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Apoptosis regulator Bcl-W Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Abt-737IC501.0 [1], 40.0 [2], 66.0 [3]
Abt-737Ki1.0 [1]
4-[8-Ethylsulfanyl-3-(4-hydroxyphenyl)-3-methyloctan-4-yl]phenolKi59320.0 [1], 210000.0 [2]
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-phenylpropanoic acidKi21500.0 [1]
GossypolKi17700.0 [1]
Chelerythrine chlorideKi106000.0 [1]
VenetoclaxKi245.0 [1]
(2Z)-2-[(5Z)-5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indoleKi1000.0 [1]
2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidKi8190.0 [1]
Antimycin A3Ki127000.0 [1]
CID 59447577Ki19.0 [1]
4-(4-Fluorophenyl)-N-[3-nitro-4-(2-phenylsulfanylethylamino)phenyl]sulfonylbenzamideIC5025000.0 [1]
2-(1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetic acidKi37530.0 [1]
3-(5-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)furan-2-yl)-2-methylbenzoic acidIC5033000.0 [1]
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]benzamideKi49.0 [1]
N-[7-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]quinazolin-4-yl]-4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrobenzenesulfonamideIC50440.0 [1]
3-(5-(1-(2-(Benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)-benzoic acidIC5010000.0 [1]
(R)-2-(3-(3-((2,4-Difluoropenyl)ethynyl)benzoyl)-3-propylureido)-3-(isobutylthio) propanoic acidIC5025000.0 [1]
2-[1-Hydroxy-4-[[(4-phenoxyphenyl)sulfonyl]amino]-2-naphthylthio]acetic acidKi1580.0 [1]
1-(2-Methoxyphenethyl)-5-butyl-4-(2-phenoxyphenyl)-1H-imidazoleIC508090.0 [1]
7-[1,3-Dimethyl-5-[[4-(4-methylsulfonylpiperazin-1-yl)phenoxy]methyl]pyrazol-4-yl]-1-(2-morpholin-4-ylethyl)-3-(3-naphthalen-1-yloxypropyl)indole-2-carboxylic acidKi660.0 [1]
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]propanoic acidKi243000.0 [1]
(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-(1H-indol-3-yl)propanoic acidKi54200.0 [1]
Ethyl 2-amino-4-(1-cyano-2-ethoxy-2-oxoethyl)-6-methyl-4H-chromene-3-carboxylateKi198980.0 [1]
Ethyl 2-amino-4-(1-cyano-2-ethoxy-2-oxoethyl)-6-propyl-4H-chromene-3-carboxylateKi56690.0 [1]
Ethyl 2-amino-4-(1-cyano-2-ethoxy-2-oxoethyl)-6-phenyl-4H-chromene-3-carboxylateKi41180.0 [1]
CID 16098792Ki20310.0 [1]
Ethyl 2-amino-4-(1-cyano-2-ethoxy-2-oxoethyl)-6-ethyl-4H-chromene-3-carboxylateKi120520.0 [1]
Ethyl 2-amino-4-(1-cyano-2-ethoxy-2-oxoethyl)-6-cyclopentyl-4H-chromene-3-carboxylateKi30810.0 [1]
Ethyl 2-amino-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylateKi696610.0 [1]
2-[(8Z)-8-(1,3-Benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acidIC505000.0 [1]
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-glutaric acidKi610000.0 [1]
(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-4-methylsulfanylbutanoic acidKi88000.0 [1]
1-Biphenyl-3-ylmethyl-5-butyl-4-(2-methoxy-phenyl)-1H-imidazoleIC5026850.0 [1]
1-(2-Methoxybenzyl)-4-(2-phenoxyphenyl)-5-propyl-1H-imidazoleIC5013990.0 [1]
(2S)-2-[(5Z)-4-Oxo-5-(1-phenylbutylidene)-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi41100.0 [1]
(2S)-4-Methyl-2-[(5Z)-4-oxo-5-(1-phenylbutylidene)-2-sulfanylidene-1,3-thiazolidin-3-yl]pentanoic acidKi24100.0 [1]
(2S)-4-Methyl-2-[(5Z)-4-oxo-5-(1-phenylethylidene)-2-sulfanylidene-1,3-thiazolidin-3-yl]pentanoic acidKi58300.0 [1]
2-[5-(Diphenylmethylidene)-4-oxo-2-thioxothiazolidin-3-yl]-4-methylpentanoic acidKi61900.0 [1]
(2S)-4-Methyl-2-[(5Z)-4-oxo-5-[phenyl-(4-phenylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl]pentanoic acidKi6980.0 [1]
Prop-2-enyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoateKi1000000.0 [1]
(5Z)-5-[(4-Bromophenyl)methylidene]-3-[(2S)-1-morpholin-4-yl-1-oxopropan-2-yl]-2-sulfanylidene-1,3-thiazolidin-4-oneKi146000.0 [1]
Prop-2-enyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi56800.0 [1]
Prop-2-enyl (2S)-2-(5-benzhydrylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)-3-phenylpropanoateKi116000.0 [1]
Ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi116000.0 [1]
2-[2-[2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethoxy]ethoxy]ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi88300.0 [1]
Ethyl (2S)-2-[(5Z)-5-[[4-[[4-[(Z)-[3-[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi39200.0 [1]
2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi101000.0 [1]
2-[2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethoxy]ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi99000.0 [1]
(2S)-2-[(5Z)-5-[[4-[2-[2-[2-[4-[(Z)-[3-[(1S)-1-Carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]ethoxy]ethoxy]ethoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi13700.0 [1]
(2S)-2-[(5Z)-5-[[4-[2-[2-[4-[(Z)-[3-[(1S)-1-Carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]ethoxy]ethoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi2200.0 [1]
(2S)-2-[(5Z)-5-[[4-[[4-[(Z)-[3-[(1S)-1-Carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi2300.0 [1]
(2S)-2-[(5Z)-5-[[4-[2-[4-[(Z)-[3-[(1S)-1-Carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]ethoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi1300.0 [1]
N-Methyl-N-[2-(3-nitro-4-thiomorpholin-4-ylanilino)-2-oxoethyl]-4-phenylbenzamideKi12950.0 [1]
N-Methyl-N-[2-(3-nitro-4-piperidin-1-ylanilino)-2-oxoethyl]-4-phenylbenzamideKi10800.0 [1]
N-[2-[4-(1-Adamantylamino)-3-nitroanilino]-2-oxoethyl]-N-methyl-4-phenylbenzamideKi9430.0 [1]
2-[1-Hydroxy-4-[(4-phenylphenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acidKi1920.0 [1]
N-[7-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]quinazolin-4-yl]-4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-nitrobenzenesulfonamideIC501000.0 [1]
N-[7-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]quinazolin-4-yl]-4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)benzenesulfonamideIC50245.0 [1]
N-[7-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]quinazolin-4-yl]-4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)benzenesulfonamideIC501000.0 [1]
N-[7-[4-[[2-(4-Chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]quinazolin-4-yl]-4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrobenzenesulfonamideIC50540.0 [1]
N-[7-[4-[[2-(4-Chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]quinazolin-4-yl]-4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-nitrobenzenesulfonamideIC501000.0 [1]
N-[7-[4-[[2-(4-Chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]quinazolin-4-yl]-4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)benzenesulfonamideIC50275.0 [1]
N-[7-[4-[[2-(4-Chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]quinazolin-4-yl]-4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)benzenesulfonamideIC501000.0 [1]
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[3,5-dimethyl-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]benzamideKi170.0 [1]
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[(2S)-2-propan-2-yl-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]benzamideKi59.0 [1]
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[(2R)-2-propan-2-yl-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]benzamideKi21.0 [1]
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[(3S)-3-methyl-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]benzamideKi63.0 [1]
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[(3R)-3-methyl-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]benzamideKi55.0 [1]
CID 6090108Ki124000.0 [1]
2-[4-[[4-(4-Chlorophenyl)phenyl]sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acidKi1360.0 [1]
2-[1-Hydroxy-4-[(3-phenylphenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acidKi2190.0 [1]
2-[1-Hydroxy-4-[(2-phenylphenyl)sulfonylamino]naphthalen-2-yl]sulfanylacetic acidKi4410.0 [1]
6-[3-[(E)-N-(1,3-Benzothiazol-2-ylamino)-C-methylcarbonimidoyl]phenyl]pyridine-2-carboxylic acidIC5010000.0 [1]
6-[5-[(E)-N-(1,3-Benzothiazol-2-ylamino)-C-methylcarbonimidoyl]thiophen-2-yl]pyridine-2-carboxylic acidIC5010000.0 [1]
4-[(8Z)-8-(1,3-Benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acidIC505000.0 [1]
6-[(4Z)-4-(1,3-Benzothiazol-2-ylhydrazinylidene)-1-ethyl-2,3-dihydroquinolin-6-yl]pyridine-2-carboxylic acidIC5010000.0 [1]
2-[(8Z)-8-(1,3-Benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyrimidine-4-carboxylic acidIC5010000.0 [1]
6-[(8Z)-8-(1,3-Benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acidIC5010000.0 [1]
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-4-methylpentanoic acidKi31200.0 [1]
Items per page: 1 - 10 of 80
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References

This online tool may be cited as follows

MLA

"Quest Database™ Apoptosis regulator Bcl-W Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/apoptosis-regulator-bcl-w-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Apoptosis regulator Bcl-W Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/apoptosis-regulator-bcl-w-inhibitors-ic50-ki.
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