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Bcl2-antagonist of cell death (BAD) Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Abt-737Ki0.6 [1], 1.0 [2]
NavitoclaxKi0.5 [1], 1.0 [2]
1-[2-[(3S)-3-(Aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N,N-dibutyl-4-chloro-5-methylpyrazole-3-carboxamideIC50250.0 [1], 5050.0 [2]
Chelerythrine chlorideIC50100000.0 [1]
SanguinarineIC5019000.0 [1]
(2Z)-2-[(5Z)-5-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indoleKi1000.0 [1]
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-phenylpropanoic acidKi5250.0 [1]
Benzo[d]thiazol-2-yl(2,3,4-trihydroxy-5-(4-phenoxybenzoyl)phenyl)methanoneKi1110.0 [1]
1,4-Bis(5,6,7-trihydroxy-8-isobutyl-2-methyl-4-oxo-4H-chromen-3-yl)benzeneKi1200.0 [1]
N-(2-Phenylethyl)-2-[2,3,4-trihydroxy-5-[methyl(3-phenylpropyl)sulfamoyl]benzoyl]-3,4-dihydro-1H-isoquinoline-7-sulfonamideKi638.0 [1]
4-(4-Fluorophenyl)-2-[(E)-2-(3-phenylphenyl)ethenyl]benzoic acidIC506900.0 [1]
7,8-DimethoxyphenanthridineIC50100000.0 [1]
(4-Phenoxyphenyl)-[2,3,4-trihydroxy-5-(naphthalene-1-carbonyl)phenyl]methanoneKi1320.0 [1]
12,14-Dioxa-8-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(10),2(7),3,5,8,11(15),16-heptaeneIC50100000.0 [1]
2,2-Dimethyl-[1,3]dioxolo[4,5-i]phenanthridineIC50100000.0 [1]
7,8-Dimethoxy-5-oxidophenanthridin-5-iumIC50100000.0 [1]
5-Oxido-[1,3]dioxolo[4,5-i]phenanthridin-5-iumIC50100000.0 [1]
2,2-Dimethyl-5-oxido-[1,3]dioxolo[4,5-i]phenanthridin-5-iumIC50100000.0 [1]
1-[2-[(3S)-3-(Aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-4-chloro-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC501610.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[3-cyano-4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]phenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)cyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)cyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethyl)phenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)cyclohepten-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[4-(4-Chlorophenyl)-3,6-dihydro-2H-pyran-5-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-(2,2,2-trifluoroacetyl)phenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-methylphenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[(1Z)-2-(4-Chlorophenyl)cycloocten-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)cyclopenten-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethoxy)phenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamideKi1.4 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-methylsulfonylphenyl]sulfonylbenzamideKi1.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]phenyl]sulfonylbenzamideKi14.0 [1]
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[3-nitro-4-(2-phenylsulfanylethylamino)phenyl]sulfonylbenzamideKi1.0 [1]
1-[2-[(3S)-3-(Aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]-4-[(2-phenoxyacetyl)amino]phenyl]-N,N-dibutyl-4-chloro-5-methylpyrazole-3-carboxamideIC50808.0 [1]
1-[2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC5012400.0 [1]
4-(4-Fluorophenyl)-N-[3-nitro-4-(2-thiopyran-1-ylethylamino)phenyl]sulfonylbenzamideIC5036.0 [1]
Ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi176000.0 [1]
2-[2-[2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethoxy]ethoxy]ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi112000.0 [1]
Ethyl (2S)-2-[(5Z)-5-[[4-[[4-[(Z)-[3-[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi58400.0 [1]
2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi134000.0 [1]
2-[2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethoxy]ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoateKi104000.0 [1]
(2S)-2-[(5Z)-5-[[4-[2-[2-[2-[4-[(Z)-[3-[(1S)-1-Carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]ethoxy]ethoxy]ethoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi8700.0 [1]
(2S)-2-[(5Z)-5-[[4-[2-[2-[4-[(Z)-[3-[(1S)-1-Carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]ethoxy]ethoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi2300.0 [1]
(2S)-2-[(5Z)-5-[[4-[[4-[(Z)-[3-[(1S)-1-Carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi2400.0 [1]
(2S)-2-[(5Z)-5-[[4-[2-[4-[(Z)-[3-[(1S)-1-Carboxy-2-phenylethyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]ethoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidKi970.0 [1]
N-Cyclohexyl-1-[2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)phenyl]-5-methyl-N-phenylpyrazole-3-carboxamideIC504110.0 [1]
1-[2-[(3S)-3-(Aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC5011360.0 [1]
1-[2-[(3S)-3-(Methoxymethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC505570.0 [1]
1-[2-[(3S)-3-(Acetamidomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC509690.0 [1]
Ethyl (3S)-2-[2-[3-(diphenylcarbamoyl)-5-methylpyrazol-1-yl]benzoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylateIC5018000.0 [1]
Methyl 2-[(3S)-2-[2-[3-(diphenylcarbamoyl)-5-methylpyrazol-1-yl]benzoyl]-3,4-dihydro-1H-isoquinolin-3-yl]acetateIC505170.0 [1]
1-[2-[(3S)-3-[(Dimethylamino)methyl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC506790.0 [1]
5-Methyl-1-[2-[(3S)-3-(methylaminomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N,N-diphenylpyrazole-3-carboxamideIC5012630.0 [1]
N,N-Dibutyl-1-[2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)phenyl]-5-methylpyrazole-3-carboxamideIC5025200.0 [1]
N,N-Dibutyl-4-chloro-1-[2-[(3S)-3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methylpyrazole-3-carboxamideIC506940.0 [1]
1-[4-Amino-2-[(3S)-3-(aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N,N-dibutyl-4-chloro-5-methylpyrazole-3-carboxamideIC506160.0 [1]
[2-[3-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-5-methylpyrazol-1-yl]phenyl]-(3,4-dihydro-1H-isoquinolin-2-yl)methanoneIC5016600.0 [1]
5-Methyl-1-[2-[(3R)-3-methyl-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N,N-diphenylpyrazole-3-carboxamideIC505240.0 [1]
4-Bromo-1-[2-[(3S)-3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC502410.0 [1]
4-Chloro-1-[2-[(3S)-3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-5-methyl-N,N-diphenylpyrazole-3-carboxamideIC502280.0 [1]
1-[4-Amino-2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)phenyl]-N,N-dibutyl-4-chloro-5-methylpyrazole-3-carboxamideIC507990.0 [1]
N,N-Dibutyl-4-chloro-1-[2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-4-[(2-phenylacetyl)amino]phenyl]-5-methylpyrazole-3-carboxamideIC502370.0 [1]
N,N-Dibutyl-4-chloro-1-[2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-4-[(2-phenoxyacetyl)amino]phenyl]-5-methylpyrazole-3-carboxamideIC502380.0 [1]
N,N-Dibutyl-1-[2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-4-phenacyloxyphenyl]-5-methylpyrazole-3-carboxamideIC503240.0 [1]
2-[4-[3-(Dibutylcarbamoyl)-5-methylpyrazol-1-yl]-3-(3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acidIC505640.0 [1]
N,N-Dibutyl-1-[2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-4-[(2-phenylsulfanylacetyl)amino]phenyl]-5-methylpyrazole-3-carboxamideIC50400.0 [1]
N,N-Dibutyl-1-[2-(3,4-dihydro-1H-isoquinoline-2-carbonyl)-4-[(2-phenoxyacetyl)amino]phenyl]-5-methylpyrazole-3-carboxamideIC503050.0 [1]
(2S,5R,6R)-6-[[7-[8-[[(2S,5R,6R)-2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl]iminomethyl]-1,4,6,7-tetrahydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl]-6-methyl-2,3,5,8-tetraoxo-4-propan-2-ylnaphthalen-1-yl]methylideneamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acidIC501760.0 [1]
7,8-Dimethoxy-5-methylphenanthridin-5-ium iodideIC50100000.0 [1]
5-Methyl-[1,3]dioxolo[4,5-i]phenanthridin-5-iumIC5012000.0 [1]
2,2,5-Trimethyl-[1,3]dioxolo[4,5-i]phenanthridin-5-iumIC50100000.0 [1]
2-(Hydroxymethyl)-7,8-dimethoxy-5-methylphenanthridin-5-ium chlorideIC50100000.0 [1]
(5-Methyl-[1,3]dioxolo[4,5-i]phenanthridin-5-ium-8-yl)methanolIC5011000.0 [1]
2-(5-Methyl-[1,3]dioxolo[4,5-i]phenanthridin-5-ium-8-yl)ethanolIC503000.0 [1]
8-(Methoxymethyl)-5-methyl-[1,3]dioxolo[4,5-i]phenanthridin-5-iumIC5011000.0 [1]
8-(2-Methoxyethyl)-5-methyl-[1,3]dioxolo[4,5-i]phenanthridin-5-iumIC506000.0 [1]
7,8-Dihydroxy-5-methylphenanthridin-5-ium chlorideIC5018000.0 [1]
7,8-Dihydroxy-2-(hydroxymethyl)-5-methylphenanthridin-5-ium chlorideIC5020000.0 [1]
7,8-Dihydroxy-2-(2-hydroxyethyl)-5-methylphenanthridin-5-ium chlorideIC5022000.0 [1]
Items per page: 1 - 10 of 82
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References

This online tool may be cited as follows

MLA

"Quest Database™ Bcl2-antagonist of cell death (BAD) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/bcl2-antagonist-of-cell-death-bad-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Bcl2-antagonist of cell death (BAD) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/bcl2-antagonist-of-cell-death-bad-inhibitors-ic50-ki.
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