 | EVNLPsiAAEF | IC50 | 10.0 [1] |
| EVNLPsiAAEF | Ki | 1.6 [1] |
 | Bace-1 inhibitor | IC50 | 25.4 [1] |
| Bace-1 inhibitor | Ki | 233.0 [1] |
 | (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine | IC50 | 240.0 [1] |
 | N-[(2S,3R)-4-[[(2S)-1-(Cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide | IC50 | 310.0 [1] |
 | (2e)-2-Imino-3-Methyl-5,5-Diphenylimidazolidin-4-One | IC50 | 3440.0 [1] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamide | IC50 | 5.0 [1] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamide | IC50 | 19.0 [1] |
 | N-[3-[(4S)-2-Amino-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide | IC50 | 51.0 [1] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-4-[(1-ethylpyrazol-4-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]benzamide | IC50 | 78.0 [1] |
 | 3-[[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(2H-tetrazole-5-carbonylamino)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-2-hydroxy-4-phenylbutanoyl]amino]benzoic acid | IC50 | 8.2 [1] |
 | 5-[[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(2H-tetrazole-5-carbonylamino)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-2-hydroxy-4-phenylbutanoyl]amino]benzene-1,3-dicarboxylic acid | IC50 | 3.9 [1] |
 | 8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine | IC50 | 38000.0 [1] |
 | N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 16.32 [1] |
 | 3-[5-[(2R)-2-Amino-1-phenylpropan-2-yl]-1,3,4-oxadiazol-2-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide | IC50 | 9.0 [1], 12.0 [2], 60.0 [3], 65.0 [4] |
| 3-[5-[(2R)-2-Amino-1-phenylpropan-2-yl]-1,3,4-oxadiazol-2-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide | Ki | 39.81 [1] |
 | N-[(2S,3R)-4-[[(4S)-6-(2,2-Dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide | IC50 | 5.0 [1] |
 | 1-N-[(2S,3R)-1-(3,5-Difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 15.0 [1], 20.0 [2], 80.0 [3] |
 | 3-Ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 2.0 [1] |
 | 2-Amino-6-[2-[3-(3-methoxyphenyl)phenyl]ethyl]-3-methylpyrimidin-4-one | IC50 | 5700.0 [1] |
 | N-[(2S,3R)-4-(Benzylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)benzamide | IC50 | 120.0 [1] |
 | N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide | IC50 | 0.54 [1], 0.9 [2], 2.2 [3], 6.4 [4] |
| N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide | Ki | 0.95 [1] |
 | Verubecestat | IC50 | 0.4 [1], 2.2 [2] |
| Verubecestat | Ki | 1.75 [1], 4.88 [2] |
 | Memoquin | IC50 | 108.0 [1], 4600.0 [2] |
 | Lanabecestat | IC50 | 0.2 [1], 0.57 [2], 0.6 [3], 25.0 [4] |
| Lanabecestat | Ki | 26.0 [1] |
 | Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate | IC50 | 2.0 [1] |
| Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate | Ki | 2.5 [1] |
 | (4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(4S,5S,7R)-8-[[(2S)-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid | IC50 | 6.0 [1] |
| (4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(4S,5S,7R)-8-[[(2S)-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid | Ki | 0.3 [1], 0.31 [2], 1.2 [3] |
 | (4S)-4-[[(2S)-2-[[(2S)-2-[[(3S,4S)-4-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-carboxy-2-[[(2S)-4-carboxy-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]butanoyl]amino]butanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acid | IC50 | 30.0 [1], 120.0 [2], 200.0 [3] |
 | Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate | IC50 | 82.0 [1], 2100.0 [2] |
 | Example 1 (WO2011029803) | IC50 | 0.84 [1], 1.0 [2], 6.7 [3], 16.0 [4], 18.0 [5] |
 | (2R)-N-[(2S,3R)-1-(1,3-Benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-2-methoxypropanamide | IC50 | 14.0 [1], 16.8 [2], 18.0 [3], 26.0 [4] |
 | 2-Amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | IC50 | 150000.0 [1], 171000.0 [2], 180000.0 [3], 220000.0 [4] |
 | N-[3-[(4S)-2-Amino-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide | IC50 | 10.0 [1], 137.0 [2], 30000.0 [3] |
 | N-[3-(3-Amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl)phenyl]-5-chloropyridine-2-carboxamide | IC50 | 78.0 [1], 98.0 [2], 348.0 [3], 447.0 [4], 1040.0 [5] |
 | (4Ar,6R,8aS)-8a-(2,4-difluorophenyl)-6-(fluoromethyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine | IC50 | 61.0 [1], 1070.0 [2], 1390.0 [3] |
 | (4Ar,6S,8aS)-8a-(2,4-difluorophenyl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine | IC50 | 39.0 [1], 700.0 [2], 704.0 [3] |
 | N-[(2S,3R)-4-(Cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 5.0 [1], 9.0 [2], 19.19 [3], 28.85 [4], 93.0 [5] |
 | N-[(2S,3R)-4-(2,6-Dimethylheptan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 5.0 [1], 9.0 [2], 21.31 [3], 27.38 [4], 72.0 [5] |
 | 3-Ethyl-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 15.0 [1], 48.9 [2], 57.03 [3], 106.0 [4] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamide | IC50 | 6.0 [1], 21.0 [2], 27.0 [3], 205.0 [4], 715.0 [5] |
 | 3-(1,1-Dioxothiazinan-2-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-5-propylbenzamide | IC50 | 5.0 [1], 40.0 [2], 366.0 [3], 844.0 [4] |
 | 3-(1,1-Dioxothiazinan-2-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-5-(propan-2-ylamino)benzamide | IC50 | 11.0 [1], 58.0 [2], 62.0 [3], 414.0 [4], 910.0 [5] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethoxy)phenyl]methylamino]butan-2-yl]benzamide | IC50 | 5.0 [1], 18.0 [2], 25.0 [3], 216.0 [4], 711.0 [5] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethoxy)phenyl]methylamino]butan-2-yl]benzamide | IC50 | 5.0 [1], 34.0 [2], 39.0 [3], 47.0 [4], 102.0 [5] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]benzamide | IC50 | 8.0 [1], 19.0 [2], 41.0 [3], 299.0 [4], 928.0 [5] |
 | N-[(2S,3R)-1-(3,5-Difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)benzamide | IC50 | 5.0 [1], 26.0 [2], 30.0 [3], 203.0 [4], 450.0 [5] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]benzamide | IC50 | 4.0 [1], 12.0 [2], 14.0 [3], 92.0 [4], 283.0 [5] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-4-[(1-ethylpyrazol-4-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-2-fluorobenzamide | IC50 | 6.0 [1], 12.0 [2], 14.0 [3], 176.0 [4], 361.0 [5] |
 | CID 86724311 | IC50 | 96.0 [1], 316.0 [2], 383.0 [3] |
 | CID 86724314 | IC50 | 2180.0 [1], 3350.0 [2], 3400.0 [3] |
 | CID 90054972 | IC50 | 400.0 [1], 588.0 [2], 1000.0 [3] |
 | CID 90054977 | IC50 | 859.0 [1], 900.0 [2], 1410.0 [3] |
 | CID 90055967 | IC50 | 747.0 [1], 810.0 [2], 1150.0 [3] |
 | CID 90055976 | IC50 | 2240.0 [1], 3040.0 [2], 3100.0 [3] |
 | CID 90055977 | IC50 | 73.0 [1], 239.0 [2], 401.0 [3] |
 | CID 90056005 | IC50 | 1400.0 [1], 2060.0 [2], 3240.0 [3] |
 | CID 90056333 | IC50 | 760.0 [1], 1270.0 [2], 2050.0 [3] |
 | CID 90236720 | IC50 | 2.2 [1], 41.8 [2], 44.4 [3] |
 | CID 90246747 | IC50 | 490.0 [1], 1770.0 [2], 2030.0 [3] |
 | CID 90246748 | IC50 | 820.0 [1], 2130.0 [2], 2590.0 [3] |
 | Quercetin | IC50 | 5400.0 [1], 5600.0 [2], 6500.0 [3] |
| Quercetin | Ki | 14000.0 [1] |
 | N-[Amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide | IC50 | 3700.0 [1] |
 | 3-N-[(2S,3R)-3-Hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide | IC50 | 0.4 [1], 1.0 [2], 2.5 [3] |
| 3-N-[(2S,3R)-3-Hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide | Ki | 1.8 [1] |
 | Tert-butyl N-[(2R)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-3-methylsulfonyl-1-oxopropan-2-yl]carbamate | Ki | 1129.0 [1] |
 | N-[(2S)-2-Amino-3-[[(2S)-1-[[(2S)-1-[[(2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-[3-(2H-tetrazol-5-yl)anilino]butan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]-2H-tetrazole-5-carboxamide | IC50 | 4.8 [1] |
 | N-[(2S,3R)-4-[[1-(3-Tert-butylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide | IC50 | 47.0 [1] |
 | N-[(2S)-2-Amino-3-[[(2S)-1-[[(2S)-1-[[(2S,3R)-4-[3,5-bis(2H-tetrazol-5-yl)anilino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]-2H-tetrazole-5-carboxamide | IC50 | 1.2 [1] |
 | N-[(2S)-2-Amino-3-[[(2S)-1-[[(2S)-3-cyclohexyl-1-[[(2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-[3-(2H-tetrazol-5-yl)anilino]butan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]-5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxamide | IC50 | 5.6 [1] |
 | 5-[(1R)-3-Amino-4-fluoro-1-[3-(5-prop-1-ynylpyridin-3-yl)phenyl]isoindol-1-yl]-1-ethyl-3-methylpyridin-2-one | IC50 | 0.16 [1], 0.2 [2], 2.0 [3], 2.44 [4] |
 | N-Carbamimidoyl-2-[2-(2-Chlorophenyl)-5-[4-(4-Ethanoylphenoxy)phenyl]pyrrol-1-Yl]ethanamide | IC50 | 160.0 [1], 700.0 [2], 3800.0 [3] |
 | (1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine | IC50 | 0.6 [1], 16.7 [2], 35.1 [3] |
| (1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine | Ki | 25.7 [1] |
 | N-[3-[(1S,7S)-3-Amino-4-thia-2-azabicyclo[5.1.0]oct-2-en-1-yl]phenyl]-5-chloropyridine-2-carboxamide | IC50 | 2.0 [1], 5.0 [2], 27.0 [3] |
 | 3-[5-[(4Ar,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile | IC50 | 16.0 [1] |
| 3-[5-[(4Ar,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrile | Ki | 4.0 [1] |
 | N-[(2S,3R)-4-[[(4S)-6-(2,2-Dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide | IC50 | 3.0 [1], 3.1 [2], 5.8 [3], 6.0 [4] |
 | 3-(Ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-5-(2-oxopyrrolidin-1-yl)benzamide | IC50 | 40.0 [1], 49.0 [2], 180.0 [3], 200.0 [4] |
 | 1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 5.0 [1], 150.0 [2] |
 | 1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-[(2R,4S)-4-ethoxypiperidin-2-yl]-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 7.0 [1], 8.0 [2], 106.0 [3] |
 | 1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 3.0 [1], 165.0 [2] |
 | 2-Amino-3-methyl-6-[2-(3-phenylphenyl)ethyl]pyrimidin-4-one | IC50 | 6500.0 [1], 29000.0 [2], 30000.0 [3] |
 | 3-Ethyl-N-[(2S,3R)-3-hydroxy-4-(oxan-4-ylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 9.0 [1], 15.0 [2], 90.0 [3] |
 | N-[3-[(2R,3R)-5-Amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide | IC50 | 9.1 [1], 12.0 [2], 13.2 [3] |
 | 1-N-[(1R,2S)-1-[(2R,4S)-4-Benzylpiperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 14.0 [1], 522.0 [2] |
 | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(6-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-phenylbutan-2-yl]benzamide | IC50 | 18.0 [1], 26.0 [2], 36.0 [3] |
 | 3-Ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-(3,3,3-trifluoropropylamino)butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 7.0 [1], 8.0 [2] |
 | 1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-hydroxy-1-[(2R)-piperidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 130.0 [1], 240.0 [2] |
 | (4Ar,7aS)-2-amino-7a-(2,5-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one | IC50 | 23.0 [1], 28.0 [2] |
| (4Ar,7aS)-2-amino-7a-(2,5-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-one | Ki | 8.5 [1], 9.0 [2] |
 | (4s)-2'-(2,2-Dimethylpropoxy)-7'-(Pyrimidin-5-Yl)spiro[1,3-Oxazole-4,9'-Xanthen]-2-Amine | IC50 | 2.0 [1], 2.2 [2], 25.0 [3] |
 | (4s)-2'-(2-Methylpropoxy)-7'-(Pyrimidin-5-Yl)spiro[1,3-Oxazole-4,9'-Xanthen]-2-Amine | IC50 | 8.0 [1], 36.0 [2] |
 | N-[3-[(3R)-5-Amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide | IC50 | 3.0 [1], 4.1 [2], 22.0 [3], 31.0 [4] |
Calculator
