki | 0.22 [1] |
 | 2-(2-Biphenylyloxymethyl)-2-imidazoline | IC50 | 27.54 [1], 66.07 [2] |
 | 3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-5-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione | Ki | 2.6 [1], 2.63 [2] |
 | N-[2-(2,6-Dimethoxyphenoxy)ethyl]-2-(2-phenylmethoxyphenoxy)ethanamine | Ki | 0.47 [1] |
 | 2-Bromo-7-chloro-11-methyl-3-oxa-11-azatricyclo[6.4.1.04,13]trideca-1,4(13),5,7-tetraene | Ki | 3300.0 [1] |
 | 2-(2-Oxopiperidin-1-yl)-N-[3-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]propyl]acetamide | Ki | 0.65 [1], 0.66 [2] |
 | 3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-5-(3-methylphenyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione | Ki | 4.17 [1], 4.2 [2] |
 | 2,9-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-3,10-diol | Ki | 616.0 [1], 630.0 [2] |
 | 2-(2,6-Dimethoxyphenoxy)-N-[[(2R)-6,6-diphenyl-1,4-dioxan-2-yl]methyl]ethanamine | Ki | 165.96 [1], 338.84 [2] |
 | N-[[(2R)-6,6-Diphenyl-1,4-dioxan-2-yl]methyl]-2-(2-methoxyphenoxy)ethanamine | Ki | 16.6 [1], 27.54 [2] |
 | N-[[(2R)-6,6-Diphenyl-1,4-dioxan-2-yl]methyl]-2-phenoxyethanamine | Ki | 128.82 [1], 169.82 [2] |
 | (4S)-2-(2-Aminoethoxymethyl)-3-N-[3-(4,4-diphenylpiperidin-1-yl)propyl]-6-ethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxamide | Ki | 0.4 [1], 0.65 [2] |
 | N-[[(3R)-2,3-Dihydro-1,4-benzodioxin-3-yl]methyl]-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride | Ki | 11.22 [1] |
 | JTH-601 free base | Ki | 0.4 [1] |
 | Unii-M7ias8PR23 | Ki | 8.7 [1], 9.3 [2] |
 | 2-(2-Oxoazepan-1-yl)-N-[2-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]ethyl]acetamide | Ki | 18.0 [1], 22.0 [2] |
 | 3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione | Ki | 3.31 [1] |
 | Methyl 1-[3-[[2,6-dimethyl-5-(methylcarbamoyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate | Ki | 3.98 [1], 607.0 [2] |
 | (4R)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-6-(methoxymethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide | Ki | 0.24 [1] |
 | Methyl 1-[3-[[5-carbamoyl-4-(2,4-difluorophenyl)-6-ethyl-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate | Ki | 0.2 [1] |
 | 1-(17-Chloro-3-oxa-2-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),7,9,11,15,17-hexaen-4-yl)-N,N-dimethylmethanamine | IC50 | 14.45 [1] |
 | (4R)-4-(3,4-Difluorophenyl)-6-(methoxymethyl)-2-oxo-N-[3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-3,4-dihydro-1H-pyrimidine-5-carboxamide | Ki | 0.45 [1] |
 | (4R)-N-[3-[4-(2-Cyanophenyl)piperidin-1-yl]propyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide | Ki | 0.13 [1] |
 | (4R)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-1,3,6-trimethyl-2-oxo-4H-pyrimidine-5-carboxamide | Ki | 0.14 [1], 0.18 [2] |
 | (4R)-4-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide | Ki | 0.17 [1] |
 | Methyl (4R)-4-(3,4-difluorophenyl)-5-[3-[4-(4-fluorophenyl)piperidin-1-yl]propylcarbamoyl]-1,6-dimethyl-2-oxo-4H-pyrimidine-3-carboxylate | Ki | 0.75 [1] |
 | Methyl 4-(3,4-difluorophenyl)-3-[5-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)pentyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate | Ki | 0.1 [1] |
 | (4R)-N-[3-[4-(2-Cyano-4-fluorophenyl)piperidin-1-yl]propyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide | Ki | 0.07 [1] |
 | (4R)-3-Acetyl-4-(3,4-difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-1,6-dimethyl-2-oxo-4H-pyrimidine-5-carboxamide | Ki | 2.2 [1] |
 | Methyl 1-[3-[[5-carbamoyl-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate | Ki | 0.84 [1], 2.4 [2] |
 | 3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-5H-pyrimido[5,4-b]indol-4-one | Ki | 3.02 [1], 3.31e+17 [2] |
 | 4-[(4-Chlorophenyl)methyl]-2-[[(2R)-1-methylpyrrolidin-2-yl]methyl]phthalazin-1-one | Ki | 25.12 [1], 31.62 [2] |
 | 5-Chloro-2-methoxy-N-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide | Ki | 1.0 [1], 3.8 [2] |
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