cAMP-dependent protein kinase (PKA) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Staurosporine	IC50	6.5 [1]
	Arcyriaflavin a	IC50	2000.0 [1], 60000.0 [2]
	6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one	IC50	2000.0 [1], 25700.0 [2]
	Ellagic acid	IC50	600.0 [1], 3500.0 [2]
	N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	IC50	73.0 [1], 1200.0 [2]
	Alvocidib	IC50	50000.0 [1], 960000.0 [2]
	Seliciclib	IC50	1000000.0 [1]
	N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide	IC50	500000.0 [1]
	(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine	IC50	2.1 [1]
	(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine	IC50	38.0 [1]
	1-(5-Isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride	IC50	3500.0 [1]
	1-(5-Isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride	Ki	3000.0 [1]
	4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	IC50	100000.0 [1]
	N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine	IC50	500000.0 [1]
	N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	IC50	500000.0 [1]
	N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamide	IC50	500000.0 [1]
	Indolocarbazole deriv. 4b	IC50	2000.0 [1]
	Indolocarbazole deriv. 4c	IC50	2000.0 [1]
	2-Methoxy-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	IC50	500000.0 [1]
	N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]naphthalene-2-carboxamide	IC50	100000.0 [1]
	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-3-hydroxy-2-[3-[2-(isoquinolin-5-ylsulfonylamino)ethylamino]propanoylamino]propanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoic acid	IC50	3.0 [1]
	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-3-hydroxy-2-[3-[2-(isoquinolin-5-ylsulfonylamino)ethylamino]propanoylamino]propanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoic acid	Ki	4.0 [1]
	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-2-(isoquinolin-5-ylsulfonylamino)propanoyl]amino]propanoyl]amino]propanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoic acid	IC50	300.0 [1]
	(2S)-5-(Diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-2-(isoquinolin-5-ylsulfonylamino)propanoyl]amino]propanoyl]amino]propanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoyl]amino]pentanoic acid	Ki	170.0 [1]
	4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide	IC50	100000.0 [1]
	2-[2,6-Dihydroxy-4-[(3R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acid	IC50	60.0 [1], 80.0 [2]
	3-[(11R,15R)-13-Methyl-1,13-diazatetracyclo[7.7.0.02,7.011,15]hexadeca-2,4,6,8-tetraen-8-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;hydrochloride	IC50	2800.0 [1], 5500.0 [2]
	Imatinib	IC50	500000.0 [1]
	4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole	IC50	50000.0 [1]
	Bisindolylmaleimide i	IC50	20000.0 [1]
	Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-	Ki	5000.0 [1]
	Fasudil	Ki	460.0 [1]
	9H-Pyrido[3,4-B]indole	IC50	25000.0 [1]
	2,4'-Dibromoacetophenone	IC50	100000.0 [1]
	Vatalanib	IC50	10000.0 [1]
	Bisindolylmaleimide IV	IC50	2000.0 [1]
	Olomoucine	IC50	2000000.0 [1]
	4'-N-Benzoylstaurosporine	IC50	2400.0 [1]
	(2S,3R,4R,6R,18S)-18-Hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	IC50	42.0 [1]
	(2R,3S,4S,6S,18R)-18-Hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	IC50	1150.0 [1]
	Saracatinib	IC50	10000.0 [1]
	Hydroxyfasudil	Ki	2200.0 [1]
	2-Bromoacetophenone	IC50	100000.0 [1]
	Doramapimod	IC50	20000.0 [1]
	Minaprine	IC50	100000.0 [1]
	Purvalanol B	IC50	3800.0 [1]
	(S)-2-Methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine	Ki	340.0 [1]
	Purvalanol A	IC50	9000.0 [1]
	3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione	IC50	223375.0 [1]
	Bisindolylmaleimide xi, HCl	IC50	5900.0 [1]
	N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide	IC50	25000.0 [1]
	N-(2-Aminoethyl)isoquinoline-5-sulfonamide	IC50	2000.0 [1]
	3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione	IC50	1200.0 [1]
	Balanol	Ki	4.7 [1]
	Azd-1152hqpa	Ki	10000.0 [1]
	9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-	IC50	335000.0 [1]
	PDGF Receptor Tyrosine Kinase Inhibitor IV	IC50	100000.0 [1]
	A-674563	Ki	16.0 [1]
	2-Bromo-4'-chloroacetophenone	IC50	100000.0 [1]
	4-(1H-Indol-3-yl)pyrimidin-2-amine	IC50	120000.0 [1]
	CID 6918852	Ki	5000.0 [1]
	1-(5-Isoquinolinesulfonyl)piperazine	IC50	6000.0 [1]
	A-770041	IC50	25000.0 [1]
	Cdk4 Inhibitor	IC50	20000.0 [1]
	3-(2-Aminopyrimidin-4-yl)-1H-indol-4-ol	IC50	11000.0 [1]
	2,4'-Dichloroacetophenone	IC50	100000.0 [1]
	4-(5-Bromo-1H-indol-3-yl)pyrimidin-2-amine	IC50	700.0 [1]
	JNK Inhibitor VIII	Ki	7500.0 [1]
	(5-Oxo-5,6-dihydro-indolo[1,2-A]quinazolin-7-YL)-acetic acid	IC50	16000.0 [1]
	Bms-509744	IC50	50000.0 [1]
	2-Bromo-4'-methoxyacetophenone	IC50	100000.0 [1]
	N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide	IC50	10000.0 [1]
	PDGF Receptor Tyrosine Kinase Inhibitor III	IC50	30000.0 [1]
	5-[(2S)-2-Methylpiperazin-1-yl]sulfonylisoquinoline	IC50	3000.0 [1]
	2-Bromo-4'-phenylacetophenone	IC50	100000.0 [1]
	[3-[[4-(Aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamate	IC50	1.0 [1]
	2-[(5,6-Diphenylfuro[2,3-D]pyrimidin-4-YL)amino]ethanol	IC50	200000.0 [1]
	N'-(Pyrrolidino[2,1-B]isoindolin-4-ON-8-YL)-N-(pyridin-2-YL)urea	IC50	20000.0 [1]
	4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amine	IC50	1500.0 [1]
	CID 9916282	IC50	100000.0 [1]
	Meridianin D	IC50	1000.0 [1]
	4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amine	IC50	24000.0 [1]
	[4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amine	Ki	1000.0 [1]
	14-Hydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-12-one	IC50	34000.0 [1]
	3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide	IC50	27000.0 [1]
	2-Chloro-1-(4,5-dibromo-2-thiophenyl)ethanone	IC50	100000.0 [1]
	4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide	IC50	30000.0 [1]
	Meridianin F	IC50	3200.0 [1]
	3-(2-Aminopyrimidin-4-yl)-6-bromo-1H-indol-4-ol	IC50	210.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	7500.0 [1]
	N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide	IC50	30000.0 [1]
	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	IC50	50000.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	7500.0 [1]
	Eudistomin N	IC50	25000.0 [1]
	3-(4-Morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol;hydrochloride	IC50	3400.0 [1]
	8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrile	IC50	100000.0 [1]
	2-Chloro-1-(3,4-dibromo-2-thienyl)-1-ethanone	IC50	100000.0 [1]
	4-[(4-Methyl-1-piperazinyl)methyl]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide	IC50	475000.0 [1]
	3-Methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione	IC50	20000.0 [1]
	3-[[5-[6-[(3-Chlorophenyl)amino]pyrazinyl]-3-pyridinyl]amino]-1-propanol	IC50	10000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ cAMP-dependent protein kinase (PKA) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/camp-dependent-protein-kinase-pka-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, May 9). Quest Database™ cAMP-dependent protein kinase (PKA) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/camp-dependent-protein-kinase-pka-inhibitors-ic50-ki.
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