AMP-activated protein kinase, AMPK Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Dorsomorphin	IC50	41.0 [1], 230.0 [2]
	3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine	IC50	1512.0 [1]
	JNK Inhibitor VIII	Ki	9800.0 [1]
	4-[2-[4-(3-Phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine	IC50	1800.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	9800.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	9800.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	4-[2-[4-(3-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine	IC50	280.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamide	Ki	9800.0 [1]
	N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	9800.0 [1]
	N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide	Ki	9800.0 [1]
	N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamide	Ki	9800.0 [1]
	N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide	IC50	1400.0 [1]
	5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4-difluorophenyl)-1,3-oxazole	IC50	10000.0 [1]
	5-(3-Propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazole	IC50	10000.0 [1]
	(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-3-hydroxypropanamide	IC50	10000.0 [1]
	(S)-1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamide	IC50	10000.0 [1]
	(R)-1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamide	IC50	10000.0 [1]
	(R)-2-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methylamino)propanamide	IC50	10000.0 [1]
	3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-(2-methoxyethyl)azetidine-3-carboxamide	IC50	10000.0 [1]
	(R)-2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)propanamide	IC50	10000.0 [1]
	(R)-1-((4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamide	IC50	10000.0 [1]
	3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-methylazetidine-3-carboxamide	IC50	10000.0 [1]
	(S)-1-((4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamide	IC50	10000.0 [1]
	2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-propan-2-ylazetidine-3-carboxamide	IC50	10000.0 [1]
	(S)-2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)propanamide	IC50	10000.0 [1]
	4-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-methylpiperidine-4-carboxamide	IC50	10000.0 [1]
	(2R)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-N-methylpropanamide	IC50	10000.0 [1]
	2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)acetamide	IC50	10000.0 [1]
	2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	2000.0 [1]
	(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-4-methoxybutanamide	IC50	10000.0 [1]
	2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Ki	10000.0 [1]
	(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-3-methoxypropanamide	IC50	10000.0 [1]
	Nintedanib impurity E	Ki	4.2 [1]
	Melk-IN-1	Ki	9.2 [1]
	2-Hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxylic acid	Ki	4.9 [1]
	5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one	IC50	10000.0 [1]
	(2E)-2-[(3,4-Dihydroxyphenyl)methylidene]-1-benzofuran-3-one	IC50	19500.0 [1]
	4-(2-Chloro-4-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazole	IC50	10000.0 [1]
	N-Ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,2,4]triazolo[4,3-a]pyridin-3-amine	IC50	10000.0 [1]
	6-[5-(2,5-Difluorophenyl)-1H-pyrazol-4-yl]-3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridine	IC50	10000.0 [1]
	(R)-1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)piperidine-2-carboxamide	IC50	10000.0 [1]
	4-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)morpholine-3-carboxamide	IC50	10000.0 [1]
	(2R)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-N,N-dimethylpropanamide	IC50	10000.0 [1]
	1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)azetidine-3-carboxamide	IC50	10000.0 [1]
	CID 44410844	IC50	10000.0 [1]
	1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)azetidine-2-carboxamide	IC50	10000.0 [1]
	(2R,4R)-1-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl]-4-methoxypyrrolidine-2-carboxamide	IC50	10000.0 [1]
	3-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)pyrrolidin-2-one	IC50	10000.0 [1]
	(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-propan-2-ylamino]propanamide	IC50	10000.0 [1]
	(2R)-1-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl]-N-methylpyrrolidine-2-carboxamide	IC50	10000.0 [1]
	(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-[2-(dimethylamino)ethyl]amino]propanamide	IC50	10000.0 [1]
	(2R)-1-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl]-N,N-dimethylpyrrolidine-2-carboxamide	IC50	10000.0 [1]
	(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-(2-methoxyethyl)amino]propanamide	IC50	10000.0 [1]
	2-[(2S)-1-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl]pyrrolidin-2-yl]acetamide	IC50	10000.0 [1]
	1-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl]-4-methylpiperazine-2-carboxamide	IC50	10000.0 [1]
	(S)-1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-3-carboxamide	IC50	10000.0 [1]
	(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-3-(dimethylamino)propanamide	IC50	10000.0 [1]
	4-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-propan-2-ylpiperidine-4-carboxamide	IC50	10000.0 [1]
	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide	IC50	50000.0 [1]
	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide	IC50	10000.0 [1]
	5-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-1H-pyridin-2-one	IC50	60.0 [1]
	5-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]pyridin-2-amine	IC50	2100.0 [1]
	4-(5-(3,4-Dihydroxyphenyl)oxazol-2-ylamino)benzenesulfonamide	IC50	2900.0 [1]
	4-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]benzene-1,2-diol	IC50	1100.0 [1]
	4-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-1H-pyridin-2-one	IC50	270.0 [1]
	4-[2-[4-(3-Bromopyrazolo[1,5-a]pyrimidin-6-yl)phenoxy]ethyl]morpholine	IC50	3500.0 [1]
	4-[2-[4-[3-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy]ethyl]morpholine	IC50	140.0 [1]
	4-[6-[4-(2-Morpholin-4-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]pyridin-2-amine	IC50	220.0 [1]
	4-(3-Bromopyrazolo[1,5-a]pyrimidin-6-yl)phenol	IC50	7700.0 [1]
	4-(5-(6-Oxo-1,6-dihydropyridin-3-yl)oxazol-2-ylamino)benzenesulfonamide	IC50	5000.0 [1]
	4-[2-[4-[3-(3,4-Dimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy]ethyl]morpholine	IC50	2200.0 [1]
	2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	IC50	10000.0 [1]
	2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine	IC50	10000.0 [1]
	N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-Diamine	IC50	10000.0 [1]
	2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine	IC50	10000.0 [1]
	2-(2,6-Dichloroanilino)-7-[(E)-3-(diethylamino)prop-1-enyl]-1,6-dimethyl-8H-imidazo[4,5-h]isoquinolin-9-one	IC50	1000.0 [1]
	3-Isopropyl-6-(4-phenyl-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine	IC50	10000.0 [1]
	5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazole	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 80 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ AMP-activated protein kinase, AMPK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/amp-activated-protein-kinase-ampk-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ AMP-activated protein kinase, AMPK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/amp-activated-protein-kinase-ampk-inhibitors-ic50-ki.
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