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C-C motif chemokine 5 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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[(3As,6aR)-2-[3-(3-fluorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC50500.0 [1]
[(3As,6aR)-2-[3-(1-cyclopentylsulfonylpiperidin-4-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5023.0 [1]
[(3As,6aR)-2-[3-[1-(2,2-difluoroethyl)piperidin-4-yl]-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5027.0 [1]
[(3As,6aR)-2-[3-[1-(2,2-difluoroethyl)piperidin-4-yl]-3-(3,5-difluorophenyl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5025.0 [1]
Methyl 4-[3-[(3aS,6aR)-5-(4,6-dimethylpyrimidine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-phenylpropyl]piperidine-1-carboxylateIC50102.0 [1]
[(3As,6aR)-2-[3-(1-cyclopropylsulfonylpiperidin-4-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5027.0 [1]
[(3As,6aR)-2-[3-phenyl-3-(1-propan-2-ylsulfonylpiperidin-4-yl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5047.0 [1]
[(3As,6aR)-2-[3-[1-(2,2-difluoroethyl)piperidin-4-yl]-3-(3-fluorophenyl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5035.0 [1]
[(3As,6aR)-2-[3-(1-cyclopropylsulfonylazetidin-3-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5040.0 [1]
[(3As,6aR)-2-[3-phenyl-3-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5017.0 [1]
5-[(3As,6aR)-2-[3-(1-methylsulfonylpiperidin-4-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]-4,6-dimethylpyran-2-oneIC5027.0 [1]
[(3As,6aR)-2-[3-(1-cyclopentylsulfonylazetidin-3-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5022.0 [1]
1-[4-[3-[(3As,6aR)-5-(4,6-dimethylpyrimidine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-phenylpropyl]piperidin-1-yl]propan-1-oneIC5032.0 [1]
1-[4-[3-[(3Ar,6aS)-5-(4,6-dimethylpyrimidine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-phenylpropyl]piperidin-1-yl]-2-methylpropan-1-oneIC5072.0 [1]
5-[(3As,6aR)-2-[3-(1-methylsulfonylpiperidin-4-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]-4,6-dimethylpyridine-2-carbonitrileIC5031.0 [1]
[(3As,6aR)-2-[3-(1-methylsulfonylazetidin-3-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5052.0 [1]
CID 52947038IC5039.0 [1]
CID 52947044IC5035.0 [1]
1-[3-[3-[(3As,6aR)-5-(4,6-dimethylpyrimidine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-phenylpropyl]azetidin-1-yl]-3-methylbutan-1-oneIC50500.0 [1]
CID 52947741IC50500.0 [1]
[(3As,6aR)-2-[3-phenyl-3-(1-propan-2-ylsulfonylazetidin-3-yl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5023.0 [1]
[(3As,6aR)-2-[3-(1-ethylsulfonylpiperidin-4-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5025.0 [1]
[(3As,6aR)-2-[3-(1-methylsulfonylpiperidin-4-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC50500.0 [1]
1-[4-[3-[(3Ar,6aS)-5-(4,6-dimethylpyrimidine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-phenylpropyl]piperidin-1-yl]-3-methylbutan-1-oneIC5068.0 [1]
4-[3-[(3As,6aR)-5-(4,6-dimethylpyrimidine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-phenylpropyl]-N-propan-2-ylpiperidine-1-carboxamideIC50500.0 [1]
[(3As,6aR)-2-[3-phenyl-3-[1-(2,2,2-trifluoroethylsulfonyl)piperidin-4-yl]propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5048.0 [1]
[3-[3-[(3Ar,6aS)-5-(4,6-dimethylpyrimidine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-phenylpropyl]azetidin-1-yl]-cyclopentylmethanoneIC50207.0 [1]
[(3As,6aR)-2-[3-[1-(benzenesulfonyl)piperidin-4-yl]-3-(3-fluorophenyl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(4,6-dimethylpyrimidin-5-yl)methanoneIC5038.0 [1]
4-[(3Ar,6aS)-2-[3-(1-methylsulfonylpiperidin-4-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]sulfonyl-3-chlorobenzonitrileIC50215.0 [1]
[(3Ar,6aS)-2-[3-(1-methylsulfonylpiperidin-4-yl)-3-phenylpropyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-(2-chloro-6-methylphenyl)sulfonylmethanoneIC50104.0 [1]
Items per page: 1 - 10 of 30
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References

This online tool may be cited as follows

MLA

"Quest Database™ C-C motif chemokine 5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/c-c-motif-chemokine-5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ C-C motif chemokine 5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/c-c-motif-chemokine-5-inhibitors-ic50-ki.
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