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Aurora kinase B/Inner centromere protein Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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MK-5108IC501.49 [1], 150.0 [2]
3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylureaIC503.16 [1]
3-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylureaKi0.38 [1]
Tak-901IC5015.0 [1]
Tak-901Ki0.02 [1]
MilrinoneKi100000.0 [1]
AmrinoneKi59300.0 [1]
AlisertibIC501.1 [1]
CFI-400945 (free base)IC5098.0 [1]
3-Amino-2-hydroxypyridineKi159700.0 [1]
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamideIC5025118.86 [1]
3-Amino-6-methyl-5-pyridin-4-yl-1H-pyridin-2-oneKi25700.0 [1]
Unii-WF9CA8UL2VIC5025118.86 [1]
N-(6-Oxo-1,6-Dihydro-3,4'-Bipyridin-5-Yl)benzamideKi41000.0 [1]
1-[3-[5-Chloro-4-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl]-N,N-dimethylmethanamineIC500.5 [1]
N-{4-[1-Ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylureaIC502.0 [1]
3-(4-(1-Ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)-1,1-dimethylureaIC5025.12 [1]
N,N-Dimethyl-1-[4-[4-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl]methanamineIC506.31 [1]
N-(6-Oxo-1,6-Dihydro-3,4'-Bipyridin-5-Yl)-4-(Piperidin-1-Yl)benzamideKi7400.0 [1]
N-[Cyclopropyl(phenyl)methyl]-3-(3-sulfamoylphenyl)-1H-indazole-5-carboxamideIC505000.0 [1]
3-Fluoro-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)benzamideKi100000.0 [1]
3-Methoxy-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)benzamideKi100000.0 [1]
3,5-Difluoro-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)benzamideKi100000.0 [1]
4-(4-Methylpiperazin-1-Yl)-N-(2-Oxo-5-(Pyridin-4-Yl)-1,2-Dihydropyridin-3-Yl)benzamideKi5500.0 [1]
N-[Cyclobutyl(thiophen-3-yl)methyl]-3-[4-[[(1S,5R)-8-formyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]phenyl]-1H-indazole-5-carboxamideIC501200.0 [1]
N-[(1-Morpholin-4-ylcyclohexyl)methyl]-3-(4-morpholin-4-ylphenyl)-1H-indazole-5-carboxamideIC50750.0 [1]
3-[4-(4-Methylpiperazin-1-yl)phenyl]-N-[(1-morpholin-4-ylcyclohexyl)methyl]-1H-indazole-5-carboxamideIC50440.0 [1]
N-[(S)-Cyclopropyl-(2-fluorophenyl)methyl]-3-[4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)phenyl]-1H-indazole-5-carboxamideIC50470.0 [1]
N-[(R)-Cyclopropyl-(2-fluorophenyl)methyl]-3-[4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)phenyl]-1H-indazole-5-carboxamideIC50980.0 [1]
N-[(S)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)phenyl]-1H-indazole-5-carboxamideIC50360.0 [1]
N-[(1S)-1-(2-Chlorophenyl)-2-methylpropyl]-3-[4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)phenyl]-1H-indazole-5-carboxamideIC501900.0 [1]
N-[(S)-Cyclopentyl(pyridin-2-yl)methyl]-3-[4-(3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)phenyl]-1H-indazole-5-carboxamideIC502800.0 [1]
N-[(R)-Cyclopentyl(pyridin-2-yl)methyl]-3-[4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)phenyl]-1H-indazole-5-carboxamideIC501400.0 [1]
N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)phenyl]-1H-indazole-5-carboxamideIC501200.0 [1]
N-[(1-Morpholin-4-ylcyclohexyl)methyl]-3-[4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)phenyl]-1H-indazole-5-carboxamideIC50800.0 [1]
3-[4-[[(1S,5R)-8-Formyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]phenyl]-N-(3-methyl-1-pyridin-2-ylbutyl)-1H-indazole-5-carboxamideIC50300.0 [1]
N-[(1S)-1-(2-Chlorophenyl)-2-methylpropyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC506300.0 [1]
N-[(S)-Cyclopropyl(phenyl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC501100.0 [1]
N-[(S)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC50790.0 [1]
N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC501700.0 [1]
N-[(S)-Cyclopentyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC506300.0 [1]
N-[(R)-Cyclopentyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC501800.0 [1]
N-[(S)-Cyclopentyl(pyrimidin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC50620.0 [1]
N-[(R)-Cyclopentyl(pyrimidin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC50850.0 [1]
3-[4-[(1S,5S)-3-Hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-N-[(1S)-3-methyl-1-pyridin-2-ylbutyl]-1H-indazole-5-carboxamideIC501500.0 [1]
3-[4-[(1S,5S)-3-Hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-N-[(1R)-3-methyl-1-pyridin-2-ylbutyl]-1H-indazole-5-carboxamideIC501600.0 [1]
N-[(1R)-2-Cyclopropyl-1-pyridin-2-ylethyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC501200.0 [1]
3-[4-[(1S,5S)-3-Hydroxy-9-azabicyclo[3.3.1]nonan-9-yl]phenyl]-N-[(1S)-3-methyl-1-pyridin-2-ylbutyl]-1H-indazole-5-carboxamideIC50980.0 [1]
3-[4-[(1R,5R)-7-Hydroxy-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl]phenyl]-N-[(1S)-3-methyl-1-pyridin-2-ylbutyl]-1H-indazole-5-carboxamideIC50230.0 [1]
N-[(R)-Cyclopentyl(pyridin-2-yl)methyl]-3-[4-[(1R,5R)-7-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl]phenyl]-1H-indazole-5-carboxamideIC50740.0 [1]
5-Amino-[3,3'-bipyridin]-6(1H)-oneKi97200.0 [1]
2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamideKi100000.0 [1]
4-[[4-[(Z)-[2-(4-Ethylphenyl)imino-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene]methyl]pyridin-2-yl]amino]benzoic acidIC501540.0 [1]
(5Z)-2-(4-Ethylphenyl)imino-3-methyl-5-[[2-[4-(2H-tetrazol-5-yl)anilino]pyridin-4-yl]methylidene]-1,3-thiazolidin-4-oneIC50830.0 [1]
3-[[4-[(Z)-[2-(4-Ethylphenyl)imino-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene]methyl]pyridin-2-yl]amino]-3-oxopropanoic acidIC502700.0 [1]
6-[[4-[(Z)-[2-(4-Ethylphenyl)imino-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene]methyl]pyridin-2-yl]amino]pyridine-3-carboxylic acidIC50150.0 [1]
3-Amino-N-[4-[(Z)-[2-(4-ethylphenyl)imino-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene]methyl]pyridin-2-yl]propanamideIC5010000.0 [1]
4-[[4-[(Z)-[2-(4-Ethylphenyl)imino-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene]methyl]pyridin-2-yl]amino]-4-oxobutanoic acidIC501700.0 [1]
(5Z)-5-[(2-Aminopyridin-4-yl)methylidene]-2-(4-ethylphenyl)imino-3-methyl-1,3-thiazolidin-4-oneIC5023000.0 [1]
(5Z)-2-(4-Ethylphenyl)imino-5-[[2-[4-(hydroxymethyl)anilino]pyridin-4-yl]methylidene]-3-methyl-1,3-thiazolidin-4-oneIC502600.0 [1]
5-[[4-[(Z)-[2-(4-Ethylphenyl)imino-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene]methyl]pyridin-2-yl]amino]-5-oxopentanoic acidIC501400.0 [1]
2-(4-Methylphenyl)-3-(pyridin-2-ylmethoxy)pyridineIC5019952.62 [1]
N-[4-[[7-Cyclopentyl-6-(dimethylcarbamoyl)pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-N'-hydroxyoctanediamideIC5019.0 [1]
[3,4'-Bipyridin]-5-amine, 6-methoxy-Ki63900.0 [1]
1-[3-(4-Methoxyphenyl)-4-(pyrimidin-4-ylmethoxy)phenyl]ethanoneIC5019952.62 [1]
2-(4-Methoxyphenyl)-6-methyl-3-(pyridin-2-ylmethoxy)pyridineIC5025118.86 [1]
2-[[4-Methoxy-2-(4-methoxyphenyl)phenoxy]methyl]pyridineIC5025118.86 [1]
3-Amino-5-[2-(cyclopropylamino)pyrimidin-4-yl]-1H-pyridin-2-oneKi12000.0 [1]
3-Amino-5-[4-[(dimethylamino)methyl]phenyl]-1H-pyridin-2-oneKi12900.0 [1]
2-[[4-Fluoro-2-(4-methoxyphenyl)phenoxy]methyl]pyridineIC5025118.86 [1]
2-(4-Methoxyphenyl)-6-methyl-3-[(5-methylpyridin-2-yl)methoxy]pyridineIC5015848.93 [1]
2-[[2-(4-Methoxyphenyl)-4-methylphenoxy]methyl]pyridineIC5025118.86 [1]
2-(4-Methoxyphenyl)-6-methyl-3-[(4-methylpyridin-2-yl)methoxy]pyridineIC5019952.62 [1]
1-[3-(4-Methoxyphenyl)-4-(pyridin-2-ylmethoxy)phenyl]ethanoneIC5015848.93 [1]
1-[3-(4-Methoxyphenyl)-4-(pyrimidin-2-ylmethoxy)phenyl]ethanoneIC5025118.86 [1]
1-[3-(3-Methoxyphenyl)-4-(pyridin-2-ylmethoxy)phenyl]ethanoneIC5025118.86 [1]
1-[3-(2-Methylphenyl)-4-(pyridin-2-ylmethoxy)phenyl]ethanoneIC5025118.86 [1]
2-[[3-Methoxy-2-(4-methoxyphenyl)phenoxy]methyl]pyridineIC5025118.86 [1]
1-[3-(4-Methoxyphenyl)-4-(pyridazin-3-ylmethoxy)phenyl]ethanoneIC5025118.86 [1]
2-[[2-(4-Methylphenyl)phenoxy]methyl]pyridineIC5025118.86 [1]
1-[4-(Pyridin-2-ylmethoxy)-3-(2,3,4,5-tetrahydro-1H-2-benzazepin-8-yl)phenyl]ethanoneIC5025118.86 [1]
2-[[3-Fluoro-2-(4-methoxyphenyl)phenoxy]methyl]pyridineIC5025118.86 [1]
1-[3-(4-Fluorophenyl)-4-(pyridin-2-ylmethoxy)phenyl]ethanoneIC5025118.86 [1]
N-[5-[2-(Cyclopropylamino)pyrimidin-4-yl]-2-oxo-1H-pyridin-3-yl]benzamideKi3600.0 [1]
1-[4-(Pyridin-2-ylmethoxy)-3-(2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)phenyl]ethanoneIC5025118.86 [1]
1-[3-Phenyl-4-(pyridin-2-ylmethoxy)phenyl]ethanoneIC50100000.0 [1]
2-(4-Methoxyphenyl)-6-methyl-3-[(3-methylpyridin-2-yl)methoxy]pyridineIC5025118.86 [1]
2-[[2-(4-Methoxyphenyl)-3-methylphenoxy]methyl]pyridineIC5025118.86 [1]
3,5-Dimethoxy-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)benzamideKi32900.0 [1]
1-[3-(4-Methoxyphenyl)-4-(pyrazin-2-ylmethoxy)phenyl]ethanoneIC5025118.86 [1]
1-[3-(4-Methylphenyl)-4-(pyridin-2-ylmethoxy)phenyl]ethanoneIC5025118.86 [1]
2-[[5-Methoxy-2-(4-methoxyphenyl)phenoxy]methyl]pyridineIC5025118.86 [1]
2-[[5-Fluoro-2-(4-methoxyphenyl)phenoxy]methyl]pyridineIC5025118.86 [1]
2-[[2-(4-Methoxyphenyl)phenoxy]methyl]pyridineIC5010000.0 [1]
1-[3-(3-Methylphenyl)-4-(pyridin-2-ylmethoxy)phenyl]ethanoneIC5025118.86 [1]
2-(4-Methoxyphenyl)-6-methyl-3-[(6-methylpyridin-2-yl)methoxy]pyridineIC5025118.86 [1]
6-Methyl-2-phenyl-3-(pyridin-2-ylmethoxy)pyridineIC5039810.72 [1]
3-Amino-5-pyrimidin-5-yl-1H-pyridin-2-oneKi18700.0 [1]
3-Amino-5-[2-(methylamino)pyrimidin-4-yl]-1H-pyridin-2-oneKi15100.0 [1]
5-Amino-1-methyl[3,4'-bipyridin]-6(1H)-oneKi102700.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Aurora kinase B/Inner centromere protein Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/aurora-kinase-b-inner-centromere-protein-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Aurora kinase B/Inner centromere protein Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/aurora-kinase-b-inner-centromere-protein-inhibitors-ic50-ki.
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