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Casein kinase I epsilon Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
PF-670462 free baseIC508.0 [1], 29.0 [2], 32.0 [3], 80.0 [4], 130.0 [5]
3-[(3-Chlorophenoxy)methyl]-1-(Tetrahydro-2h-Pyran-4-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-4-AmineIC5032.0 [1]
Bischof-5IC50199.0 [1]
N-(2,2-Difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-2-[[2-(trifluoromethoxy)benzoyl]amino]-1,3-thiazole-4-carboxamideIC50190.0 [1], 210.0 [2]
N-(2,2-Difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-3-methoxybenzamideIC50160.0 [1], 520.0 [2]
Chir-99021IC505000.0 [1]
N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-YL)ureaIC50100000000.0 [1]
3-[(2,4,6-Trimethoxy-phenyl)-methylene]-indolin-2-oneIC501000.0 [1]
(3Z)-3-[(2,4,6-Trimethoxyphenyl)methylidene]-1H-indol-2-oneIC50600.0 [1]
CID 2155128IC504030.0 [1]
CID 53396311IC505000.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amineIC50260.0 [1]
2-[[3-(4-Fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamideIC5010000.0 [1]
2-[[3-(2-Methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamideIC507070.0 [1]
CID 9957049IC5010000.0 [1]
2-[(3-Benzyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamideIC507340.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-fluorobenzonitrileIC50100000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-[(4-Oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetamideIC504120.0 [1]
N-(2,2-Difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-2-(dimethylamino)pyridine-4-carboxamideIC50420.0 [1]
N-(2,2-Difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-2-methoxypyridine-4-carboxamideIC5010000.0 [1]
N-(2,2-Difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-3-(2H-tetrazol-5-yl)benzamideIC50620.0 [1]
N-(2,2-Difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-3-(difluoromethoxy)benzamideIC50320.0 [1]
N-(2,2-Difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-5-methoxypyridine-3-carboxamideIC50990.0 [1]
N-(5-Chloro-6-fluoro-1H-benzimidazol-2-yl)-2-[[2-(trifluoromethoxy)benzoyl]amino]-1,3-thiazole-4-carboxamideIC5032.6 [1]
3-(3-Chlorophenoxy)-1-(piperidin-4-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amineIC50100.0 [1]
3-(3-Chlorophenoxy)-1-[(3,3-difluoropiperidin-4-yl)methyl]pyrazolo[3,4-d]pyrimidin-4-amineIC50100.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amineIC501145.0 [1]
N-[(6-Methoxy-1H-benzimidazol-2-yl)methyl]-2-piperazin-1-yl-9-pyridin-3-ylpurin-6-amineIC501765.0 [1]
N-[(6-Methoxy-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amineIC50975.0 [1]
6-N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-N-(3-morpholin-4-ylpropyl)purine-2,6-diamineIC501310.0 [1]
6-N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)purine-2,6-diamineIC50170.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(4-fluorophenyl)-2-morpholin-4-ylpurin-6-amineIC50395.0 [1]
2-[(3-Benzyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetamideIC501410.0 [1]
9-(3-Fluorophenyl)-2-morpholin-4-yl-N-[(5-phenyl-1H-imidazol-2-yl)methyl]purin-6-amineIC50280.0 [1]
9-(3-Fluorophenyl)-N-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]methyl]-2-morpholin-4-ylpurin-6-amineIC5054.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-(1,1-dioxo-1,4-thiazinan-4-yl)-9-(3-fluorophenyl)purin-6-amineIC50370.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(2,4-difluorophenyl)-2-morpholin-4-ylpurin-6-amineIC50250.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-(2-methylpyridin-4-yl)purin-6-amineIC50385.0 [1]
6-N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-N-(2-morpholin-4-ylethyl)purine-2,6-diamineIC501230.0 [1]
N-(1H-Benzimidazol-2-ylmethyl)-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amineIC502095.0 [1]
6-N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-N-(oxan-4-ylmethyl)purine-2,6-diamineIC50375.0 [1]
[1-[6-[(4,5-Difluoro-1H-benzimidazol-2-yl)methylamino]-9-(3-fluorophenyl)purin-2-yl]piperidin-4-yl]methanolIC5050.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-[4-(methylamino)piperidin-1-yl]purin-6-amineIC50655.0 [1]
N-[(5,6-Dichloro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amineIC50320.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(2-methylpyridin-4-yl)-2-morpholin-4-ylpurin-6-amineIC50245.0 [1]
N-[(5,6-Dichloro-1H-benzimidazol-2-yl)methyl]-2-piperazin-1-yl-9-pyridin-3-ylpurin-6-amineIC50255.0 [1]
2-[[3-[(2,3-Dimethoxyphenyl)methyl]-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetamideIC501230.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-2-ylpurin-6-amineIC501905.0 [1]
N-(1H-Benzimidazol-2-ylmethyl)-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amineIC502955.0 [1]
N-[(5,6-Difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amineIC50340.0 [1]
2-N-Butyl-6-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)purine-2,6-diamineIC502010.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(2-fluoropyridin-4-yl)-2-morpholin-4-ylpurin-6-amineIC50245.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-thiophen-3-ylpurin-6-amineIC50125.0 [1]
N-[(5,6-Dichloro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amineIC50105.0 [1]
N-[(6-Chloro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amineIC50630.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-4-ylpurin-6-amineIC50385.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-4-ylpurin-6-amineIC50315.0 [1]
N-[(5,6-Difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amineIC50660.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-2-ylpurin-6-amineIC50860.0 [1]
9-(3-Fluorophenyl)-N-(1H-imidazol-2-ylmethyl)-2-morpholin-4-ylpurin-6-amineIC50205.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(2-methylphenyl)-2-morpholin-4-ylpurin-6-amineIC50135.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(2,5-difluorophenyl)-2-morpholin-4-ylpurin-6-amineIC5016.0 [1]
N-(1H-Benzimidazol-2-ylmethyl)-2-piperazin-1-yl-9-pyridin-3-ylpurin-6-amineIC501840.0 [1]
9-(6-Chloropyridin-3-yl)-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-ylpurin-6-amineIC501195.0 [1]
N-[(6-Methoxy-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amineIC50335.0 [1]
2-[[6-[(4,5-Difluoro-1H-benzimidazol-2-yl)methylamino]-9-(3-fluorophenyl)purin-2-yl]amino]ethanolIC50205.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(2-fluoropyridin-4-yl)-2-(4-methylpiperazin-1-yl)purin-6-amineIC50660.0 [1]
N-(1,3-Benzoxazol-2-ylmethyl)-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amineIC50150.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3,4-difluorophenyl)-2-morpholin-4-ylpurin-6-amineIC50990.0 [1]
1-[6-[(4,5-Difluoro-1H-benzimidazol-2-yl)methylamino]-9-(3-fluorophenyl)purin-2-yl]piperidin-4-oneIC50265.0 [1]
N-[(6-Chloro-1H-benzimidazol-2-yl)methyl]-2-piperazin-1-yl-9-pyridin-3-ylpurin-6-amineIC50915.0 [1]
9-(3-Fluorophenyl)-2-morpholin-4-yl-N-[(4-phenyl-1,3-oxazol-2-yl)methyl]purin-6-amineIC5010000.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-thiophen-3-ylpurin-6-amineIC50105.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-thiomorpholin-4-ylpurin-6-amineIC50310.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-methoxypiperidin-1-yl)purin-6-amineIC50205.0 [1]
N-[(6-Chloro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amineIC50715.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-ethyl-2-morpholin-4-ylpurin-6-amineIC506560.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3,5-difluorophenyl)-2-morpholin-4-ylpurin-6-amineIC50145.0 [1]
2-[[3-[(4-Methoxyphenyl)methyl]-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]acetamideIC50560.0 [1]
6-N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-N-(1-methylpiperidin-4-yl)purine-2,6-diamineIC50305.0 [1]
9-(3-Fluorophenyl)-N-[[4-(4-methylpiperazin-1-yl)phenyl]methyl]-2-morpholin-4-ylpurin-6-amineIC50380.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-[2-(trifluoromethyl)phenyl]purin-6-amineIC50175.0 [1]
9-(6-Chloropyridin-3-yl)-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)purin-6-amineIC50860.0 [1]
9-(3-Fluorophenyl)-2-morpholin-4-yl-N-[(4-phenyl-1,3-thiazol-2-yl)methyl]purin-6-amineIC5010000.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-methyl-2-morpholin-4-ylpurin-6-amineIC5010000.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-9-(2,3-difluorophenyl)-2-morpholin-4-ylpurin-6-amineIC5080.0 [1]
N-[(4,5-Difluoro-1H-benzimidazol-2-yl)methyl]-2-[4-(dimethylamino)piperidin-1-yl]-9-(3-fluorophenyl)purin-6-amineIC501200.0 [1]
4-[1-Methyl-3-(4-fluorophenyl)-1H-pyrazole-4-yl]pyridineIC50305.0 [1]
2-[(4-Phenylphenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazoleIC50100000.0 [1]
2-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrileIC50100000.0 [1]
2-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrileIC50100000.0 [1]
(E)-3-(2,4-Dimethoxyphenyl)-N-[4-[5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-4-yl]pyridin-2-yl]prop-2-enamideIC5073.0 [1]
(E)-3-(2,4-Dimethoxyphenyl)-N-[4-[5-(4-fluorophenyl)-2-methylsulfinyl-1H-imidazol-4-yl]pyridin-2-yl]prop-2-enamideIC50447.0 [1]
3-[4-[3-(4-Fluorophenyl)-1-methylpyrazol-4-yl]pyridin-2-yl]morpholineIC5028.2 [1]
1-[(4-Methoxyphenyl)methyl]-3-[6-(2H-tetrazol-5-yl)-1,3-benzothiazol-2-yl]ureaIC5015300000.0 [1]
1-[(4-Methoxyphenyl)methyl]-3-[4-(2H-tetrazol-5-yl)pyridin-2-yl]ureaIC50100000000.0 [1]
1-[(4-Methoxyphenyl)methyl]-3-(6-nitro-1,3-benzothiazol-2-yl)ureaIC50100000000.0 [1]
1-(4-Cyanopyridin-2-yl)-3-[(4-methoxyphenyl)methyl]ureaIC50100000000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Casein kinase I epsilon Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 9 May. 2024, https://www.aatbio.com/data-sets/casein-kinase-i-epsilon-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 9). Quest Database™ Casein kinase I epsilon Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/casein-kinase-i-epsilon-inhibitors-ic50-ki.
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