 | 4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine | Ki | 112.0 [1], 133.0 [2] |
 | 4,5,6,7-Tetrabromobenzimidazole | Ki | 270.0 [1], 343.0 [2] |
 | 4,5,6,7-Tetraiodo-1H-benzimidazole | Ki | 21.0 [1], 71.0 [2] |
 | [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid | Ki | 21.0 [1], 66.0 [2] |
 | 4-[2-[(4-Methoxyphenyl)carbonylamino]-1,3-Thiazol-5-Yl]benzoic Acid | IC50 | 11.0 [1], 46.0 [2] |
 | ((4,5,6,7-Tetrabromo-1H-benzimidazol-2-yl)sulfanyl)-acetic acid | Ki | 37.0 [1], 49.0 [2] |
 | 4,5,6,7-Tetrabromo-N,N,1-trimethylbenzimidazol-2-amine | Ki | 35.0 [1], 109.0 [2] |
 | 2-[(4,5,6,7-Tetraiodo-1H-benzimidazol-2-yl)sulfanyl]acetic acid | Ki | 78.0 [1], 106.0 [2] |
 | 2-(4,5,6,7-Tetraiodobenzimidazol-1-yl)acetic acid | Ki | 62.0 [1], 324.0 [2] |
 | (4,5,6,7-Tetrabromo-1h-Benzimidazol-1-Yl)acetic Acid | Ki | 342.0 [1], 609.0 [2] |
 | 5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide | IC50 | 10000.0 [1] |
 | 4-[(4,5,6,7-Tetrabromo-1H-benzimidazol-2-yl)sulfanyl]butanoic acid | Ki | 44.0 [1], 88.0 [2] |
 | 4-(4,5,6,7-Tetrabromobenzimidazol-1-yl)butyric acid | Ki | 188.0 [1], 195.0 [2] |
 | 4-[4,5,6,7-Tetrabromo-2-(dimethylamino)benzimidazol-1-yl]butanoic acid | Ki | 93.0 [1], 139.0 [2] |
 | 3-[(4,5,6,7-Tetrabromo-1H-benzimidazol-2-yl)sulfanyl]propanoic acid | Ki | 31.0 [1], 35.0 [2] |
 | 3-(4,5,6,7-Tetrabromo-1-methylbenzimidazol-2-yl)sulfanylpropanoic acid | Ki | 55.0 [1], 100.0 [2] |
 | 4-(4,5,6,7-Tetrabromo-1-methylbenzimidazol-2-yl)sulfanylbutanoic acid | Ki | 83.0 [1], 768.0 [2] |
 | 2-(4,5,6,7-Tetrabromo-1-methylbenzimidazol-2-yl)sulfanylacetic acid | Ki | 24.0 [1], 200.0 [2] |
 | Silmitasertib | IC50 | 11.0 [1] |
 | (2e)-3-{3-[6-(4-Methyl-1,4-Diazepan-1-Yl)pyrazin-2-Yl]phenyl}prop-2-Enoic Acid | IC50 | 701.0 [1] |
 | (1-{6-[6-(Cyclopentylamino)-1h-Indazol-1-Yl]pyrazin-2-Yl}-1h-Pyrrol-3-Yl)acetic Acid | IC50 | 190.0 [1] |
 | Unii-7N5LJ2Z26C | IC50 | 2.7 [1] |
 | N-[5-(4-Nitrophenyl)-1,3,4-thiadiazol-2-yl]acetamide | IC50 | 32200.0 [1] |
 | N-[2-[2-Aminoethyl(methyl)amino]-5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]phenyl]acetamide | IC50 | 3000.0 [1] |
 | 6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one | IC50 | 10000.0 [1] |
 | N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]phenyl]acetamide | IC50 | 4000.0 [1] |
 | 5-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]pyridine-2-carboxylic acid | IC50 | 4.6 [1] |
 | 6-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxylic acid | IC50 | 10.0 [1] |
 | 4-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]naphthalene-1-carboxylic acid | IC50 | 280.0 [1] |
 | 4-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]-3-phenoxybenzoic acid | IC50 | 10.0 [1] |
 | 4-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]-3-phenylmethoxybenzoic acid | IC50 | 12.0 [1] |
 | 4-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]-3-(phenoxymethyl)benzoic acid | IC50 | 12.0 [1] |
 | 4-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]-3-(2-phenylethoxy)benzoic acid | IC50 | 11.0 [1] |
 | 3-[(2-Chlorophenyl)methoxy]-4-[2-[(4-methoxybenzoyl)amino]-1,3-thiazol-5-yl]benzoic acid | IC50 | 9.8 [1] |
 | 3-[(3-Chlorophenyl)methoxy]-4-[2-[(4-methoxybenzoyl)amino]-1,3-thiazol-5-yl]benzoic acid | IC50 | 160.0 [1] |
 | 3-[(4-Chlorophenyl)methoxy]-4-[2-[(4-methoxybenzoyl)amino]-1,3-thiazol-5-yl]benzoic acid | IC50 | 19.0 [1] |
 | 3-[(2-Bromophenyl)methoxy]-4-[2-[(4-methoxybenzoyl)amino]-1,3-thiazol-5-yl]benzoic acid | IC50 | 14.0 [1] |
 | 4-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]-3-[(2-methoxyphenyl)methoxy]benzoic acid | IC50 | 13.0 [1] |
 | 3-[(2-Cyanophenyl)methoxy]-4-[2-[(4-methoxybenzoyl)amino]-1,3-thiazol-5-yl]benzoic acid | IC50 | 11.0 [1] |
 | 4-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]-3-(pyridin-2-ylmethoxy)benzoic acid | IC50 | 9.5 [1] |
 | 6-[2-[(4-Methoxybenzoyl)amino]-1,3-thiazol-5-yl]pyridazine-3-carboxylic acid | IC50 | 9.6 [1] |
 | 3-[(2-Fluorophenyl)methoxy]-4-[2-[(4-methoxybenzoyl)amino]-1,3-thiazol-5-yl]benzoic acid | IC50 | 8.8 [1] |
 | 4-[5-(4-Methoxybenzoylamino)-1,3,4-oxadiazole-2-yl]benzoic acid | IC50 | 32000.0 [1] |
 | 4-[3-(4-Methoxybenzoylamino)-1H-pyrazole-5-yl]benzoic acid | IC50 | 63.0 [1] |
 | 4-[5-(4-Methoxybenzoylamino)-thiazole-2-yl]benzoic acid | IC50 | 25000.0 [1] |
 | 4-(5-Acetamido-1,3,4-thiadiazol-2-yl)benzoic acid | IC50 | 5300.0 [1] |
 | 4-[5-(Benzoylamino)-1,3,4-thiadiazole-2-yl]benzoic acid | IC50 | 3300.0 [1] |
 | 4-[5-[(4-Fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 1700.0 [1] |
 | 4-[5-(4-Methoxybenzoylamino)-1,3,4-thiadiazole-2-yl]benzoic acid | IC50 | 1200.0 [1] |
 | 4-[5-(Thiophene-2-carbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 5800.0 [1] |
 | 4-[5-(Furan-2-carbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 1800.0 [1] |
 | 4-[5-(2-Hydroxyacetamido)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 2800.0 [1] |
 | 4-[5-(2-Methoxyacetamido)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 4300.0 [1] |
 | 4-[5-(Cyclopropanecarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 1600.0 [1] |
 | 4-[5-[[(E)-2-Methylbut-2-enoyl]amino]-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 2900.0 [1] |
 | 4-[5-(2-Methoxyethoxycarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 4300.0 [1] |
 | 4-[5-(Prop-2-enoxycarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 2700.0 [1] |
 | 4-[5-(Propoxycarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 3000.0 [1] |
 | 4-[5-(Propan-2-yloxycarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 8200.0 [1] |
 | 4-[5-(Butoxycarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 3100.0 [1] |
 | 4-[5-(2-Methylpropoxycarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 5700.0 [1] |
 | 4-[5-(Pentoxycarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 2400.0 [1] |
 | 4-[5-(Hexoxycarbonylamino)-1,3,4-thiadiazol-2-yl]benzoic acid | IC50 | 2100.0 [1] |
 | 4-Amino-N-[4-[(2-hydroxy-2-methylpropanoyl)amino]cyclohexyl]-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 2.7 [1] |
 | 4-Amino-7-(2-fluoropyridin-4-yl)-N-(4-hydroxycyclohexyl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 50.0 [1] |
 | Ethyl N-[4-[[4-amino-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carbonyl]amino]cyclohexyl]carbamate | IC50 | 2.8 [1] |
 | 4-Amino-N-[4-[(2,2-dimethyl-3-pyrrolidin-1-ylpropanoyl)amino]cyclohexyl]-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 3.7 [1] |
 | 4-Amino-N-[4-(hydroxymethyl)cyclohexyl]-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 3.4 [1] |
 | 4-Amino-N-(4-hydroxycyclohexyl)-7-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 50.0 [1] |
 | 4-Amino-N-(3-aminopropyl)-N-methyl-7-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 810.0 [1] |
 | 4-Amino-7-(2-methoxypyridin-4-yl)-N-[(3S)-oxolan-3-yl]pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 2.2 [1] |
 | 4-[[4-Amino-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carbonyl]amino]cyclohexane-1-carboxylic acid | IC50 | 3.6 [1] |
 | 4-Amino-N-[4-[(3-hydroxy-3-methylbutanoyl)amino]cyclohexyl]-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 50.0 [1] |
 | 4-Amino-N-[(3R)-1-(1-aminocyclopropanecarbonyl)piperidin-3-yl]-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 2.5 [1] |
 | 4-Amino-N-[4-(2,2-dimethylpropoxy)cyclohexyl]-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 50.0 [1] |
 | [4-Amino-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-(4-hydroxypiperidin-1-yl)methanone | IC50 | 560.0 [1] |
 | 4-Amino-N-[4-[[1-(aminomethyl)cyclopropanecarbonyl]amino]cyclohexyl]-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 3.6 [1] |
 | 4-Amino-7-pyridin-4-yl-N-(2-pyridin-2-ylethyl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 50.0 [1] |
 | N-(4-Acetamidocyclohexyl)-4-amino-7-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 50.0 [1] |
 | 4-Amino-N-(4-aminocyclohexyl)-7-[2-(2-hydroxyethyl)pyridin-4-yl]pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 330.0 [1] |
 | 4-Amino-7-(4-carbamoyl-3-methoxyphenyl)-N-(4-hydroxycyclohexyl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 790.0 [1] |
 | 4-Amino-N-(oxan-4-yl)-7-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 60.0 [1] |
 | 4-Amino-7-(3-carbamoylphenyl)-N-(4-hydroxycyclohexyl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 1000.0 [1] |
 | 4-Amino-N-(4-aminocyclohexyl)-7-(2-propan-2-yloxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 700.0 [1] |
 | 4-Amino-N-[3-(methylamino)propyl]-7-pyridin-4-ylpyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 380.0 [1] |
 | 4-Amino-N-[(4-hydroxycyclohexyl)methyl]-7-(2-methoxypyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide | IC50 | 3.2 [1] |
 | 2-[2-Chloro-5-cyano-3-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)anilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 0.87 [1] |
 | 2-[2-Chloro-5-cyano-3-[4-(oxolan-3-yl)piperazin-1-yl]anilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 0.2 [1] |
 | 2-[2-Chloro-5-cyano-3-[4-(2,2-difluoroethylamino)piperidin-1-yl]anilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 153.6 [1] |
 | 2-[2-Chloro-5-cyano-3-[3-(3-methylsulfonylpyrrolidin-1-yl)azetidin-1-yl]anilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 0.11 [1] |
 | Methyl N-[(3R,4R)-1-[2-chloro-5-cyano-3-[[7-cyano-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]-3-hydroxypiperidin-4-yl]carbamate | IC50 | 0.27 [1] |
 | Oxetan-3-yl N-[(3R,4R)-1-[2-chloro-5-cyano-3-[[7-cyano-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]-3-hydroxypiperidin-4-yl]carbamate | IC50 | 0.26 [1] |
 | 2-[2-Chloro-5-cyano-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)anilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 0.23 [1] |
 | 2-[3-[1-[(3R,4R)-4-Amino-3-[tert-butyl(dimethyl)silyl]oxycyclohexyl]piperidin-4-yl]-2-chloro-5-cyanoanilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 8.18 [1] |
 | 2-[3-(1-Acetylpiperidin-4-yl)-2-chloro-5-cyanoanilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 0.16 [1] |
 | Methyl N-[(3S,4R)-1-[2-chloro-3-[[7-cyano-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazin-2-yl]amino]-5-(difluoromethyl)phenyl]-4-methoxypyrrolidin-3-yl]carbamate | IC50 | 1.17 [1] |
 | 2-[2-Chloro-5-(difluoromethyl)-3-[4-(1-methylazetidin-3-yl)piperazin-1-yl]anilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 0.47 [1] |
 | 2-[2-Chloro-5-(difluoromethyl)-3-[4-(3-methyloxetan-3-yl)piperazin-1-yl]anilino]-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 0.75 [1] |
 | 2-[2-Chloro-5-cyano-3-[4-(oxetan-3-yl)piperazin-1-yl]anilino]-4-(ethylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 0.23 [1] |
 | 2-(5-Cyano-4-fluoro-2-piperidin-4-yloxyanilino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile | IC50 | 2.75 [1] |
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