Bone morphogenetic protein receptor type-1A Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline	IC50	2.15 [1], 5.0 [2], 19.0 [3]
	Staurosporine	IC50	4288.0 [1]
	Dorsomorphin	IC50	95.0 [1]
	Vactosertib	IC50	10000.0 [1]
	5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	IC50	539.0 [1]
	1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine	IC50	1171.0 [1]
	5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	IC50	10800.0 [1]
	4-[6-(4-Propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	IC50	5.0 [1]
	4-(6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline	IC50	6.78 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	CID 60182364	IC50	5.0 [1]
	CID 60182389	IC50	5.0 [1]
	4-(4-(3-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)morpholine	IC50	10.4 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	IC50	7.0 [1]
	3-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]benzenesulfonamide	IC50	2534.0 [1]
	4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-2-methylbenzenesulfonamide	IC50	16550.0 [1]
	2-Amino-4-[6-[4-[(2R,6S)-2,6-dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]benzenesulfonamide	IC50	10000.0 [1]
	4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	3466.0 [1]
	4-[6-[4-(2-Piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-N,N-dimethylnaphthalene-1-sulfonamide	IC50	64750.0 [1]
	4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-N-methylnaphthalene-1-sulfonamide	IC50	10000.0 [1]
	4-[6-[4-(2-Methyl-1-piperidin-1-ylpropan-2-yl)oxyphenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]-3-(4-methylsulfonylphenyl)pyrazolo[1,5-a]pyrimidine	IC50	10000.0 [1]
	4-[6-(6-Piperazin-1-ylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	4-[6-[4-(2-Aminopropan-2-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	4-[6-[6-(2-Piperidin-1-ylethoxy)pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	N-[4-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalen-1-yl]methanesulfonamide	IC50	8897.0 [1]
	4-[6-[4-(Pyrrolidin-1-ylmethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	4-[6-[4-(2-Pyrrolidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	4-[6-[4-(1-Aminocyclobutyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	8195.0 [1]
	4-[6-[6-[2-(Dimethylamino)ethoxy]pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	5-[6-[4-[(2S,6R)-2,6-Dimethylpiperazin-1-yl]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	444.0 [1]
	4-[6-(4-Piperidin-4-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	10000.0 [1]
	4-[6-[4-(1-Aminoethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]naphthalene-1-sulfonamide	IC50	12830.0 [1]
	(4S,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dione	IC50	6267.0 [1]
	Alk2-IN-2	IC50	6439.0 [1]
	6-(4-Methoxyphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine	IC50	41.0 [1]
	4-[[(3S,4R)-1-(5-Cyanopyridin-2-yl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide	IC50	1000.0 [1]
	6-(4-Piperazin-1-ylphenyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine	IC50	55.0 [1]
	N-[4-[(6-Chloro-[1,3]dioxolo[4,5-B]pyridin-7-Yl)amino]-2-Pyridyl]cyclopropanecarboxamide	IC50	2.4 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Bone morphogenetic protein receptor type-1A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/bone-morphogenetic-protein-receptor-type-1a-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Bone morphogenetic protein receptor type-1A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/bone-morphogenetic-protein-receptor-type-1a-inhibitors-ic50-ki.
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