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Beta-glucocerebrosidase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonylpiperidine-3,4,5-triolIC50660.0 [1]
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonylpiperidine-3,4,5-triolKi300.0 [1], 620.0 [2], 1300.0 [3]
(1S,2R,4S,5R)-6-(Nonylamino)cyclohexane-1,2,3,4,5-pentolIC503900.0 [1]
(1S,2R,4S,5R)-6-(Nonylamino)cyclohexane-1,2,3,4,5-pentolKi1900.0 [1], 17900.0 [2]
1-DeoxynojirimycinIC50118000.0 [1], 195000.0 [2], 240000.0 [3], 300000.0 [4], 500000.0 [5]
1-DeoxynojirimycinKi2000.0 [1], 47000.0 [2], 79000.0 [3], 300000.0 [4]
(1S,2R,4S,5S)-6-(Nonylamino)cyclohexane-1,2,3,4,5-pentolIC5025.0 [1]
(1S,2R,4S,5S)-6-(Nonylamino)cyclohexane-1,2,3,4,5-pentolKi32.0 [1]
(1S,2R,3S,4R,5S,6S)-5-Nonoxy-6-(nonylamino)cyclohexane-1,2,3,4-tetrolIC504.0 [1], 4.3 [2], 5.0 [3]
(1S,2R,3S,4R,5S,6S)-5-Nonoxy-6-(nonylamino)cyclohexane-1,2,3,4-tetrolKi1.0 [1]
AfegostatIC5059.0 [1], 60.0 [2], 63.0 [3], 740.0 [4], 1520.0 [5]
AfegostatKi220.0 [1]
(1S,2R,3S,4R,5R,6S)-5-Nonoxy-6-(nonylamino)cyclohexane-1,2,3,4-tetrolIC50170.0 [1], 670.0 [2]
(1S,2R,3S,4R,5R,6S)-5-Nonoxy-6-(nonylamino)cyclohexane-1,2,3,4-tetrolKi280.0 [1]
(1S,2R,3S,4R,5R,6S)-5-Methoxy-6-(nonylamino)cyclohexane-1,2,3,4-tetrolIC50670.0 [1], 4400.0 [2]
(1S,2R,3S,4R,5R,6S)-5-Methoxy-6-(nonylamino)cyclohexane-1,2,3,4-tetrolKi1580.0 [1]
(1S,2R,3S,4R,5S,6S)-5-Methoxy-6-(nonylamino)cyclohexane-1,2,3,4-tetrolIC5019.0 [1], 130.0 [2]
(1S,2R,3S,4R,5S,6S)-5-Methoxy-6-(nonylamino)cyclohexane-1,2,3,4-tetrolKi53.0 [1]
(1R,2S,3R,4S,5S,6S)-5-Amino-6-nonoxycyclohexane-1,2,3,4-tetrolIC50120.0 [1], 450.0 [2]
(1R,2S,3R,4S,5S,6S)-5-Amino-6-nonoxycyclohexane-1,2,3,4-tetrolKi130.0 [1]
(1S,2S,4R,5S)-6-[Di(nonyl)amino]cyclohexane-1,2,3,4,5-pentolIC50530.0 [1], 1720.0 [2]
(1S,2S,4R,5S)-6-[Di(nonyl)amino]cyclohexane-1,2,3,4,5-pentolKi820.0 [1]
MiglustatIC50259000.0 [1], 300000.0 [2], 399000.0 [3], 400000.0 [4]
(1R,2S,4R,5S)-6-[(1-Decyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolIC5090.0 [1], 93.33 [2], 100.0 [3], 150.0 [4]
(1R,2S,4R,5S)-6-[(1-Decyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolKi90.0 [1]
(1S,2R,4S,5R)-6-[(1-Octyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolIC501000.0 [1], 1047.13 [2], 1100.0 [3], 2250.0 [4]
(1S,2R,4S,5R)-6-[(1-Octyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolKi1800.0 [1]
2-[4-(5-Chloro-2-methoxy-phenylamino)-6-pyrrolidin-1-yl-[1,3,5]triazin-2-ylamino]-ethanolIC50400.0 [1], 700.0 [2], 7900.0 [3]
2-[4-(5-Chloro-2-methoxy-phenylamino)-6-pyrrolidin-1-yl-[1,3,5]triazin-2-ylamino]-ethanolKi320.0 [1]
Piperidine-3,4,5-triolIC502300.0 [1], 8800.0 [2]
Piperidine-3,4,5-triolKi1300.0 [1], 2800.0 [2]
4,4,5,5,6,6,7,7,7-Nonafluoro-N-[9-[[(1R,2R,3S,4R,5S)-2,3,4-trihydroxy-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioyl]amino]nonyl]heptanamideKi900.0 [1], 8200.0 [2], 9300.0 [3], 80000.0 [4]
4,4,5,5,6,6,7,7,7-Nonafluoro-N-[4-[[(1R,2R,3S,4R,5S)-2,3,4-trihydroxy-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioyl]amino]butyl]heptanamideKi300.0 [1], 4500.0 [2], 20800.0 [3], 35000.0 [4]
4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluoro-N-[9-[[(1R,2R,3S,4R,5S)-2,3,4-trihydroxy-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioyl]amino]nonyl]nonanamideKi600.0 [1], 4100.0 [2], 7200.0 [3], 32600.0 [4]
4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluoro-N-[4-[[(1R,2R,3S,4R,5S)-2,3,4-trihydroxy-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioyl]amino]butyl]nonanamideKi90.0 [1], 1400.0 [2], 11900.0 [3], 90000.0 [4]
(1S,2R,4S,5R)-6-[(1-Nonyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolIC50200.0 [1], 223.87 [2]
(1S,2R,4S,5R)-6-[(1-Nonyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolKi330.0 [1]
(1S,2R,4S,5R)-6-[(1-Dodecyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolIC5030.0 [1], 30.2 [2], 60.0 [3]
(1S,2R,4S,5R)-6-[(1-Dodecyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolKi60.0 [1]
(1S,2R,4S,5R)-6-[(1-Tetradecyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolIC5089.13 [1], 90.0 [2], 100.0 [3]
(1S,2R,4S,5R)-6-[(1-Tetradecyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolKi80.0 [1]
(1R,2S,4R,5S)-6-[[1-(6-Propoxyhexyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolIC506200.0 [1], 7400.0 [2], 13803.84 [3]
(1R,2S,4R,5S)-6-[[1-(6-Propoxyhexyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolKi2400.0 [1]
(1R,2S,4R,5S)-6-[[1-(2-Phenylethyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolIC5010715.19 [1], 10800.0 [2], 25000.0 [3]
(1R,2S,4R,5S)-6-[[1-(2-Phenylethyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolKi19100.0 [1]
(1S,2R,4S,5R)-6-[2-(1-Undecyltriazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentolIC504900.0 [1], 25400.0 [2], 25703.96 [3]
(1S,2R,4S,5R)-6-[2-(1-Undecyltriazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentolKi20200.0 [1]
(1R,2S,4R,5S)-6-[3-(1-Octyltriazol-4-yl)propylamino]cyclohexane-1,2,3,4,5-pentolIC5018200.0 [1], 35400.0 [2], 35481.34 [3]
(1R,2S,4R,5S)-6-[3-(1-Octyltriazol-4-yl)propylamino]cyclohexane-1,2,3,4,5-pentolKi19900.0 [1]
(1S,2R,4S,5R)-6-[3-(1-Decyltriazol-4-yl)propylamino]cyclohexane-1,2,3,4,5-pentolIC501200.0 [1], 3467.37 [2], 3500.0 [3]
(1S,2R,4S,5R)-6-[3-(1-Decyltriazol-4-yl)propylamino]cyclohexane-1,2,3,4,5-pentolKi7600.0 [1]
N-(1-Adamantyl)-4-[[(2R,3S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]amino]butanamideIC5058000.0 [1], 257000.0 [2]
N-(1-Adamantyl)-4-[[(2R,3S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]amino]butanamideKi45000.0 [1], 183000.0 [2]
N-(1-Adamantyl)-4-[[(2S,3S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]amino]butanamideIC50370.0 [1], 5400.0 [2]
N-(1-Adamantyl)-4-[[(2S,3S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]amino]butanamideKi250.0 [1], 2900.0 [2]
Calystegine B2IC501000.0 [1], 5100.0 [2]
Calystegine B2Ki3800.0 [1]
4-(Benzenesulfonamido)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamideIC50100.0 [1], 3200.0 [2]
4-(Benzenesulfonamido)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamideKi52.0 [1]
N-[4-Methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamideIC5030.0 [1], 2200.0 [2]
N-[4-Methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamideKi21.0 [1]
(2S,3S,4R,5R)-6-(Hydroxyamino)-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridine-3,4,5-triolIC505840.0 [1], 65810.0 [2]
(2S,3S,4R,5R)-6-(Hydroxyamino)-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridine-3,4,5-triolKi4280.0 [1]
N-DecylaminocyclitolIC501800.0 [1]
N-DecylaminocyclitolKi300.0 [1]
N-(2,3-Dihydro-1H-inden-2-yl)-2-pyridin-3-ylquinazolin-4-amineIC508.3 [1], 12.7 [2], 25.9 [3]
2-Pyridin-3-yl-N-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amineIC508.7 [1], 16.9 [2], 22.4 [3]
N-(2,3-Dihydro-1H-inden-2-yl)-2-thiophen-2-ylquinazolin-4-amineIC508.2 [1], 12.9 [2], 13.9 [3]
2-Pyridin-3-yl-N-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amineIC509.9 [1], 18.8 [2], 30.1 [3]
N-(2,3-Dihydro-1H-inden-2-yl)-2-thiophen-3-ylquinazolin-4-amineIC505.2 [1], 6.6 [2], 8.9 [3]
N-(2,3-Dihydro-1H-inden-2-yl)-2-phenylquinazolin-4-amineIC506.5 [1], 9.4 [2], 10.5 [3]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-phenylcarbamateIC5012500.0 [1], 19320.0 [2]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-phenylcarbamateKi11550.0 [1]
(1S,2R,4S,5R)-6-[2-(1-Octyltriazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentolIC5055900.0 [1], 165958.69 [2], 167000.0 [3]
(1R,2S,4R,5S)-6-[2-(1-Nonyltriazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentolIC5011000.0 [1], 44668.36 [2], 44700.0 [3]
(1S,2R,4S,5R)-6-[3-(1-Hexyltriazol-4-yl)propylamino]cyclohexane-1,2,3,4,5-pentolIC5044600.0 [1], 257000.0 [2], 257039.58 [3]
(1R,2S,4R,5S)-6-[[1-[[3,5-Bis(phenylmethoxy)phenyl]methyl]triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolIC5050.0 [1], 60.0 [2]
(1R,2S,4R,5S)-6-[[1-[[3,5-Bis(phenylmethoxy)phenyl]methyl]triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolKi50.0 [1]
(1S,2R,4S,5R)-6-[[1-(3,3-Diphenylpropyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolIC501500.0 [1], 1800.0 [2]
(1S,2R,4S,5R)-6-[[1-(3,3-Diphenylpropyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolKi770.0 [1]
(1R,2S,4R,5S)-6-[[1-(1-Adamantylmethyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolIC501900.0 [1], 2200.0 [2]
(1R,2S,4R,5S)-6-[[1-(1-Adamantylmethyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolKi1050.0 [1]
(1R,2S,4R,5S)-6-[[1-(4-Cyclohexylbutyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolIC50300.0 [1], 1500.0 [2]
(1R,2S,4R,5S)-6-[[1-(4-Cyclohexylbutyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolKi290.0 [1]
(1S,2R,4S,5R)-6-[(1-Undecyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolIC5060.0 [1], 100.0 [2]
(1S,2R,4S,5R)-6-[(1-Undecyltriazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentolKi50.0 [1]
(1R,2S,4R,5S)-6-[[1-(10-Hydroxydecyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolIC501300.0 [1], 2190.0 [2]
(1R,2S,4R,5S)-6-[[1-(10-Hydroxydecyl)triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentolKi890.0 [1]
(3Ar,4S,5R,6R,7S,7aS)-4,5,6,7-tetrahydroxy-1,3-di(nonyl)-3a,4,5,6,7,7a-hexahydrobenzimidazol-2-oneIC501210.0 [1], 1610.0 [2]
(3Ar,4S,5R,6R,7S,7aS)-4,5,6,7-tetrahydroxy-1,3-di(nonyl)-3a,4,5,6,7,7a-hexahydrobenzimidazol-2-oneKi700.0 [1]
(1S,2R,3R,4S,5S,6R)-5-Amino-6-(nonylamino)cyclohexane-1,2,3,4-tetrol;dihydrochlorideIC5081.0 [1], 640.0 [2]
(1S,2R,3R,4S,5S,6R)-5-Amino-6-(nonylamino)cyclohexane-1,2,3,4-tetrol;dihydrochlorideKi170.0 [1]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-(2,6-difluorophenyl)carbamateIC5016820.0 [1], 21870.0 [2]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-(2,6-difluorophenyl)carbamateKi17370.0 [1]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-(2,1,3-benzothiadiazol-5-yl)carbamateIC505750.0 [1], 12460.0 [2]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-(2,1,3-benzothiadiazol-5-yl)carbamateKi6380.0 [1]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-(1-adamantyl)carbamateIC501850.0 [1], 8370.0 [2]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-(1-adamantyl)carbamateKi1520.0 [1]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-tert-butylcarbamateIC5021500.0 [1], 29060.0 [2]
[[(2R,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridin-6-yl]amino] N-tert-butylcarbamateKi30080.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Beta-glucocerebrosidase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 8 May. 2024, https://www.aatbio.com/data-sets/beta-glucocerebrosidase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 8). Quest Database™ Beta-glucocerebrosidase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/beta-glucocerebrosidase-inhibitors-ic50-ki.
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