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Cathepsin L Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
[2-(Cyclohexylamino)-1-[(2S,3R)-3-heptyloxiran-2-yl]-2-oxoethyl] 4-iodobenzoateIC507170.0 [1]
[2-(Cyclohexylamino)-1-[(2S,3R)-3-heptyloxiran-2-yl]-2-oxoethyl] 4-iodobenzoateKi1330.0 [1]
e-64IC5013.0 [1], 16.0 [2], 30.0 [3], 47.0 [4]
e-64Ki30.0 [1]
BalicatibIC5048.0 [1], 503.0 [2]
BalicatibKi503.0 [1], 3260.0 [2], 18000.0 [3]
(2R)-N-(Cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamideIC50320.0 [1], 2600.0 [2], 3725.0 [3]
(2R)-N-(Cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamideKi4641.0 [1]
L-873724IC50264.0 [1], 1221.0 [2]
N-(1-((Cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamideIC50340.0 [1], 3903.0 [2], 6300.0 [3]
N-(1-((Cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamideKi6000.0 [1]
N-[(2S)-1-[2-(4-Methoxyanilino)ethylamino]-4-methyl-1-oxopentan-2-yl]-3-methylbenzamideIC5032.0 [1]
N-[(2S)-1-[2-(4-Methoxyanilino)ethylamino]-4-methyl-1-oxopentan-2-yl]-3-methylbenzamideKi7.0 [1], 7.2 [2], 26.0 [3]
Morpholine-4-carboxylic acid (1-(3-benzenesulfonyl-1-phenethylallylcarbamoyl)-3-methylbutyl)-amideIC503.0 [1], 5.7 [2], 7.0 [3]
Benzyl N-[(2S)-4-methyl-1-[3-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-4-oxopyrrolidin-1-yl]-1-oxopentan-2-yl]carbamateKi39.0 [1]
(2S)-N-(Cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-piperazin-1-ylphenyl)phenyl]ethyl]amino]pentanamideIC5016.0 [1], 47.0 [2]
Benzyl 1-((cyanomethyl)carbamoyl)cyclohexylcarbamateKi5000.0 [1], 26500.0 [2], 95000.0 [3]
5-Tert-butyl-N-[(2S)-1-(cyanomethylamino)-3-(3-methylphenyl)-1-oxopropan-2-yl]-2-methylpyrazole-3-carboxamideIC5012.59 [1], 44.0 [2]
N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamideKi2.2 [1]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamideIC5010000.0 [1], 24000.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamideKi74000.0 [1]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamideIC5010000.0 [1], 32000.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamideKi50000.0 [1]
N-[(2S)-1-[(3As,6R,6aR)-6-ethynyl-3-oxo-3a,5,6,6a-tetrahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxopentan-2-yl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamideKi2000.0 [1], 3000.5 [2]
N-[(2S)-1-[(3As,6R,6aR)-6-ethynyl-3-oxo-3a,5,6,6a-tetrahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxopentan-2-yl]-4-[5-fluoro-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamideKi1700.0 [1], 3000.5 [2]
LeupeptinIC502.5 [1], 6.6 [2]
OdanacatibIC502995.0 [1], 4843.0 [2]
RelacatibIC502.0 [1]
RelacatibKi0.07 [1]
Z-FY-ChoIC500.85 [1]
Z-FY-ChoKi0.47 [1]
Pyrrolidine-1-carbonitrileIC501584.89 [1], 4000.0 [2]
CID 44572423Ki8400.0 [1]
Cathepsin inhibitor 1IC5012.59 [1]
1,3-Bis[[n-[(phenylmethoxy)carbonyl]-l-leucyl]amino]-2-propanoneKi340.0 [1]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-piperazin-1-ylphenyl)benzamideIC502274.0 [1]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-piperazin-1-ylphenyl)benzamideKi7900.0 [1]
N-[(2S)-3-Cyclohexyl-1-[2-(4-methoxyanilino)ethylamino]-1-oxopropan-2-yl]-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamideKi17000.0 [1], 17400.0 [2]
(2S)-N-[(1S)-1-Cyano-2-phenylethyl]-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamideIC5067.0 [1], 117.0 [2]
Tert-butyl N-[(2S)-1-[2-[2-(2-ethylanilino)-2-oxoethyl]sulfanylcarbonylhydrazinyl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamateIC5056.0 [1]
(2S)-1-Phenylpropan-2-yl [(2S)-1-oxohexan-2-yl]carbamateIC50740.0 [1]
CID 44572421Ki5900.0 [1]
(2S)-N-(Cyanomethyl)-4-methyl-2-[[4-(4-piperazin-1-ylphenyl)thiophen-3-yl]amino]pentanamideIC50352.0 [1]
1-(Phenylmethyl)cyclopentyl[(1S)-1-formylpentyl]carbamateIC502000.0 [1]
N-[1-[[(2S)-1-Oxo-1-(5-phenyl-1,3,4-oxadiazol-2-yl)pentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi19000.0 [1]
N-[1-[[(2S)-1-(5-Ethyl-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi300.0 [1]
N-[1-[[(2S)-1-[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi37000.0 [1]
N-[1-[[(2S)-1-Oxo-1-[5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]pentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi1400.0 [1]
Benzyl N-[(2S)-4-methyl-1-oxo-1-[[3-oxo-1-(4-phenoxyphenyl)sulfonylpiperidin-4-yl]amino]pentan-2-yl]carbamateKi1000.0 [1]
Benzyl N-[(2S)-4-methyl-1-[4-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-oxopiperidin-1-yl]-1-oxopentan-2-yl]carbamateKi16.0 [1]
Pyridin-3-ylmethyl N-[(2S)-4-methyl-1-oxo-1-[[(3S)-2-oxo-5-phenyl-1-(3-phenylpropylsulfanyl)pentan-3-yl]amino]pentan-2-yl]carbamateKi144.4 [1]
(2R)-N-(1-Cyanocyclopropyl)-3-(cyclopropylmethylsulfonyl)-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propanamideIC5062.0 [1], 188.0 [2]
N-[(2S)-3-Naphthalen-2-yl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]propan-2-yl]naphthalene-1-carboxamideKi0.43 [1]
Benzyl N-[(2S)-1-[[(2S)-4-fluoro-3-oxo-1-phenylbutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC5083.7 [1], 510.0 [2]
N-[1-[[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi1000.0 [1]
N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-cyclohexylethyl]thiophene-3-carboxamideIC5010000.0 [1], 20000.0 [2]
N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-(4-methylcyclohexyl)ethyl]thiophene-3-carboxamideIC5015000.0 [1], 20000.0 [2]
CID 16108900IC501.1 [1], 1100.0 [2]
(2R)-N-(1-Cyanocyclopropyl)-3-methylsulfonyl-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propanamideIC50230.0 [1], 1013.0 [2]
(2R)-2-[[(1S)-1-(4-Bromophenyl)-2,2,2-trifluoroethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfonylpropanamideIC50427.0 [1], 430.0 [2]
6-[[4-(4-Acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)pyrrolo[2,3-d]pyrimidine-2-carbonitrileIC504000.0 [1], 5200.0 [2]
Benzyloxycarbonyl-leucyl-methionine-HIC505.0 [1]
Benzyloxycarbonyl-leucyl-methionine-HKi1.3 [1]
N-[(2S)-3-(3-Chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl]benzamideIC50251.19 [1]
N-[1-[[(2S)-1-(5-Methoxy-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi160.0 [1]
N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-[2-(3-pyridin-2-ylphenyl)acetyl]azepan-4-yl]amino]pentan-2-yl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamideKi0.49 [1], 1.2 [2]
6-(Cyclohexylamino)-9-[2-(4-methylpiperazin-1-YL)-ethyl]-9H-purine-2-carbonitrileIC5089.0 [1]
[(E)-[(3-Bromophenyl)-(3-hydroxyphenyl)methylidene]amino]thioureaIC50131.4 [1]
[(E)-[(3-Bromophenyl)-(3-hydroxyphenyl)methylidene]amino]thioureaKi3.7 [1]
(1R,2R)-N-(Cyanomethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamideIC5010000.0 [1], 100000.0 [2]
(1r,2r)-N-(1-Cyanocyclopropyl)-2-{[4-(4-Fluorophenyl)piperazin-1-Yl]carbonyl}cyclohexanecarboxamideIC5010000.0 [1], 100000.0 [2]
(3S)-19-Chloro-N-(1-cyanocyclopropyl)-5-oxo-9-(trifluoromethyl)-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(20),6(11),7,9,18,21-hexaene-3-carboxamideIC5050.0 [1]
(3S)-19-Chloro-N-(1-cyanocyclopropyl)-5-oxo-9-(trifluoromethyl)-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(20),6(11),7,9,18,21-hexaene-3-carboxamideKi10.0 [1]
(2R)-N'-Hydroxy-2-(2-methylpropyl)-N-[(2S)-1-oxo-1-[[(2S)-1-oxopropan-2-yl]amino]-3-phenylpropan-2-yl]butanediamideIC5015.0 [1], 25.0 [2]
[(E)-[(3,5-Dibromophenyl)-(3-hydroxyphenyl)methylidene]amino]thioureaIC50202.0 [1]
[(E)-[(3,5-Dibromophenyl)-(3-hydroxyphenyl)methylidene]amino]thioureaKi8.4 [1]
4-[1,3-Benzodioxol-5-ylmethyl-[4-(trifluoromethyl)cyclohexyl]amino]-5-fluoropyrimidine-2-carbonitrileKi3500.0 [1], 5100.0 [2]
N-(Cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamideKi155000.0 [1]
(2S,3R)-N-[(2R)-1-(1H-Indol-3-yl)-3-oxopropan-2-yl]-3-methyl-2-(naphthalen-1-ylsulfonylamino)pentanamideIC501.9 [1], 2.0 [2]
2-(4-Butylphenyl)-1H-quinolin-4-oneIC501600.0 [1]
2-(4-Butylphenyl)-1H-quinolin-4-oneKi1500.0 [1]
3-Phenylmethoxy-10H-acridin-9-oneIC503900.0 [1]
3-Phenylmethoxy-10H-acridin-9-oneKi900.0 [1]
2-Nitro-7-phenylmethoxy-10H-acridin-9-oneIC50500.0 [1]
2-Nitro-7-phenylmethoxy-10H-acridin-9-oneKi200.0 [1]
3-(3-Methoxy-4-phenylmethoxyanilino)naphthalene-2-carboxylic acidIC502100.0 [1]
3-(3-Methoxy-4-phenylmethoxyanilino)naphthalene-2-carboxylic acidKi1900.0 [1]
3-(3-Nitro-4-phenylmethoxyanilino)naphthalene-2-carboxylic acidIC502900.0 [1]
3-(3-Nitro-4-phenylmethoxyanilino)naphthalene-2-carboxylic acidKi1900.0 [1]
(3S,14E)-19-Chloro-N-(1-cyanocyclopropyl)-5-oxo-9-(trifluoromethyl)-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(20),6(11),7,9,14,18,21-heptaene-3-carboxamideIC5047.7 [1]
(3S,14E)-19-Chloro-N-(1-cyanocyclopropyl)-5-oxo-9-(trifluoromethyl)-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(20),6(11),7,9,14,18,21-heptaene-3-carboxamideKi2.4 [1]
(3S)-23-Chloro-N-(1-cyanocyclopropyl)-5-oxo-16,21-dioxa-4-azatetracyclo[20.2.2.06,15.08,13]hexacosa-1(24),6(15),7,13,22,25-hexaene-3-carboxamideIC5013.0 [1]
(3S)-23-Chloro-N-(1-cyanocyclopropyl)-5-oxo-16,21-dioxa-4-azatetracyclo[20.2.2.06,15.08,13]hexacosa-1(24),6(15),7,13,22,25-hexaene-3-carboxamideKi3.0 [1]
[(E)-[[3-(3-Methylbenzoyl)phenyl]-(3-methylphenyl)methylidene]amino]thioureaIC50654.0 [1], 7823.0 [2]
[(E)-[[3-(4-Propan-2-yloxybenzoyl)phenyl]-(4-propan-2-yloxyphenyl)methylidene]amino]thioureaIC5010000.0 [1]
N-[(2S)-1-(Cyanomethylamino)-3-cyclohexyl-1-oxopropan-2-yl]benzamideIC5055.0 [1], 230.0 [2]
N-[(2S)-1-[(6R)-6-Ethynyl-3-oxo-3a,5,6,6a-tetrahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxopentan-2-yl]-3-fluoro-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamideKi750.5 [1], 1400.0 [2]
Ethyl acetateIC5010000.0 [1]
PepstatinIC50800.0 [1]
TelaprevirIC503500.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cathepsin L Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/cathepsin-l-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Cathepsin L Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cathepsin-l-inhibitors-ic50-ki.
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