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C-C chemokine receptor type 3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-[3-(1-methyltetrazol-5-yl)phenyl]ureaIC500.01 [1]
1-((1R,2S)-2-(((S)-3-(4-Fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-acetylphenyl)ureaIC500.04 [1]
(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionateIC505.0 [1]
Unii-pon9ofp69GIC500.04 [1], 0.87 [2]
CCR3 AntagonistIC500.03 [1], 0.5 [2], 0.9 [3], 4.0 [4]
(S)-1-(3-(3-(4-Fluorobenzyl)piperidin-1-yl)propyl)-3-(3-acetylphenyl)ureaIC502.5 [1], 25.0 [2]
J-113863 Cation, trans-IC500.58 [1], 6.1 [2]
CID 11753159IC508.1 [1]
CID 11753159Ki6.31 [1]
1-[3-[4-(4-Fluorobenzyl)piperidino]propyl]-3-(3-acetylphenyl)ureaIC5010.0 [1]
1-[3-[4-(4-Fluorobenzyl)piperidino]propyl]-3-(3-cyanophenyl)ureaIC5020.0 [1], 80.0 [2]
1-[3-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]propyl]-3-[3-methyl-5-(1-methyltetrazol-5-yl)phenyl]ureaIC501.0 [1], 1.5 [2]
(S)-1-(3-(3-(4-Fluorobenzyl)piperidin-1-yl)propyl)-3-(3,5-diacetylphenyl)ureaIC501.2 [1], 3.0 [2]
1-(3-((S)-3-(4-Fluorobenzyl)piperidin-1-yl)propyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)ureaIC500.6 [1], 3.2 [2]
3-[3-(3-Acetyl-phenyl)-ureido]-2-[4-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-N-methyl-benzamideIC501.0 [1], 30.0 [2]
1-[3,5-Bis(1-methyltetrazol-5-yl)phenyl]-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC500.04 [1], 1.0 [2], 2.0 [3]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(1H-indol-5-yl)ureaIC500.02 [1], 0.4 [2], 2.0 [3]
1-(3-Acetyl-4-fluorophenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC500.01 [1], 1.5 [2], 4.0 [3]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(2-methoxyphenyl)ureaIC501.4 [1], 10.0 [2], 115.0 [3]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(1H-indazol-6-yl)ureaIC500.06 [1], 0.7 [2], 4.0 [3]
1-(3,5-Diacetylphenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC500.01 [1], 1.1 [2], 2.0 [3]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-[3-(5-methyltetrazol-1-yl)phenyl]ureaIC500.1 [1], 1.4 [2], 2.0 [3]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(1H-indazol-5-yl)ureaIC500.04 [1], 0.3 [2], 2.0 [3]
1-[(3S,4S)-1-Acetyl-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]-3-(5-acetyl-4-methyl-1,3-thiazol-2-yl)ureaIC500.07 [1], 1.9 [2], 2.6 [3]
6-[2-Ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-3-carboxylic acidIC5040.0 [1], 531.8 [2]
6-[2-Ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-3-carboxylic acidKi16.0 [1]
4-[[2-(4-Chlorophenyl)ethyl-[1-(2,6-difluorobenzoyl)piperidin-4-yl]amino]methyl]-2-(4-fluorophenyl)-1,5-dimethylpyrazol-3-oneIC5016.0 [1], 20.0 [2]
Banyu (I)IC502.3 [1]
N-[8-[(6-Fluoronaphthalen-2-yl)methyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-phenylbenzamideIC5020.0 [1], 62.0 [2]
1-(3-Acetyl-phenyl)-3-{2-[4-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-phenyl}-ureaIC50125.0 [1]
2-(Benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamideIC5032.0 [1]
1-[3-[4-(4-Fluorobenzyl)piperidino]propyl]-3-[3-(1-methyl-1H-tetrazole-5-yl)phenyl]ureaIC505.0 [1]
1-[3-[4-(4-Fluorobenzyl)piperidino]propyl]-3-(3-methoxyphenyl)ureaIC5030.0 [1]
1-[3-Acetyl-5-(1-methyltetrazol-5-yl)phenyl]-3-[3-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]propyl]ureaIC502.6 [1]
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1-methylpiperidin-3-yl]ureaIC501.2 [1]
N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-4-yl}biphenyl-2-carboxamideIC5038.0 [1]
4-Fluoro-N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamideIC50640.0 [1]
(2E)-N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-4-yl}-3-phenylacrylamideIC509700.0 [1]
N-[(3R)-1-[(6-Fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]-2-[1-(2-hydroxybenzoyl)piperidin-4-ylidene]acetamideIC501.0 [1], 8.4 [2]
1-[3-(4-Benzylpiperidino)propyl]-3-(3-cyanophenyl)ureaIC50200.0 [1]
1-(3-Acetylphenyl)-3-[3-[(2R,4S)-4-benzyl-2-[(1S)-1-hydroxypropyl]piperidin-1-yl]propyl]ureaIC506.0 [1], 20.0 [2]
N-[(2R)-3-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl]-1-oxo-2H-isoquinoline-4-carboxamideKi1.58 [1]
1-[3-(4-Benzylpiperidino)propyl]-3-(3-methoxyphenyl)ureaIC50300.0 [1]
1-[(2R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]-4-oxobutan-2-yl]-3-[3-(1-methyltetrazol-5-yl)phenyl]ureaIC500.2 [1], 4.2 [2]
1-[3-Ethyl-5-(1-methyltetrazol-5-yl)phenyl]-3-[(2R,3S)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-3-hydroxybutan-2-yl]ureaIC500.01 [1], 1.8 [2]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(2-methylphenyl)ureaIC501.6 [1], 100.0 [2]
1-(4-Bromophenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC506.0 [1], 50.0 [2]
1-(4-Chloro-1,3-benzothiazol-2-yl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC500.09 [1], 4.0 [2]
1-[(1R,2S)-2-[[3-(4-Fluorophenyl)propyl-methylamino]methyl]cyclohexyl]-3-[3-(1-methyltetrazol-5-yl)phenyl]ureaIC500.6 [1]
1-(4-Fluorophenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC505.0 [1], 50.0 [2]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(4-methoxyphenyl)ureaIC501.0 [1], 2.0 [2]
1-(3-Acetylphenyl)-3-[(1R,2S)-2-[[(3R)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC500.36 [1], 2.5 [2]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-[4-(1-methyltetrazol-5-yl)phenyl]ureaIC500.25 [1], 0.7 [2]
1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-3-phenyl-ureaIC502.5 [1], 17.0 [2]
1-(3-Fluoro-4-methylphenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC504.0 [1], 35.0 [2]
1-{3-[4-(4-Chloro-benzyl)-piperidin-1-yl]-propyl}-3-(3-cyano-phenyl)-ureaIC5020.0 [1], 200.0 [2]
Tert-butyl 2-[[4-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-4-[(3-methoxyphenyl)carbamoyl]piperazine-1-carboxylateIC5040.0 [1], 200.0 [2]
2-[[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]-N-(3-methoxyphenyl)morpholine-4-carboxamideIC5050.0 [1], 220.0 [2]
3-[[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]-N-(3-methoxyphenyl)piperazine-1-carboxamideIC5030.0 [1], 140.0 [2]
3-[[4-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]-N-(3-methoxyphenyl)piperidine-1-carboxamideIC5050.0 [1], 820.0 [2]
1-[(2S,3S)-1-[3-[(4-Chlorophenyl)methyl]-8-azabicyclo[3.2.1]octan-8-yl]-3-hydroxybutan-2-yl]-3-(3-methylsulfonylphenyl)ureaIC504.4 [1], 12.0 [2]
1-[(2R)-1-[3-[(4-Chlorophenyl)methyl]-8-azabicyclo[3.2.1]octan-8-yl]propan-2-yl]-3-(3-methylsulfonylphenyl)ureaIC5012.0 [1], 65.0 [2]
1-[(2R)-1-[3-[(4-Chlorophenyl)methyl]-8-azabicyclo[3.2.1]octan-8-yl]propan-2-yl]-3-(3,4,5-trimethoxyphenyl)ureaIC504.7 [1], 11.0 [2]
1-[(2S,3S)-1-[3-[(4-Chlorophenyl)methyl]-8-azabicyclo[3.2.1]octan-8-yl]-3-hydroxybutan-2-yl]-3-(3,4,5-trimethoxyphenyl)ureaIC502.4 [1], 8.2 [2]
1-(3-Acetyl-phenyl)-3-[2-(4-fluoro-benzyl)-piperidin-1-yl]-ureaIC502.6 [1], 71.0 [2]
N-[[1-[1-[(3,4-Dichlorophenyl)methyl]piperidin-4-yl]piperidin-3-yl]methyl]quinoline-6-carboxamideIC50136.0 [1]
N-[[1-[1-[(3,4-Dichlorophenyl)methyl]piperidin-4-yl]piperidin-3-yl]methyl]quinoline-6-carboxamideKi23.0 [1]
1-(3-Cyano-4-pyrazol-1-ylcyclohexa-2,4-dien-1-yl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]ureaIC502.0 [1], 4.0 [2]
1-[(1R,2S)-2-[[3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(1H-indol-5-yl)ureaIC501.9 [1], 2.1 [2]
1-[(1R,2S)-2-[[3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(1H-indazol-5-yl)ureaIC502.3 [1], 23.0 [2]
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4R)-3-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-4-yl]ureaIC500.1 [1], 1.9 [2]
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]piperidin-3-yl]ureaIC500.07 [1], 2.1 [2]
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(3S,4S)-4-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]-1,1-dioxothiolan-3-yl]ureaIC500.9 [1], 1.2 [2]
1-[3-Ethyl-5-(1-methyltetrazol-5-yl)phenyl]-3-[(2R,3S)-4-[3-(4-fluorophenyl)propyl-methylamino]-3-hydroxybutan-2-yl]ureaIC500.3 [1], 2.6 [2]
1-[(2R,3S)-4-[Cyclopropylmethyl-[3-(4-fluorophenyl)propyl]amino]-3-hydroxybutan-2-yl]-3-[3-ethyl-5-(1-methyltetrazol-5-yl)phenyl]ureaIC500.01 [1], 0.6 [2]
1-[(2R,3S)-3-Hydroxy-4-[[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-methylamino]butan-2-yl]-3-[3-(1-methyltetrazol-5-yl)phenyl]ureaIC500.4 [1], 22.0 [2]
1-[(2R,3S)-4-[Ethyl-[3-(4-fluorophenyl)propyl]amino]-3-hydroxybutan-2-yl]-3-[3-ethyl-5-(1-methyltetrazol-5-yl)phenyl]ureaIC500.0 [1], 0.4 [2]
1-[3,5-Bis(1,2-oxazol-3-yl)phenyl]-3-[(2R,4R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]ureaIC500.1 [1], 1.1 [2]
1-(3,5-Diacetylphenyl)-3-[(2R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]ureaIC500.2 [1], 2.7 [2]
2-[3-[[(2R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]carbamoylamino]-5-(1-methyltetrazol-5-yl)phenyl]-2-methylpropanoic acidIC500.1 [1], 0.7 [2]
2-[3-[3-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]propylcarbamoylamino]-5-(1-methyltetrazol-5-yl)phenyl]-2-methylpropanoic acidIC500.3 [1], 1.1 [2]
1-[3-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]propyl]-3-[3-(1-methyltetrazol-5-yl)-5-propan-2-ylphenyl]ureaIC500.3 [1], 2.6 [2]
1-[(2R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]-3-[3-(1-methyltetrazol-5-yl)-5-propan-2-ylphenyl]ureaIC500.02 [1], 2.6 [2]
1-[3-Ethyl-5-(1-methyltetrazol-5-yl)phenyl]-3-[(2R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]ureaIC500.02 [1], 2.0 [2]
1-[(2R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]-3-[3-methyl-5-(1-methyltetrazol-5-yl)phenyl]ureaIC500.03 [1], 1.2 [2]
1-[(2R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]-3-[3-(1-methyltetrazol-5-yl)phenyl]ureaIC501.1 [1], 1.3 [2]
1-[(2R,4R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]-3-[3-(1-methylimidazol-2-yl)phenyl]ureaIC500.3 [1], 1.0 [2]
1-[3,5-Di(pyrazol-1-yl)phenyl]-3-[(2R,4R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]ureaIC500.05 [1], 2.6 [2]
1-[(2R,4R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]-3-[3-(1-methyltetrazol-5-yl)-5-propan-2-ylphenyl]ureaIC500.02 [1], 1.0 [2]
1-[3-Ethyl-5-(1-methyltetrazol-5-yl)phenyl]-3-[(2R,4R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]ureaIC500.01 [1], 1.8 [2]
1-[(2R,4R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]-3-[3-methyl-5-(1-methyltetrazol-5-yl)phenyl]ureaIC500.03 [1], 0.5 [2]
1-[3-Bromo-5-(1-methyltetrazol-5-yl)phenyl]-3-[(2R,4R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]ureaIC500.05 [1], 1.8 [2]
1-[(2R,4R)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]pentan-2-yl]-3-[3-(1-methyltetrazol-5-yl)phenyl]ureaIC500.06 [1], 1.8 [2]
1-(3,5-Diacetylphenyl)-3-[(2S,4S)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]ureaIC501.0 [1], 2.7 [2]
1-[(2R,4S)-4-(Dimethylamino)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]-3-[3-ethyl-5-(1-methyltetrazol-5-yl)phenyl]ureaIC500.03 [1], 0.5 [2]
1-[(2S)-4-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]butan-2-yl]-3-[3-(1-methyltetrazol-5-yl)phenyl]ureaIC501.0 [1], 4.0 [2]
1-(3,5-Diacetylphenyl)-3-[(2R,4R)-4-[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]-4-hydroxybutan-2-yl]ureaIC500.06 [1], 0.8 [2]
[(1R,3R)-1-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]-3-[[3-(1-methyltetrazol-5-yl)phenyl]carbamoylamino]butyl] N-methylcarbamateIC500.5 [1], 0.87 [2]
1-[(3R)-1-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]hexan-3-yl]-3-[3-(2-hydroxypropan-2-yl)-5-(1-methyltetrazol-5-yl)phenyl]ureaIC500.01 [1], 1.5 [2]
1-[(3R)-1-[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]pentan-3-yl]-3-[3-(2-hydroxypropan-2-yl)-5-(1-methyltetrazol-5-yl)phenyl]ureaIC500.1 [1], 2.4 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ C-C chemokine receptor type 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/c-c-chemokine-receptor-type-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ C-C chemokine receptor type 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/c-c-chemokine-receptor-type-3-inhibitors-ic50-ki.
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