 | Icatibant | IC50 | 0.49 [1], 3.3 [2] |
| Icatibant | Ki | 0.03 [1], 0.06 [2], 0.18 [3] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide;hydrochloride | IC50 | 1.1 [1] |
 | Bradykinin | IC50 | 1.8 [1] |
| Bradykinin | Ki | 0.07 [1], 0.11 [2], 0.65 [3], 0.68 [4] |
 | Arg-3-hyp-7-phe-bradykinin | IC50 | 7.0 [1], 10.0 [2], 14.0 [3] |
 | 4-[(E)-3-[[2-[3-[(3-Bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2,4-dichloro-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide;hydrochloride | IC50 | 1.5 [1], 9.0 [2] |
 | (E)-3-(6-Acetamidopyridin-3-yl)-N-[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]prop-2-enamide | IC50 | 1.4 [1] |
 | 4-[(E)-3-[[2-[3-[(3-Bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2,4-dichloro-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N,N-dimethylbenzamide | IC50 | 1.4 [1], 2.2 [2] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[(2-methyl-1,3-benzoxazol-4-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 860.0 [1], 1100.0 [2] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[(2-methylquinazolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 56.0 [1], 59.0 [2] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[(2-methylquinoxalin-5-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 2900.0 [1], 4300.0 [2] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[(3-methylquinoxalin-5-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide;hydrochloride | IC50 | 3.1 [1], 5.2 [2] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[(1,2-dimethylbenzimidazol-4-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 43.0 [1], 67.0 [2] |
 | N-[2-[3-(Dimethylamino)propyl-methylamino]ethyl]-1-[3-nitro-4-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylcarbamoyl)hydrazinyl]phenyl]sulfonylpyrrole-2-carboxamide | IC50 | 12.0 [1], 55.0 [2] |
| N-[2-[3-(Dimethylamino)propyl-methylamino]ethyl]-1-[3-nitro-4-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylcarbamoyl)hydrazinyl]phenyl]sulfonylpyrrole-2-carboxamide | Ki | 2.79 [1] |
 | 2-[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]sulfanyl-1,3-thiazole | IC50 | 29.0 [1], 50.0 [2], 470.0 [3] |
 | (2S)-N-[2-[3-(Dimethylamino)propyl-methylamino]ethyl]-1-[3-nitro-4-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylcarbamoyl)hydrazinyl]phenyl]sulfonylpyrrolidine-2-carboxamide | IC50 | 17.0 [1], 91.0 [2] |
| (2S)-N-[2-[3-(Dimethylamino)propyl-methylamino]ethyl]-1-[3-nitro-4-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylcarbamoyl)hydrazinyl]phenyl]sulfonylpyrrolidine-2-carboxamide | Ki | 0.79 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[[2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl]oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 0.41 [1] |
 | Fasitibant | Ki | 0.05 [1] |
 | (2R)-2-[[(2S)-2-[[(2S)-2-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2R)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-1-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid | Ki | 12.59 [1], 20.0 [2] |
 | N-[1-[4-[(2S)-2-Amino-6-(dimethylamino)hexanoyl]piperazin-1-yl]-2-methyl-1-oxopropan-2-yl]-2,4-dichloro-3-[(2,4-dimethylquinolin-8-yl)oxymethyl]benzenesulfonamide | Ki | 0.63 [1] |
 | N-[1-[4-[(2S)-2-Amino-5-(dimethylamino)pentanoyl]piperazin-1-yl]-2-methyl-1-oxopropan-2-yl]-2,4-dichloro-3-[(2,4-dimethylquinolin-8-yl)oxymethyl]benzenesulfonamide | Ki | 0.4 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 1.1 [1] |
 | N-[1-[4-[(3S)-3-Amino-6-(dimethylamino)hexanoyl]piperazin-1-yl]-2-methyl-1-oxopropan-2-yl]-2,4-dichloro-3-[(2,4-dimethylquinolin-8-yl)oxymethyl]benzenesulfonamide | Ki | 0.63 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[(2,3-dimethyl-1-benzofuran-7-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 270.0 [1] |
 | 4-[(E)-3-[[2-[3-[[2-(Dimethylamino)-1-methylbenzimidazol-4-yl]oxymethyl]-N,2,4-trimethylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 160.0 [1] |
 | 4-[(E)-3-[[2-[3-[(2-Acetyl-1-methylbenzimidazol-4-yl)oxymethyl]-N,2,4-trimethylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 94.0 [1] |
 | Ethyl 2-[4-[[2,6-dimethyl-3-[methyl-[2-[[(E)-3-[4-(methylcarbamoyl)phenyl]prop-2-enoyl]amino]acetyl]amino]phenyl]methoxy]-1-methylbenzimidazol-2-yl]acetate | IC50 | 8400.0 [1] |
 | 4-[(E)-3-[[2-[3-[[2-(Methoxymethyl)-1-methylbenzimidazol-4-yl]oxymethyl]-N,2,4-trimethylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 9100.0 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[(1-ethyl-2-methylbenzimidazol-4-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 48.0 [1] |
 | (E)-3-(6-Acetamidopyridin-3-yl)-N-[2-[2,4-dichloro-3-[(2-methoxy-1-methylbenzimidazol-4-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]prop-2-enamide | IC50 | 4.2 [1] |
 | 4-[(E)-3-[[2-[3-[(2-Methoxy-1-methylbenzimidazol-4-yl)oxymethyl]-N,2,4-trimethylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 7.2 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[(2-methoxy-1-methylbenzimidazol-4-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 2.2 [1] |
 | N-Methyl-4-[(E)-3-oxo-3-[[2-oxo-2-[N,2,4-trimethyl-3-[(1-methyl-2-methylsulfanylbenzimidazol-4-yl)oxymethyl]anilino]ethyl]amino]prop-1-enyl]benzamide | IC50 | 79.0 [1] |
 | N-Methyl-4-[(E)-3-oxo-3-[[2-oxo-2-[N,2,4-trimethyl-3-[[1-methyl-2-(methylamino)benzimidazol-4-yl]oxymethyl]anilino]ethyl]amino]prop-1-enyl]benzamide | IC50 | 670.0 [1] |
 | 4-[(E)-3-[[2-[3-[(2-Ethoxy-1-methylbenzimidazol-4-yl)oxymethyl]-N,2,4-trimethylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 730.0 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N,N-dimethylbenzamide;hydrochloride | IC50 | 3.9 [1] |
 | (2R)-N-[3-[(4-Carbamimidoylbenzoyl)amino]propyl]-1-[2,4-dichloro-3-[(2,4-dimethylquinolin-8-yl)oxymethyl]phenyl]sulfonylpyrrolidine-2-carboxamide | Ki | 0.4 [1], 0.79 [2] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[(2-ethyl-1-methylbenzimidazol-4-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide;hydrochloride | IC50 | 22.0 [1] |
 | N-Methyl-4-[(E)-3-oxo-3-[[2-oxo-2-[N,2,4-trimethyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]ethyl]amino]prop-1-enyl]benzamide;hydrochloride | IC50 | 4.8 [1] |
 | Unii-8PY38jsg1Y | Ki | 9.16 [1], 9.2 [2] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[[4-(dimethylamino)-2-methylquinolin-8-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide;dihydrochloride | IC50 | 3.2 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[[4-(dimethylamino)-2-methylquinolin-8-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N,N-dimethylbenzamide;dihydrochloride | IC50 | 2.1 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[[2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 2000.0 [1], 3500.0 [2] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-N-methyl-3-[(6-methylpyridin-2-yl)methoxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 10000.0 [1] |
 | 4-[(E)-3-[[2-[2,4-Dichloro-3-[(4-ethoxy-2-methylquinolin-8-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide | IC50 | 34.0 [1] |
 | Unii-1Q3KX3563S | IC50 | 1.1 [1], 8.7 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinoline | IC50 | 50.0 [1], 180.0 [2] |
 | 8-((3,5-Dichloropyridin-4-yl)methoxy)-2-methyl-4-(4-methyl-1H-pyrazol-3-yl)quinoline | IC50 | 110.0 [1], 390.0 [2] |
 | 8-((3,5-Dichloropyridin-4-yl)methoxy)-2-methyl-4-(5-methyl-1H-pyrazol-4-yl)quinoline | IC50 | 3600.0 [1], 6300.0 [2] |
 | 5-(8-((3,5-Dichloropyridin-4-yl)methoxy)-2-methylquinolin-4-yl)thiazole | IC50 | 135.0 [1], 420.0 [2] |
 | 8-[(3,5-Dichloropyridin-4-yl)methoxy]-2-methyl-4-(2-methyl-1,2,4-triazol-3-yl)quinoline | IC50 | 68.0 [1], 2400.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-thiazol-2-yl-quinoline | IC50 | 420.0 [1], 480.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-thiazol-5-yl)-quinoline | IC50 | 67.0 [1], 110.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(5-methyl-thiazol-4-yl)-quinoline | IC50 | 64.0 [1], 400.0 [2] |
 | 4-(8-((3,5-Dichloropyridin-4-yl)methoxy)-2-methylquinolin-4-yl)-3-methylisothiazole | IC50 | 200.0 [1], 330.0 [2] |
 | 5-[8-[(3,5-Dichloropyridin-4-yl)methoxy]-2-methylquinolin-4-yl]-4-methyl-1,3-oxazole | IC50 | 5000.0 [1], 6050.0 [2] |
 | N-[[4-Methyl-3-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-2-yl]methyl]cyclohexanecarboxamide | IC50 | 1.8 [1], 10.0 [2] |
 | 4-(4-Chloro-thiazol-5-yl)-8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-quinoline | IC50 | 980.0 [1], 2500.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-thiazol-4-yl-quinoline | IC50 | 80.0 [1], 300.0 [2] |
 | 4-(5-Chloro-thiazol-4-yl)-8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-quinoline | IC50 | 210.0 [1], 730.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-isothiazol-3-yl)-quinoline | IC50 | 20.0 [1], 70.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(3-methyl-isoxazol-4-yl)-quinoline | IC50 | 430.0 [1], 3800.0 [2] |
 | 2-Methyl-N-[[4-methyl-3-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-2-yl]methyl]propanamide | IC50 | 3.8 [1], 5.4 [2] |
 | 8-[(3-Chloropyridin-4-yl)methoxy]-2-methyl-4-(2-methylpyrazol-3-yl)quinoline | IC50 | 517.0 [1], 1600.0 [2] |
 | 8-[[3-Chloro-5-(1-methylimidazol-2-yl)sulfanylpyridin-4-yl]methoxy]-2-methyl-4-(2-methylpyrazol-3-yl)quinoline | IC50 | 18.0 [1], 43.0 [2] |
 | 2-[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]sulfanyl-N,N-dimethylacetamide | IC50 | 7.5 [1], 24.0 [2] |
 | 2-[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]sulfinyl-N,N-dimethylacetamide | IC50 | 37.0 [1], 76.0 [2] |
 | 2-[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]oxy-N,N-dimethylacetamide | IC50 | 6.5 [1], 91.0 [2] |
 | 3-[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]-N,N-dimethylpropanamide | IC50 | 36.0 [1], 73.0 [2] |
 | N-[[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]-2-methylpropanamide | IC50 | 2.3 [1], 7.8 [2] |
 | 3-[[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]-1,1-dimethylurea | IC50 | 2.8 [1], 6.6 [2] |
 | [5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl N,N-dimethylcarbamate | IC50 | 8.3 [1], 12.0 [2] |
 | 3-[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]propanamide | IC50 | 33.0 [1], 190.0 [2] |
 | N-[[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]acetamide | IC50 | 12.0 [1], 24.0 [2] |
 | N-[[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]methanesulfonamide | IC50 | 14.0 [1], 110.0 [2] |
 | 1-[[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]pyridin-2-one | IC50 | 3.6 [1], 5.1 [2] |
 | 8-[[3-Chloro-5-(pyridin-2-yloxymethyl)pyridin-4-yl]methoxy]-2-methyl-4-(2-methylpyrazol-3-yl)quinoline | IC50 | 140.0 [1], 260.0 [2] |
 | 1-[[5-Chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]-3-(trifluoromethyl)pyridin-2-one | IC50 | 1.4 [1], 4.0 [2] |
 | 1-[[4-Methyl-3-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-2-yl]methyl]-3-(trifluoromethyl)pyridin-2-one | IC50 | 0.54 [1], 8.8 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-4-imidazol-1-yl-2-methyl-quinoline | IC50 | 580.0 [1], 2500.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2-methyl-imidazol-1-yl)-quinoline | IC50 | 200.0 [1], 1300.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(1-methyl-1H-imidazol-2-yl)-quinoline | IC50 | 90.0 [1], 760.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-4-(1,5-dimethyl-1H-imidazol-2-yl)-2-methylquinoline | IC50 | 200.0 [1], 3400.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-pyrazol-1-yl-quinoline | IC50 | 32.0 [1], 920.0 [2] |
 | 8-(3,5-Dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2H-pyrazol-3-yl)-quinoline | IC50 | 310.0 [1], 350.0 [2] |
 | [5-Chloro-4-[2-methyl-4-(2-methylpyrazol-3-yl)quinoline-8-carbonyl]pyridin-3-yl]methyl acetate | IC50 | 6.0 [1], 260.0 [2] |
 | 1-[[3-[[4-(5-Chloro-1,3-thiazol-4-yl)-2-methylquinolin-8-yl]oxymethyl]-4-methylpyridin-2-yl]methyl]-3-(trifluoromethyl)pyridin-2-one | IC50 | 1.3 [1], 10.0 [2] |
 | Tributyl-[[4-[[(2S)-2-[(N,N'-dicyclohexylcarbamimidoyl)amino]-3-naphthalen-2-ylpropanoyl]amino]phenyl]methyl]phosphanium;dihydrochloride | Ki | 60.0 [1] |
 | 4,4'-Bis[(tripentylphosphonio)methyl]benzophenone | Ki | 770.0 [1] |
 | Tamoxifen | Ki | 12048.0 [1] |
 | Amiodarone | Ki | 7674.0 [1] |
 | [Leu8,des-Arg9]bradykinin | Ki | 10.0 [1] |
 | Labradimil | Ki | 19.0 [1] |
 | Cipargamin | IC50 | 30000.0 [1] |
 | Fasitibant chloride | IC50 | 0.05 [1] |
 | Bradyzide | Ki | 772.0 [1] |
 | CID 9916412 | Ki | 10000.0 [1] |
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