Bromodomain testis-specific protein Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate	IC50	103.0 [1], 183.0 [2], 217.0 [3]
	4-[(2s,4r)-1-Acetyl-4-[(4-Chlorophenyl)amino]-2-Methyl-1,2,3,4-Tetrahydroquinolin-6-Yl]benzoic Acid	IC50	50.12 [1], 31622.78 [2]
	BET Inhibitor C3	IC50	2300.0 [1], 5200.0 [2]
	BET Inhibitor C3	Ki	450.0 [1]
	BI-2536	IC50	260.0 [1], 1400.0 [2]
	Apabetalone	IC50	708.0 [1], 4836.0 [2]
	Tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate	IC50	110.0 [1], 169.0 [2]
	8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-one	IC50	31622.78 [1], 50118.72 [2]
	5-(5-Methoxypyridin-3-Yl)-3-Methyl-8-[(Piperidin-4-Yl)amino]-1,2-Dihydro-1,7-Naphthyridin-2-One	IC50	6309.57 [1], 25118.86 [2]
	3-Methyl-5-(5-methylpyridin-3-yl)-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-one	IC50	7943.28 [1], 31622.78 [2]
	8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]-1-methylpiperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-one	IC50	50118.72 [1]
	4-[(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-cyclopentylbenzenesulfonamide	IC50	3082.0 [1], 3292.0 [2]
	6-[(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-1H-quinolin-2-one	IC50	2781.0 [1], 3183.0 [2]
	5-[(2S)-1-Acetyl-2-cyclopropyl-4-[[2-(hydroxymethyl)phenyl]methyl]-2,3-dihydroquinoxalin-6-yl]pyrimidine-2-carboxamide	IC50	100.0 [1], 501.19 [2]
	1-[(2S)-2-Cyclopropyl-4-[[2-(hydroxymethyl)phenyl]methyl]-6-(1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydroquinoxalin-1-yl]ethanone	IC50	199.53 [1], 1584.89 [2]
	8-(4-Methylphenyl)-13-(2,2,2-trifluoroethyl)-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	450.0 [1], 850.0 [2]
	4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole	IC50	20000.0 [1]
	4-[[(7S)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	3513.0 [1]
	Dinaciclib	IC50	37000.0 [1]
	Fedratinib	IC50	340.0 [1]
	8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one	IC50	3500.0 [1]
	CID 16722832	IC50	230.0 [1]
	Mivebresib	Ki	2.2 [1]
	5-Ethyl-5-methyl-5,6-dihydrobenzo[h]quinazolin-4(3H)-one	IC50	220000.0 [1]
	4-[(8-Cyclopentyl-5-methyl-6-oxo-7H-pteridin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	25990.0 [1]
	11,13-Dimethyl-8-(4-methylphenyl)-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	40000.0 [1]
	N-[3-(3-Methyl-4-Oxo-4,5,6,7-Tetrahydro-2h-Isoindol-1-Yl)-4-Phenoxyphenyl]methanesulfonamide	Ki	110.0 [1]
	1-[2-(2,4-Difluorophenoxy)-5-methylsulfonylphenyl]-3-methyl-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-4-one	Ki	140.0 [1]
	3-[(4-Chlorophenyl)methyl]-7-Ethyl-Purine-2,6-Dione	IC50	2300.0 [1]
	4-[[(7R)-8-Cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	342.0 [1]
	4-[[(7R)-8-Cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-piperidin-4-ylbenzamide	IC50	560.0 [1]
	3-Butyl-7-ethylpurine-2,6-dione	IC50	7900.0 [1]
	8-[(5-Amino-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-3-[(4-chlorophenyl)methyl]-7-ethylpurine-2,6-dione	IC50	100000.0 [1]
	5-(4-Hydroxy-3,5-dimethylphenyl)-11-methyl-8-thia-4,6,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5-trien-3-one	IC50	100000.0 [1]
	13-Cyclopropyl-8-(4-methylphenyl)-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	40000.0 [1]
	5-Benzyl-13-ethyl-8-(4-methylphenyl)-2,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	IC50	550.0 [1]
	13-Ethyl-8-(4-methylphenyl)-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1,3(7),8-triene-6,10,12-trione	Ki	40000.0 [1]
	4-(2,5-Dimethoxyphenyl)-3-methyl-5-propyl-2,4-dihydropyrrolo[3,4-c]pyrrol-6-one	IC50	67000.0 [1]
	13-Ethyl-5-methyl-8-(4-methylphenyl)-2,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	5600.0 [1]
	8-(4-Methoxyphenyl)-13-methyl-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	40000.0 [1]
	13-Ethyl-11-methyl-8-(4-methylphenyl)-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	40000.0 [1]
	13-Ethyl-5-[2-(4-hydroxyphenyl)ethyl]-8-(4-methylphenyl)-2,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	IC50	760.0 [1]
	13-Ethyl-8-(4-methylphenyl)-5-(2-phenylethyl)-2,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	IC50	1000.0 [1]
	13-Ethyl-8-(4-methylphenyl)-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	23000.0 [1]
	13-Ethyl-8-[4-(trifluoromethyl)phenyl]-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	4700.0 [1]
	13-Ethyl-5-[2-(4-methoxyphenyl)ethyl]-8-(4-methylphenyl)-2,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	IC50	1000.0 [1]
	8-(2-Hydroxyethylamino)-7-(naphthalen-1-ylmethyl)-3H-purine-2,6-dione	IC50	87000.0 [1]
	Methyl 4-[[(7R)-8-cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-cyclopentyloxybenzoate	IC50	933.0 [1]
	4-[[(7R)-8-Cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-N-[2-(dimethylamino)ethyl]-3-methoxybenzamide	IC50	392.0 [1]
	N-Cyclohexyl-4-[[(7R)-8-cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxybenzamide	IC50	378.0 [1]
	4-[[(7R)-8-Cyclopentyl-5-methyl-6-oxo-7-propyl-7H-pteridin-2-yl]amino]-3-cyclopentyloxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	1951.0 [1]
	4-[[(7R)-5,7-Dimethyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	978.0 [1]
	8-(4-Fluorophenyl)-12-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one	Ki	5.9 [1]
	4-[[(7R)-8-Cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methyl-2H-pyridin-4-yl)benzamide	IC50	289.0 [1]
	4-[[(7S)-8-Cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	229.0 [1]
	4-[[(7R)-8-Cyclopentyl-5-methyl-6-oxo-7-propyl-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	8468.0 [1]
	3-Methoxy-4-[[(7R)-5-methyl-7-(2-methylpropyl)-8-(oxan-4-yl)-6-oxo-7H-pteridin-2-yl]amino]-N-(1-methylpiperidin-4-yl)benzamide	IC50	50000.0 [1]
	4-[[(7R)-8-Cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-cyclopentyloxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	102.0 [1]
	4-[[(7R)-8-Cyclohexyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	750.0 [1]
	4-[[(7S)-8-Cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-cyclopentyloxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	245.0 [1]
	4-[(8-Cyclopentyl-5-methyl-6-oxo-7H-pteridin-2-yl)amino]-3-cyclopentyloxy-N-(1-methylpiperidin-4-yl)benzamide	IC50	3543.0 [1]
	(7R)-8-Cyclopentyl-2-[2-methoxy-4-(piperidine-1-carbonyl)anilino]-5,7-dimethyl-7H-pteridin-6-one	IC50	369.0 [1]
	4-[[(7R)-8-Cyclopentyl-5,7-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(2-phenylethyl)benzamide	IC50	558.0 [1]
	13-Methyl-8-phenyl-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	40000.0 [1]
	8-Phenyl-13-propyl-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	2400.0 [1]
	5-(2-Furyl)-1-(tetrahydro-2-furanylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione	IC50	130000.0 [1]
	8-Chloro-6-(4-chlorophenyl)-1-methyl-3H,4H-benzo[g]1,5-diazocin-2-one	IC50	220000.0 [1]
	8-(4-Chlorophenyl)-13-ethyl-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	1100.0 [1]
	8-(4-Methoxyphenyl)-11,13-dimethyl-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	40000.0 [1]
	13-Ethyl-8-phenyl-5-oxa-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7)-diene-6,10,12-trione	Ki	1400.0 [1]
	3-Butyl-8-[(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanylmethyl]-7-ethylpurine-2,6-dione	IC50	100000.0 [1]
	1,3-Diethyl-2-oxo-2,3-dihydro-1H-benzoimidazole-5-carbaldehyde	IC50	140000.0 [1]
	7-(4-Fluorobenzyl)-3-methyl-8-(methylamino)-1H-purine-2,6(3H,7H)-dione	IC50	68000.0 [1]
	3-[2-(2,4-Difluorophenoxy)-5-methylsulfonylphenyl]-1-methyl-6H-pyrrolo[2,3-c]pyridin-7-one	Ki	490.0 [1]
	15-Methyl-4-(methylsulfonylmethyl)-8-pyridin-2-yl-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one	Ki	0.69 [1]
	8-(2,4-Difluorophenyl)-15-methyl-4-(methylsulfonylmethyl)-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaen-14-one	Ki	4.2 [1]
	N-Methoxy-N'-(7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanimidamide	IC50	120000.0 [1]
	5-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-hydroxy-3-(2-oxocyclohexyl)-1H-indol-2-one	IC50	58.0 [1]
	5-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-[[(2R)-1-hydroxypropan-2-yl]amino]-3-phenyl-1H-indol-2-one	IC50	69.0 [1]
	3-Amino-5-(3,5-dimethyl-1,2-oxazol-4-yl)-3-phenyl-1H-indol-2-one	IC50	95.0 [1]
	5-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-[(3S)-3-hydroxypiperidin-1-yl]-3-phenyl-1H-indol-2-one	IC50	23.0 [1]
	3-Cyclohexyl-5-(3,5-dimethyl-1,2-oxazol-4-yl)-3-[[(2R)-2-hydroxypropyl]amino]-1H-indol-2-one	IC50	42.0 [1]
	3-[(3S)-3-Aminopiperidin-1-yl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-3-phenyl-1H-indol-2-one	IC50	14.0 [1]
	5-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-hydroxy-3-thiophen-3-yl-1H-indol-2-one	IC50	31.0 [1]
	5-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-hydroxy-3-(oxan-4-yl)-1H-indol-2-one	IC50	510.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 85 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Bromodomain testis-specific protein Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/bromodomain-testis-specific-protein-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ Bromodomain testis-specific protein Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/bromodomain-testis-specific-protein-inhibitors-ic50-ki.
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