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Caspase-2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-3-(2,2-dimethylpropyl)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5050.0 [1], 2360.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5041.0 [1], 1690.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5086.0 [1], 1120.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(1S)-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5022.0 [1], 2260.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-3-butan-2-yloxy-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50413.0 [1], 50000.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-1,3-dihydroisoindol-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50150.0 [1], 781.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[7-bromo-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50573.0 [1], 3110.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3-(2-methylpropoxy)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50453.0 [1], 32000.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3-propan-2-yloxypiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5052800.0 [1], 100000.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5046.0 [1], 1334.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[6-hydroxy-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC501980.0 [1], 12823.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[6-bromo-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50163.0 [1], 7470.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-3-cyclopentyloxy-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50772.0 [1], 35667.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3-pyrimidin-2-yloxypyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50219.0 [1], 17400.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC502190.0 [1], 100000.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3R)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3-phenylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50441.0 [1], 50000.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3R)-3-cyclohexyl-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50136.0 [1], 13607.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5041.0 [1], 635.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-6-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5050.0 [1], 6670.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3R)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3-(4-methylphenyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC501600.0 [1], 65000.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3-methoxypyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50108.0 [1], 1940.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[(2S,3S)-2-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3-propan-2-yloxypyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50246.0 [1], 12600.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[7-hydroxy-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50459.0 [1], 23567.0 [2]
(3S)-3-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-7-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC5060.0 [1], 5533.0 [2]
Isoquinoline-1,3,4(2H)-trioneIC501530.0 [1]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneKi4900.0 [1]
Caspase-3/7 Inhibitor IKi25000.0 [1]
Isatin Sulfonamide 34Ki4000.0 [1]
Grassystatin AIC505000.0 [1]
1-Methyl-5-nitroindoline-2,3-dioneKi50000.0 [1]
N'-(2-Methoxyphenyl)-N-(1,3,4-trioxoisoquinolin-6-yl)butanediamideIC50537.0 [1]
5-(Pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi50000.0 [1]
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi11000.0 [1]
1-Benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dioneKi25000.0 [1]
Inhibitor 62bKi30000.0 [1]
3-Chloro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)propanamideIC50530.0 [1]
3-[(1,3,4-Trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)carbamoyl]propanoic acidIC50859.0 [1]
Phenyl[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)carbamoyl]methyl acetateIC50233.0 [1]
4-Oxo-4-piperidin-1-yl-N-(1,3,4-trioxo-1,2,3,4-tetrahydro-isoquinolin-6-yl)-butyramideIC50231.0 [1]
N-(1,2,3,4-Tetrahydro-1,3,4-trioxoisoquinolin-7-yl)-4-nitrobenzamideIC505670.0 [1]
5-[[5-[[(2S)-1-Carboxy-4-(2-chlorophenyl)sulfanyl-3-oxobutan-2-yl]carbamoyl]pyridin-2-yl]methylsulfamoyl]-2-hydroxybenzoic acidKi11000.0 [1]
3-[2-[5-Tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-5-[hexyl(methyl)amino]-4-oxopentanoic acid;hydrochlorideIC5010.0 [1]
Inhibitor 47cKi30000.0 [1]
(3S)-3-[4-(3-Carboxy-4-hydroxyphenylsulfonylaminomethyl)benzoylamino]-4-oxobutanoic acidKi9000.0 [1]
CID 5327304Ki960.0 [1]
Inhibitor 64bKi16000.0 [1]
Inhibitor 66aKi21000.0 [1]
Inhibitor 66bKi64000.0 [1]
Inhibitor 69bKi37000.0 [1]
(E,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-3-Carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-2-phenylacetyl]amino]-3-methylbutanoyl]amino]-6-ethoxy-6-oxohex-4-enoic acidIC50100000.0 [1]
(E,3S)-3-[[(2S)-1-[(2S)-2-[[(2S)-3-Carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-3,3-dimethylbutanoyl]azetidine-2-carbonyl]amino]-5-methylsulfonylpent-4-enoic acidIC5013100.0 [1]
(E,3S)-3-[[(2S,3S)-2-[[(2S)-5-Amino-2-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-5-methylsulfonylpent-4-enoic acidIC50100000.0 [1]
(E,3S)-3-[[(2S,3S)-2-[[(2S)-5-Amino-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-5-methylsulfonylpent-4-enoic acidIC50100000.0 [1]
(E,3S)-3-[[(2S)-1-[(2R)-2-[(4-Amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-5-methylsulfonylpent-4-enoic acidIC50100000.0 [1]
5-[(2S)-2-(Anilinomethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dioneKi6500.0 [1]
3-[2-[5-Tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-5-[methyl(pentyl)amino]-4-oxopentanoic acidIC5010.0 [1]
Items per page: 1 - 10 of 56
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References

This online tool may be cited as follows

MLA

"Quest Database™ Caspase-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/caspase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Caspase-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/caspase-2-inhibitors-ic50-ki.
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