Amiloride-sensitive sodium channel alpha-subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Amiloride	IC50	776.0 [1]
	Benzamil	IC50	66.0 [1]
	Phenamil	IC50	401.0 [1]
	552-02 Free base	IC50	8.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[4-(3-hydroxypropoxy)phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	7.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[4-[(2R)-2,3-dihydroxypropoxy]phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	9.0 [1]
	1-(4-(4-Aminophenyl)butyl)-3-(3,5-diamino-2-chloropyrazine-6-carbonyl)guanidine	IC50	21.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[4-(hydroxymethyl)phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	14.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[4-(2-hydroxyethoxy)phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	9.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-(3,4-dihydroxyphenyl)butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	42.0 [1]
	1-(3,5-Diamino-2-chloropyrazine-6-carbonyl)-3-(5-(4-hydroxyphenyl)pentyl)guanidine	IC50	64.0 [1]
	3,5-Diamino-6-chloro-N-[N'-(6-phenylhexyl)carbamimidoyl]pyrazine-2-carboxamide	IC50	58.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[5-(4-methoxyphenyl)pentyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	77.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[3-(4-methoxyphenyl)propyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	124.0 [1]
	Methyl 4-[4-[[amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]butyl]benzoate	IC50	22.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[2-(2,3-dihydroxypropoxy)phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	28.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[2-(2-hydroxyethoxy)phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	31.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[3-(4-methoxyphenoxy)propyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	25.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[3-(2,3-dihydroxypropoxy)phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	26.0 [1]
	2-[4-[4-[[Amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]butyl]phenoxy]acetic acid	IC50	48.0 [1]
	3,5-Diamino-6-chloro-N-[N'-(4-phenylbutyl)carbamimidoyl]pyrazine-2-carboxamide	IC50	29.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[3-(2-hydroxyethoxy)phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	17.0 [1]
	3-[4-[4-[[Amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]butyl]phenoxy]propanoic acid	IC50	20.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-(2-hydroxyphenyl)butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	30.0 [1]
	3,5-Diamino-6-chloro-N-(N'-hexylcarbamimidoyl)pyrazine-2-carboxamide	IC50	87.0 [1]
	3,5-Diamino-6-chloro-N-[N'-(2-hydroxyethyl)carbamimidoyl]pyrazine-2-carboxamide	IC50	107.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[2-[(4-methoxyphenyl)methoxy]ethyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	41.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-(4-methoxyphenyl)butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	15.0 [1]
	4-[4-[[Amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]butyl]benzoic acid	IC50	51.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-(3-hydroxyphenyl)butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	20.0 [1]
	3,5-Diamino-6-chloro-N-(N'-octylcarbamimidoyl)pyrazine-2-carboxamide	IC50	108.0 [1]
	3,5-Diamino-6-chloro-N-[N'-(3-phenylpropyl)carbamimidoyl]pyrazine-2-carboxamide	IC50	50.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-[4-[(2S)-2,3-dihydroxypropoxy]phenyl]butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	7.0 [1]
	3,5-Diamino-6-chloro-N-[N'-(5-phenylpentyl)carbamimidoyl]pyrazine-2-carboxamide	IC50	68.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[3-(4-hydroxyphenyl)propyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	88.0 [1]
	3,5-Diamino-6-chloro-N-[N'-(2-phenylethyl)carbamimidoyl]pyrazine-2-carboxamide	IC50	66.0 [1]
	3,5-Diamino-6-chloro-N-[N'-(8-phenyloctyl)carbamimidoyl]pyrazine-2-carboxamide	IC50	477.0 [1]
	(2S,3S,4S,5R)-6-[4-[4-[[Amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]butyl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid	IC50	73.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[2-(4-hydroxyphenyl)ethyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	62.0 [1]
	4-[4-[[Amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]butyl]benzenesulfonic acid	IC50	21.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[4-(4-hydroxyphenyl)butyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	17.0 [1]
	3,5-Diamino-6-chloro-N-[N'-[3-(4-hydroxyphenoxy)propyl]carbamimidoyl]pyrazine-2-carboxamide	IC50	32.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 42 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Amiloride-sensitive sodium channel alpha-subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/amiloride-sensitive-sodium-channel-alpha-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Amiloride-sensitive sodium channel alpha-subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/amiloride-sensitive-sodium-channel-alpha-subunit-inhibitors-ic50-ki.
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