cAMP-dependent protein kinase alpha-catalytic subunit Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	1.5 [1], 1.58 [2], 2.3 [3]
	H-89 Dihydrochloride	IC50	100.0 [1], 850.0 [2]
	(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide	IC50	54.0 [1]
	2-(3-Methoxyphenyl)-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamide	Ki	1400.0 [1], 2500.0 [2]
	N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide	IC50	14.0 [1], 82.0 [2]
	Nvp-aew541	IC50	10000.0 [1]
	Entrectinib	IC50	10000.0 [1]
	Balanol	IC50	50.0 [1]
	2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one	IC50	10000.0 [1]
	Milciclib	IC50	10000.0 [1]
	1-Tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	500.0 [1]
	Amg-458	IC50	100000.0 [1]
	Pha-793887	IC50	10000.0 [1]
	Acrylophenone	IC50	100000.0 [1]
	(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione	IC50	10000.0 [1]
	(S)-1-(4-(1H-Pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol	IC50	10.0 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	Pyrimidone, 22	IC50	100000.0 [1]
	2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one	IC50	100000.0 [1]
	4-(1-Ethyl-1H-benzimidazol-2-yl)-1,2,5-oxadiazol-3-amine	Ki	960.0 [1]
	N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide	IC50	100000.0 [1]
	[3-[[4-(Aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamate	IC50	1.0 [1]
	4-(1-Methyl-1H-benzoimidazol-2-yl)-furazan-3-ylamine	Ki	4000.0 [1]
	2-(4-Methoxyphenyl)-N-(4-(pyridin-4-yl)thiazol-2-yl)acetamide	Ki	5000.0 [1]
	8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	IC50	10000.0 [1]
	(11R,15R,17R)-17-Methyl-12,16-dioxatetracyclo[8.7.0.03,8.011,15]heptadeca-1(10),3,5,7-tetraene-2,9,13-trione	IC50	100000.0 [1]
	5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamide	IC50	10000.0 [1]
	2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide	IC50	10000.0 [1]
	(7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one	IC50	4000.0 [1]
	Khk-IN-1	IC50	40000.0 [1]
	cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol	IC50	780.0 [1]
	7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine	IC50	10000.0 [1]
	4-(1-Isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine	Ki	3300.0 [1]
	3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamide	IC50	332.0 [1]
	1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanone	IC50	100000.0 [1]
	CID 24832012	Ki	1850.0 [1]
	(2S,3S,4R,5R)-N-[6-[[(2R)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide	IC50	2600.0 [1]
	(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide	IC50	5.32 [1]
	(2S,3S,4R,5R)-N-[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide	IC50	109.0 [1]
	N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamide	IC50	5.5 [1]
	4-[1-(Cyclopropylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine	Ki	380.0 [1]
	2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-one	IC50	10000.0 [1]
	2-[2,6-Dihydroxy-4-[(3R,4R)-3-[(4-hydroxybenzoyl)amino]oxepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid	IC50	450.0 [1]
	2-[2,6-Dihydroxy-4-[(3S,4R)-3-[(4-hydroxybenzoyl)amino]thiepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid	IC50	7500.0 [1]
	2-[2,6-Dihydroxy-4-[[(3R,4R)-3-[(4-hydroxybenzoyl)amino]-1-azabicyclo[3.2.2]nonan-4-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acid	IC50	1700.0 [1]
	4-(1-(Cyclobutylmethyl)-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine	Ki	1400.0 [1]
	4-(1-Cyclopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine	Ki	3300.0 [1]
	4-(1-Phenyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine	Ki	1300.0 [1]
	2-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)benzonitrile	Ki	5000.0 [1]
	4-(1-Cyclohexyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine	Ki	600.0 [1]
	2-[4-[(1R,2R,4S)-4-(Aminomethyl)-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acid	IC50	170.0 [1]
	2-Fluoro-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]benzamide	Ki	5000.0 [1]
	N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3,5-difluorobenzamide	IC50	10000.0 [1]
	2-[2,6-Dihydroxy-4-[(1R,2R,4S)-2-[(4-hydroxybenzoyl)amino]-4-(hydroxymethyl)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid	IC50	230.0 [1]
	2-[4-[(1R,2R,4R)-4-Amino-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acid	IC50	50.0 [1]
	2-[2,6-Dihydroxy-4-[(1R,2R,4R)-4-hydroxy-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid	IC50	250.0 [1]
	2-[2,6-Dihydroxy-4-[(1R,2R,4R)-2-[(4-hydroxybenzoyl)amino]-4-(hydroxymethyl)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid	IC50	220.0 [1]
	2-[2,6-Dihydroxy-4-[(3S,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid	IC50	5200.0 [1]
	2-[2,6-Dihydroxy-4-[(3S,4R)-3-[(4-hydroxybenzoyl)amino]-1,1-dioxothiepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid	IC50	38000.0 [1]
	2-[4-[(1R,2R,4R)-4-(Aminomethyl)-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acid	IC50	90.0 [1]
	2-[(2R,3R)-3-Hydroxy-5-oxooxolan-2-yl]naphthalene-1,4-dione	IC50	430.0 [1]
	4-(1-Isobutyl-4-phenyl-1H-imidazol-2-yl)-1,2,5-oxadiazol-3-amine	Ki	1200.0 [1]
	4-(1-Isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxadiazol-3-amine	Ki	3300.0 [1]
	2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-isobutyl-1H-imidazole-4-carbonitrile	Ki	3300.0 [1]
	3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-ol	IC50	10000.0 [1]
	5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(2H-tetrazol-5-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amine	Ki	4000.0 [1]
	[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]phosphonic acid	Ki	4000.0 [1]
	2-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethylphosphonic acid	Ki	4000.0 [1]
	2-[[(2R,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]methyl]-1,2,4-oxadiazolidine-3,5-dione	Ki	4000.0 [1]
	3-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-2H-1,2-oxazol-5-one	Ki	590.0 [1]
	N-[[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]sulfonyl]acetamide	Ki	4000.0 [1]
	5-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-1,2-oxazol-3-one	Ki	4000.0 [1]
	(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-sulfonamide	Ki	490.0 [1]
	1-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethane-1,2-diol	Ki	230.0 [1]
	5-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-1,2-dihydropyrazol-3-one	Ki	4000.0 [1]
	(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-methylbicyclo[2.2.2]octane-2-carboxamide	Ki	4000.0 [1]
	1-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethanol	Ki	4000.0 [1]
	5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(3-methyl-1,2,4-oxadiazol-5-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amine	Ki	1100.0 [1]
	5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(5-methyl-1,3,4-oxadiazol-2-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amine	Ki	4000.0 [1]
	5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-methylsulfonyl-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amine	Ki	1500.0 [1]
	2-(4-Chloro-1,3-benzodioxol-5-yl)-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	Ki	310.0 [1]
	2-(3-Methoxyphenyl)-N-(3-pyridin-4-yl-1,2,4-thiadiazol-5-yl)acetamide	Ki	500.0 [1]
	2-(Benzylamino)-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]-1,3-thiazol-4-ol	IC50	50.0 [1]
	3-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-4H-1,2,4-oxadiazol-5-one	Ki	4000.0 [1]
	1-Phenyl-4-methoxy-2-butene-1-one	IC50	100000.0 [1]
	2-Phenyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	Ki	3500.0 [1]
	N-[4-(2-Chloropyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide	Ki	3300.0 [1]
	2-(4-Fluorophenyl)-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamide	Ki	1580.0 [1]
	(2E)-2-[(3,4-Dihydroxyphenyl)methylidene]-1-benzofuran-3-one	IC50	100000.0 [1]
	2-[2,6-Dihydroxy-4-[[2-[(4-hydroxybenzoyl)amino]-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acid	IC50	50000.0 [1]
	2-[2,6-Dihydroxy-4-[[(8R,9R)-9-[(4-hydroxybenzoyl)amino]-8-tricyclo[5.2.1.02,6]decanyl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acid	IC50	32000.0 [1]
	Methyl (1S,3R,4R)-3-(6-aminopurin-9-yl)-4-hydroxycyclopentane-1-carboxylate	IC50	169824.37 [1]
	2-(4-Fluoroanilino)-5-[5-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxypyridin-2-yl]-3-methylpyrimidin-4-one	IC50	25000.0 [1]
	2-(3-Methoxyphenyl)-N-[4-[2-(methylamino)pyridin-4-yl]-1,3-thiazol-2-yl]acetamide	Ki	3300.0 [1]
	2-(3-Methoxyphenyl)-N-[4-(2-methylpyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Ki	3300.0 [1]
	N-[4-(2-Fluoropyridin-4-yl)thiophen-2-yl]-2-(3-methoxyphenyl)acetamide	Ki	780.0 [1]
	N-[4-(2-Chloropyridin-4-yl)thiophen-2-yl]-2-(3-methoxyphenyl)acetamide	Ki	2200.0 [1]
	N-[4-(2-Chloropyridin-4-yl)thiophen-2-yl]-2-[3-(methanesulfonamido)phenyl]acetamide	Ki	3300.0 [1]
	N-[4-(2-Aminopyridin-4-yl)thiophen-2-yl]-2-(3-methoxyphenyl)acetamide	Ki	140.0 [1]
	N-[4-(2-Fluoropyridin-4-Yl)thiophen-2-Yl]-2-{3-[(Methylsulfonyl)amino]phenyl}acetamide	Ki	3000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ cAMP-dependent protein kinase alpha-catalytic subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/camp-dependent-protein-kinase-alpha-catalytic-subunit-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ cAMP-dependent protein kinase alpha-catalytic subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/camp-dependent-protein-kinase-alpha-catalytic-subunit-inhibitors-ic50-ki.
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