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Cathepsin S Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
BalicatibIC502900.0 [1], 65000.0 [2]
BalicatibKi28000.0 [1], 30100.0 [2], 65000.0 [3]
(2R)-N-(Cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamideIC501340.0 [1], 2010.0 [2], 20000.0 [3]
(2R)-N-(Cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamideKi1695.0 [1]
L-873724IC5095.0 [1], 178.0 [2]
1-Methyl-6-[4-(2-piperidin-4-ylethoxy)-3-(trifluoromethyl)phenyl]imidazo[4,5-c]pyridine-4-carbonitrileIC508.0 [1], 8.3 [2], 9.0 [3]
6-[4-[3-(Dimethylamino)propoxy]-3-(trifluoromethyl)phenyl]-1-methylimidazo[4,5-c]pyridine-4-carbonitrileIC5032.0 [1], 41.0 [2], 84.0 [3]
N-(1-((Cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamideIC50790.0 [1], 10000.0 [2], 47000.0 [3]
N-(1-((Cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamideKi47000.0 [1]
4-Propyl-6-(3-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrileIC5041.0 [1], 60.0 [2]
N-[(2S)-1-[2-(4-Methoxyanilino)ethylamino]-4-methyl-1-oxopentan-2-yl]-3-methylbenzamideIC5070.0 [1]
N-[(2S)-1-[2-(4-Methoxyanilino)ethylamino]-4-methyl-1-oxopentan-2-yl]-3-methylbenzamideKi62.0 [1], 68.0 [2]
N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamideIC5080.0 [1]
N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamideKi4.0 [1], 4.3 [2]
[1-[5-Carbamoyl-3-(4-iodophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(2-cyanophenyl)piperazin-1-yl]propan-2-yl] carbamateIC5010.0 [1], 20.0 [2], 800.0 [3]
1-[4-[2-[2-Chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]-N-[(4-chlorophenyl)methyl]methanamineIC50140.0 [1], 1500.0 [2]
5-Methylsulfonyl-3-[3-(2-piperidin-1-ylethylsulfanyl)-4-(trifluoromethyl)phenyl]-1-(3-piperidin-1-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridineIC50380.0 [1]
1-[1-[3-[5-Methylsulfonyl-3-[3-(2-piperidin-1-ylethylsulfanyl)-4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]pyrrolidin-2-oneIC5040.0 [1], 170.0 [2]
6-[4-[3-(4-Ethylpiperazin-1-yl)propoxy]-3-(trifluoromethyl)phenyl]-1-methylimidazo[4,5-c]pyridine-4-carbonitrileIC507.2 [1], 63.0 [2]
2-[3-[3-[2-(4-Fluoropiperidin-1-yl)ethylsulfanyl]-4-(trifluoromethyl)phenyl]-1-[(2S)-2-hydroxy-3-piperidin-1-ylpropyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoacetamideIC5070.0 [1], 190.0 [2]
1-Methyl-6-[4-[2-(2-oxopyrrolidin-1-yl)ethoxy]-3-(trifluoromethyl)phenyl]imidazo[4,5-c]pyridine-4-carbonitrileIC507.8 [1], 1420.0 [2]
N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-[2-(3-pyridin-2-ylphenyl)acetyl]azepan-4-yl]amino]pentan-2-yl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamideIC508.3 [1], 940.0 [2]
N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-[2-(3-pyridin-2-ylphenyl)acetyl]azepan-4-yl]amino]pentan-2-yl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamideKi8.3 [1], 14.0 [2]
OdanacatibIC5045.0 [1], 60.0 [2], 183.0 [3]
Morpholine-4-carboxylic acid (1-(3-benzenesulfonyl-1-phenethylallylcarbamoyl)-3-methylbutyl)-amideIC501.0 [1], 1.2 [2], 1.9 [3]
(2S)-N-(Cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-piperazin-1-ylphenyl)phenyl]ethyl]amino]pentanamideIC507.0 [1], 451.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamideIC5010000.0 [1], 27000.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamideKi13000.0 [1]
4-[1-[2-Hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-oneIC5010.0 [1], 28.0 [2], 800.0 [3]
N-[(2S)-1-[[(1R)-1-Cyano-2-phenylmethoxyethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]morpholine-4-carboxamideIC505.5 [1], 6.0 [2]
(2R)-N-(1-Cyanocyclopropyl)-3-(cyclopropylmethylsulfonyl)-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propanamideIC500.4 [1], 0.5 [2], 33.0 [3]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamideIC504800.0 [1], 52000.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamideKi42000.0 [1]
N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-cyclohexylethyl]thiophene-3-carboxamideIC5010.0 [1], 76.0 [2]
N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-cyclohexylethyl]thiophene-3-carboxamideKi18.0 [1]
N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-(4-methylcyclohexyl)ethyl]thiophene-3-carboxamideIC509.0 [1], 30.0 [2]
N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-(4-methylcyclohexyl)ethyl]thiophene-3-carboxamideKi15.0 [1]
1-[1-[3-[3-(3,4-Dichlorophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-3-methylbenzimidazol-2-oneIC5010.0 [1], 50.0 [2], 800.0 [3]
(2R)-N-(1-Cyanocyclopropyl)-3-methylsulfonyl-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propanamideIC501.8 [1], 2.5 [2], 5.0 [3]
N-[2-[5-[1-[2-Hydroxy-3-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanylethyl]-2-phenylacetamideIC50130.0 [1], 10000.0 [2]
2-(4-Ethoxy-3-(trifluoromethyl)phenyl)-9H-purine-6-carbonitrileIC503.9 [1], 10000.0 [2]
2-[4-[2-[4-(4-Cyano-1-methylimidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy]ethyl]piperidin-1-yl]-N,N-dimethylacetamideIC508.3 [1], 22.0 [2]
TelaprevirIC50300.0 [1], 100000.0 [2]
BoceprevirIC50120.0 [1], 100000.0 [2]
RelacatibIC508.0 [1]
RelacatibKi1.6 [1]
(1R,21S,24S)-21-Tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,7.06,11]heptacosa-6(11),7,9-triene-24-carboxamideIC5010000.0 [1], 78000.0 [2]
Benzyl (S)-1-cyanomethylcarbamoyl-3-methylbutylcarbamateKi130.0 [1], 143.0 [2]
Cathepsin inhibitor 1IC501000.0 [1]
[(2S)-3,3-Dimethyl-1-[3-[4-(trifluoromethyl)phenyl]pyrazol-1-yl]butan-2-yl] N-[(3S)-1,2-dioxo-1-(1H-pyrazol-5-ylamino)heptan-3-yl]carbamateIC500.21 [1], 210.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-piperazin-1-ylphenyl)benzamideIC5010000.0 [1]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-piperazin-1-ylphenyl)benzamideKi4900.0 [1]
N-[(2S)-3-Cyclohexyl-1-[2-(4-methoxyanilino)ethylamino]-1-oxopropan-2-yl]-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamideKi3.0 [1], 3.3 [2]
5-Tert-butyl-N-[(2S)-1-(cyanomethylamino)-3-(3-methylphenyl)-1-oxopropan-2-yl]-2-methylpyrazole-3-carboxamideIC50794.33 [1]
(2S)-N-(Cyanomethyl)-4-methyl-2-[[4-(4-piperazin-1-ylphenyl)thiophen-3-yl]amino]pentanamideIC50102.0 [1]
1-[3-[4-(2-Cyanophenyl)piperazin-1-yl]-2-hydroxypropyl]-3-(4-iodophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamideIC5050.0 [1]
N-[1-[[(2S)-1-Oxo-1-(5-phenyl-1,3,4-oxadiazol-2-yl)pentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi45000.0 [1]
N-[1-[[(2S)-1-(5-Ethyl-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi470.0 [1]
N-[1-[[(2S)-1-[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi20000.0 [1]
N-[1-[[(2S)-1-Oxo-1-[5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]pentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi3300.0 [1]
2-[4-[3-[5-Acetyl-3-(4-iodophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperazin-1-yl]benzonitrileIC50120.0 [1]
1-[1-[3-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropyl]-3-(4-chlorophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5020.0 [1], 1000.0 [2]
N-[(2S)-4-Methyl-1-oxo-1-[[(2S)-3-oxo-4-(pyridin-2-ylsulfonylamino)butan-2-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamideIC5020.0 [1]
N-[(2S)-4-Methyl-1-oxo-1-[[(2S)-3-oxo-4-(pyridin-2-ylsulfonylamino)butan-2-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamideKi20.0 [1]
N-[(2S)-3-Naphthalen-2-yl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]propan-2-yl]naphthalene-1-carboxamideKi15.6 [1]
N-[(2S)-1-[[(1R)-2-[(4-Chlorophenyl)methoxy]-1-cyanoethyl]amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamideIC509.0 [1], 27.0 [2]
N-[1-[[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi350.0 [1]
CID 16108900IC500.13 [1], 130.0 [2]
(2R)-2-[[(1S)-1-(4-Bromophenyl)-2,2,2-trifluoroethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfonylpropanamideIC5010.0 [1], 11.0 [2]
6-[[4-(4-Acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)pyrrolo[2,3-d]pyrimidine-2-carbonitrileIC509.0 [1]
N-[(2S)-3-(3-Chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl]benzamideIC50125.89 [1]
N-[1-[[(2S)-1-(5-Methoxy-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamideKi320.0 [1]
6-(4-Chlorobenzyl)-7-neopentyl-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrileIC50460.0 [1]
4-(3-Tert-butylphenyl)-6-propylpyrimidine-2-carbonitrileIC50191.0 [1]
4-(3-Cyclopentylphenyl)-6-propylpyrimidine-2-carbonitrileIC50155.0 [1]
4-(3-(Methylsulfonyl)phenyl)-6-propylpyrimidine-2-carbonitrileIC5093.0 [1]
4-Propyl-6-m-tolylpyrimidine-2-carbonitrileIC50950.0 [1], 1300.0 [2]
4-Phenyl-6-propylpyrimidine-2-carbonitrileIC5010000.0 [1]
4-Propyl-6-(2-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrileIC5010000.0 [1]
4-Propyl-6-(4-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrileIC501259.0 [1]
4-(4-Chloro-3-(trifluoromethyl)phenyl)-6-propylpyrimidine-2-carbonitrileIC5028.0 [1]
4-(4-Ethoxy-3-(trifluoromethyl)phenyl)-6-propylpyrimidine-2-carbonitrileIC506.0 [1]
6-(4-(2-(2-Oxopyrrolidin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)picolinonitrileIC5029.0 [1]
6-(4-Ethoxy-3-(trifluoromethyl)phenyl)picolinonitrileIC501660.0 [1]
6-(Cyclohexylamino)-9-[2-(4-methylpiperazin-1-YL)-ethyl]-9H-purine-2-carbonitrileIC50150.0 [1]
(1R,2R)-N-(Cyanomethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamideIC501030.0 [1]
(1r,2r)-N-(1-Cyanocyclopropyl)-2-{[4-(4-Fluorophenyl)piperazin-1-Yl]carbonyl}cyclohexanecarboxamideIC501258.93 [1], 1310.0 [2]
N-[(2S)-3-(1-Methylcyclohexyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]morpholine-4-carboxamideIC500.4 [1], 570.0 [2]
N-[(2S)-4,4-Dimethyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopentan-2-yl]furan-2-carboxamideIC501.3 [1], 4800.0 [2]
Ethyl 3-[1-[2-hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1H-indole-5-carboxylateIC5027.0 [1], 410.0 [2]
N-Ethyl-6-fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1-benzothiophene-2-carboxamideIC5037.0 [1], 1200.0 [2]
N-(2-Aminoethyl)-6-fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1-benzothiophene-2-carboxamideIC5047.0 [1], 5500.0 [2]
1-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[2,3-c]pyridin-3-yl)piperidin-1-yl]propan-2-olIC5030.0 [1], 38.0 [2]
1-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl]propan-2-olIC5027.0 [1], 860.0 [2]
1-[4-(5-Hydroxypyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl]-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propan-2-olIC50200.0 [1], 240.0 [2]
1-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[3,2-b]pyridin-3-yl)piperidin-1-yl]propan-2-olIC5095.0 [1], 120.0 [2]
1-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl]propan-2-olIC5077.0 [1], 150.0 [2]
6-Fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-N-(2-morpholin-4-ylethyl)-1-benzothiophene-2-carboxamideIC5039.0 [1], 340.0 [2]
1-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl]propan-2-olIC5025.0 [1], 58.0 [2]
N-[(2S)-3-(1-Methylcyclohexyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamideIC500.4 [1], 1400.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cathepsin S Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 10 May. 2024, https://www.aatbio.com/data-sets/cathepsin-s-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, May 10). Quest Database™ Cathepsin S Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cathepsin-s-inhibitors-ic50-ki.
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